F G E Perabo

Summary

Publications

  1. ncbi Carboxyamido-triazole (CAI), a signal transduction inhibitor induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2
    Frank G E Perabo
    Department of Urology, University Hospital, Bonn University, 53105 Bonn, USA
    Anticancer Res 24:2869-77. 2004
  2. ncbi New agents in intravesical chemotherapy of superficial bladder cancer
    Frank G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Scand J Urol Nephrol 39:108-16. 2005
  3. doi Antiproliferative and apoptosis inducing effects of indirubin-3'-monoxime in renal cell cancer cells
    Frank G E Perabo
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Urol Oncol 29:815-20. 2011
  4. doi [A critical assessment of phytotherapy for prostate cancer]
    F G E Perabo
    Klinik und Poliklinik fur Urologie, Universitatsklinikum, Sigmund Freud Strasse 25, 53105 Bonn
    Urologe A 48:270-1, 274-83. 2009
  5. ncbi Soy isoflavone genistein in prevention and treatment of prostate cancer
    F G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Prostate Cancer Prostatic Dis 11:6-12. 2008
  6. ncbi New agents for treatment of advanced transitional cell carcinoma
    F G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Ann Oncol 18:835-43. 2007
  7. ncbi Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer
    Frank G E Perabo
    Department of Urology, Rheinische Friedrich Wilhelms University Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 26:2129-35. 2006
  8. ncbi Superantigen-activated mononuclear cells induce apoptosis in transitional cell carcinoma
    Frank G E Perabo
    Department of Urology, University of Bonn, 53105 Bonn, Germany
    Anticancer Res 25:3565-73. 2005
  9. ncbi Carboxyamido-triazole (CAI) reverses the balance between proliferation and apoptosis in a rat bladder cancer model
    Frank G E Perabo
    Department of Urology, University of Bonn, 53105 Bonn, Germany
    Anticancer Res 25:725-9. 2005
  10. ncbi Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer
    Frank G E Perabo
    Department of Urology, University of Bonn, Bonn, Germany
    Int J Cancer 115:591-8. 2005

