Javad Parvizi

Summary

Publications

  1. pmc Periprosthetic joint infection: Current concept
    Vinay K Aggarwal
    Department of Adult Reconstruction Surgery, Rothman Institute of Orthopaedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Indian J Orthop 47:10-7. 2013
  2. pmc Does the surgical approach in one stage bilateral total hip arthroplasty affect blood loss?
    Javad Parvizi
    Orthopaedic Surgery at the Rothman Institute, Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA, 19107, USA
    Int Orthop 37:2357-62. 2013
  3. doi Spinal anesthesia: should everyone receive a urinary catheter?: a randomized, prospective study of patients undergoing total hip arthroplasty
    Adam G Miller
    Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 95:1498-503. 2013
  4. doi Multimodal pain management in orthopedics: implications for joint arthroplasty surgery
    Javad Parvizi
    Thomas Jefferson University Medical School, Rothman Institute Orthopaedics, 925 Chestnut St, Philadelphia, PA 19107, USA
    Orthopedics 36:7-14. 2013
  5. doi Simultaneous-bilateral TKA: double trouble - affirms
    J Parvizi
    Rothman Institute of Orthopaedics, Thomas Jefferson University, 925 Chestnut Street 2nd Floor, Philadelphia, Pennsylvania 19107, USA
    J Bone Joint Surg Br 94:90-2. 2012
  6. doi Acetabular components in total hip arthroplasty: is there evidence that cementless fixation is better?
    Nader Toossi
    Rothman Institute of Orthopedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 95:168-74. 2013
  7. doi Management of periprosthetic joint infection: the current knowledge: AAOS exhibit selection
    Javad Parvizi
    The Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 94:e104. 2012
  8. doi Treatment of femoroacetabular impingement in athletes using a mini-direct anterior approach
    Steven B Cohen
    Rothman Institute at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Am J Sports Med 40:1620-7. 2012
  9. pmc Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective
    Hangama C Fayaz
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Patient Saf Surg 5:23. 2011
  10. pmc Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty
    Theresa A Freeman
    School of Biomedical Engineering and College of Drexel Medicine, Drexel University, 3120 Market Street, 323 Bossone, Philadelphia, PA 19104, USA
    Fibrogenesis Tissue Repair 3:17. 2010

Research Grants

Detail Information

Publications130 found, 100 shown here

  1. pmc Periprosthetic joint infection: Current concept
    Vinay K Aggarwal
    Department of Adult Reconstruction Surgery, Rothman Institute of Orthopaedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Indian J Orthop 47:10-7. 2013
    ..In this review, we will discuss diagnosis and management of PJI following TJA and highlight some recent advances in this field...
  2. pmc Does the surgical approach in one stage bilateral total hip arthroplasty affect blood loss?
    Javad Parvizi
    Orthopaedic Surgery at the Rothman Institute, Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA, 19107, USA
    Int Orthop 37:2357-62. 2013
    ..This study therefore aims to examine if type of surgical approach can affect peri-operative blood loss and allogeneic blood transfusion in patients undergoing one-stage bilateral THA...
  3. doi Spinal anesthesia: should everyone receive a urinary catheter?: a randomized, prospective study of patients undergoing total hip arthroplasty
    Adam G Miller
    Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 95:1498-503. 2013
    ..The objective of this randomized prospective study was to determine whether a urinary catheter is necessary for all patients undergoing total hip arthroplasty under spinal anesthesia...
  4. doi Multimodal pain management in orthopedics: implications for joint arthroplasty surgery
    Javad Parvizi
    Thomas Jefferson University Medical School, Rothman Institute Orthopaedics, 925 Chestnut St, Philadelphia, PA 19107, USA
    Orthopedics 36:7-14. 2013
    ..The goal of this review is to provide a concise overview of the principles and results of multimodal pain management regimens as a practical guide for the management of joint arthroplasty patients...
  5. doi Simultaneous-bilateral TKA: double trouble - affirms
    J Parvizi
    Rothman Institute of Orthopaedics, Thomas Jefferson University, 925 Chestnut Street 2nd Floor, Philadelphia, Pennsylvania 19107, USA
    J Bone Joint Surg Br 94:90-2. 2012
    ..Based on available evidence, it is our opinion that simultaneous bilateral TKA carries a higher risk of morbidity and mortality and should be reserved for select few...
