Pablo Pelegrin

Summary

Publications

  1. pmc P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells
    Alberto Baroja-Mazo
    Unidad de Inflamación y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas CIBERehd, Instituto Murciano de Investigación Biosanitaria IMIB, Hospital Universitario Virgen de la Arrixaca Fundación Formación Investigación Sanitaria Región Murcia FFIS, Murcia, Spain
    PLoS ONE 8:e70577. 2013
  2. pmc Many ways to dilate the P2X7 receptor pore
    Pablo Pelegrin
    Inflammation and Experimental Surgery Unit, University Hospital, Murcia, Spain
    Br J Pharmacol 163:908-11. 2011
  3. pmc Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates
    Pablo Pelegrin
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    EMBO J 28:2114-27. 2009
  4. doi request reprint Cell volume regulation modulates NLRP3 inflammasome activation
    Vincent Compan
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Immunity 37:487-500. 2012
  5. ncbi request reprint Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream
    Pablo Pelegrin
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain
    Dev Comp Immunol 28:229-37. 2004
  6. doi request reprint P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release
    Maria Barberà-Cremades
    Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University Hospital Virgen de Arrixaca Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    FASEB J 26:2951-62. 2012
  7. ncbi request reprint Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum
    Elena Chaves-Pozo
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain
    Cell Tissue Res 320:61-8. 2005
  8. doi request reprint The participation of plasma membrane hemichannels to purinergic signaling
    Alberto Baroja-Mazo
    University Hospital Virgen de la Arrixaca, Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    Biochim Biophys Acta 1828:79-93. 2013
  9. doi request reprint P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
  10. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009

Collaborators

Detail Information

Publications17

  1. pmc P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells
    Alberto Baroja-Mazo
    Unidad de Inflamación y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas CIBERehd, Instituto Murciano de Investigación Biosanitaria IMIB, Hospital Universitario Virgen de la Arrixaca Fundación Formación Investigación Sanitaria Región Murcia FFIS, Murcia, Spain
    PLoS ONE 8:e70577. 2013
    ..Furthermore, P2X7R stimulation was able to inhibit activation of CD8(+) T cells via specific MHC I-oligopeptide complexes. Our study suggests that P2X7R activation on APCs is a novel inhibitor of adaptive CD8(+) T cell immunity. ..
  2. pmc Many ways to dilate the P2X7 receptor pore
    Pablo Pelegrin
    Inflammation and Experimental Surgery Unit, University Hospital, Murcia, Spain
    Br J Pharmacol 163:908-11. 2011
    ..This report suggests that the dye uptake associated with activation of P2X7 receptors is distinct from the P2X7 receptor ion channel and could be a therapeutic target for the treatment of chronic inflammation...
  3. pmc Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates
    Pablo Pelegrin
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    EMBO J 28:2114-27. 2009
    ....
  4. doi request reprint Cell volume regulation modulates NLRP3 inflammasome activation
    Vincent Compan
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Immunity 37:487-500. 2012
    ..Collectively, our data identify cell volume regulation as a basic conserved homeostatic mechanism associated with the formation of the NLRP3 inflammasome and reveal a mechanism for NLRP3 inflammasome activation...
  5. ncbi request reprint Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream
    Pablo Pelegrin
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain
    Dev Comp Immunol 28:229-37. 2004
    ..Notably, the post-translational processing of IL-1beta by SAF-1 cells is abrogated by a specific ICE inhibitor...
  6. doi request reprint P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release
    Maria Barberà-Cremades
    Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University Hospital Virgen de Arrixaca Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    FASEB J 26:2951-62. 2012
    ..Barberà-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release...
  7. ncbi request reprint Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum
    Elena Chaves-Pozo
    Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo, 30100, Murcia, Spain
    Cell Tissue Res 320:61-8. 2005
    ..Collectively, these results suggest that, in addition to being actively involved in bacterial clearance, fish phagocytic granulocytes play a role in the initiation and support of the adaptive immune response...
  8. doi request reprint The participation of plasma membrane hemichannels to purinergic signaling
    Alberto Baroja-Mazo
    University Hospital Virgen de la Arrixaca, Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    Biochim Biophys Acta 1828:79-93. 2013
    ..This article is part of a Special Issue entitled: The communicating junctions, roles and dysfunctions...
  9. doi request reprint P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
    ..Our results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins independently of its proinflammatory actions via IL-1 cytokines...
  10. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
    ..These data provide new insights into the mechanisms of caspase-1 activation and how zinc metabolism contributes to inflammatory mechanisms...
  11. doi request reprint Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules
    Gloria Lopez-Castejon
    Faculty of Life Science, University of Manchester, Michael Smith Building D3315, Manchester, M13 9PT, UK
    Cell Mol Life Sci 68:3095-107. 2011
    ..Therefore, our study reveals an additional level of plasticity modulating the resolution of inflammation...
  12. pmc Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
    Weihong Ma
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 328:409-18. 2009
    ....
  13. pmc A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity
    Vincent Compan
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Immunol 189:2131-7. 2012
    ..Using this sensor, to our knowledge, we describe for the first time the kinetic of the inflammasome activity in living macrophages. With this new probe, we also demonstrated that the pro-IL-1β processing occurs all over the cytoplasm...
  14. doi request reprint Current status of inflammasome blockers as anti-inflammatory drugs
    Gloria Lopez-Castejon
    University of Manchester, Faculty of Life Science, AV Hill Building, 2 021, Manchester, M13 9PT, UK
    Expert Opin Investig Drugs 21:995-1007. 2012
    ..Drug-like antagonists acting up- or down-stream of the inflammasome pathway have been successfully used in clinics as important therapeutics to treat different inflammatory diseases...
  15. pmc Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates
    Alberto Baroja-Mazo
    Inflammation and Experimental Surgery Unit, CIBERehd, University Hospital Virgen de la Arrixaca and Foundation for Healthcare Training and Research of The Region of Murcia FFIS, Carretera Madrid Cartagena s n, 30120 Murcia, Spain
    J Osteoporos 2012:408242. 2012
    ..Bisphosphonates are arising per se as promising anti-inflammatory drugs to treat RA, and this therapy could be improved when administrated in combination with P2X7 receptor antagonists...
  16. doi request reprint Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding
    Sebastien Roger
    Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:6393-401. 2008
    ..This is the first example of CaM deregulating, rather than tightly controlling, calcium entry through an ion channel...
  17. pmc The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, M13 9PT, UK
    Purinergic Signal 5:129-37. 2009
    ..Thus, pannexin-1 is linked to both dye uptake and IL-1beta release but via distinct mechanisms...