Ekambaram Perumal



  1. Manickam V, Dhakshinamoorthy V, Perumal E. Iron Oxide Nanoparticles Affects Behaviour and Monoamine Levels in Mice. Neurochem Res. 2019;: pubmed publisher
    ..Along with all these factors, over expression of glial fibrillary acidic protein (GFAP) confirms the neuronal damage, suggesting the evidences for behavioural changes. ..
  2. Bhattacharjee M, Perumal E. Potential plant-derived catecholaminergic activity enhancers for neuropharmacological approaches: A review. Phytomedicine. 2019;55:148-164 pubmed publisher
    ..However, hurdles are to be met for analyzing the mode and mechanism of action associated with these phytomedicines and their proper scientific documentation. ..
  3. Raghunath A, Sundarraj K, Arfuso F, Sethi G, Perumal E. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance. Cancers (Basel). 2018;10: pubmed publisher
    ..This review summarizes the role and mechanism(s) of action of Nrf2 dysregulation in HCC and therapeutic options that can be employed to modulate this transcription factor. ..
  4. Raghunath A, Nagarajan R, Sundarraj K, Panneerselvam L, Perumal E. Genome-wide identification and analysis of Nrf2 binding sites - Antioxidant response elements in zebrafish. Toxicol Appl Pharmacol. 2018;360:236-248 pubmed publisher
    ..Our results help to understand the dynamic complexity of the Nrf2-ARE system in zebrafish. ..
  5. Ameeramja J, Raghunath A, Perumal E. Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats. Environ Sci Pollut Res Int. 2018;25:26157-26166 pubmed publisher
    ..The data suggested that the TSCE had beneficial effects in alleviating the F--induced toxicity and hence can serve as a promising neutraceutical agent. ..
  6. Raghunath A, Perumal E. Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development. Methods Mol Biol. 2018;1797:337-363 pubmed publisher
    ..Based on the scoring of the malformations, the test compound can be classified as a teratogen or a nonteratogen and its teratogenic potential is evaluated. ..
  7. Ameeramja J, Kanagaraj V, Perumal E. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018;118:235-244 pubmed publisher
    ..Thus PCAME can be used as a nutraceutical agent for F- toxicity. ..
  8. Raghunath A, Sundarraj K, Nagarajan R, Arfuso F, Bian J, Kumar A, et al. Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox Biol. 2018;17:297-314 pubmed publisher
    ..A thorough understanding of AREs will pave the way for the development of therapeutic agents against cancer, neurodegenerative, cardiovascular, metabolic and other diseases with oxidative stress. ..
  9. Panneerselvam L, Govindarajan V, Ameeramja J, Nair H, Perumal E. Single oral acute fluoride exposure causes changes in cardiac expression of oxidant and antioxidant enzymes, apoptotic and necrotic markers in male rats. Biochimie. 2015;119:27-35 pubmed publisher
    ..Taken together, these findings reveal that acute F(-) exposure causes cardiac impairment by altering the expression of oxidative stress, apoptosis and necrotic markers. ..