  6. doi Acetabular components in total hip arthroplasty: is there evidence that cementless fixation is better?
    Nader Toossi
    Rothman Institute of Orthopedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 95:168-74. 2013
    ..The objective of this systematic review and meta-analysis was to compare the survivorship and revision rate of cemented and cementless acetabular components utilized in total hip arthroplasty...
  7. doi Management of periprosthetic joint infection: the current knowledge: AAOS exhibit selection
    Javad Parvizi
    The Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 94:e104. 2012
    ..Given the current knowledge and planned future research, the medical community should be prepared to effectively manage this increasingly prevalent disease...
  8. doi Treatment of femoroacetabular impingement in athletes using a mini-direct anterior approach
    Steven B Cohen
    Rothman Institute at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Am J Sports Med 40:1620-7. 2012
    ..Surgical options for FAI include arthroscopy, open surgical dislocation, or mini-direct anterior approaches. Arthroscopic and open treatments of FAI have been commonly performed and have had promising results in athletes. Hypothesis/..
  9. pmc Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective
    Hangama C Fayaz
    Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Patient Saf Surg 5:23. 2011
    ..abstract:..
  10. pmc Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty
    Theresa A Freeman
    School of Biomedical Engineering and College of Drexel Medicine, Drexel University, 3120 Market Street, 323 Bossone, Philadelphia, PA 19104, USA
    Fibrogenesis Tissue Repair 3:17. 2010
    ..abstract:..
  11. doi Periprosthetic proximal femur fractures: current concepts
    Javad Parvizi
    The Rothman Institute, Thomas Jefferson University Hospital Department of Orthopaedics, Philadelphia, PA 19107, USA
    J Orthop Trauma 25:S77-81. 2011
    ..Such an approach should prevent the mismanagement of these complications...
  12. ncbi Revision total hip arthroplasty in octogenarians. A case-control study
    Javad Parvizi
    Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:2612-8. 2007
    ..We evaluated the early outcomes and prevalence of complications following revision total hip arthroplasty in patients older than eighty years of age and compared them with those in a younger patient population...
  13. doi Efficacy of antibiotic-impregnated cement in total hip replacement
    Javad Parvizi
    The Rothman Institute, Philadelphia, PA, USA
    Acta Orthop 79:335-41. 2008
    ..With this meta-analysis of the published literature, we intended to assess efficacy and safety in the use of antibiotic-impregnated cement for uninfected arthroplasty...
  14. ncbi The rise in the incidence of pulmonary embolus after joint arthroplasty: is modern imaging to blame?
    Javad Parvizi
    Rothman Institute of Orthopedics, Thomas Jefferson Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 463:107-13. 2007
    ..The challenge is to distinguish which require treatment and which do not...
  15. ncbi Proximal femoral replacement in patients with non-neoplastic conditions
    Javad Parvizi
    Rothman Institute of Orthopaedics, Thomas Jefferson Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:1036-43. 2007
    ..In this study, we sought to determine the outcome of reconstructive surgery with the use of a modular proximal femoral replacement (a so-called megaprosthesis) in patients with proximal femoral bone loss due to non-neoplastic conditions...
  16. ncbi Bilateral total hip arthroplasty: one-stage versus two-stage procedures
    Javad Parvizi
    Rothman Institute of Orthopedics, Thomas Jefferson Hospital, Philadelphia, PA, USA
    Clin Orthop Relat Res 453:137-41. 2006
    ..Young and healthy patients may be candidates for one-stage bilateral total hip arthroplasty without an increase in complications and with lower costs...
  17. ncbi Institutional review board approval: why it matters
    Javad Parvizi
    Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:418-26. 2007
    ..Regulations regarding conflict of interest represent an attempt to ensure that research is not biased by financial or other interest and to maintain public trust...
  18. ncbi Total joint arthroplasty: When do fatal or near-fatal complications occur?
    Javad Parvizi
    Rothman Institute of Orthopedics, Thomas Jefferson Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:27-32. 2007
    ....
  19. ncbi Selfprotective smart orthopedic implants
    Javad Parvizi
    Thomas Jefferson University, Rothman Institute of Orthopedics, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Expert Rev Med Devices 4:55-64. 2007
    ..This new technology has the potential to eliminate periprosthetic infection, a major and growing problem in orthopedic practice...
