Parenteral transmission during excision and treatment of tuberculosis and trypanosomiasis may be responsible for the HIV-2 epidemic in Guinea-BissauJacques Pepin
Department of Microbiology and Infectious Diseases and Center for International Health, Centre Hospitalier Universitaire 3001, University of Sherbrooke, 12th Avenue North, Sherbrooke, Quebec, Canada
AIDS 20:1303-11. 2006
..We sought to verify the hypothesis that parenteral transmission was the key factor in the building-up of the HIV-2 epidemic...
Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strainAlex Carignan
Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 46:1838-43. 2008
..The purpose of this study was to determine the risk of PAP-induced CDI after selected surgical procedures and to compare such risk before with such risk after the emergence of the hypervirulent strain of C. difficile...
- Outcomes of Clostridium difficile-associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Am J Gastroenterol 102:2781-8. 2007
..To reassess the comparative efficacy of vancomycin versus metronidazole in the treatment of Clostridium difficile-associated disease (CDAD) after the emergence in 2003 of the hypervirulent NAP1/027 strain...
Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strainAnnie Claude Labbe
Department of Microbiology, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
Antimicrob Agents Chemother 52:3180-7. 2008
..Stringent antibiotic stewardship measures, combined with aggressive infection control, are required to curtail the epidemic of C. difficile infections...
- The syndromic management of vaginal discharge using single-dose treatments: a randomized controlled trial in West Africa
Jacques Pepin
Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada
Bull World Health Organ 84:729-38. 2006
..To evaluate whether single-dose treatments are as effective as standard therapy in the syndromic management of vaginal discharge...
- Increasing risk of infectious complications after transrectal ultrasound-guided prostate biopsies: time to reassess antimicrobial prophylaxis?
Alex Carignan
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Quebec, Canada
Eur Urol 62:453-9. 2012
..An increasing risk of infectious complications following transrectal ultrasound-guided prostate needle biopsy (PNB) has been observed recently in some centers...
- The price of development: HIV infection in a semiurban community of Ghana
Nadine Sauve
Centre for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 29:402-8. 2002
..To describe the epidemiology of HIV infection in the Manya Krobo District, Ghana, and its potential link to the building of the Akosombo dam...
- Human parvovirus 4 infection, Cameroon
Myriam Lavoie
Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Emerg Infect Dis 18:680-3. 2012
..Findings suggest parenteral acquisition of some PARV4 infections...
- Transactional sex is the driving force in the dynamics of HIV in Accra, Ghana
Anne Marie Côté
Centre for International Health, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
AIDS 18:917-25. 2004
..To delineate the population attributable fraction (PAF) of transactional sex in prevalent cases of HIV infection in the male adult population of Accra, Ghana...
- Iatrogenic transmission of human T cell lymphotropic virus type 1 and hepatitis C virus through parenteral treatment and chemoprophylaxis of sleeping sickness in colonial Equatorial Africa
Jacques Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 51:777-84. 2010
....
- Clostridium difficile infection in the intensive care unit
Marc André Leclair
Intensive Care Unit, Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
J Intensive Care Med 25:23-30. 2010
..The current review focuses on recent changes in the epidemiology, diagnostic methods, and treatment of CDI, with special emphasis on complicated cases managed in the ICU...
- A tale of two countries: HIV among core groups in Togo
Francois Sobela
Centre de Santé Internationale de l Université de Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 51:216-23. 2009
..To describe the epidemiology of HIV among core groups in Togo...
- Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain
Louis Valiquette
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 45:S112-21. 2007
..The inefficacy of infection control measures targeting transmission through hospital personnel might be a result of their implementation late in the epidemic, when the environment was heavily contaminated with spores...
- Hepatitis C virus infection in Guinea-Bissau: a sexually transmitted genotype 2 with parenteral amplification?
Mireille Plamondon
Department of Microbiology and Infectious Diseases and Centre for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
PLoS ONE 2:e372. 2007
..Genotype 2 HCV is thought to have originated from West Africa several hundred years ago. Mechanisms of transmission remain poorly understood...
- Noble goals, unforeseen consequences: control of tropical diseases in colonial Central Africa and the iatrogenic transmission of blood-borne viruses
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Canada
Trop Med Int Health 13:744-53. 2008
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- Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain
Francois Lamontagne
University of Sherbrooke, Sherbrooke, Canada
Ann Surg 245:267-72. 2007
..To determine whether emergency colectomy reduces mortality in patients with fulminant Clostridium difficile-associated disease (CDAD), and to identify subgroups of patients more likely to benefit from the procedure...
- Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patient
Mireille Plamondon
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Canada
Clin Infect Dis 51:e1-3. 2010
....
- Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001
Jacques Pepin
Centre for International Health and Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Emerg Infect Dis 11:921-7. 2005
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- Risk factors for hepatitis C virus transmission in colonial Cameroon
Jacques Pepin
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 51:768-76. 2010
....
- Risk factors for mortality following emergency colectomy for fulminant Clostridium difficile infection
Jacques Pepin
University of Sherbrooke, Sherbrooke, Quebec, Canada
Dis Colon Rectum 52:400-5. 2009
..This study evaluated risk factors for mortality after emergency colectomy for fulminant Clostridium difficile infection...
- Vancomycin for the treatment of Clostridium difficile Infection: for whom is this expensive bullet really magic?
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 46:1493-8. 2008
..In practice, because it is not yet possible to rapidly type the strains, all patients with severe CDI should be treated with vancomycin. Future trials should use complicated CDI and recurrences as their primary outcomes...
- The expansion of HIV-1 in colonial Leopoldville, 1950s: driven by STDs or STD control?
