D Payen

Summary

Publications

  1. ncbi Which general intensive care unit patients can benefit from placement of the pulmonary artery catheter?
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere University Hospital, Paris, France
    Crit Care 10:S7. 2006
  2. ncbi Gene profiling in human blood leucocytes during recovery from septic shock
    Didier Payen
    Lariboisiere University Hospital, Assistance Publique Hopitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Paris, France
    Intensive Care Med 34:1371-6. 2008
  3. ncbi Bench-to-bedside review: Glucose and stress conditions in the intensive care unit
    Marie Reine Losser
    Laboratoire de Recherche Paris 7 EA 3509, Service d Anesthesie Reanimation, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Université Diderot Paris 7, 75475 Paris Cedex 10, France
    Crit Care 14:231. 2010
  4. ncbi Factors associated with septic shock and mortality in generalized peritonitis: comparison between community-acquired and postoperative peritonitis
    Florence C Riché
    Department of Anesthesiology and Intensive Care, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris AP HP, Paris 75010, France
    Crit Care 13:R99. 2009
  5. ncbi Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
    Laurent Heyer
    AP HP, Department of Anesthesiology and Critical Care Medicine, University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Crit Care 13:S8. 2009
  6. ncbi A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008
  7. ncbi Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, University Paris, Paris, France
    Crit Care Med 37:803-10. 2009
  8. ncbi Expression of monocyte human leukocyte antigen-DR in relation with sepsis severity and plasma mediators
    D Payen
    Department of Anesthesiology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada
    Minerva Anestesiol 75:484-93. 2009
  9. ncbi [Acute renal failure: epidemiology, incidence and prognostic criteria]
    D Payen
    , , , , 2, rue Ambroise-Par, 75475 Paris Cedex 10, France
    Ann Fr Anesth Reanim 24:134-9. 2005
  10. ncbi Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome?
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine SAMU and Laboratory of Anesthesiology, EA322, Hospital Lariboisiere, AP HP and Paris 7 Diderot University, 2 rue Ambroise Pare, 75010 Paris, France
    Crit Care 13:S6. 2009

Collaborators

Detail Information

Publications54

  1. ncbi Which general intensive care unit patients can benefit from placement of the pulmonary artery catheter?
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere University Hospital, Paris, France
    Crit Care 10:S7. 2006
    ..Because many techniques may be used to measure cardiac output, the indications for PAC use have become founded on other parameters that are useful in more specific situations, essentially involving the right circulation...
  2. ncbi Gene profiling in human blood leucocytes during recovery from septic shock
    Didier Payen
    Lariboisiere University Hospital, Assistance Publique Hopitaux de Paris, Department of Anesthesiology and Critical Care Medicine, Paris, France
    Intensive Care Med 34:1371-6. 2008
    ..To assess blood leucocytes gene profiling during recovery phase of septic shock; to test the relation between encoding gene expression and protein level...
  3. ncbi Bench-to-bedside review: Glucose and stress conditions in the intensive care unit
    Marie Reine Losser
    Laboratoire de Recherche Paris 7 EA 3509, Service d Anesthesie Reanimation, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Université Diderot Paris 7, 75475 Paris Cedex 10, France
    Crit Care 14:231. 2010
    ..Since chronic exposure to glucose metabolites, as encountered in diabetes, induces adverse effects, the proper roles of these metabolites during acute conditions need further elucidation...
  4. ncbi Factors associated with septic shock and mortality in generalized peritonitis: comparison between community-acquired and postoperative peritonitis
    Florence C Riché
    Department of Anesthesiology and Intensive Care, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris AP HP, Paris 75010, France
    Crit Care 13:R99. 2009
    ..Our aim was to analyze clinical and bacteriological factors associated with the occurrence of shock and mortality in patients with secondary generalized peritonitis...
  5. ncbi Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
    Laurent Heyer
    AP HP, Department of Anesthesiology and Critical Care Medicine, University Paris 7, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Crit Care 13:S8. 2009
    ..The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage...
  6. ncbi A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008
    ..The aim of the present observational study was to analyze the influence of patient characteristics and fluid balance on the outcome of ARF in intensive care unit (ICU) patients...