  20. ncbi Revision total hip arthroplasty for instability: surgical techniques and principles
    Javad Parvizi
    Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 90:1134-42. 2008
  21. doi Informed consent: is it always necessary?
    Javad Parvizi
    Department of Orthopaedic Surgery, Rothman Institute of Orthopaedics, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Injury 39:651-5. 2008
    ..While informed consent is mandated for almost all clinical trial involving human subjects, there are situations of emergency research and trials with minimal risk that call for a waiver of the consent...
  22. pmc Aseptic loosening of total hip arthroplasty: infection always should be ruled out
    Javad Parvizi
    Department of Orthopaedic Surgery, Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:1401-5. 2011
    ..However, it is unclear whether preoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are more likely elevated in these patients than those without overt infection...
  23. ncbi Who needs autologous blood donation in joint replacement?
    Javad Parvizi
    Department of Orthopaedics, Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Knee Surg 24:25-31. 2011
    ..PAD seems to be effective in reducing allogenic transfusions after THA but not TKA...
  24. doi Periprosthetic joint infection: treatment options
    Javad Parvizi
    Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Orthopedics 33:659. 2010
    ..While amputation may be unpopular with patients it provides a greater ability to reconstruct, with an external prosthesis, a functioning joint...
  25. pmc Definition of periprosthetic joint infection: is there a consensus?
    Javad Parvizi
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:3022-30. 2011
    ..Use of multiple diagnostic criteria within the joint arthroplasty community raises concerns in patient treatment and comparison of research pertaining to PJI...
  26. pmc Mark B. Coventry Award: synovial C-reactive protein: a prospective evaluation of a molecular marker for periprosthetic knee joint infection
    Javad Parvizi
    Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 470:54-60. 2012
    ..C-reactive protein (CRP) serum assays are a standard element of the diagnostic workup for periprosthetic joint infection (PJI). However, because CRP is a marker for systemic inflammation, this test is not specific to PJI...
  27. ncbi Aggressive Anticoagulation after TJA: an evaluation of the ACCP guidelines for Thromboprophylaxis
    Javad Parvizi
    Rothman Institute of Orthopaedics, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    J Long Term Eff Med Implants 17:359-65. 2007
    ..We believe that the AAOS guidelines for thromboprophylaxis take into account all risks associated with anticoagulation therapy and may prove to be a safer option for our patients...
  28. ncbi Periprosthetic infection: are current treatment strategies adequate?
    Javad Parvizi
    Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Acta Orthop Belg 74:793-800. 2008
    ..Hence novel techniques for the treatment of periprosthetic infection are desperately needed...
  29. ncbi The role of patient restrictions in reducing the prevalence of early dislocation following total hip arthroplasty. A randomized, prospective study
    E Louis Peak
    Department of Orthopaedic Surgery, Rothman Institute, of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 87:247-53. 2005
    ..Our hypothesis was that dislocation was more likely to occur in patients who were not placed on these restrictions...
  30. ncbi Management of stiffness following total knee arthroplasty
    Javad Parvizi
    J Bone Joint Surg Am 88:175-81. 2006
  31. ncbi Revision hip arthroplasty for late instability secondary to polyethylene wear
    Javad Parvizi
    Department of Orthopedic Surgery, Rothman Institute of Orthopedics, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 447:66-9. 2006
    ..Exchange of polyethylene lining of a metal backed implant or revision of the all polyethylene acetabular component can successfully address late instability in the majority of patients...
  32. ncbi Failure to resurface the patella during total knee arthroplasty may result in more knee pain and secondary surgery
    Javad Parvizi
    Department of Orthopedic Surgery, Rothman Institute of Orthopedics at Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 438:191-6. 2005
    ....
  33. ncbi Total knee arthroplasty following proximal tibial osteotomy: risk factors for failure
    Javad Parvizi
    The Rothman Institute, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 86:474-9. 2004
    ....
  34. ncbi Pulsed low-intensity ultrasound for fracture healing
    Javad Parvizi
    Department of Orthopedic Surgery, Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Foot Ankle Clin 10:595-608, vii. 2005
    ..This article presents the findings of some of these studies and briefly discusses our current understanding of its molecular mechanisms...
  35. ncbi Periprosthetic patellar fractures
    Javad Parvizi
    Rothman Institute of Orthopedics at Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 446:161-6. 2006
    ..Level of Evidence: Therapeutic studies, level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence...
