Pu Pei-Yu

Summary

Publications

  1. pmc MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
    Kai Liang Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital Laboratory of Neuro Oncology, Tianjin Neurological Institute Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China
    Mol Cancer 13:63. 2014
  2. pmc MiR-30a-5p antisense oligonucleotide suppresses glioma cell growth by targeting SEPT7
    Zhifan Jia
    Department of Neurosurgery, Tianjin Medical University, General Hospital, Tianjin Neurolgical Institute, Laboratory of Neuro Oncology, Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, People s Republic of China
    PLoS ONE 8:e55008. 2013
  3. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
  4. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
  5. pmc MicroRNA roles in beta-catenin pathway
    Kai Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:252. 2010
  6. ncbi request reprint Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth
    P Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People s Republic of China
    Cancer Gene Ther 16:351-61. 2009
  7. ncbi request reprint The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, People s Republic of China
    J Neurooncol 76:1-11. 2006
  8. ncbi request reprint Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivo
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, People s Republic of China
    Technol Cancer Res Treat 5:271-80. 2006
  9. ncbi request reprint Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo
    P Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, People s Republic of China
    J Neurosurg 92:132-9. 2000
  10. ncbi request reprint [Effect of transfected Cx43 gene on the gap junction intercellular communication and the human glioma cells proliferation]
    Z Xia
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhonghua Zhong Liu Za Zhi 23:465-8. 2001

Collaborators

  • Peiyu Pu
  • Hao Jiang
  • Han Lei
  • Zhang Qing-Yu
  • Zhang Chun-Zhi
  • Jie Li
  • Z Zhang
  • Yue Xiao
  • Z Xia
  • Q Huang
  • Ning Liu
  • J Cui
  • G Wang
  • Y Zhang
  • Yongping You
  • Lei Han
  • Tao Jiang
  • Jun Xia Zhang
  • Chun Sheng Kang
  • Chunsheng Kang
  • Peng Zhao
  • Kai Liang Zhang
  • Zhifan Jia
  • Chunzhi Zhang
  • Zhen Dong Shi
  • Chun zhi Zhang
  • Yong Ping You
  • Kai Huang
  • Zhen Fu
  • Cunzu Wang
  • Qingdi Q Li
  • Chunyan Wang
  • Rongcai Jiang
  • Lu Yue Chen
  • Yu Ren
  • Min Li
  • Ling Chao Chen
  • Jian ning Zhang
  • Chuan bao Zhang
  • Xuan Zhou
  • Eric J Wagner
  • Ming Yang
  • Jing Xuan Yang
  • Thomas S Frank
  • Anling Zhang
  • Kun Wang
  • Jianwei Hao
  • Jinhuan Wang
  • Shizhu Yu
  • Yingyi Wang
  • Junxia Zhang
  • Zhendong Shi
  • Meili Liu
  • An Ling Zhang
  • Jin Quan Cheng
  • Wei Dong Yang
  • Zhi fan Jia
  • Ailing Lu
  • Kevin Gardner
  • Xiaolong Fan
  • Yunxiang Cheng
  • Xiaoming Lu
  • Ailin Lu
  • Susan I V Judge
  • Shengwu Chao
  • Leif G Salford
  • Yun Ge
  • Chunsheng Kong
  • Xiaozeng Geng
  • Jing Jie Yu
  • Chunzhao Yu
  • Eddie Reed
  • Yu Zheng