  7. ncbi Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, University Paris, Paris, France
    Crit Care Med 37:803-10. 2009
    ..We sought to assess the effect of early application of hemofiltration on the degree of organ dysfunction and plasma cytokine levels in patients with severe sepsis or septic shock...
  8. ncbi Expression of monocyte human leukocyte antigen-DR in relation with sepsis severity and plasma mediators
    D Payen
    Department of Anesthesiology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada
    Minerva Anestesiol 75:484-93. 2009
    ..The aim of this study was to characterize the monocyte functional phenotype by HLA-DR expression in septic patients at the onset of sepsis and during recovery in relation to organ failure and plasma mediators...
  9. ncbi [Acute renal failure: epidemiology, incidence and prognostic criteria]
    D Payen
    , , , , 2, rue Ambroise-Par, 75475 Paris Cedex 10, France
    Ann Fr Anesth Reanim 24:134-9. 2005
  10. ncbi Is thenar tissue hemoglobin oxygen saturation in septic shock related to macrohemodynamic variables and outcome?
    Didier Payen
    Department of Anesthesiology and Critical Care Medicine SAMU and Laboratory of Anesthesiology, EA322, Hospital Lariboisiere, AP HP and Paris 7 Diderot University, 2 rue Ambroise Pare, 75010 Paris, France
    Crit Care 13:S6. 2009
    ....
  11. ncbi Inhaled nitric oxide and acute lung injury
    D M Payen
    Department of Anesthesiology and Critical Care, McGill University, Montreal, Quebec, Canada
    Clin Chest Med 21:519-29, ix. 2000
    ..Because of the inhaled NO uptake by the lung, the extra vascular lung effects might be in the future the most important development in relation with platelet anti-agregant and anti-inflammatory properties...
  12. ncbi Assessment of immunological status in the critically ill
    D Payen
    Critical Care Division, Department of Anesthesiology, McGrill University, Montreal, Canada
    Minerva Anestesiol 66:757-63. 2000
    ....
  13. ncbi Accelerated in vitro differentiation of blood monocytes into dendritic cells in human sepsis
    V Faivre
    INSERM U662, Paris, France
    Clin Exp Immunol 147:426-39. 2007
    ..These DC fail, however, to increase their T cell activation abilities upon maturation...
  14. ncbi Benefit of active compression-decompression cardiopulmonary resuscitation as a prehospital advanced cardiac life support. A randomized multicenter study
    P Plaisance
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    Circulation 95:955-61. 1997
    ..We compared short-term prognosis of active compression-decompression (ACD) and standard (STD) cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrests...
  15. ncbi Anti-inflammatory profile of circulating immune cells after surgery for seizure
    A C Lukaszewicz
    Department of Anesthesiology, Royal Victoria Hospital, McGill University, Montreal, Canada
    Minerva Anestesiol 76:477-84. 2010
    ..Brain lesions have been associated with impaired immunity and postoperative infections. We studied alterations of the inflammatory response in relation to neurohormonal patterns after neurosurgery for seizure...
  16. ncbi Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, prostaglandins, and nitric oxide
    A Mebazaa
    Laboratoire d Anesthöesiologie, Döepartement d Anesthöesie Röeanimation, INSERM U127, Paris, France
    Circulation 104:3137-44. 2001
    ....
  17. ncbi Interest of a therapeutic optimization strategy in severe ARDS
    N Guinard
    Department of Anesthesiology and Critical Care Medicine, Hôpital Universitaire Lariboisière, Paris, France
    Chest 111:1000-7. 1997
    ..Evaluate the interest of the response to a therapeutic optimization as a predictor of prognosis in ARDS...
  18. ncbi A comparison of standard cardiopulmonary resuscitation and active compression-decompression resuscitation for out-of-hospital cardiac arrest. French Active Compression-Decompression Cardiopulmonary Resuscitation Study Group
    P Plaisance
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    N Engl J Med 341:569-75. 1999
    ..In the current study, we assessed the effects of the active compression-decompression method on one-year survival...
  19. ncbi Is monocyte HLA-DR expression monitoring a useful tool to predict the risk of secondary infection?
    A C Lukaszewicz
    Laboratory of Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, APHP, University of Paris 7 Diderot, Paris, France
    Minerva Anestesiol 76:737-43. 2010
    ..This review focuses on the use of monocyte HLA-DR expression to detect immune hyporesponsiveness and to select the appropriate immunomodulating therapy, as well as the efficiency of this technique in controlling secondary infections...
  20. ncbi Neurosurgery and elderly: analysis through the years
    Salvatore Chibbaro
    Neurosurgery Department, Lariboisiere University Hospital, Paris, France
    Neurosurg Rev 34:229-34. 2010
    ..However, downstream structures for postoperative elderly patients must be further developed to reduce the mean hospital stay in neurosurgical departments because this trend is likely to continue to grow...
  21. ncbi Intravenous almitrine bismesylate reversibly induces lactic acidosis and hepatic dysfunction in patients with acute lung injury
    A B'chir
    Departement d Anesthesie Reanimation, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, France
    Anesthesiology 89:823-30. 1998
    ..However, recent research has suggested a potentially harmful effect on lactate metabolism and hepatic function...
  22. ncbi Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis
    Ioulia Belikova
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    Crit Care Med 35:2702-8. 2007
    ..Because the mechanisms of such down-regulation are unclear, we investigated the hypothesis of an energetic failure of immune cells to participate in immune dysfunction...
  23. ncbi Inspiratory impedance during active compression-decompression cardiopulmonary resuscitation: a randomized evaluation in patients in cardiac arrest
    P Plaisance
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France plaisance claranet fr
    Circulation 101:989-94. 2000
    ..The long-term benefits of this new CPR technology are under investigation...
  24. ncbi Prolonged severe hypercapnia complicating near fatal asthma in a 35-year-old woman
    F Adnet
    Department of Anesthesiology, University of Paris VII, France
    Intensive Care Med 24:1335-8. 1998
    ..We describe a patient with a prolonged and severe hypercapnia occurring during an episode of status asthmaticus induced by ophthalmic instillation of carteolol...
  25. ncbi A randomized study of out-of-hospital continuous positive airway pressure for acute cardiogenic pulmonary oedema: physiological and clinical effects
    P Plaisance
    Department of Anaesthesiology and Critical Care, Lariboisière University Hospital AP HP, 2 rue Ambroise Pare, Paris 75010, France
    Eur Heart J 28:2895-901. 2007
    ..The present study was designed to assess the benefit of CPAP as a first line treatment of ACPE in the out-of-hospital environment...
  26. ncbi [Secondary ischaemic lesions: how to prevent?]
    D Payen
    Département d Anesthésie Réanimation SMUR, Hopital Lariboisiere, Universite Paris VII, APHP, 2, rue Ambroise Pare, 75475 Paris Cedex 10, France
    Ann Fr Anesth Reanim 26:878-82. 2007
    ..Such an early detection helps to limit the consequences of the initial trauma, and may improve outcome...
  27. ncbi Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction
    Anne Claire Lukaszewicz
    Department of Anesthesiology and Critical Care Medicine SAMU, Laboratory of Anesthesiology, Lariboisiere Hospital, AP HP and Paris 7 Diderot University, Paris, France
    Crit Care Med 37:2746-52. 2009
    ....
  28. ncbi [Transfers for postpartum haemorrhage in a Reference center (Lariboisière hospital): our experience during two years (2008 and 2009)]
    C Brugier
    Service de Gynecologie Obstetrique, Hopital Lariboisiere, AP HP, 2, rue Ambroise Pare, 75010 Paris, France
    Gynecol Obstet Fertil 39:681-6. 2011
    ..We realized a study on the transfers for postpartum haemorrhage in 2008 and 2009 in a Reference center (Lariboisière Hospital)...
  29. ncbi [Out-of-hospital assessment of elderly patients' preference for ICU care]
    R Pirracchio
    Service d Anesthesie Reanimation, Université Paris 5 Descartes, Sorbonne Paris Cité, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France
    Ann Fr Anesth Reanim 31:114-9. 2012
    ..To estimate the adequacy between elderly patients' preference for ICU care when treated for a life-threatening pathology, and the strategy proposed by the medical team on scene...