Jacques Pepin
CHUS, Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec J1H 5N4, Canada
Sex Transm Infect 88:307-12. 2012
..To understand the factors that drove the exponential spread of HIV-1 in Léopoldville (Kinshasa) in the 1950s...
- Risk of secondary cases of Clostridium difficile infection among household contacts of index cases
Jacques Pepin
Department of Microbiology Infectious Diseases, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, 3001 12eme Avenue Nord, Sherbrooke, Quebec, Canada
J Infect 64:387-90. 2012
..We aimed to estimate the risk of secondary cases of Clostridium difficile infection (CDI) among household contacts of index cases...
- Prediction of complicated Clostridium difficile infection by pleural effusion and increased wall thickness on computed tomography
Louis Valiquette
Department of Microbiology and Infectious Diseases, University of Sherbrooke, 3001, 12ème AveNord, Sherbrooke, Quebec J1H 5N4, Canada
Clin Infect Dis 49:554-60. 2009
..difficile. We sought to describe and correlate abdominal CT findings with complicated CDI and to compare them before and after the emergence of the epidemic strain...
- The Indian Ocean paradox revisited: HIV and sexually transmitted infections in the Comoros
Yasmina Dada
Center for International Health, University of Sherbrooke, Sherbrooke, Quebec, Canada
Int J STD AIDS 18:596-600. 2007
..Only 1/70 (1.4%) and 0/83 sex workers sampled in 2004 and 2005 were HIV-infected. The Comoros have been protected by their insular status, male circumcision and paucity of syphilis. HIV control should focus on sex workers...
- Faecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infection
Milagros Gonzales
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, 3001 12eme Avenue Nord, Sherbrooke, Quebec, Canada
BMC Infect Dis 10:363. 2010
..We wished to determine to what extent faecal levels of vancomycin vary according to diarrhoea severity and dosage, and whether it is rational to administer high-dose vancomycin to selected patients...
- Prediction tools for unfavourable outcomes in Clostridium difficile infection: a systematic review
Claire Nour Abou Chakra
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
PLoS ONE 7:e30258. 2012
..Clinical prediction rules (CPRs) can improve the accuracy of medical decision-making. Several CPRs have been developed for CDI, but none has gained a widespread acceptance...
- Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
Clin Infect Dis 42:758-64. 2006
....
- Impact of guideline-consistent therapy on outcome of patients with healthcare-associated and community-acquired pneumonia
Cynthia Grenier
Department of Microbiology and Infectious Diseases, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
J Antimicrob Chemother 66:1617-24. 2011
..The optimal empirical management of patients with HCAP remains controversial and adherence to guidelines is inconsistent...
- Clinical utility and prognostic value of bronchoalveolar lavage galactomannan in patients with hematologic malignancies
Me Linh Luong
Department of Microbiology, McGill University Health Center, Montreal, Quebec, Canada
Diagn Microbiol Infect Dis 68:132-9. 2010
..The BAL GM assay is a highly sensitive screening test for IPA in patients with hematologic malignancies. Increasing the cutoff value to 2.0 would improve the performance of this assay...
- The impact of syphilis, HIV-1, and HIV-2 on pregnancy outcome in Bissau, Guinea-Bissau
Anne Claude Labbé
Centre for International Health, University of Sherbrooke, Quebec, Canada
Sex Transm Dis 29:157-67. 2002
..Syphilis remains a major cause of fetal loss and neonatal mortality in sub-Saharan Africa. Guinea-Bissau is the epicenter of the HIV-2 epidemic, and little is known about the impact of HIV-2 on pregnancy...
- Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 173:1037-42. 2005
..The effects of this epidemic on mortality and duration of hospital stay remain unknown. We measured these effects among patients admitted to a hospital in Quebec during 2003 and 2004...
- Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
Clin Infect Dis 41:1254-60. 2005
..In 2003, a total of 55% of patients with CDAD at our hospital had received fluoroquinolones in the preceding 2 months. It has been suggested that massive use of proton pump inhibitors might have facilitated this epidemic...
- Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada
J Acquir Immune Defic Syndr 42:490-3. 2006
..Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them...
- Emergence of and risk factors for ciprofloxacin-gentamicin-resistant Escherichia coli urinary tract infections in a region of Quebec
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec
Can J Infect Dis Med Microbiol 20:e163-8. 2009
..The risk factors for such infections remained unclear...
- Cost-effectiveness of a 3-dose pneumococcal conjugate vaccine program in the province of Quebec, Canada
Béatrice Poirier
Department of Community Health Sciences, University of Sherbrooke, Sherbrooke, Canada
Vaccine 27:7105-9. 2009
..The incremental cost-effectiveness ratio was $18,000 per QALY gained for the health system and the program was close to the break-even threshold in a societal perspective...
- Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis
Jacques Pepin
Department of Microbiology and Infectious Diseases and Centre for International Health, University of Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada
Trans R Soc Trop Med Hyg 100:437-41. 2006
..Graded dosing, which was associated with a much lower efficacy and more frequent convulsions, should be abandoned...
- From the Old World to the New World: an ecologic study of population susceptibility to HIV infection
Jacques Pepin
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Canada
Trop Med Int Health 10:627-39. 2005
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- Trypanosoma brucei gambiense African trypanosomiasis: differences between men and women in severity of disease and response to treatment
Jacques Pepin
Centre for International Health, University of Sherbrooke, Quebec, Canada
Trans R Soc Trop Med Hyg 96:421-6. 2002
..8%) (P = 0.004), even after adjustment for other independent risk factors in multivariate analysis. The cause of this higher risk of treatment failure among men treated with melarsoprol remains unclear...
