Improving outcomes in patients with vestibular schwannomas: microsurgery versus radiosurgeryJ M Sarmiento
Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Neurosurg Sci 57:23-44. 2013
..SRS has been shown to be efficacious and have a lower morbidity in most patients with tumors that are <3cm. SRS can be considered as the primary modality of choice for treatment of most VS that are <3cm...
High levels of phosphorylated MAP kinase are associated with poor survival among patients with glioblastoma during the temozolomide eraChirag G Patil
Center for Neurosurgical Outcomes Research, Department of Neurosurgery, Cedars Sinai Medical Center, 8631 W Third St, Suite 800E, Los Angeles, CA 90048, USA
Neuro Oncol 15:104-11. 2013
..It confirms the significant and independent prognostic relevance of p-MAPK in predicting survival of patients with GBM treated in the temozolomide era and highlights the need for therapies targeting the p-MAPK oncogenic pathway...
Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastasesChirag G Patil
Department ofNeurosurgery, MaxineDunitz Neurosurgical Institute, Los Angeles, CA, USA
Cochrane Database Syst Rev 9:CD006121. 2012
..The benefit of adding SRS to WBRT is unclear. This is an updated version of the original Cochrane review published in Issue 6, 2010...
- Management of multifocal and multicentric gliomas
Chirag G Patil
Department of Neurological Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
Neurosurg Clin N Am 23:343-50, x. 2012
....
- National inpatient complications and outcomes after surgery for spinal metastasis from 1993-2002
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
Cancer 110:625-30. 2007
..The aim of this study was to report inpatient mortality, complications, and outcomes on a national level...
- Cost-effectiveness analysis of mechanical thrombectomy in acute ischemic stroke
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosurg 110:508-13. 2009
..In this study, the authors evaluated the cost and effectiveness of mechanical thrombectomy compared with standard medical therapy in patients who are ineligible to receive tissue plasminogen activator...
- Predictors of peritumoral edema after stereotactic radiosurgery of supratentorial meningiomas
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford Hospital, Stanford, California 94305, USA
Neurosurgery 63:435-40; discussion 440-2. 2008
..Potential predictors of postradiosurgical peritumoral edema, including parasagittal tumor location, tumor size, and treatment dose, were evaluated...
- Outcomes after repeat transsphenoidal surgery for recurrent Cushing's disease
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
Neurosurgery 63:266-70; discussion 270-1. 2008
..To systematically analyze patient outcomes after repeat transsphenoidal (TS) surgery for recurrent Cushing's disease...
- Inpatient complications, mortality, and discharge disposition after surgical correction of idiopathic scoliosis: a national perspective
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive Room R200, MC5327, Stanford, CA 94305, USA
Spine J 8:904-10. 2008
..Information about complications and mortality after surgery for correction of idiopathic scoliosis has been largely derived from single-institution series. Regional or national studies have been lacking...
- Non-surgical management of hormone-secreting pituitary tumors
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Neurosci 16:985-93. 2009
..Medical management with standard and novel drugs as well as the role and effectiveness of radiation therapy and radiosurgery are discussed in detail...
- National trends, complications, and outcomes following transsphenoidal surgery for Cushing's disease from 1993 to 2002
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
Neurosurg Focus 23:E7. 2007
..In this study the authors report on inpatient death, morbidity, and outcomes following TSS for Cushing's disease on a national level...
- CyberKnife radiosurgical rhizotomy for the treatment of atypical trigeminal nerve pain
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5327, USA
Neurosurg Focus 23:E9. 2007
..This study represents the first report of the treatment of atypical TN with frameless CyberKnife stereotactic radiosurgery (SRS)...
- Brain atrophy and cognitive deficits in Cushing's disease
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
Neurosurg Focus 23:E11. 2007
..In this review, the timing, pathology, and pathophysiology of the brain atrophy in Cushing's disease are discussed. The correlation of atrophy with cognitive deficits and its reversibility is also reviewed...
- Late recurrences of Cushing's disease after initial successful transsphenoidal surgery
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Endocrinol Metab 93:358-62. 2008
..Few studies have systematically analyzed the long-term recurrence rates of Cushing's disease after initial successful transsphenoidal surgery...
- Complications and outcomes after spinal cord tumor resection in the United States from 1993 to 2002
C G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford Hospital, Stanford, CA 94305, USA
Spinal Cord 46:375-9. 2008
..Retrospective cohort study...
- Racial and gender disparities and the role of primary tumor type on inpatient outcomes following craniotomy for brain metastases
Miriam Nuno
Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
Ann Surg Oncol 19:2657-63. 2012
..Our study evaluated the role of race, gender, and tumor primary site in predicting in-hospital mortality, discharge disposition, and complications among patients with brain metastases...
