V F Patel

Summary

Publications

  1. ncbi request reprint Novel cryptophycin antitumor agents: synthesis and cytotoxicity of fragment "B" analogues
    V F Patel
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 42:2588-603. 1999
  2. ncbi request reprint LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    C Shih
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Cancer Res 57:1116-23. 1997
  3. ncbi request reprint Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
    R M Schultz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Anticancer Res 19:437-43. 1999

Collaborators

  • R M Schultz
  • C Shih
  • L S Gossett
  • K A Shackelford
  • M Ratnam
  • J R Bewley
  • D J Soose
  • E A Rayl
  • W Kohler
  • W C MacKellar
  • B A Moroson
  • L L Habeck
  • S B Gates
  • L G Mendelsohn
  • G P Beardsley
  • S L Andis
  • V J Chen

Detail Information

Publications3

  1. ncbi request reprint Novel cryptophycin antitumor agents: synthesis and cytotoxicity of fragment "B" analogues
    V F Patel
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 42:2588-603. 1999
    ....
  2. ncbi request reprint LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    C Shih
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Cancer Res 57:1116-23. 1997
    ..Therefore, our data suggest that LY231514 is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multiple inhibition of several key folate-requiring enzymes via its polyglutamated metabolites...
  3. ncbi request reprint Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
    R M Schultz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Anticancer Res 19:437-43. 1999
    ..The data demonstrate that inhibition of thymidylate synthase is a prominent mechanism for antitumor activity by LY231514, but important secondary sites of action exist for this multitargeted molecule...