  36. ncbi Management of arthritis of the hip in the young adult
    J Parvizi
    Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Bone Joint Surg Br 88:1279-85. 2006
    ..Recent years have witnessed extensive research related to the management of this condition. This article reviews the current status with regard to aetiology, diagnosis and treatment of arthritis of the hip in the young adult...
  37. ncbi Recurrent instability after total hip arthroplasty: beware of subtle component malpositioning
    Javad Parvizi
    Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 447:60-5. 2006
    ..Component malpositioning was found to be the major cause of recurrent instability in this successfully treated cohort...
  38. ncbi Can epidural anesthesia and warfarin be coadministered?
    Javad Parvizi
    Rothman Institute of Orthopedics, Department of Anesthesia, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 456:133-7. 2007
    ....
  39. ncbi Periprosthetic infection: what are the diagnostic challenges?
    Javad Parvizi
    J Bone Joint Surg Am 88:138-47. 2006
  40. doi Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme
    Javad Parvizi
    Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 93:2242-8. 2011
    ..In this prospective study, we determined the sensitivity and specificity of one of these enzymes, leukocyte esterase, in diagnosing periprosthetic joint infection...
  41. pmc Aspirin: an alternative for pulmonary embolism prophylaxis after arthroplasty?
    Ibrahim J Raphael
    Orthopaedic Research at the Rothman Institute, Thomas Jefferson Hospital, Philadelphia, PA, USA
    Clin Orthop Relat Res 472:482-8. 2014
    ..The paucity of literature comparing different methods of pulmonary embolism (PE) prophylaxis and fear of litigation make it difficult for surgeons to abandon the use of aggressive chemical prophylaxis...
  42. pmc High level of residual symptoms in young patients after total knee arthroplasty
    Javad Parvizi
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA, 19107, USA
    Clin Orthop Relat Res 472:133-7. 2014
    ..Global knee scores have a ceiling effect and do not capture the presence of difficulty or dissatisfaction with specific activities important to patients...
  43. pmc Do tantalum and titanium cups show similar results in revision hip arthroplasty?
    S Mehdi Jafari
    Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:459-65. 2010
    ..Radiographically in the major group, tantalum cups yielded better fixation. Level of Evidence: Level III, retrospective comparative study. See the Guidelines for Authors for a complete description of levels of evidence...
  44. doi Symptomatic pulmonary embolus after joint arthroplasty: stratification of risk factors
    Javad Parvizi
    Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA, 19107, USA
    Clin Orthop Relat Res 472:903-12. 2014
    ..Risk stratification of patients undergoing TJA is needed to tailor prophylaxis based on thrombotic and bleeding risk...
  45. doi Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty
    Elie Ghanem
    Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 90:1637-43. 2008
    ..We sought to identify definite cutoff values for both the fluid leukocyte count and the neutrophil percentage that may help to diagnose infection at the site of a prosthetic joint...
  46. pmc In vivo oxidation contributes to delamination but not pitting in polyethylene components for total knee arthroplasty
    Francisco J Medel
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 26:802-10. 2011
    ..Despite the lower oxidation displayed by conventional retrievals, this study provides strong evidence that delamination secondary to in vivo oxidation may occur during the second decade of implantation...
  47. pmc Isolated polyethylene exchange versus acetabular revision for polyethylene wear
    Camilo Restrepo
    Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 467:194-8. 2009
    ..Level of Evidence: Level II, prognostic study. See the Guidelines for Authors for a complete description of levels of evidence...
  48. pmc Gamma inert sterilization: a solution to polyethylene oxidation?
    Francisco J Medel
    Implant Research Center, School of Biomedical Engineering, Science and Health Systems, Drexel University, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 91:839-49. 2009
    ..In addition, the potential influence of the different sterilization processes on the wear performance of the polyethylene components was examined...
  49. pmc Modular femoral stems for revision total hip arthroplasty
    Camilo Restrepo
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:476-82. 2011
    ..The complexity of revision THA usually leads surgeons to use multiple revision hip designs to address these issues...
  50. doi Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis
    Christopher S Adams
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Orthop Res 27:701-9. 2009
    ..These results clearly demonstrate that this novel thin sol-gel technology can be used for the targeted delivery of antibiotics for the treatment of periprosthetic as well as other bone infections...
