Gustavo F Gonzales

Summary

Affiliation: Universidad Peruana Cayetano Heredia
Country: Peru

Publications

  1. pmc The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii)
    Gustavo F Gonzales
    Av Honorio Delgado 430, Lima 31, Peru
    Evid Based Complement Alternat Med 6:315-6. 2009
  2. doi request reprint Lepidium meyenii (Maca): a plant from the highlands of Peru--from tradition to science
    Gustavo F Gonzales
    Instituto de Investigaciones de la Altura, and Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Forsch Komplementmed 16:373-80. 2009
  3. pmc High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men
    Gustavo F Gonzales
    Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Alberto Cazorla Tálleri Universidad Peruana Cayetano Heredia, Ave Honorio Delgado 430, Lima 31, Peru
    Am J Physiol Endocrinol Metab 296:E1319-25. 2009
  4. doi request reprint Birth weight charts for gestational age in 63,620 healthy infants born in Peruvian public hospitals at low and at high altitude
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Acta Paediatr 98:454-8. 2009
  5. doi request reprint Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice
    G F Gonzales
    Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Andrologia 40:179-85. 2008
  6. doi request reprint Serum testosterone levels and score of chronic mountain sickness in Peruvian men natives at 4340 m
    G F Gonzales
    Universidad Peruana Cayetano Heredia, Lima, Peru
    Andrologia 43:189-95. 2011
  7. ncbi request reprint Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats
    Carla Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P O Box 1843, Lima, Peru
    J Ethnopharmacol 103:448-54. 2006
  8. ncbi request reprint Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats
    Sandra Yucra
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Lima, Peru
    Fertil Steril 89:1461-7. 2008
  9. ncbi request reprint Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats
    Francisco Chung
    Department of Biological and Physiological Sciences and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru
    J Ethnopharmacol 98:143-7. 2005
  10. ncbi request reprint Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats
    Julio Rubio
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Food Chem Toxicol 44:1114-22. 2006

