Evelyn Peelen

Summary

Publications

  1. doi request reprint Effects of vitamin D on the peripheral adaptive immune system: a review
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 10:733-43. 2011
  2. doi request reprint Fraction of IL-10(+) and IL-17(+) CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators
    E Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands Academic MS Center Limburg, Department of Neurology, Orbis Medical Center, Sittard, The Netherlands Department of Internal Medicine, Division of Clinical and Experimental Immunology, Maastricht University Medical Center, Maastricht, The Netherlands Electronic address
    J Neuroimmunol 258:77-84. 2013
  3. doi request reprint Relatively high serum vitamin D levels do not impair the antibody response to encapsulated bacteria
    E Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, room 5 302, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:61-9. 2013
  4. doi request reprint Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 240:97-103. 2011
  5. doi request reprint Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011
  6. doi request reprint Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Neuroimmunol 235:91-7. 2011
  7. doi request reprint Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht, The Netherlands
    J Neuroimmunol 239:80-6. 2011
  8. pmc Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e6635. 2009
  9. doi request reprint Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands
    J Steroid Biochem Mol Biol 121:243-6. 2010
  10. pmc Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 5:e15235. 2010

Collaborators

Detail Information

Publications11

  1. doi request reprint Effects of vitamin D on the peripheral adaptive immune system: a review
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 10:733-43. 2011
    ..Upcoming vitamin D supplementation trials will further elucidate the in vivo effects of vitamin D on the immune system and its potency to serve as an immune regulating agent in autoimmune diseases...
  2. doi request reprint Fraction of IL-10(+) and IL-17(+) CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators
    E Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands Academic MS Center Limburg, Department of Neurology, Orbis Medical Center, Sittard, The Netherlands Department of Internal Medicine, Division of Clinical and Experimental Immunology, Maastricht University Medical Center, Maastricht, The Netherlands Electronic address
    J Neuroimmunol 258:77-84. 2013
    ..We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens...
  3. doi request reprint Relatively high serum vitamin D levels do not impair the antibody response to encapsulated bacteria
    E Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, room 5 302, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:61-9. 2013
    ..These data indicate that a relatively high vitamin D status does not seem to hamper an adequate antibody response upon infection or vaccination, suggesting that vitamin D, in this setting, is not immunosuppressive...
  4. doi request reprint Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 240:97-103. 2011
    ..A clear role for vitamin D in this regulation could not be established...
  5. doi request reprint Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011
    ..Since there is an increasing interest in the role of B cells in the pathophysiology of MS, we studied the role of vitamin D on B cells in vivo in patients with MS...
  6. doi request reprint Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Neuroimmunol 235:91-7. 2011
    ..Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment...
  7. doi request reprint Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht, The Netherlands
    J Neuroimmunol 239:80-6. 2011
    ..We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers...
  8. pmc Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e6635. 2009
    ..A poor vitamin D status has been linked with MS incidence and MS disease activity. In the present study, we assess a potential in vivo correlation between vitamin D status and Treg function in relapsing remitting MS (RRMS) patients...
  9. doi request reprint Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands
    J Steroid Biochem Mol Biol 121:243-6. 2010
    ..These results suggest that the serum levels of 1,25(OH)2D, PTH, and total calcium are not critically involved in the correlation between vitamin D status and T cell regulation...
  10. pmc Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 5:e15235. 2010
    ..In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures...
  11. doi request reprint The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 8:621-6. 2009
    ..We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS...