Matthew P Pase



  1. Westwood A, Beiser A, Jain N, Himali J, DeCarli C, Auerbach S, et al. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017;88:1172-1179 pubmed publisher
    ..Prolonged sleep duration may be a marker of early neurodegeneration and hence a useful clinical tool to identify those at a higher risk of progressing to clinical dementia within 10 years. ..
  2. Pase M, Davis Plourde K, Himali J, Satizabal C, Aparicio H, Seshadri S, et al. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology. 2018;91:e1479-e1486 pubmed publisher
    ..Vascular risk factors at younger ages appear to have detrimental effects on current and future brain volume. ..
  3. Pase M, Grima N, Sarris J. Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials. Br J Nutr. 2011;106:974-80 pubmed publisher
    ..Reduction in arterial stiffness by n-3 may account for some of its purported cardioprotective effects. ..
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    Pase M, Grima N, Stough C, Scholey A, Pipingas A. Cardiovascular disease risk and cerebral blood flow velocity. Stroke. 2012;43:2803-5 pubmed
    ..05, P<0.05) and sex (?R(2)=0.06, P<0.01). Cardiovascular risk has divergent effects on mean and pulsatile blood flow velocity, each of which may independently contribute to cerebral pathology and cognitive impairment. ..
  5. Pase M, Grima N, Cockerell R, Pipingas A. Habitual intake of fruit juice predicts central blood pressure. Appetite. 2015;84:68-72 pubmed publisher
    ..Central systolic BP was 3-4 mmHg higher for those who consumed fruit juice daily rather than rarely or occasionally. In conclusion, more frequent fruit juice consumption was associated with higher central BPs. ..
  6. Pase M, Beiser A, Aparicio H, DeCarli C, Vasan R, Murabito J, et al. Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury. Alzheimers Dement. 2016;12:438-45 pubmed publisher
    ..High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were APOE ε4 positive. ..
  7. Pase M, Beiser A, Himali J, Tsao C, Satizabal C, Vasan R, et al. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia. Stroke. 2016;47:2256-61 pubmed publisher
    ..Our findings suggest aortic stiffness as a potentially modifiable risk factor for clinical cognitive impairment and dementia. ..
  8. Pase M, Himali J, Mitchell G, Beiser A, Maillard P, Tsao C, et al. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. 2016;67:513-9 pubmed publisher
    ..Prospective studies are needed to examine whether aortic stiffening in young adulthood is associated with vascular cognitive impairment later in life. ..
  9. Pase M, Kean J, Sarris J, Neale C, Scholey A, Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012;18:647-52 pubmed publisher
    ..Similarly, future research should examine the nootropic effects of Bacopa at varied dosages and across different extracts. ..

More Information


  1. Pase M, Himali J, Beiser A, Aparicio H, Satizabal C, Vasan R, et al. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017;48:1139-1146 pubmed publisher
    ..18-7.07) for Alzheimer's disease. Sugar-sweetened beverages were not associated with stroke or dementia. Artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia. ..
  2. Pase M, Himali J, Grima N, Beiser A, Satizabal C, Aparicio H, et al. Sleep architecture and the risk of incident dementia in the community. Neurology. 2017;89:1244-1250 pubmed publisher
    ..Stages of non-REM sleep were not associated with dementia risk. Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia. ..
  3. Pase M, Himali J, Jacques P, DeCarli C, Satizabal C, Aparicio H, et al. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimers Dement. 2017;13:955-964 pubmed publisher
    ..05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes. Higher intake of sugary beverages was associated cross-sectionally with markers of preclinical AD. ..