Justin M Percival

Summary

Publications

  1. doi request reprint Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Pathol 228:77-87. 2012
  2. pmc Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
    Candace M Adamo
    Departments of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:19079-83. 2010
  3. ncbi request reprint Differential targeting of nNOS and AQP4 to dystrophin-deficient sarcolemma by membrane-directed alpha-dystrobrevin
    Marvin E Adams
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 121:48-54. 2008
  4. pmc Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195 7290, USA
    J Clin Invest 120:816-26. 2010
  5. pmc Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 3:e3387. 2008
  6. ncbi request reprint rAAV6-microdystrophin rescues aberrant Golgi complex organization in mdx skeletal muscles
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Box 357290, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Traffic 8:1424-39. 2007
  7. pmc Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
    Michael P Siegel
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Aging Cell 12:763-71. 2013
  8. pmc Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington Medical School, Seattle, WA, USA
    Hum Mol Genet 22:153-67. 2013
  9. ncbi request reprint Golgi complex organization in skeletal muscle: a role for Golgi-mediated glycosylation in muscular dystrophies?
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Traffic 8:184-94. 2007
  10. ncbi request reprint gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins
    Amy Alessi
    Department of Physiology and Biophysics, University of Washington, 1959 Pacific St NE, Seattle, WA 98195 7290, USA
    Exp Cell Res 312:3084-95. 2006

Collaborators

Detail Information

Publications10

  1. doi request reprint Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Pathol 228:77-87. 2012
    ..This study provides new insights into the therapeutic utility of targeting defects in NO-cGMP signalling with PDE5 inhibitors in dystrophin-deficient muscle...
  2. pmc Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
    Candace M Adamo
    Departments of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:19079-83. 2010
    ..Overall, the data suggest that PDE5 inhibitors may be a useful treatment for the cardiomyopathy affecting patients with DMD at early and late stages of the disease...
  3. ncbi request reprint Differential targeting of nNOS and AQP4 to dystrophin-deficient sarcolemma by membrane-directed alpha-dystrobrevin
    Marvin E Adams
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 121:48-54. 2008
    ..Thus, although nNOS and AQP4 both require interaction with the PDZ domain of alpha-syntrophin for sarcolemmal association, their localization is regulated differentially...
  4. pmc Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195 7290, USA
    J Clin Invest 120:816-26. 2010
    ..We conclude therefore that nNOS splice variants are critical regulators of skeletal muscle exercise performance...
  5. pmc Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 3:e3387. 2008
    ..Our study suggests that restoration of sarcolemmal nNOSmu expression in dystrophic muscles may be more important than previously appreciated and that it should be a feature of any fully effective gene therapy-based intervention...
  6. ncbi request reprint rAAV6-microdystrophin rescues aberrant Golgi complex organization in mdx skeletal muscles
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Box 357290, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Traffic 8:1424-39. 2007
    ..In summary, GC distribution abnormalities are a novel component of mdx skeletal muscle pathology rescued by microdystrophin expression...
  7. pmc Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
    Michael P Siegel
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Aging Cell 12:763-71. 2013
    ..These data demonstrate that SS-31 represents a new strategy for reversing age-related deficits in skeletal muscle with potential for translation into human use. ..
  8. pmc Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington Medical School, Seattle, WA, USA
    Hum Mol Genet 22:153-67. 2013
    ..These findings further understanding of how mitochondrial bioenergetic dysfunction contributes to disease pathogenesis in dystrophin-deficient skeletal muscle in vivo...
  9. ncbi request reprint Golgi complex organization in skeletal muscle: a role for Golgi-mediated glycosylation in muscular dystrophies?
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Traffic 8:184-94. 2007
    ..Here, we review the current understanding of the dynamic regulation of GC organization in skeletal muscle and focus on the targeting of fukutin, fukutin-related protein and large1 to the GC in muscle cells...
  10. ncbi request reprint gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins
    Amy Alessi
    Department of Physiology and Biophysics, University of Washington, 1959 Pacific St NE, Seattle, WA 98195 7290, USA
    Exp Cell Res 312:3084-95. 2006
    ..In both neurons and muscle, gamma-syntrophin isoforms localize to the endoplasmic reticulum where they may form a scaffold for signaling and trafficking...