  51. pmc Impact of socioeconomic factors on outcome of total knee arthroplasty
    Robert L Barrack
    Department of Orthopaedic Surgery, Washington University School of Medicine, One Barnes Jewish Hospital Plaza, 11300 West Pavilion, St Louis, MO, 63110, USA
    Clin Orthop Relat Res 472:86-97. 2014
    ..Predictors of TKA outcomes have focused primarily on surgical technique, implant details, and individual patient clinical factors. The relative importance of these factors compared to patient socioeconomic status is not known...
  52. pmc Do young, active patients perceive advantages after surface replacement compared to cementless total hip arthroplasty?
    Robert L Barrack
    Department of Orthopaedic Surgery, Washington University School of Medicine Barnes Jewish Hospital, Washington University School of Medicine, One Barnes Jewish Hospital Plaza, 11300 West Pavilion, Campus Box 8233, St Louis, MO, 63110, USA
    Clin Orthop Relat Res 471:3803-13. 2013
    ..Potential advantages suggested but not confirmed for surface replacement arthroplasty (SRA) over THA include lower frequency of limp, less thigh pain, less limb length discrepancy, and higher activity...
  53. pmc Oxidative properties and surface damage mechanisms of remelted highly crosslinked polyethylenes in total knee arthroplasty
    Daniel W MacDonald
    Implant Research Center, Drexel University, Philadelphia, PA 19104, USA
    Int Orthop 37:611-5. 2013
    ..The purpose of this study was to investigate the damage mechanisms and oxidative stability of remelted HXLPEs used in TKR...
  54. pmc Bacterial colonization of bone allografts: establishment and effects of antibiotics
    Constantinos Ketonis
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Clin Orthop Relat Res 468:2113-21. 2010
    ..Bone grafts are frequently used to supplement bone stock and to establish structural stability. However, graft-associated infection represents a challenging complication leading to increased patient morbidity and healthcare costs...
  55. pmc Vancomycin bonded to bone grafts prevents bacterial colonization
    Constantinos Ketonis
    Department of Orthopaedic Surgery, Jefferson Medical College, Philadelphia, PA 19107, USA
    Antimicrob Agents Chemother 55:487-94. 2011
    ..Since the covalently tethered antibiotic is stable, is active, retains its specificity, and does not exhibit toxicity, it is concluded that this modified allograft holds great promise for decreasing bone graft-associated infections...
  56. pmc The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection
    Valentin Antoci
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Biomaterials 29:4684-90. 2008
    ..These findings indicate that antibiotic derivatization of implants can result in a surface that can resist bacterial colonization. This technology holds great promise for the prevention and treatment of periprosthetic infections...
  57. pmc Periprosthetic infection: where do we stand with regard to Gram stain?
    Elie Ghanem
    Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, PA, USA
    Acta Orthop 80:37-40. 2009
    ..We examined the role of this diagnostic test in a large cohort of patients from a single institution...
  58. pmc Two-stage exchange knee arthroplasty: does resistance of the infecting organism influence the outcome?
    Mark F Kurd
    The Rothman Institute of Orthopedics at Thomas Jefferson University, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:2060-6. 2010
    ..Two-stage exchange arthroplasty is the accepted standard of care, but reported failure rates are increasing. It has been suggested this is due to the increased prevalence of methicillin-resistant infections...
  59. ncbi The effect of malnutrition on patients undergoing elective joint arthroplasty
    Ronald Huang
    Rothman Institute at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
    J Arthroplasty 28:21-4. 2013
    ..Malnutrition remains prevalent in patients >55years-old undergoing TJA and is associated with a significant increase in post-operative complications. ..
  60. pmc Do ceramic femoral heads reduce taper fretting corrosion in hip arthroplasty? A retrieval study
    Steven M Kurtz
    Implant Research Center, School of Biomedical Engineering, Science, and Heath Systems, Drexel University, 3401 Market Street, Suite 345, Philadelphia, PA, 19104, USA
    Clin Orthop Relat Res 471:3270-82. 2013
    ..Previous studies regarding modular head-neck taper corrosion were largely based on cobalt chrome (CoCr) alloy femoral heads. Less is known about head-neck taper corrosion with ceramic femoral heads...
  61. pmc Do dynamic cement-on-cement knee spacers provide better function and activity during two-stage exchange?