- Prognosis of patients with multifocal glioblastoma: a case-control study
Chirag G Patil
Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Neurosurg 117:705-11. 2012
..The prognosis of patients with glioblastoma who present with multifocal disease is not well documented. The objective of this study was to determine whether multifocal disease on initial presentation is associated with worse survival...
- The effect of centralization of caseload for primary brain tumor surgeries: trends from 2001-2007
Miriam Nuno
Department of Neurosurgery, Cedars Sinai Medical Center, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
Acta Neurochir (Wien) 154:1343-50. 2012
..The aim of this study is two-fold: (1) to evaluate whether the trend towards centralization of primary brain tumor care in the US has continued during the period of between 2001 and 2007, and (2) to analyze volume-outcome effects...
- Laminectomy and fusion after spinal cord injury: national inpatient complications and outcomes
Maxwell Boakye
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurotrauma 25:173-83. 2008
..This study represents the first major national estimate of in-hospital mortality and complication rates after nonoperative and operative treatment for SCI...
- Effects of age and comorbidities on complication rates and adverse outcomes after lumbar laminectomy in elderly patients
Gordon Li
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA
Spine (Phila Pa 1976) 33:1250-5. 2008
..This is a retrospective cohort study using the National Inpatient Sample database...
- National trends in vertebral augmentation procedures for the treatment of vertebral compression fractures
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Surg Neurol 71:580-4; discussion 584-5. 2009
..Vertebroplasty and kyphoplasty have been gaining popularity in the treatment of symptomatic compression fractures that are often secondary to osteoporosis or neoplasia...
- Risk factors for postoperative spinal wound infections after spinal decompression and fusion surgeries
Anand Veeravagu
Stanford University School of Medicine, Stanford, CA, USA
Spine (Phila Pa 1976) 34:1869-72. 2009
..This is a multivariate analysis of a prospectively collected database...
- National trends in spinal fusion for cervical spondylotic myelopathy
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Surg Neurol 71:66-9; discussion 69. 2009
..The objective of this study is to provide a retrospective analysis using an NIS database to examine national trends in outcomes for CSM from 1993 to 2002...
- Cervical corpectomy: complications and outcomes
Maxwell Boakye
Outcomes Research Lab, Palo Alto Veterans Health Care System, and Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94304, USA
Neurosurgery 63:295-301; discussion 301-2. 2008
..The aim of this study was to report 30-day mortality and complication rates after cervical corpectomy using multicenter prospective data from the Veterans Affairs National Surgical Quality Improvement Program database...
- Cervical spondylotic myelopathy: complications and outcomes after spinal fusion
Maxwell Boakye
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
Neurosurgery 62:455-61; discussion 461-2. 2008
..The aim of this study was to report inpatient mortality, complications, and outcomes on a national level...
- Visual loss after spine surgery: a population-based study
Chirag G Patil
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA
Spine (Phila Pa 1976) 33:1491-6. 2008
..Retrospective cohort study using National inpatient sample administrative data...
- A population-based study of inpatient outcomes after operative management of nontraumatic intracerebral hemorrhage in the United States
Chirag G Patil
Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Cedars Sinai Medical Center, Los Angeles, California, USA
World Neurosurg 78:640-5. 2012
..Given that outcomes of patients treated at these specialized centers may differ from those treated at community hospitals, our aim was to report patient outcomes on a population-based, national level...
- CyberKnife stereotactic radiosurgery for recurrent, metastatic, and residual hemangiopericytomas
Anand Veeravagu
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA
J Hematol Oncol 4:26. 2011
..The purpose of this study was to evaluate the role of CyberKnife stereotactic radiosurgery (CK) in the management of recurrent, metastatic, and residual hemangiopericytomas...
- Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era
Christine Carico
Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
PLoS ONE 7:e33684. 2012
..We investigated whether loss of PTEN predicted shorter survival in the temozolomide era. The role of PTEN in the PI3K/Akt pathway is also reviewed...
- National trends in spinal arteriovenous malformations
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
Neurosurg Focus 26:1-5. 2009
..These lesions are challenging entities to treat because of their complicated anatomy and physiology. Current management options include open microsurgery, endovascular embolization, and stereotactic radiosurgery...
- Craniotomy for resection of meningioma in the elderly: a multicentre, prospective analysis from the National Surgical Quality Improvement Program
Chirag G Patil
Outcomes Research Lab, Palo Alto Veterans Health Care System, Palo Alto, California, USA
J Neurol Neurosurg Psychiatry 81:502-5. 2010
..Utilising multicentre, prospective data from the National Surgical Quality Improvement Program, the present study sought to address this controversy...