  30. ncbi Sepsis is associated with reciprocal expressional modifications of constitutive nitric oxide synthase (NOS) in human skeletal muscle: down-regulation of NOS1 and up-regulation of NOS3
    S Lanone
    Institut National de la Santé et de la Recherche Médicale INSERM U408 and IFR 02, Faculte X Bichat, Hopital Lariboisiere, Paris, France
    Crit Care Med 29:1720-5. 2001
    ..To study the expression (mRNA and protein) and activity of the constitutive isoforms of nitric oxide synthase (NOS1 and NOS3) in a skeletal muscle of septic patients...
  31. ncbi Uncontrollable high-frequency tachypnea: a rare and nearly fatal complication of endoscopic third ventriculostomy: case report and literature review
    R Bernard
    Neuro ICU, Lariboisere University Hospital, Paris, France
    Minim Invasive Neurosurg 53:270-2. 2010
    ..Endoscopic third ventriculostomy (ETV) is considered a safe procedure although it carries its rate of risks and complications that may occasionally be life-threatening...
  32. ncbi Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone
    Damien Barraud
    Equipe d Accueil 322, Universite, Paris, France
    Crit Care Med 35:1376-82. 2007
    ..Our study aimed to fully characterize both systolic and diastolic abnormalities of sepsis-associated heart failure and to identify treatment that would support full-cycle cardiac improvement...
  33. ncbi Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock
    Vincent Caille
    Department of Anesthesiology and Critical Care Medicine and Laboratory of Hematology, , IFR 06, University Paris 7, Paris, France
    Shock 22:521-6. 2004
    ..Thus, the decrease in HLA-DR expression is specific to septic shock and is associated, in septic shock patients, with increased mortality risk...
  34. ncbi Impaired plasma B-type natriuretic peptide clearance in human septic shock
    Romain Pirracchio
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, APHP, University Paris 7 Diderot, Paris, France
    Crit Care Med 36:2542-6. 2008
    ..We further evaluated whether baseline plasma BNP can predict fluid responsiveness and whether BNP can still be released in plasma despite high initial BNP levels, in response to overloading...
  35. ncbi Diastolic arterial blood pressure: a reliable early predictor of survival in human septic shock
    Samir Benchekroune
    Department of Anesthesiology and Intensive Care, Lariboisiere University Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    J Trauma 64:1188-95. 2008
    ....
  36. ncbi Adrenal response in patients with septic shock of abdominal origin: relationship to survival
    Florence C Riché
    Department of Anesthesiology and Intensive Care, Hopital Lariboisiere, AP HP, Universite Paris VII, 2 rue Ambroise Pare, 75010, Paris, France
    Intensive Care Med 33:1761-6. 2007
    ..To evaluate the prognostic value of adrenocortical response to corticotropin in septic shock patients operated on exclusively for an intra-abdominal source of infection...
  37. ncbi Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits
    Martin Albert
    Critical Care Division, Royal Victoria Hospital, Victoria, BC, Canada
    Crit Care Med 32:1891-8. 2004
    ..CONCLUSIONS: Preservation of renal blood flow with arginine vasopressin during endotoxemia, in particular to the cortex, suggests it could be a promising agent for hemodynamic support during septic shock...
  38. ncbi Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway
    Christophe Rabuel
    Department of Anesthesiology and Critical Care Medicine, , Paris, France
    Anesthesiology 101:583-90. 2004
    ..Activation of ubiquitin pathway could be involved in sepsis-related muscle catabolism and wasting...
  39. ncbi International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: analysis of efficacy and safety data in a large surgical cohort
    Didier Payen
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    Surgery 141:548-61. 2007
    ..This database broadens the experience reported on a comparatively small set of surgical patients from the pivotal Protein C Worldwide Evaluation in Severe Sepsis trial to examine issues of safety and efficacy in a much larger cohort...
  40. ncbi Cytokine cascade in sepsis
    Jean Marc Cavaillon
    UP Cytokine and Inflammation, Institut Pasteur, Paris, France
    Scand J Infect Dis 35:535-44. 2003
    ..Although TNF contributes towards favouring the production of many other cytokines within a complex cascade, there are numerous examples to illustrate that its presence is not a prerequisite for these productions...