    David J Jaekel
    Implant Research Center, School of Biomedical Engineering, Science, and Heath Systems, Drexel University, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 470:2599-604. 2012
    ..However, their direct impact on patient mobility and wear damage while implanted remains poorly understood...
  62. pmc Causes of failure of ceramic-on-ceramic and metal-on-metal hip arthroplasties
    Manny Porat
    Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA
    Clin Orthop Relat Res 470:382-7. 2012
    ..A number of unique mechanisms of failure, including fracture, squeaking, and adverse tissue reactions, have been reported with these hard bearing surfaces. However, the incidence varies among the published studies...
  63. ncbi Covalently attached vancomycin provides a nanoscale antibacterial surface
    Valentin Antoci
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 461:81-7. 2007
    ..Based on these observations, covalent modification of the titanium surface with an antibiotic may be viewed as a potential new tool in preventing or eliminating periprosthetic infection...
  64. pmc Natural history of squeaking after total hip arthroplasty
    Camilo Restrepo
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:2340-5. 2010
    ..In recent years, a number of alternative bearing surfaces, such as ceramic on ceramic, are being used in THA. Squeaking after THA is a recently recognized complication; however, its incidence is unknown...
  65. doi The noisy ceramic hip: is component malpositioning the cause?
    Camilo Restrepo
    Rothman Institute of Orthopedics at Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 23:643-9. 2008
    ..Although malposition could be an important contributing factor, the latter cannot be the sole reason based on our findings. Further investigation to elucidate the etiology is warranted...
  66. doi The value of intraoperative Gram stain in revision total knee arthroplasty
    Patrick M Morgan
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Joint Surg Am 91:2124-9. 2009
    ..While intraoperative Gram stains are routinely performed during revision total knee arthroplasty, their value remains unclear...
  67. ncbi Vancomycin covalently bonded to titanium alloy prevents bacterial colonization
    Valentin Antoci
    Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, Pennsylvania 19107, USA
    J Orthop Res 25:858-66. 2007
    ..These results demonstrate that we have effectively engineered a stable, bactericidal Ti surface. This new surface holds great promise in terms of mitigating or preventing periprosthetic infection...
  68. pmc In vivo oxidation and surface damage in retrieved ethylene oxide-sterilized total knee arthroplasties
    Daniel MacDonald
    Implant Research Center, School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Clin Orthop Relat Res 470:1826-33. 2012
    ..It is unclear whether in vivo oxidation will occur in unirradiated inserts sterilized with EtO...
  69. doi Revision hip arthroplasty for ceramic-on-ceramic squeaking hips does not compromise the results
    Wadih Y Matar
    Rothman Institute of Orthopedics, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:81-6. 2010
    ..There were no morbidities or complications after the revision surgery rendering isolated head-and-liner exchange to a metal-on-highly cross-linked polyethylene a relatively benign procedure...
  70. ncbi Minimally invasive hip arthroplasty: what role does patient preconditioning play?
    Aidin Eslam Pour
    Rothman Institute of Orthopaedics, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:1920-7. 2007
    ..The objective of this study was to investigate the role of patient education, accelerated rehabilitation, and improved pain control on the outcome of total hip arthroplasty performed through a small incision...
  71. doi Irrigation and debridement in the management of prosthetic joint infection: traditional indications revisited
    Khalid A Azzam
    Rothman Institute of Orthopedics at Thomas Jefferson University, Department of Orthopedic Surgery, Thomas Jefferson University Hospital Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:1022-7. 2010
    ..The high failure rate of this procedure implies that it should be preferably limited to select healthy patients with low virulence organisms and equivocal intraoperative findings...
  72. ncbi Periprosthetic infection does not preclude good outcome for revision arthroplasty
    Elie Ghanem
    Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 461:54-9. 2007
    ..This data suggest infected patients benefit from revision arthroplasty and achieve functional, pain, and mental health status at 2-year followup similar to those of noninfected patients...
  73. ncbi Revision for recurrent instability: what are the predictors of failure?
    Aaron H Carter
    Rothman Institute of Orthopaedics at Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Arthroplasty 26:46-52. 2011
    ..A total of 20.3% (12/59) of constrained liners failed. Isolated liner exchange, history of revision, and use of a 28-mm head were associated with failure in revision THA for instability...
