Omar D Perez

Summary

Publications

  1. pmc Differential role of ICAM ligands in determination of human memory T cell differentiation
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMC Immunol 8:2. 2007
  2. ncbi request reprint Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
    Omar D Perez
    Department of Microbiology and Immunology, and The Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 4:1083-92. 2003
  3. ncbi request reprint Single cell profiling of potentiated phospho-protein networks in cancer cells
    Jonathan M Irish
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University, Stanford, CA 94305, USA
    Cell 118:217-28. 2004
  4. pmc Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
    Catherine M Shachaf
    Department of Medicine and Pathology, Division of Medical Oncology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Cancer Res 68:5132-42. 2008
  5. doi request reprint Multiparameter analysis of intracellular phosphoepitopes in immunophenotyped cell populations by flow cytometry
    Omar D Perez
    Stanford University School of Medicine, Stanford, California, USA
    Curr Protoc Cytom . 2005
  6. pmc Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, Stanford, CA 94305 5151, USA
    Blood 110:2674-84. 2007
  7. ncbi request reprint LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells
    Omar D Perez
    Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA, USA
    Blood 104:1083-93. 2004
  8. ncbi request reprint Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications
    Peter O Krutzik
    Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305, USA
    Clin Immunol 110:206-21. 2004
  9. ncbi request reprint Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Immunol Rev 210:208-28. 2006
  10. ncbi request reprint Activation of the PKB/AKT pathway by ICAM-2
    Omar D Perez
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 16:51-65. 2002

Collaborators

Detail Information

Publications15

  1. pmc Differential role of ICAM ligands in determination of human memory T cell differentiation
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMC Immunol 8:2. 2007
    ..By applying a multivariate intracellular phospho-proteomic analysis, we demonstrate that LFA-1 differentially activates signaling molecules...
  2. ncbi request reprint Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
    Omar D Perez
    Department of Microbiology and Immunology, and The Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 4:1083-92. 2003
    ..LFA-1 stimulation lowered the threshold of T cell activation. Thus, LFA-1 signaling contributes to T cell activation and effects T cell differentiation...
  3. ncbi request reprint Single cell profiling of potentiated phospho-protein networks in cancer cells
    Jonathan M Irish
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University, Stanford, CA 94305, USA
    Cell 118:217-28. 2004
    ..Thus, single cell measurements of phospho-protein responses reveal shifts in signaling potential of a phospho-protein network, allowing for categorizing of cell network phenotypes by multidimensional molecular profiles of signaling...
  4. pmc Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance
    Catherine M Shachaf
    Department of Medicine and Pathology, Division of Medical Oncology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Cancer Res 68:5132-42. 2008
    ..Thus, at the MYC threshold, there is a loss of its ability to maintain tumorigenesis, with associated shifts in gene and protein expression that reestablish cell cycle checkpoints, halt protein translation, and promote apoptosis...
  5. doi request reprint Multiparameter analysis of intracellular phosphoepitopes in immunophenotyped cell populations by flow cytometry
    Omar D Perez
    Stanford University School of Medicine, Stanford, California, USA
    Curr Protoc Cytom . 2005
    ....
  6. pmc Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, Stanford, CA 94305 5151, USA
    Blood 110:2674-84. 2007
    ..Thus, atorvastatin, by inhibiting HMGcoA reductase, induces changes in phosphoprotein signaling that in turn prevent MYC-induced lymphomagenesis...
  7. ncbi request reprint LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells
    Omar D Perez
    Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA, USA
    Blood 104:1083-93. 2004
    ..These results identify novel, specific functional consequence of LFA-1-mediated cytolytic activity in perforin-containing human NK subsets...
  8. ncbi request reprint Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications
    Peter O Krutzik
    Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305, USA
    Clin Immunol 110:206-21. 2004
    ....
  9. ncbi request reprint Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Immunol Rev 210:208-28. 2006
    ..Flow cytometry, as a platform that is well situated in both the research and clinical settings, can contribute to drug discovery as well as having utility for both biomarker and patient-stratification...
  10. ncbi request reprint Activation of the PKB/AKT pathway by ICAM-2
    Omar D Perez
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Immunity 16:51-65. 2002
    ..These results attribute a novel signaling function to ICAM-2 that might suggest mechanisms by which ICAM-2 signals intracellular communication at various immunological synapses...
  11. ncbi request reprint Flow cytometric analysis of kinase signaling cascades
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Department of Microbiologyand Immunology, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 263:67-94. 2004
    ....
  12. pmc Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells
    Omar D Perez
    Department of Microbiology and Immunology, The Baxter Laboratories of Genetic Pharmacology, Stanford University, Stanford, CA 94305 5175, USA
    Proc Natl Acad Sci U S A 99:2270-4. 2002
    ..These findings suggest that Gd-Tex may have therapeutic utility as an anti-HIV agent capable of selectively targeting and removing HIV-infected cells in an infected host...
  13. ncbi request reprint Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry
    Omar D Perez
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    Nat Biotechnol 20:155-62. 2002
    ....
  14. ncbi request reprint Appreciating the heterogeneity in autoimmune disease: multiparameter assessment of intracellular signaling mechanisms
    Omar D Perez
    The Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University, 269 Campus Dr, CCSR 4225, Stanford, CA 94305, USA
    Ann N Y Acad Sci 1062:155-64. 2005
    ..This article also describes how single-cell signal network analysis can be used to stratify patients and may be useful for understanding mechanisms of disease progression, treatment resistance, and development of diagnostic indicators...
  15. ncbi request reprint Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors
    Omar D Perez
    Department of Chemistry, University of California, Berkeley 94720, USA
    Chem Biol 9:475-83. 2002
    ..These results suggest that myoseverin may have applications in muscle regeneration and stem cell differentiation...