Semaphorin junction: making tracks toward neural connectivityR Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Curr Opin Neurobiol 13:79-89. 2003
..Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling...
Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migrationR Jeroen Pasterkamp
Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 1001 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA
BMC Dev Biol 7:98. 2007
..To gain further insight into the function(s) of Sema7A and plexinC1 during neural development, we present here a detailed analysis of Sema7A and plexinC1 expression in the developing rat nervous system...
- MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function
Alicia L Degano
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 42:243-54. 2009
..These findings have broad implications for the role of MECP2 in neurodevelopment and RTT, given the critical role of the semaphorins in the formation of neural circuits...
- MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat
R Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cell Neurosci 31:52-69. 2006
..These results implicate MICALs in neuronal regeneration and support the possibility of employing EGCG to attenuate Sema3-mediated axon repulsion in the injured spinal cord...
- R-Ras fills another GAP in semaphorin signalling
R Jeroen Pasterkamp
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Trends Cell Biol 15:61-4. 2005
..These results indicate that plexins not only bind to but also regulate directly the activity of some of their downstream effectors...
- Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
R Jeroen Pasterkamp
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Nature 424:398-405. 2003
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- MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
Jonathan R Terman
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cell 109:887-900. 2002
..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance...
- Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin
Kazuhiro Suzuki
Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nature 446:680-4. 2007
..These findings not only identify a function of Sema7A as an effector molecule in T-cell-mediated inflammation, but also reveal a mechanism of integrin-mediated immune regulation...
- MICAL flavoprotein monooxygenases: structure, function and role in semaphorin signaling
Sharon M Kolk
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Adv Exp Med Biol 600:38-51. 2007
..This review summarizes our current understanding of MICALs, with an emphasis on their role in semaphorin signaling...
- Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively
Isabelle Chabbert-de Ponnat
INSERM U448, Faculty of Medicine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Int Immunol 17:439-47. 2005
..Together these results suggest that sCD100 plays a critical role in the regulation of antigen-presenting cell migration and functions via a tightly regulated process of receptor expression...
Getting connected in the dopamine systemDianne M A Van den Heuvel
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Prog Neurobiol 85:75-93. 2008
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- Semaphorin signaling: progress made and promises ahead
Yeping Zhou
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
Trends Biochem Sci 33:161-70. 2008
..These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases...
- Semaphorins in axon regeneration: developmental guidance molecules gone wrong?
R Jeroen Pasterkamp
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Philos Trans R Soc Lond B Biol Sci 361:1499-511. 2006
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