  74. pmc Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin
    Constantinos Ketonis
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    Bone 48:631-8. 2011
    ..Since the tethered antibiotic appeared to have little or no effect on any of these activities, it was concluded that the stable, tethered antibiotic prevented bacterial infection while not modifying bone cell function...
  75. pmc Two-stage exchange arthroplasty for infected total knee arthroplasty: predictors of failure
    S M Javad Mortazavi
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:3049-54. 2011
    ..Currently, there are no proper indicators that can guide orthopaedic surgeons in patient selection for two-stage exchange or the appropriate conditions in which to reimplant...
  76. doi Is deep vein thrombosis a good proxy for pulmonary embolus?
    Javad Parvizi
    Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    J Arthroplasty 25:138-44. 2010
    ..The high association between DVT and PE that is assumed to exist does not seem to hold true for orthopedic surgery patients...
  77. doi The use of receiver operating characteristics analysis in determining erythrocyte sedimentation rate and C-reactive protein levels in diagnosing periprosthetic infection prior to revision total hip arthroplasty
    Elie Ghanem
    The Rothman Institute of Orthopedics, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Int J Infect Dis 13:e444-9. 2009
    ..The current study aimed to determine the cut-off values for ESR and CRP that improve clinical differentiation between aseptic failure and PPI in total hip arthroplasty (THA)...
  78. pmc Periprosthetic infection due to resistant staphylococci: serious problems on the horizon
    Javad Parvizi
    Department of Orthopedic Surgery, Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut St, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 467:1732-9. 2009
    ..Antibiotic-resistant Staphylococci continue to compromise treatment outcome of prosthetic joint infections, especially in patients with medical comorbidities. New preventive and therapeutic strategies are needed...
  79. pmc Topographic features retained after antibiotic modification of Ti alloy surfaces: retention of topography with attachment of antibiotics
    Constantinos Ketonis
    Department of Orthopedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 467:1678-87. 2009
    ..Using this technique, we believe it is possible to passivate many complex implant designs/geometries as a first step toward covalent bonding of antibiotics or other bioactive factors...
  80. ncbi Revision total knee arthroplasty: the patient's perspective
    Robert L Barrack
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Orthop Relat Res 464:146-50. 2007
    ....
  81. pmc Staged revision for knee arthroplasty infection: what is the role of serologic tests before reimplantation?
    Elie Ghanem
    Rothman Institute of Orthopedics at Jefferson, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 467:1699-705. 2009
    ..More accurate diagnostic tools are needed to support clinical judgment in monitoring infection progress and thus deciding whether to proceed with TKA reimplantation...
  82. ncbi What's new in hip arthroplasty
    Michael H Huo
    Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8883, USA
    J Bone Joint Surg Am 88:2100-13. 2006
  83. doi The assessment of intraoperative prosthetic knee range of motion using two methods
    Matthew S Austin
    Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 23:515-21. 2008
    ..Our study confirms that navigation is a reliable tool for performing in vivo assessment of range of motion...
  84. ncbi Delayed surgery for patients with femur and hip fractures-risk of deep venous thrombosis
    Eric B Smith
    Department of Orthopaedics, Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    J Trauma 70:E113-6. 2011
    ..We also evaluated the results of preoperative treatment with inferior vena cava (IVC) filter...
  85. pmc Incidence and reasons for nonrevision reoperation after total knee arthroplasty
    Benjamin Zmistowski
    The Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:138-45. 2011
    ..A dramatic increase in the demand for TKA is expected. The current burden of revision TKA is well known but the incidence and etiology of nonrevision reoperations after primary TKA is not...
  86. ncbi What's new in total hip arthroplasty
    Michael H Huo
    Department of Orthopedic Surgery, University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390 8883, USA
    J Bone Joint Surg Am 89:1874-85. 2007
  87. ncbi Prevention of symptomatic pulmonary embolism in patients undergoing total hip or knee arthroplasty
    Norman A Johanson
    Department of Orthopaedic Surgery, Drexel University College of Medicinbne, Philadelphia, PA, USA
    J Am Acad Orthop Surg 17:183-96. 2009
    ..0, or none. Patients at elevated (above standard) risk of both PE and major bleeding should be considered for aspirin, warfarin with an INR goal of < or =2.0, or none...
