Manickam V, Dhakshinamoorthy V, Perumal E. Iron Oxide Nanoparticles Affects Behaviour and Monoamine Levels in Mice. Neurochem Res. 2019;: pubmed publisher
..Along with all these factors, over expression of glial fibrillary acidic protein (GFAP) confirms the neuronal damage, suggesting the evidences for behavioural changes. ..
Bhattacharjee M, Perumal E. Potential plant-derived catecholaminergic activity enhancers for neuropharmacological approaches: A review. Phytomedicine. 2019;55:148-164 pubmed publisher
..However, hurdles are to be met for analyzing the mode and mechanism of action associated with these phytomedicines and their proper scientific documentation. ..
Raghunath A, Sundarraj K, Arfuso F, Sethi G, Perumal E. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance. Cancers (Basel). 2018;10: pubmed publisher
..This review summarizes the role and mechanism(s) of action of Nrf2 dysregulation in HCC and therapeutic options that can be employed to modulate this transcription factor. ..
Raghunath A, Nagarajan R, Sundarraj K, Panneerselvam L, Perumal E. Genome-wide identification and analysis of Nrf2 binding sites - Antioxidant response elements in zebrafish. Toxicol Appl Pharmacol. 2018;360:236-248 pubmed publisher
..Our results help to understand the dynamic complexity of the Nrf2-ARE system in zebrafish. ..
Ameeramja J, Raghunath A, Perumal E. Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats. Environ Sci Pollut Res Int. 2018;25:26157-26166 pubmed publisher
..The data suggested that the TSCE had beneficial effects in alleviating the F--induced toxicity and hence can serve as a promising neutraceutical agent. ..
Raghunath A, Perumal E. Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development. Methods Mol Biol. 2018;1797:337-363 pubmed publisher
..Based on the scoring of the malformations, the test compound can be classified as a teratogen or a nonteratogen and its teratogenic potential is evaluated. ..
Ameeramja J, Kanagaraj V, Perumal E. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018;118:235-244 pubmed publisher
..Thus PCAME can be used as a nutraceutical agent for F- toxicity. ..
Raghunath A, Sundarraj K, Nagarajan R, Arfuso F, Bian J, Kumar A, et al
. Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox Biol. 2018;17:297-314 pubmed publisher
..A thorough understanding of AREs will pave the way for the development of therapeutic agents against cancer, neurodegenerative, cardiovascular, metabolic and other diseases with oxidative stress. ..
Panneerselvam L, Govindarajan V, Ameeramja J, Nair H, Perumal E. Single oral acute fluoride exposure causes changes in cardiac expression of oxidant and antioxidant enzymes, apoptotic and necrotic markers in male rats. Biochimie. 2015;119:27-35 pubmed publisher
..Taken together, these findings reveal that acute F(-) exposure causes cardiac impairment by altering the expression of oxidative stress, apoptosis and necrotic markers. ..