Shuangqing Peng



  1. Zhang T, Wang Y, Zhao J, Xia M, Peng S, Ikejima T. Induction of protective autophagy against apoptosis in HepG2 cells by isoniazid independent of the p38 signaling pathway. Toxicol Res (Camb). 2016;5:963-972 pubmed publisher
    ..Thus, activation of autophagy and p38 signaling is presumably a therapeutic strategy for INH-induced hepatotoxicity. ..
  2. Yuan H, Zhang Q, Guo J, Zhang T, Zhao J, Li J, et al. A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C. Toxicol Sci. 2016;150:400-17 pubmed publisher
  3. Yan X, Shu Y, He J, Zhao J, Jia L, Xie J, et al. Therapeutic Effects of Human Umbilical Cord Mesenchymal Stromal Cells in Sprague Dawley Rats with Percutaneous Exposure to Sulfur Mustard. Stem Cells Dev. 2018;: pubmed publisher
    ..Intravenous injection of MSCs exerted significant therapeutic effects in rats with percutaneous exposure to SM. ..
  4. Yin J, Guo J, Zhang Q, Cui L, Zhang L, Zhang T, et al. Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway. Toxicol In Vitro. 2018;51:1-10 pubmed publisher
    ..Taken together, these findings suggest that DOX-induced mitophagy and mitochondrial damage in cardiomyocytes are mediated, at least in part, by dysregulation of the PINK1/parkin pathway. ..
  5. Ren M, Wang Y, Zhao J, Zhao J, Zhao Z, Zhang T, et al. Metallothioneins attenuate paraquat-induced acute lung injury in mice through the mechanisms of anti-oxidation and anti-apoptosis. Food Chem Toxicol. 2014;73:140-7 pubmed publisher
    ..Our results clearly demonstrate that endogenous MT can attenuate PQ-induced acute lung injury, possibly through the mechanisms of anti-oxidation and anti-apoptosis. ..
  6. Liu Y, Zhang L, Wang Y, Wu R, Hua C, Zhao J, et al. Effects of low dose T-2 toxin on secretion of gonadotropin-releasing hormone in the immortalized hypothalamic GT1-7 cell line. Toxicon. 2015;100:67-72 pubmed publisher
  7. Fang H, Cong L, Zhi Y, Xu H, Jia X, Peng S. T-2 toxin inhibits murine ES cells cardiac differentiation and mitochondrial biogenesis by ROS and p-38 MAPK-mediated pathway. Toxicol Lett. 2016;258:259-266 pubmed publisher
  8. Zhang T, Zhang Q, Guo J, Yuan H, Peng H, Cui L, et al. Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells. Environ Toxicol Pharmacol. 2016;46:71-79 pubmed publisher
  9. Lu C, Yuan X, Li L, Zhou W, Zhao J, Wang Y, et al. Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells. Ecotoxicol Environ Saf. 2015;122:537-44 pubmed publisher
    ..Factorial analyses indicated that the potentiation of combined toxicity of nano-SiO2 and Pb was induced by additive or synergistic interactions. ..

More Information


  1. Yang R, Wang Y, Zhang L, Zhang L, Zhao Z, Zhao J, et al. Delay of the onset of puberty in female rats by prepubertal exposure to T-2 toxin. Toxins (Basel). 2015;7:4668-83 pubmed publisher
  2. Rong J, Li L, Jing L, Fang H, Peng S. JAK2/STAT3 Pathway Mediates Protection of Metallothionein Against Doxorubicin-Induced Cytotoxicity in Mouse Cardiomyocytes. Int J Toxicol. 2016;35:317-26 pubmed publisher
  3. Yang R, Wang Y, Zhang L, Zhao Z, Zhao J, Peng S. Prepubertal exposure to an oestrogenic mycotoxin zearalenone induces central precocious puberty in immature female rats through the mechanism of premature activation of hypothalamic kisspeptin-GPR54 signaling. Mol Cell Endocrinol. 2016;437:62-74 pubmed publisher
  4. Lian Y, Zhao J, Wang Y, Zhao J, Peng S. Metallothionein protects against isoniazid-induced liver injury through the inhibition of CYP2E1-dependent oxidative and nitrosative impairment in mice. Food Chem Toxicol. 2017;102:32-38 pubmed publisher
    ..Taken together, these findings clearly demonstrate that MT protects against INH-induced liver toxicity by ameliorating CYP2E1-dependent oxidative and nitrosative impairment. ..
  5. Lu C, Li L, Zhou W, Zhao J, Wang Y, Peng S. Silica nanoparticles and lead acetate co-exposure triggered synergistic cytotoxicity in A549 cells through potentiation of mitochondria-dependent apoptosis induction. Environ Toxicol Pharmacol. 2017;52:114-120 pubmed publisher
    ..Factorial analyses revealed synergistic interactions were responsible for the potentiation of joint apoptotic responses. ..
  6. Zhou W, Tian D, He J, Zhang L, Tang X, Zhang L, et al. Exposure scenario: Another important factor determining the toxic effects of PM2.5 and possible mechanisms involved. Environ Pollut. 2017;226:412-425 pubmed publisher
    ..5 exposure scenarios induce distinct forms cytotoxicity and adaptive response. In addition to particle size and chemical composition, exposure scenario may be a critical factor determining the toxic health effects of PM2.5. ..
  7. Cui L, Guo J, Zhang Q, Yin J, Li J, Zhou W, et al. Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity. Toxicol Lett. 2017;275:28-38 pubmed publisher
    ..Taken together, our results indicated that EPO may activate SIRT1 to enhance mitochondrial function and protect against DOX-induced cardiotoxicity. ..
  8. Zhou W, Yuan X, Zhang L, Su B, Tian D, Li Y, et al. Overexpression of HO-1 assisted PM2.5-induced apoptosis failure and autophagy-related cell necrosis. Ecotoxicol Environ Saf. 2017;145:605-614 pubmed publisher
    ..Further, this study reveals dual roles for HO-1 in PM2.5-induced cytotoxicity and presents a possible explanation for the onset of acute respiratory symptoms under extreme particulate air pollution. ..
  9. Wang Y, Yu Z, Zhao Z, Jia L, Fang H, Zhang T, et al. Subchronic toxicity study of yttrium nitrate by 90-day repeated oral exposure in rats. Regul Toxicol Pharmacol. 2017;90:116-125 pubmed publisher
    ..Under the present experimental condition, the NOAEL in rats was thus set at 90 mg/kg for yttrium nitrate, i.e. 29.1 mg/kg for yttrium. ..
  10. Jing L, Yang M, Li Y, Yu Y, Liang B, Cao L, et al. Metallothionein prevents doxorubicin cardiac toxicity by indirectly regulating the uncoupling proteins 2. Food Chem Toxicol. 2017;110:204-213 pubmed publisher
    ..Therefore, attenuating free radical damage with UCP2 help MT antagonize the Dox-induced cardiac toxicity, but does not directly bind MT. MT may regulate UCP2 expression by up-regulating Nrf2. ..
  11. Wu R, Cui Y, Yuan X, Yuan H, Wang Y, He J, et al. SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation. Toxicol Lett. 2014;229:405-13 pubmed publisher
    ..In conclusion, our results indicated that cadmium-induced SENP1 enhanced AR transcriptional activity by decreasing AR SUMOylation. ..