  88. ncbi Total joint arthroplasty in human immunodeficiency virus-positive patients: an alarming rate of early failure
    Javad Parvizi
    Department of Orthopedic Surgery, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Arthroplasty 18:259-64. 2003
    ....
  89. ncbi Surgical treatment of limb-length discrepancy following total hip arthroplasty
    Javad Parvizi
    Rothman Institute of Orthopedics, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 85:2310-7. 2003
    ..The purpose of the present study was to evaluate the results of revision hip surgery for the treatment of symptomatic limb-length discrepancy...
  90. ncbi Rotating hinged total knee replacement: use with caution
    Aidin Eslam Pour
    Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA
    J Bone Joint Surg Am 89:1735-41. 2007
    ..We evaluated the outcome of salvage knee reconstructions that had been performed with use of modern-generation modular segmental kinematic rotating hinged total knee prostheses...
  91. ncbi Primary total hip arthroplasty with an uncemented femoral component: two- to seven-year results
    Thomas Lettich
    Department of Orthopedic Surgery, Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 22:43-6. 2007
    ..There were 4 revisions for aseptic loosening of the femoral component in this series, accounting for an overall survivorship of 99.4%. The study confirms that the midterm outcome of this stem is excellent, with a low revision rate...
  92. ncbi Diagnosis of periprosthetic infection
    Thomas W Bauer
    Department of Pathology, The Cleveland Clinic Foundation, L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Bone Joint Surg Am 88:869-82. 2006
    ..Polymerase chain reactions can detect necrotic bacteria, so the clinical importance of positive results of this analysis in the absence of other features of infection remains to be determined...
  93. ncbi Uncemented total hip arthroplasty in young adults with osteonecrosis of the femoral head: a comparative study
    Michael A Mont
    Center for Joint Preservation and Reconstruction, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    J Bone Joint Surg Am 88:104-9. 2006
    ..This study evaluated the clinical and radiographic results of uncemented total hip arthroplasty in young adults with osteonecrosis of the femoral head and compared these results to those seen in young adults with osteoarthritis...
  94. pmc Revision hip arthroplasty: infection is the most common cause of failure
    S Mehdi Jafari
    Department of Orthopaedic Surgery, Rothman Institute at Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 468:2046-51. 2010
    ..Revision total hip arthroplasty (THA), although relieving pain and restoring function, fails in some patients. In contrast to failures in primary THA, the frequency of the causes of failure in revision THA has been less well established...
  95. ncbi Isolated acetabular polyethylene exchange through the anterolateral approach
    Frazer A Wade
    Department of Orthopedic Surgery, Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 19:498-500. 2004
    ..Isolated acetabular liner exchange performed through an anterolateral approach carries an acceptable dislocation rate...
  96. ncbi The effect of tibial polyethylene insert design on range of motion: evaluation of in vivo knee kinematics by a computerized navigation system during total knee arthroplasty
    Gregg R Klein
    Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 19:986-91. 2004
    ..This may, in turn, translate to better clinical outcome of the knee arthroplasty...
  97. ncbi Alternative bearing surfaces in total hip arthroplasty
    Richard Tuli
    Rothman Institute at Thomas Jefferson University, Philadelphia, PA 19107, USA
    Expert Rev Med Devices 2:445-52. 2005
    ..The purpose of this review is to discuss the recent technologic advances in bearing surfaces and offer an insight to the potential benefits and concerns with the alternative bearing surfaces...
  98. doi Prospective randomized study of two surgical approaches for total hip arthroplasty
    Camilo Restrepo
    Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:671-9.e1. 2010
    ..At 2 years, the results in both groups were the same...
  99. doi Stiffness after revision total knee arthroplasty
    Gregory K Kim
    Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:844-50. 2010
    ..Because of the challenges of treating stiffness, efforts should be invested in preventing this complication...
  100. ncbi A constrained liner cemented into a secure cementless acetabular shell
    John J Callaghan
    Department of Orthopaedic Surgery, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 86:2206-11. 2004
    ..The purpose of this study was to evaluate the clinical and radiographic outcome of this technique with use of a tripolar constrained liner that was cemented into a well-fixed cementless acetabular shell...

Research Grants2

  1. Smart Hip Implants with Modified Biological Surface
    Javad Parvizi; Fiscal Year: 2007
    ..As a result, patient pain, suffering and morbidity will be minimized. ..