Carlos N Pato

Summary

Publications

  1. ncbi request reprint Selection of homogeneous populations for genetic study: the Portugal genetics of psychosis project
    C N Pato
    Department of Psychiatry, SUNY at Buffalo, New York 14203, USA
    Am J Med Genet 74:286-8. 1997
  2. ncbi request reprint Detection of expansion regions in Portuguese bipolar families
    C N Pato
    Department of Psychiatry, State University of New York at Buffalo, Buffalo, New York 14214 3000, USA
    Am J Med Genet 96:854-7. 2000
  3. ncbi request reprint Genetic analyses of schizophrenia
    C N Pato
    Department of Psychiatry, State University of New York at Buffalo, Laboratory of Psychiatric and Molecular Genetics, G 10 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Curr Psychiatry Rep 2:137-42. 2000
  4. ncbi request reprint Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 127:30-4. 2004
  5. doi request reprint Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population
    Ayman H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC, USA
    Am J Med Genet B Neuropsychiatr Genet 159:383-91. 2012
  6. ncbi request reprint Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 134:119-21. 2005
  7. ncbi request reprint Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study
    Alda M Ambrósio
    Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004 517 Coimbra, Portugal
    Am J Med Genet B Neuropsychiatr Genet 128:1-5. 2004
  8. ncbi request reprint Association between schizophrenia and the syntaxin 1A gene
    Albert H C Wong
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 56:24-9. 2004
  9. ncbi request reprint Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches
    Frank A Middleton
    Center for Neuropsychiatric Genetics, Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 136:12-25. 2005
  10. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005

Detail Information

Publications15

  1. ncbi request reprint Selection of homogeneous populations for genetic study: the Portugal genetics of psychosis project
    C N Pato
    Department of Psychiatry, SUNY at Buffalo, New York 14203, USA
    Am J Med Genet 74:286-8. 1997
    ..13 in a rural American population and 0.38 in an urban American population. The results of this analysis indicate that the Azores have the highest degree of homogeneity, and mainland Portugal has a high degree of homogeneity...
  2. ncbi request reprint Detection of expansion regions in Portuguese bipolar families
    C N Pato
    Department of Psychiatry, State University of New York at Buffalo, Buffalo, New York 14214 3000, USA
    Am J Med Genet 96:854-7. 2000
    ..One family shows segregation with the chromosome 18 locus, whereas the other family segregates with expansions at the SCA8 locus. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:854-857, 2000...
  3. ncbi request reprint Genetic analyses of schizophrenia
    C N Pato
    Department of Psychiatry, State University of New York at Buffalo, Laboratory of Psychiatric and Molecular Genetics, G 10 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Curr Psychiatry Rep 2:137-42. 2000
    ..This review highlights some of the latest progress and findings in the molecular genetic analyses of schizophrenia, including both candidate gene analyses and genome scan studies...
  4. ncbi request reprint Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 127:30-4. 2004
    ..Our findings provide additional support for a susceptibility locus for bipolar disorder on 6q, as well as, suggesting the importance of denser scans. Published 2004 Wiley-Liss, Inc...
  5. doi request reprint Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population
    Ayman H Fanous
    Mental Health Service Line, Washington VA Medical Center, Washington, DC, USA
    Am J Med Genet B Neuropsychiatr Genet 159:383-91. 2012
    ..These results suggest that high-density marker maps may provide greater power and precision in linkage studies than lower density maps. They also further support the hypothesis that SZ and BP share at least some risk alleles...
  6. ncbi request reprint Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 134:119-21. 2005
    ..Taken together these observations suggest a shared genetic liability among Portuguese populations for bipolar disorder on chromosome 6q, and that the PIC population is likely representative of Caucasians in general...
  7. ncbi request reprint Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study
    Alda M Ambrósio
    Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004 517 Coimbra, Portugal
    Am J Med Genet B Neuropsychiatr Genet 128:1-5. 2004
    ..Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population...
  8. ncbi request reprint Association between schizophrenia and the syntaxin 1A gene
    Albert H C Wong
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 56:24-9. 2004
    ..Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia...
  9. ncbi request reprint Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches
    Frank A Middleton
    Center for Neuropsychiatric Genetics, Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 136:12-25. 2005
    ..Verification of selected changes in expression was performed using quantitative real-time RT-PCR. Our results provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders...
  10. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  11. ncbi request reprint Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder
    Albert H C Wong
    Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Canada
    Schizophr Res 78:137-46. 2005
    ..The 14-3-3 genes code for a family of proteins that bind to and regulate other proteins, and they modulate neurodevelopment, cell-division, signal transduction and gene transcription...
  12. ncbi request reprint Human p53 tumor suppressor gene (TP53) and schizophrenia: case-control and family studies
    Xingqun Ni
    Neuroscience Research Department, Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Canada M5T 1R8
    Neurosci Lett 388:173-8. 2005
    ..017) in Portuguese schizophrenia families. Haplotype analysis also showed a significant association between TP53 and schizophrenia. These results provide further evidence that TP53 may play a role in the pathogenesis of schizophrenia...
  13. ncbi request reprint No evidence of association or linkage disequilibrium between polymorphisms in the 5' upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese population
    Alda M Ambrósio
    Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Am J Med Genet B Neuropsychiatr Genet 125:20-4. 2004
    ..These data suggest that polymorphisms (-C616G, -C521T, and 48 bp repeat) at the DRD4 gene do not have a minor effect in the susceptibility to schizophrenia in our sample...
  14. ncbi request reprint A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses
    Alda M Ambrósio
    Unit of Clinical and Molecular Genetics, National Institute of Legal Medicine, Faculty of Medicine, University of Coimbra, Largo da Se Nova, 3000 213 Coimbra, Portugal
    CNS Spectr 10:57-61. 2005
    ..Alterations of the gamma-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses...