The fallacy of racial pharmacogenomicsS D J Pena
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Braz J Med Biol Res 44:268-75. 2011
..The conclusion is that "next-generation" genomic sequencing is advancing at a tremendous rate and that true personalized pharmacogenomics, based on individual genotyping, should soon become a clinical reality...
- DNA tests probe the genomic ancestry of Brazilians
S D J Pena
Gene, Núcleo de Genética Médica, Belo Horizonte, MG, Brasil
Braz J Med Biol Res 42:870-6. 2009
..In Brazil, one cannot predict the color of persons from their genomic ancestry nor the opposite. Brazilians should be assessed on a personal basis, as 190 million human beings, and not as members of color groups...
- Isolation and characterization of HC1: a novel human DNA repair gene
D O Lopes
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Genet Mol Res 8:247-60. 2009
..These data indicate a new human repair gene, which we named HC1; it is involved in the recognition of two kinds of DNA lesions and it contributes to the 5' DNA incision step in NER...
DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediateM A Rajão
Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Caixa Postal 486, Belo Horizonte 30161 970, MG, Brazil
Mol Microbiol 71:185-97. 2009
..cruzi resistance to high doses of gamma irradiation and zeocin and can catalyse DNA synthesis within recombination intermediates...
- Cell culture and animal infection with distinct Trypanosoma cruzi strains expressing red and green fluorescent proteins
S F Pires
Departamento de Bioquimica e Imunologia, Instituto de Ciências Biológicas UFMG, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
Int J Parasitol 38:289-97. 2008
..cruzi infection including the mechanisms of cell invasion, genetic exchange among parasites and the differential tissue distribution in animal models of Chagas disease...
- Sex-biased gene flow in African Americans but not in American Caucasians
V F Gonçalves
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Genet Mol Res 6:256-61. 2007
....
- Worldwide diversity of the Y-chromosome tetra-local microsatellite DYS464
F S G Kehdy
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Genet Mol Res 9:1525-34. 2010
..Consequently, genotypes are degenerate, which limits phylogeographical analyses. Yet, because of its high variability, DYS464 still constitutes an informative tool for population and evolutionary studies...
- Efficient human paternity testing with a panel of 40 short insertion-deletion polymorphisms
J R Pimenta
GENE Núcleo de Genética Médica, Belo Horizonte, MG, Brasil
Genet Mol Res 9:601-7. 2010
..Thus, especially because of its simplicity and low cost, and the fact that it is composed of genomic markers that have very low mutation rates, it represents a useful new tool for human paternity testing...
- PedExpert: a computer program for the application of Bayesian networks to human paternity testing
R R Gomes
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Genet Mol Res 8:273-83. 2009
..PedExpert is user-friendly and greatly reduces the time of analysis for complex cases of paternity testing, eliminating most sources of logical and operational error...
- Determination of ancestral proportions in synthetic bovine breeds using commonly employed microsatellite markers
H M S Bicalho
, Belo Horizonte, MG, Brasil
Genet Mol Res 5:432-7. 2006
..This microsatellite set might also be useful for estimating the proportions of taurine and zebu origins in commercial meat products...
- Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer
D O Lopes
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Genet Mol Res 6:250-5. 2007
..This technique allows quantification of the DNA polymerase activity of the Klenow fragment using different templates and under different conditions with similar sensitivity to the radioactive assay...
- Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues
J M Freitas
, , Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil
Int J Parasitol 35:411-7. 2005
..Our findings provide definitive proof of this hypothesis and will also allow the establishment of which group of T. cruzi is responsible for Chagas disease in other countries...