More Information


  1. Ameeramja J, Perumal E. Possible Modulatory Effect of Tamarind Seed Coat Extract on Fluoride-Induced Pulmonary Inflammation and Fibrosis in Rats. Inflammation. 2018;41:886-895 pubmed publisher
    ..Thus, TSCE offers protection against F--induced pulmonary inflammation and fibrosis in rats. ..
  2. Manickam V, Dhakshinamoorthy V, Perumal E. Iron Oxide Nanoparticles Induces Cell Cycle-Dependent Neuronal Apoptosis in Mice. J Mol Neurosci. 2018;64:352-362 pubmed publisher
    ..Further, hyperphosphorylation of p38 (Thr 180/Tyr 182) confirms the activation of DNA damage-dependent checkpoint. Expression patterns of pro- and anti-apoptotic markers, TUNEL and TEM indicate the occurrences of apoptosis. ..
  3. Raghunath A, Jeyabaskar D, Sundarraj K, Panneerselvam L, Perumal E. In silico prediction of microRNAs on fluoride induced sperm toxicity in mice. Food Chem Toxicol. 2016;98:34-49 pubmed publisher
    ..Our data contribute towards elucidating the function of miRNAs in the fluoride induced infertility. miRNA molecular pathways in F intoxication will open new avenues on the use of antagomirs in recovering fertility. ..
  4. Ameeramja J, Panneerselvam L, Govindarajan V, Jeyachandran S, Baskaralingam V, Perumal E. Tamarind seed coat ameliorates fluoride induced cytotoxicity, oxidative stress, mitochondrial dysfunction and apoptosis in A549 cells. J Hazard Mater. 2016;301:554-65 pubmed publisher
    ..In conclusion, our study demonstrated that TSCE as a potential protective agent against F toxicity, which can be utilized as a neutraceutical. ..
  5. Sundarraj K, Raghunath A, Panneerselvam L, Perumal E. Iron oxide nanoparticles modulate heat shock proteins and organ specific markers expression in mice male accessory organs. Toxicol Appl Pharmacol. 2017;317:12-24 pubmed publisher
    ..These findings provide evidence that Fe2O3-NPs could be an environmental risk factor for reproductive disease. ..
  6. Panneerselvam L, Raghunath A, Perumal E. Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats. Int J Cardiol. 2017;229:96-101 pubmed publisher
    ..Taken together, these findings reveal that acute F- exposure causes sudden heart failure by altering the expression of cytoskeletal proteins and AMPK signaling molecules. ..
  7. Sundarraj K, Raghunath A, Perumal E. A review on the chemotherapeutic potential of fisetin: In vitro evidences. Biomed Pharmacother. 2018;97:928-940 pubmed publisher
    ..In addition, the increased bioavailability and sustained release of fisetin improved through conjugation and enhanced effect of fisetin through synergism on various cancers are also highlighted. ..
  8. Manickam V, Periyasamy M, Dhakshinamoorthy V, Panneerselvam L, Perumal E. Recurrent exposure to ferric oxide nanoparticles alters myocardial oxidative stress, apoptosis and necrotic markers in male mice. Chem Biol Interact. 2017;278:54-64 pubmed publisher
    ..In addition, triphenyl tetrazolium chloride (TTC) staining confirms cardiac necrosis in 50 mg/kg Fe2O3-NPs treated group...
  9. Ameeramja J, Perumal E. Pulmonary fluorosis: a review. Environ Sci Pollut Res Int. 2017;24:22119-22132 pubmed publisher
    ..The goal of this review is to present an overview of the research carried out till date on the molecular aspects of fluoride exposure with emphasis on pulmonary system and their possible mechanisms. ..
  10. Panneerselvam L, Raghunath A, Perumal E. Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride. Cell Stress Chaperones. 2017;22:743-750 pubmed publisher
    ..Our result suggests that differential expression of Hsps in the rat myocardium could serve as a balance between pro-survival and death signal during acute F--induced heart failure. ..
  11. Dhakshinamoorthy V, Manickam V, Perumal E. Neurobehavioural Toxicity of Iron Oxide Nanoparticles in Mice. Neurotox Res. 2017;32:187-203 pubmed publisher
    ..Thus, repeated Fe2O3-NP exposure causes neurobehavioural impairments by nanoparticle accumulation, oxidative stress and apoptosis in the mouse brain. ..
  12. Raghunath A, Perumal E. Metal oxide nanoparticles as antimicrobial agents: a promise for the future. Int J Antimicrob Agents. 2017;49:137-152 pubmed publisher
    ..This review discusses the mechanisms of action of MeO-NPs against micro-organisms, safety concerns, challenges and future perspectives. ..
  13. Ameeramja J, Perumal E. Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol. 2017;109:941-950 pubmed publisher
    ..Thus PCAME can be used as a nutraceutical agent for F- toxicity. ..