De Sheng Pei



  1. Deng S, Fu A, Junaid M, Wang Y, Yin Q, Fu C, et al. Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish. Biomaterials. 2019;206:61-72 pubmed publisher
    ..Our results in this study provided solid data for biosafety evaluations of various types of GQDs, and created an alert for the future biomedical applications of N-GQDs. ..
  2. Jia P, Sun T, Junaid M, Yang L, Ma Y, Cui Z, et al. Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo. Environ Pollut. 2019;247:595-606 pubmed publisher
    ..In short, this study provided deep insights on the negative effects of GFNs exposure. ..
  3. Junaid M, Jia P, Tang Y, Xiong W, Huang H, Strauss P, et al. Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China. Environ Pollut. 2018;242:1939-1949 pubmed publisher
    ..In short, DEHP at ERC has extended potential to induce diverse in vitro and in vivo toxicity at concentrations that also cause impairment of biochemical function in aquatic species of the TGRA. ..
  4. Liu Y, Junaid M, Wang Y, Tang Y, Bian W, Xiong W, et al. New toxicogenetic insights and ranking of the selected pharmaceuticals belong to the three different classes: A toxicity estimation to confirmation approach. Aquat Toxicol. 2018;201:151-161 pubmed publisher
    ..Overall, our findings confirmed that IM has higher toxicity than that of TH and BF, therefore, the consumption of these pharmaceuticals should be regulated in the same manner to ensure human and environmental safety. ..
  5. Deng S, Jia P, Zhang J, Junaid M, Niu A, Ma Y, et al. Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). J Hazard Mater. 2018;357:146-158 pubmed publisher
  6. Junaid M, Hashmi M, Malik R, Pei D. Toxicity and oxidative stress induced by chromium in workers exposed from different occupational settings around the globe: A review. Environ Sci Pollut Res Int. 2016;23:20151-20167 pubmed
    ..This study will also assist occupational health and safety management authorities to devise or change the Cr recommended exposure limits (REL) for different occupational settings. ..
  7. Luo J, Su D, Xie S, Liu Y, Liu P, Yang X, et al. Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. FASEB J. 2018;: pubmed publisher
    ..Luo, J.-J., Su, D.-S., Xie, S.-L., Liu, Y., Liu, P., Yang, X.-J., Pei D.-S. Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. ..
  8. Jia P, Junaid M, Ma Y, Ahmad F, Jia Y, Li W, et al. Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review. DNA Repair (Amst). 2017;59:9-19 pubmed publisher
  9. Junaid M, Syed J, Abbasi N, Hashmi M, Malik R, Pei D. Status of indoor air pollution (IAP) through particulate matter (PM) emissions and associated health concerns in South Asia. Chemosphere. 2018;191:651-663 pubmed publisher
    ..Current review also highlighted the prospects of IAP reduction strategies, which in future can help to improve the status of indoor air quality and public health in South Asia. ..

More Information


  1. Wang C, Chen Y, Bian W, Xie S, Qi G, Liu L, et al. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish Shellfish Immunol. 2018;72:572-580 pubmed publisher
    ..While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-κB pathway, and mstna is likely to act upstream of NF-κB at some as yet unidentified target. ..
  2. Xie S, Junaid M, Bian W, Luo J, Syed J, Wang C, et al. Generation and application of a novel transgenic zebrafish line Tg(cyp1a:mCherry) as an in vivo assay to sensitively monitor PAHs and TCDD in the environment. J Hazard Mater. 2018;344:723-732 pubmed publisher
    ..Taken together, the newly established zebrafish line will prove as a sensitive, efficient and convenient tool for monitoring PAHs and TCDD contamination in the environment. ..
  3. Junaid M, Hashmi M, Tang Y, Malik R, Pei D. Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan. Sci Rep. 2017;7:8848 pubmed publisher
    ..Taken together, our results highlighted the occupationally exposed groups would likely to experience the potential health risks due to excessive exposure to the heavy metals from the leather industries. ..
  4. Lu C, Jiang X, Junaid M, Ma Y, Jia P, Wang H, et al. Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo. Chemosphere. 2017;184:795-805 pubmed publisher
    ..Taken all together, the exposure to elevated GO concentration could cause DNA damage to HEK293T cells and zebrafish embryos; BER pathway could be proposed as the possible inner response mechanism. ..
  5. Zhang J, Sun T, Niu A, Tang Y, Deng S, Luo W, et al. Perturbation effect of reduced graphene oxide quantum dots (rGOQDs) on aryl hydrocarbon receptor (AhR) pathway in zebrafish. Biomaterials. 2017;133:49-59 pubmed publisher
    ..This study offered an opportunity to reveal the potential hazards of in vivo bio-probes, which provided a valuable reference for investigating the graphene-based materials on the disturbance of AhR pathway in biological organisms. ..
  6. Junaid M, Malik R, Pei D. Health hazards of child labor in the leather products and surgical instrument manufacturing industries of Sialkot, Pakistan. Environ Pollut. 2017;226:198-211 pubmed publisher
    ..Taken all together, children were facing serious health implications in these industries and need immediate protective measures to remediate the current situation. ..
  7. Tang Y, Junaid M, Niu A, Deng S, Pei D. Diverse toxicological risks of PAHs in surface water with an impounding level of 175m in the Three Gorges Reservoir Area, China. Sci Total Environ. 2017;580:1085-1096 pubmed publisher
    ..Taken together, different approaches were employed to firstly reveal the real status of ecological toxicity of PAHs and explore the underlying mechanisms at the highest impounding level of 175m in the TGRA. ..
  8. Li J, Niu A, Lu C, Zhang J, Junaid M, Strauss P, et al. A novel forward osmosis system in landfill leachate treatment for removing polycyclic aromatic hydrocarbons and for direct fertigation. Chemosphere. 2017;168:112-121 pubmed publisher