Collaborators

Detail Information

Publications42

  1. pmc The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii)
    Gustavo F Gonzales
    Av Honorio Delgado 430, Lima 31, Peru
    Evid Based Complement Alternat Med 6:315-6. 2009
    ..We present evidence that MTCA is a natural constituent of Maca, and on consumption no toxicity is found. This suggests that, when consumed as multi-component, MTCA may loose its adversity as drug action...
  2. doi request reprint Lepidium meyenii (Maca): a plant from the highlands of Peru--from tradition to science
    Gustavo F Gonzales
    Instituto de Investigaciones de la Altura, and Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Forsch Komplementmed 16:373-80. 2009
    ..The exact mechanisms of action are still unclear, but so far research clearly indicates that various bioactive constituents contribute to the clinical effects reported...
  3. pmc High serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men
    Gustavo F Gonzales
    Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Alberto Cazorla Tálleri Universidad Peruana Cayetano Heredia, Ave Honorio Delgado 430, Lima 31, Peru
    Am J Physiol Endocrinol Metab 296:E1319-25. 2009
    ..In conclusion, high androgen activity could be involved in the etiopathogeny of CMS. This evidence provides an opportunity to develop new therapeutic strategies...
  4. doi request reprint Birth weight charts for gestational age in 63,620 healthy infants born in Peruvian public hospitals at low and at high altitude
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Acta Paediatr 98:454-8. 2009
    ..To construct distribution curves for birth weight, length and head circumference using a large sample of infants born at low (150 m) and high (3000-4400 m) altitude...
  5. doi request reprint Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice
    G F Gonzales
    Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Andrologia 40:179-85. 2008
    ..The reduction in prostatic stroma area by RM was 1.42 times. RM has an anti-hyperplastic effect on the prostate of adult mice when hyperplasia was induced with TE acting first at prostatic stromal level...
  6. doi request reprint Serum testosterone levels and score of chronic mountain sickness in Peruvian men natives at 4340 m
    G F Gonzales
    Universidad Peruana Cayetano Heredia, Lima, Peru
    Andrologia 43:189-95. 2011
    ..Some symptoms of CMS as sleep disorders and paraesthesia were more related to high serum T level; cyanosis was more related to higher haemoglobin values. In conclusion, higher serum T levels were associated to higher scores of CMS...
  7. ncbi request reprint Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats
    Carla Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P O Box 1843, Lima, Peru
    J Ethnopharmacol 103:448-54. 2006
    ..In conclusion, there were differences in the biological response of the three ecotypes of Maca (Yellow, Red and Black). Black Maca appeared to have more beneficial effect on sperm counts and epididymal sperm motility...
  8. ncbi request reprint Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats
    Sandra Yucra
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Lima, Peru
    Fertil Steril 89:1461-7. 2008
    ..To evaluate the effect of different fractions of Black Maca (Lepidium meyenii), obtained from the hydroalcoholic extract, on spermatogenesis...
  9. ncbi request reprint Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats
    Francisco Chung
    Department of Biological and Physiological Sciences and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru
    J Ethnopharmacol 98:143-7. 2005
    ..2 g dry Maca hypocotyls/kg...
  10. ncbi request reprint Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats
    Julio Rubio
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Food Chem Toxicol 44:1114-22. 2006
    ..Maca prevented LA-induced spermatogenic disruption in rats and it may become in a potential treatment of male infertility associated with lead exposure...
  11. ncbi request reprint Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia
    Gustavo F Gonzales
    Biological and Physiological Sciences, Cayetano Heredia University, Lima, Peru
    Asian J Androl 9:245-51. 2007
    ..To determine the effect of two different extracts of red maca in male rats...
  12. pmc Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice
    Julio Rubio
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    BMC Complement Altern Med 6:23. 2006
    ..Maca is a cultivated plant and different cultivars are described according to the color of the hypocotyls...
  13. doi request reprint High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes
    Gustavo F Gonzales
    Laboratory of Endocrinology and Reproduction, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Endocrine 40:472-80. 2011
    ..In conclusion, higher serum testosterone levels and Zn levels were associated with EE, and low scores of signs/symptoms of CMS were associated with higher Zn and nitric oxide levels...
  14. doi request reprint Maternal hemoglobin concentration and adverse pregnancy outcomes at low and moderate altitudes in Peru
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Lima, Peru
    J Matern Fetal Neonatal Med 25:1105-10. 2012
    ..To identify associations of maternal hemoglobin (Hb) with perinatal outcomes at low and moderate altitudes in Peru...
  15. pmc Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters
    Sandra Yucra