Detail Information

Publications19

  1. pmc MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
    Kai Liang Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital Laboratory of Neuro Oncology, Tianjin Neurological Institute Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China
    Mol Cancer 13:63. 2014
    ..Whether microRNAs can impact the therapeutic effects of EGFR inhibitors in glioblastoma is unknown...
  2. pmc MiR-30a-5p antisense oligonucleotide suppresses glioma cell growth by targeting SEPT7
    Zhifan Jia
    Department of Neurosurgery, Tianjin Medical University, General Hospital, Tianjin Neurolgical Institute, Laboratory of Neuro Oncology, Key Laboratory of Post trauma Neuro repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, People s Republic of China
    PLoS ONE 8:e55008. 2013
    ..Our study demonstrates,for the first time, that miR-30a-5p is a bona fide negative regulator of SEPT7 and the oncogenic activity of miR-30a-5p in human gliomas is at least in part through the repression of SEPT7...
  3. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
    ..MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. However, the association of miR-221/222 with glioma cell invasion and survival remains unknown...
  4. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
    ..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
  5. pmc MicroRNA roles in beta-catenin pathway
    Kai Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:252. 2010
    ..Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment...
  6. ncbi request reprint Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth
    P Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People s Republic of China
    Cancer Gene Ther 16:351-61. 2009
    ..In conclusion, the canonical Wnt pathway is of critical importance in the gliomagenesis and intervention of this pathway may provide a new therapeutic approach for malignant gliomas...
  7. ncbi request reprint The effects of antisense AKT2 RNA on the inhibition of malignant glioma cell growth in vitro and in vivo
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, People s Republic of China
    J Neurooncol 76:1-11. 2006
    ..These results suggest that AKT pathway may play an important role in the development and progression of gliomas. Anti-AKT approach will open a new perspective for a targeted molecular therapy of malignant gliomas...
  8. ncbi request reprint Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivo
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin 300052, People s Republic of China
    Technol Cancer Res Treat 5:271-80. 2006
    ..These results demonstrate that PIK3CB overexpression may play an oncogenic role in the PI3K pathway, and the plasmid-based siRNA targeting of PIK3CB is a potential and promising approach for the treatment of malignant gliomas...
  9. ncbi request reprint Inhibitory effect of antisense epidermal growth factor receptor RNA on the proliferation of rat C6 glioma cells in vitro and in vivo
    P Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, People s Republic of China
    J Neurosurg 92:132-9. 2000
    ....
  10. ncbi request reprint [Effect of transfected Cx43 gene on the gap junction intercellular communication and the human glioma cells proliferation]
    Z Xia
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhonghua Zhong Liu Za Zhi 23:465-8. 2001
    ..CONCLUSION: These results indicate that Cx gene and gap junction intercellular communication are of crucial importance in malignant glioma cell growth and development. Cx43 gene may be a target for gene therapy of gliomas...
  11. pmc MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
    Zhang Chun-Zhi
    Department of Neurosurgery, Tianjin Medical University General Hospital and Lab of Neuro oncology, Tianjin Neurological Institute, Tianjin 300052, China
    BMC Cancer 10:367. 2010
    ..In this study, we examined the impact of miR-221 and miR-222 on human gastric cancer cells, and identified target genes for miR-221 and miR-222 that might mediate their biology...
  12. ncbi request reprint Antisense telomerase RNA inhibits the growth of human glioma cells in vitro and in vivo
    Yongping You
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China
    Int J Oncol 28:1225-32. 2006
    ..Our study conclusively demonstrates that antisense hTR effectively inhibits the growth of human glioma cells in vitro and in vivo and, thus, may be potentially used for gene therapy of malignant gliomas and other cancers...
  13. ncbi request reprint [Connexin 43 gene in the in vivo treatment of cerebral glioma in C6 rats]
    Zhibai Xia
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Zhonghua Zhong Liu Za Zhi 24:212-4. 2002
    ..To study the role of connexin gene (Cx43) in the suppression of C6 glioma...
  14. ncbi request reprint Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neurooncology, Tianjin Neurological Institute, Tianjin, People s Republic of China
    Tumour Biol 25:172-8. 2004
    ..In conclusion, AKT2 plays an important role in glioma cell motility and invasion. Therapy based on AKT inhibition may complement currently available treatment to control glioma cell invasion...
  15. ncbi request reprint Altered expression of Cx43 in astrocytic tumors
    Peiyu Pu
    Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, PR China
    Clin Neurol Neurosurg 107:49-54. 2004
    ..To evaluate the Cx43 expression of astrocytic tumors and correlate their expression with degrees of malignancy and proliferation activity of tumors...
  16. ncbi request reprint Lentiviral vector mediated siRNA knock-down of hTERT results in diminished capacity in invasiveness and in vivo growth of human glioma cells in a telomere length-independent manner
    Peng Zhao
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P R China
    Int J Oncol 31:361-8. 2007
    ..Thus, efficient knock-down of hTERT can inhibit glioma cell proliferation and migration prior to its effect on telomere length...
  17. ncbi request reprint Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts
    Yongping You
    Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P R China
    Cell Mol Life Sci 64:621-31. 2007
    ....
  18. ncbi request reprint Exogenous wt-p53 enhances the antitumor effect of HSV-TK/GCV on C6 glioma cells
    Qiang Huang
    Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin, 300052, People s Republic of China
    J Neurooncol 82:239-48. 2007
    ..To study on the antitumor effect of combining wt-p53 gene with suicide gene therapy (HSV-tk+GCV) for malignant gliomas...
  19. ncbi request reprint [Preliminary study on the gene expression profiles of oligodendrogliom as with cDNA array]
    Rongcai Jiang
    Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, 300052 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:379-82. 2002
    ..To study the gene expression profiles of oligodendrogliomas with gene cDNA array...