Collaborators

Detail Information

Publications16

  1. ncbi Carboxyamido-triazole (CAI), a signal transduction inhibitor induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2
    Frank G E Perabo
    Department of Urology, University Hospital, Bonn University, 53105 Bonn, USA
    Anticancer Res 24:2869-77. 2004
    ..It may cause transformation of cell homeostasis that leads to the alteration of apoptotic mechanisms, thus allowing highly malignant tumor cells to re-enter the physiological course of cell elimination...
  2. ncbi New agents in intravesical chemotherapy of superficial bladder cancer
    Frank G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Scand J Urol Nephrol 39:108-16. 2005
    ..Although the initial results achieved with these agents in clinical development seem encouraging, long-term data on the prevention of recurrence, disease progression and survival have yet to be obtained...
  3. doi Antiproliferative and apoptosis inducing effects of indirubin-3'-monoxime in renal cell cancer cells
    Frank G E Perabo
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Urol Oncol 29:815-20. 2011
    ..This study investigated if indirubin-3'-monoxime can induce apoptosis and tumor cell death in 3 human (A498, CAKI-1, CAKI-2) and 1 murine renal cell cancer (RENCA) cell line...
  4. doi [A critical assessment of phytotherapy for prostate cancer]
    F G E Perabo
    Klinik und Poliklinik fur Urologie, Universitatsklinikum, Sigmund Freud Strasse 25, 53105 Bonn
    Urologe A 48:270-1, 274-83. 2009
    ..The question about an improved immune function or quality of life remains open. Potentially the use of phytochemicals could play a role in a preventive setting...
  5. ncbi Soy isoflavone genistein in prevention and treatment of prostate cancer
    F G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Prostate Cancer Prostatic Dis 11:6-12. 2008
    ..However, at present there is no convincing clinical proof or evidence that genistein might be useful in PCa therapy...
  6. ncbi New agents for treatment of advanced transitional cell carcinoma
    F G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Ann Oncol 18:835-43. 2007
    ..4610), histone deacetylase inhibitor (CI-994) and monoclonal antibodies (epidermal growth factor receptor, Her 2/neu)...
  7. ncbi Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer
    Frank G E Perabo
    Department of Urology, Rheinische Friedrich Wilhelms University Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Anticancer Res 26:2129-35. 2006
    ..Cdk expression was not significantly altered by indirubin-3'-monoxime. In summary, indirubin-3'-monoxime might be a promising candidate for targeted cancer therapy, however, its molecular action remains to be further evaluated...
  8. ncbi Superantigen-activated mononuclear cells induce apoptosis in transitional cell carcinoma
    Frank G E Perabo
    Department of Urology, University of Bonn, 53105 Bonn, Germany
    Anticancer Res 25:3565-73. 2005
    ....
  9. ncbi Carboxyamido-triazole (CAI) reverses the balance between proliferation and apoptosis in a rat bladder cancer model
    Frank G E Perabo
    Department of Urology, University of Bonn, 53105 Bonn, Germany
    Anticancer Res 25:725-9. 2005
    ..Normal urothelium was not affected by CAI. This animal model confirms the anti-tumor effect of CAI and shows induction of apoptosis and growth inhibition in bladder cancer by the drug...
  10. ncbi Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer
    Frank G E Perabo
    Department of Urology, University of Bonn, Bonn, Germany
    Int J Cancer 115:591-8. 2005
    ..These preclinical findings suggest that SEB might be an interesting candidate for further clinical evaluation...
  11. ncbi Preclinical evaluation of a radiosensitizing effect of gemcitabine in p53 mutant and p53 wild type bladder cancer cells
    G Fechner
    Department of Urology, Bonn University, Bonn, Germany
    Urology 61:468-73. 2003
    ..Despite clinical use, the radiosensitizing effect of gemcitabine (2'2'-difluorodeoxycytidine) in human transitional cell carcinoma (TCC) has not been shown to date. We investigated gemcitabine as a radiosensitizer for human TCC cells...
  12. ncbi Gemcitabine monotherapy as second-line treatment in cisplatin-refractory transitional cell carcinoma - prognostic factors for response and improvement of quality of life
    P Albers
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Germany
    Onkologie 25:47-52. 2002
    ..ii) To assess prognostic parameters for response to treatment and for improvement of QoL parameters...
  13. ncbi Flavopiridol, an inhibitor of cyclin-dependent kinases, induces growth inhibition and apoptosis in bladder cancer cells in vitro and in vivo
    Andreas Wirger
    Department of Urology, Medical University, 23562 Luebeck, Germany
    Anticancer Res 25:4341-7. 2005
    ..In summary, our results indicated that flavopiridol could be a useful therapeutic agent for bladder cancer, inhibiting tumor growth, malignant progression and inducing apoptosis...
  14. ncbi Current and new strategies in immunotherapy for superficial bladder cancer
    Frank G E Perabo
    Department of Urology, University Hospital, Bonn, Germany
    Urology 64:409-21. 2004
  15. ncbi Superselective embolization of arterial bleeding as a late complication 3 months after nephron sparing surgery for renal cell carcinoma
    J Thomas
    Department of Urology, Rheinische Friedrich Wilhelms University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    ScientificWorldJournal 4:350-2. 2004
    ..The high efficacy of superselective embolization as a minimally invasive procedure in this and other cases of bleeding Vessels should be the preferred method instead of open surgery...
  16. ncbi Review. Facts and fiction of phytotherapy for prostate cancer: a critical assessment of preclinical and clinical data
    Eva C Von Löw
    Department of Urology, University Hospital, Bonn, Germany
    In Vivo 21:189-204. 2007
    ..At present, there is no convincing clinical proof or evidence that the cited phythochemicals might be used in an attempt to cure cancer of the prostate...