- Tethered cord syndrome: nationwide inpatient complications and outcomes
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
Neurosurg Focus 23:E3. 2007
..Previous investigations of health outcome after spinal surgery for tethered cord syndrome (TCS) have been single-institution studies. The aim of this study was to report inpatient complications and outcomes on a nationwide level...
- National complication rates and disposition after posterior lumbar fusion for acquired spondylolisthesis
Paul S Kalanithi
Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
Spine (Phila Pa 1976) 34:1963-9. 2009
..Database study using Nationwide Inpatient Sample (NIS) administrative data from 1993 to 2002...
- The role of inferior petrosal sinus sampling in the diagnostic localization of Cushing's disease
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, 94305, USA
Neurosurg Focus 23:E2. 2007
..Management is best undertaken by a comprehensive multidisciplinary team taking into account the results of all the biochemical and imaging studies available, to provide the best advice in patient treatment decisions...
- The effect of weight in the outcomes of meningioma patients
Holly Dickinson
Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
Surg Neurol Int 4:45. 2013
..Meningiomas are more prevalent in women and mostly benign in nature. Our aim was to evaluate the association of weight and outcomes of meningioma patients undergoing craniotomy...
- Biopsy versus resection for the management of low-grade gliomas
Anand Veeravagu
Department of Neurosurgery, Stanford School of Medicine, 679 Oxford Ave, Palo Alto, CA, USA, 94306
Cochrane Database Syst Rev 4:CD009319. 2013
..There remains controversy about the role of biopsy versus resection and the relative clinical outcomes for the management of LGG...
- Racial disparities in Medicaid patients after brain tumor surgery
Debraj Mukherjee
Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Clin Neurosci 20:57-61. 2013
..Interventions aimed at reducing complications among African-American patients with brain tumor may help reduce post-operative disparities...
- A Socioeconomic Survey of Spinal Cord Stimulation (SCS) Surgery
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA and Outcomes Research Center, VA Palo Alto Health Care System, Palo Alto, CA, USA
Neuromodulation 13:265-9. 2010
..Future studies should be designed with these important outcome measures in mind...
- Racial disparities in outcomes of spinal surgery for lumbar stenosis
Shivanand P Lad
Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC Departments of Neurosurgery and Bioinformatics and Biostatistics, University of Louisville, Louisville, KY and Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA
Spine (Phila Pa 1976) 38:927-35. 2013
..8450, P < 0.0007). CONCLUSION.: At the national level, there are several racial disparities in the rate of complications, length of stay, and costs after surgery for lumbar spinal stenosis.Level of Evidence: 3...
- Predictors of inpatient complications and outcomes following surgical resection of hypothalamic hamartomas
Debraj Mukherjee
Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048
Surg Neurol Int 2:105. 2011
..Our aim was to identify the preoperative factors associated with a greater risk of poor inpatient outcomes in those undergoing resection of hypothalamic hamartomas...
- Socioeconomic Trends in Deep Brain Stimulation (DBS) Surgery
Shivanand P Lad
Outcomes Research Laboratory, VA Palo Alto Health Care System, Palo Alto, CA, USA Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA and Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA
Neuromodulation 13:182-6. 2010
..Conclusions: Future studies will need to include the socioeconomic impact of the technology on disease status, patient access, and costs as it expands to novel indications...
- Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
Surasak Phuphanich
Neuro Oncology Program, Department of Neurosurgery and Neurology, Cedars Sinai Medical Center, 8631 W 3rd Street Suite 410 E, Los Angeles, CA, 90048, USA
Cancer Immunol Immunother 62:125-35. 2013
....
- Trends in pathological vertebral fractures in the United States: 1993 to 2004
Shivanand P Lad
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosurg Spine 7:305-10. 2007
..The authors examined trends in epidemiology and surgical management of pathological vertebral fractures in the US between 1993 and 2004...
- Epidemiology and the global burden of stroke
Debraj Mukherjee
Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
World Neurosurg 76:S85-90. 2011
..As numerous countries throughout the world undergo the epidemiological transition of diseases, trends in the prevalence of stroke have dramatically changed...
- The effect of transfer and hospital volume in subarachnoid hemorrhage patients
Miriam Nuno
Department of Neurosurgery, Cedars Sinai Medical Center, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
Neurocrit Care 17:312-23. 2012
..Providers are often unclear about the safety of transferring critical patients. This study evaluated the "transfer effect" in a large sample of aneurysmal SAH patients undergoing treatment...
- Moyamoya disease in pediatric patients: outcomes of neurosurgical interventions
Anand Veeravagu
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA
Neurosurg Focus 24:E16. 2008
..Additional, larger studies are needed to determine the advantages and disadvantages of the different techniques for the pediatric age group...