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Environ Health 7:59. 2008
    ..We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru...
  16. doi request reprint Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats
    Carla Gonzales
    Biological and Physiological Science Department, Universidad Peruana Cayetano Heredia, Lima, Peru
    Forsch Komplementmed 17:137-43. 2010
    ..This study was designed to determine the effect of different varieties of maca (Lepidium meyenii) on bone structure in ovariectomized (OVX) rats...
  17. doi request reprint Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate
    Karina Paola Leiva
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia, Lima, Peru
    Toxicol Mech Methods 21:495-502. 2011
    ..EEP showed an antioxidant activity similar to that of AA. EEP prevented LA-induced spermatogenic disruption in rats and its antioxidant activity could explain its capacity to reverse the damage produced by LA on spermatogenesis...
  18. ncbi request reprint Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers
    Sandra Yucra
    Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Occup Environ Health 12:355-61. 2006
    ..These findings provide further evidence that occupational exposures to OP pesticides adversely affect semen quality and sex hormones...
  19. doi request reprint Association of hemoglobin values at booking with adverse maternal outcomes among Peruvian populations living at different altitudes
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Gynaecol Obstet 117:134-9. 2012
    ..To determine hemoglobin values associated with adverse maternal outcomes among Peruvian populations at different altitudes...
  20. ncbi request reprint Association between biofuel exposure and adverse birth outcomes at high altitudes in Peru: a matched case-control study
    Sandra Yucra
    Instituto de Investigaciones de la Altura, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Occup Environ Health 17:307-13. 2011
    ..The use of biofuel for cooking was found to be strongly associated with increased risks of LBW, but was not significantly linked to preterm births...
  21. ncbi request reprint Peruvian contributions to the study on human reproduction at high altitude: from the chronicles of the Spanish conquest to the present
    Gustavo F Gonzales
    Instituto de Investigaciones de la Altura High Altitude Research Institute and Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima 31, Peru
    Respir Physiol Neurobiol 158:172-9. 2007
    ..Clearly, antiquity and genetics are important components in determining survival and quality of life at high altitude...
  22. doi request reprint Hypocotyls of Lepidium meyenii (maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and C-induced skin damage in rats
    Cynthia Gonzales-Castañeda
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Photodermatol Photoimmunol Photomed 24:24-31. 2008
    ..Lepidium meyenii (maca) is a plant that grows exclusively in the Peruvian Central Andes, where ultraviolet radiation (UVR) is predominant. Objective: Determine if two extracts of maca can provide dermal protection against UVR...
  23. doi request reprint Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
    Julio Rubio
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Toxicol Mech Methods 21:628-34. 2011
    ..Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose-response manner due, in part, to its content of polyphenolic compounds...
  24. pmc Red maca (Lepidium meyenii) reduced prostate size in rats
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Reprod Biol Endocrinol 3:5. 2005
    ..The absolute content of glucosinolates in Maca hypocotyls is relatively higher than that reported in other cruciferous crops. Therefore, Maca may have proapoptotic and anti-proliferative effects in the prostate...
  25. pmc Lepidium meyenii (Maca) increases litter size in normal adult female mice
    Ana C Ruiz-Luna
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Reprod Biol Endocrinol 3:16. 2005
    ..The present study was aimed to investigate the effects of Maca on several fertility parameters of female mice at reproductive age...
  26. ncbi request reprint [Maternal hemoglobin in Peru: regional differences and its association with adverse perinatal outcomes]
    Gustavo F Gonzales
    Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
    Rev Peru Med Exp Salud Publica 28:484-91. 2011
    ....
  27. ncbi request reprint Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice
    Julio Rubio
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, P O Box 1843, Lima, Peru
    Food Chem Toxicol 45:1882-90. 2007
    ..Black Maca extracts inhibited AChE activity, whereas MAO activity was not affected. These results indicate that Black Maca improves scopolamine-induced memory deficits...
  28. pmc Maternal hemoglobin level and fetal outcome at low and high altitudes
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Am J Physiol Regul Integr Comp Physiol 297:R1477-85. 2009
    ..Our data suggest, that maternal hemoglobin above 11 g/dl but below 13 g/dl is the area of minimal risk of poor adverse outcomes. Living at HA had an adverse effect independent of hemoglobin level...
  29. ncbi request reprint [Hemoglobin and testosterone: importance on high altitude acclimatization and adaptation]
    Gustavo F Gonzales
    Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Peru
    Rev Peru Med Exp Salud Publica 28:92-100. 2011
    ....
  30. ncbi request reprint Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination
    Luis Noriega-Portella
    PRANOR, Group of Assisted Reproduction, Universidad Peruana Cayetano Heredia, Lima, Peru
    Fertil Steril 90:1818-25. 2008
    ..To determine the effect of combined therapy of letrozole (2.5 mg or 5.0 mg) with recombinant follicle-stimulating hormone (FSH) in comparison with the administration of recombinant FSH alone in an intrauterine insemination (IUI) program...
  31. ncbi request reprint Cycloheximide prevents production of arresting, a fraction of 30-50 kDa obtained from seminiferous tubule conditioned medium
    Gustavo F Gonzales
    Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Asian J Androl 6:359-64. 2004
    ..To evaluate the effect of a protein synthesis inhibitor cycloheximide on arresting activity in spermatogenesis and sperm count in male rats...
  32. ncbi request reprint Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Postal Office 1843, Lima, Peru
    Asian J Androl 5:349-52. 2003
    ..To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats...
  33. ncbi request reprint Stillbirth rates in Peruvian populations at high altitude
    Gustavo F Gonzales
    High Altitude Research Institute, Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Gynaecol Obstet 100:221-7. 2008
    ..To compare the stillbirth rates in 4 cities at different altitudes in Peru...
  34. pmc Arterial oxygen saturation in healthy newborns delivered at term in Cerro de Pasco (4340 m) and Lima (150 m)
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Av, Honorio Delgado 430, Urb, Ingenieria, Lima, Peru, PO Box 1843, Lima, Peru
    Reprod Biol Endocrinol 3:46. 2005
    ....
  35. pmc Chronic mountain sickness score was related with health status score but not with hemoglobin levels at high altitudes
    Gustavo F Gonzales
    Instituto de Investigaciones de la Altura, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Peru Electronic address
    Respir Physiol Neurobiol 188:152-60. 2013
    ..Health status score was significantly higher in subjects without CMS. In conclusion, elevated hemoglobin levels were not associated with elevated CMS clinical score. ..
  36. pmc Maternal and perinatal outcomes in second hemoglobin measurement in nonanemic women at first booking: effect of altitude of residence in peru
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Universidad Peruana Cayetano Heredia, Lima 31, Peru
    ISRN Obstet Gynecol 2012:368571. 2012
    ..Prevalence of anemia increases as pregnancy progress, and that a normal value at first booking may not be considered sufficient as Hb values should be observed throughout pregnancy. BMI was a risk for anemia in a second measurement...
  37. ncbi request reprint Medicinal plants from Peru: a review of plants as potential agents against cancer
    Gustavo F Gonzales
    Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Anticancer Agents Med Chem 6:429-44. 2006
    ..In addition, this review will discuss areas requiring future study and the inherent limitations in their experimental use as anti-cancer agents...
  38. ncbi request reprint Mercury exposures in informal gold miners and relatives in southern Peru
    Jasmin Hurtado
    Department of Micdrobiology, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Av Honorio Delgado N 430 Lima 31, Apartado Postal 4314, Lima 100, Peru
    Int J Occup Environ Health 12:340-5. 2006
    ..5 microg/m3 (12-55) during amalgamation, and 12 microg/m3 (3-23) in the mining town. Smelters are highly contaminated with mercury, as are the people living around smelters...
  39. ncbi request reprint Blood lead levels among police officers in Lima and Callao, 2004
    Wilfredo Mormontoy
    Departament of Statistics, Demography, Humanity and Social Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Hyg Environ Health 209:497-502. 2006
    ..This may be a consequence of the policy to eliminate leaded gasoline in Peru. However, it is still necessary to monitor this policy to ensure the elimination of lead in gasoline...
  40. doi request reprint [Association of high altitude-induced hypoxemia to lipid profile and glycemia in men and women living at 4,100m in the Peruvian Central Andes]
    Gustavo F Gonzales
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
    Endocrinol Nutr 60:79-86. 2013
    ..It is not known whether higher hypoxemia levels (as measured by higher Hb values) affect basal glucose and lipid profile at an altitude of 4,100mg (Carhuamayo and Junln)...
  41. ncbi request reprint [Impact of high altitude on pregnancy and newborn parameters]
    Gustavo F Gonzales
    Unidad de Reproducción Humana, Instituto de Investigaciones de Altura, Universidad Peruana Cayetano Heredia, Lima, Peru
    Rev Peru Med Exp Salud Publica 29:242-9. 2012
    ..5 g/dl). In conclusion, a pregnant woman exposed briefly, intermittently, or permanently to high altitudes results in increased risk of adverse outcomes when compared to pregnancies observed at sea level...
  42. pmc Sperm chromatin stability and its relationship with fertilization rate after intracytoplasmic sperm injection (ICSI) in an assisted reproduction program
    Javier Garcia
    Laboratory of Assisted Reproduction, PRANOR Group of Assisted Reproduction, Instituto de Ginecología y Reproducción, Lima, Peru
    J Assist Reprod Genet 24:587-93. 2007
    ..Evaluate sperm chromatin stability and its relationship with the rate of fertilization after procedures of intracytoplasmic sperm injection (ICSI) in a program of assisted reproduction...