  41. ncbi Lack of alteration of endogenous nitric oxide pathway during prolonged nitric oxide inhalation in intensive care unit patients
    Anne-Claire Lukaszewicz
    Department of Anesthesiology and Critical Care Medicine, , University Paris 7, Paris, France
    Crit Care Med 33:1008-14. 2005
    ....
  42. ncbi Noninvasive techniques for measurements of cardiac output
    Bernard P Cholley
    Department of Anesthesiology and Critical Care Medicine, Hopital Lariboisiere, Paris, France
    Curr Opin Crit Care 11:424-9. 2005
    ..The new noninvasive techniques are gaining acceptance among intensivists and anesthesiologists who have been trained almost exclusively in the pulmonary artery catheter and the thermodilution technique...
  43. ncbi Activation of the ubiquitin proteolytic pathway in human septic heart and diaphragm
    Christophe Rabuel
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Cardiovasc Pathol 19:158-64. 2010
    ....
  44. ncbi International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: analysis of efficacy and safety data in a large surgical cohort
    Didier Payen
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    Surgery 140:726-39. 2006
    ..Future analyses are needed to evaluate the special relationships among sepsis severity, bleeding management, and the postoperative timing of DrotAA administration...
  45. ncbi Systemic and hepatosplanchnic macro- and microcirculatory dose response to arginine vasopressin in endotoxic rabbits
    Tal Kopel
    Critical Care Division, Royal Victoria Hospital, 687 Pine Av West, H3A 1A1, Montreal, QC, Canada
    Intensive Care Med 34:1313-20. 2008
    ..Arginine vasopressin (AVP) is being used increasingly to treat vasodilatory hypotension, although its effects on hepatosplanchnic perfusion have been debated...
  46. ncbi Inhaled nitric oxide therapy in adults: European expert recommendations
    Peter Germann
    Department of Anaesthesiology and General Intensive Care, Medical University of Vienna, Waehringerguertel 18 20, 1090 Vienna, Austria
    Intensive Care Med 31:1029-41. 2005
    ..Inhaled nitric oxide (iNO) has been used for treatment of acute respiratory failure and pulmonary hypertension since 1991 in adult patients in the perioperative setting and in critical care...
  47. ncbi Functional hemodynamic monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 9:566-72. 2005
    ..Potentially, as these and newer, less invasive hemodynamic measures are validated, they could be incorporated into such protocolized care in a cost-effective manner...
  48. ncbi Renal hypoxia and dysoxia after reperfusion of the ischemic kidney
    Matthieu Legrand
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Med 14:502-16. 2008
    ..Their role in the development of ischemia-induced renal damage and ischemic acute renal failure are discussed...
  49. ncbi An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study
    Charles L Sprung
    Hadassah Hebrew University, Medical Center, Department of Anaesthesiology and Critical Care Medicine, P O Box 1200, 91120, Jerusalem, Israel
    Intensive Care Med 32:421-7. 2006
    ..To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs...
  50. ncbi The pulmonary artery catheter: in medio virtus
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:3093-6. 2008
    ..To clarify the role of the pulmonary artery catheter in the intensive care unit...
  51. ncbi Pulmonary-artery catheters in high-risk surgical patients
    Bernard P Cholley
    N Engl J Med 348:2035-7; author reply 2035-7. 2003
  52. ncbi Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity
    Sophie Lanone
    Institut National de la Santé et de la Recherche Médicale INSERM U408 and IFR 02, Faculte X Bichat, 75018 Paris, France
    Biochem J 366:399-404. 2002
    ..This phenomenon could be an endogenous mechanism of in vivo modulation of NOS2 enzymic activity...
  53. ncbi Extracranial complications in patients with acute brain injury: a post-hoc analysis of the SOAP study
    Luciana Mascia
    Department of Anesthesiology and Intensive Care, University of Turin, Ospedale S Giovanni Battista, Corso Dogliotti 14, 10126, Turin, Italy
    Intensive Care Med 34:720-7. 2008
    ..To assess the incidence and severity of nonneurological organ dysfunction and its effect on outcome in acute neurological patients in an international cohort observational study...
  54. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean-Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    ..In addition to age, a positive fluid balance was among the strongest prognostic factors for death. Patients with intensive care unit acquired sepsis have a worse outcome despite similar severity scores on intensive care unit admission...