Hepatitis C infection: a clinical reviewBrian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, GA 30312, USA
South Med J 97:364-73; quiz 374. 2004
..Common side effects of therapy include neuropsychiatric symptoms, influenza-like symptoms and hematological abnormalities...
Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: the new standard of careBrian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, GA 30309, USA
Lancet Infect Dis 12:717-28. 2012
..Protease inhibitors are the first of many antiviral medications that will probably be combined in future interferon-free regimens...
- Sustained virologic response to antiviral therapy for chronic hepatitis C virus infection: a cure and so much more
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, Georgia 30312, USA
Clin Infect Dis 52:889-900. 2011
..In summary, chronic HCV infection is curable with SVR attainment, and with cure comes improved liver histology and more favorable clinical outcomes, in comparison with patients who do not achieve the same therapeutic milestone...
- The IL-28 genotype: how it will affect the care of patients with hepatitis C virus infection
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, GA 30312, USA
Curr Gastroenterol Rep 13:78-86. 2011
..Perhaps more importantly, the test can help the clinician personally tailor the duration and even the type of therapy that is most appropriate for an individual patient, newly or chronically infected with the hepatitis C virus...
- Salicylate intoxication: a clinical review
Brian L Pearlman
Atlanta Medical Center, Atlanta, GA, USA
Postgrad Med 121:162-8. 2009
..The prognosis depends on prompt recognition and treatment. Delayed diagnosis results in increased morbidity and mortality, particularly in the elderly...
Extended-therapy duration for chronic hepatitis C, genotype 1: the long and the short of itBrian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Medical College of Georgia, Emory School of Medicine, 315 Boulevard NE Suite 200, Atlanta, Georgia 30312, United States
World J Gastroenterol 14:3621-7. 2008
..Based on data from both viral kinetic and clinical studies, therapy prolongation in slow responders may be a reasonable strategy to improve response rates in these treatment-refractory patients...
- Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype 1-infected slow responders
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, GA 30309, USA
Hepatology 46:1688-94. 2007
..Treatment extension does not seem to increase the rate of dose reduction or therapy discontinuation...
- Chronic hepatitis C therapy: changing the rules of duration
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, 30312, USA
Clin Gastroenterol Hepatol 4:963-71. 2006
..This review focuses on the evidence supporting such treatment individualization and discusses potential treatment algorithm modifications...
- Hepatitis C virus infection in African Americans
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Medical College of Georgia, Atlanta, GA, USA
Clin Infect Dis 42:82-91. 2006
..Some of the postulated mechanisms for these disparate treatment responses and natural histories of infection are also reviewed...
- Hepatitis C treatment update
Brian L Pearlman
Center For Hepatitis C, Atlanta Medical Center, Atlanta, Georgia 30312, USA
Am J Med 117:344-52. 2004
..Four broad groups of investigational therapeutic agents appear promising for future therapy: modified interferons and ribavirins, immunomodulators, viral life-cycle targets, and antifibrotic agents...
- The new cholesterol guidelines. Applying them in clinical practice
Brian L Pearlman
Department of Internal Medicine, Atlanta Medical Center, 285 Boulevard NE, Suite 140, Atlanta, GA 30312, USA
Postgrad Med 112:13-6, 19-22, 25-6 passim. 2002
..In this article, Dr Pearlman reviews the latest guidelines and offers case examples that demonstrate how to incorporate the recommendations routinely into clinical practice...
