MiR-221 and miR-222 target PUMA to induce cell survival in glioblastomaChun zhi Zhang
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Mol Cancer 9:229. 2010
..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
- MicroRNA roles in beta-catenin pathway
Kai Huang
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Mol Cancer 9:252. 2010
..Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment...
- MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
Zhang Chun-Zhi
Department of Neurosurgery, Tianjin Medical University General Hospital and Lab of Neuro oncology, Tianjin Neurological Institute, Tianjin 300052, China
BMC Cancer 10:367. 2010
..In this study, we examined the impact of miR-221 and miR-222 on human gastric cancer cells, and identified target genes for miR-221 and miR-222 that might mediate their biology...
Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growthP Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People s Republic of China
Cancer Gene Ther 16:351-61. 2009
..In conclusion, the canonical Wnt pathway is of critical importance in the gliomagenesis and intervention of this pathway may provide a new therapeutic approach for malignant gliomas...
Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivoPeiyu Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, People s Republic of China
Technol Cancer Res Treat 5:271-80. 2006
..These results demonstrate that PIK3CB overexpression may play an oncogenic role in the PI3K pathway, and the plasmid-based siRNA targeting of PIK3CB is a potential and promising approach for the treatment of malignant gliomas...
- The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo
Peiyu Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, People s Republic of China
J Neurooncol 76:1-11. 2006
..These results suggest that AKT pathway may play an important role in the development and progression of gliomas. Anti-AKT approach will open a new perspective for a targeted molecular therapy of malignant gliomas...
- Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo
P Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, People s Republic of China
J Neurosurg 92:132-9. 2000
....
- [Effect of transfected Cx43 gene on the gap junction intercellular communication and the human glioma cells proliferation]
Z Xia
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Zhonghua Zhong Liu Za Zhi 23:465-8. 2001
..CONCLUSION: These results indicate that Cx gene and gap junction intercellular communication are of crucial importance in malignant glioma cell growth and development. Cx43 gene may be a target for gene therapy of gliomas...
- [Connexin 43 gene in the in vivo treatment of cerebral glioma in C6 rats]
Zhibai Xia
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Zhonghua Zhong Liu Za Zhi 24:212-4. 2002
..This could become a target of choice in the gene treatment of malignant gliomas...
- Lentiviral vector mediated siRNA knock-down of hTERT results in diminished capacity in invasiveness and in vivo growth of human glioma cells in a telomere length-independent manner
Peng Zhao
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P R China
Int J Oncol 31:361-8. 2007
..Thus, efficient knock-down of hTERT can inhibit glioma cell proliferation and migration prior to its effect on telomere length...
- Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts
Yongping You
Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P R China
Cell Mol Life Sci 64:621-31. 2007
....
- Exogenous wt-p53 enhances the antitumor effect of HSV-TK/GCV on C6 glioma cells
Qiang Huang
Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin, 300052, People s Republic of China
J Neurooncol 82:239-48. 2007
..To study on the antitumor effect of combining wt-p53 gene with suicide gene therapy (HSV-tk+GCV) for malignant gliomas...
- Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion
Peiyu Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neurooncology, Tianjin Neurological Institute, Tianjin, People s Republic of China
Tumour Biol 25:172-8. 2004
..In conclusion, AKT2 plays an important role in glioma cell motility and invasion. Therapy based on AKT inhibition may complement currently available treatment to control glioma cell invasion...
- Antisense telomerase RNA inhibits the growth of human glioma cells in vitro and in vivo
Yongping You
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China
Int J Oncol 28:1225-32. 2006
..Our study conclusively demonstrates that antisense hTR effectively inhibits the growth of human glioma cells in vitro and in vivo and, thus, may be potentially used for gene therapy of malignant gliomas and other cancers...
- Altered expression of Cx43 in astrocytic tumors
Peiyu Pu
Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, PR China
Clin Neurol Neurosurg 107:49-54. 2004
..To evaluate the Cx43 expression of astrocytic tumors and correlate their expression with degrees of malignancy and proliferation activity of tumors...
- [Preliminary study on the gene expression profiles of oligodendrogliom as with cDNA array]
Rongcai Jiang
Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, 300052 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:379-82. 2002
..To study the gene expression profiles of oligodendrogliomas with gene cDNA array...
