A synthetic HIV-1 Tat protein breaches the skin barrier and elicits Tat-neutralizing antibodies and cellular immunityCharalambos D Partidos
UPR 9021, , CNRS, Strasbourg, France
Eur J Immunol 34:3723-31. 2004
..Transcutaneous immunization may be advantageous for the non-invasive delivery of other HIV candidate vaccine antigens...
Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccineCharalambos D Partidos
Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, USA
Vaccine 30:4638-43. 2012
..These findings highlight the potential of the CHIKV/IRES vaccine to protect humans against not only CHIKV but also against ONNV-induced disease...
- Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling
Charalambos D Partidos
Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, United States
Vaccine 29:3067-73. 2011
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Immunomodulatory consequences of ODN CpG-polycation complexesCharalambos D Partidos
CNRS UPR 9021, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
Methods 49:328-33. 2009
..Overall, our findings together with published data support the view that for harnessing the beneficial effects of ODN CpGs a careful consideration has to be given depending on the target intervention...
- The binding affinity of double-stranded RNA motifs to HIV-1 Tat protein affects transactivation and the neutralizing capacity of anti-Tat antibodies elicited after intranasal immunization
Charalambos D Partidos
UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France
Eur J Immunol 35:1521-9. 2005
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- Modulation of immune responses with transcutaneously deliverable adjuvants
Charalambos D Partidos
UPR 9021, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084 Strasbourg, France
Vaccine 22:2385-90. 2004
..In this review we give a brief overview of transcutaneously deliverable adjuvants and we discuss how they modulate immune responses to topically applied antigens...
- Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties
Alberto Bianco
Institut de Biologie Moleculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France
J Am Chem Soc 127:58-9. 2005
..Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs...
- Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice
Joseph N Brewoo
Inviragen, Inc, Madison, WI, United States
Vaccine 30:1513-20. 2012
....
- Cross-protective immunity against multiple influenza virus subtypes by a novel modified vaccinia Ankara (MVA) vectored vaccine in mice
Joseph N Brewoo
Inviragen, Inc, 6502 Odana Rd, Madison, WI 53719, USA
Vaccine 31:1848-55. 2013
..Our findings highlight MVA as suitable vector to express multiple influenza antigens that could afford broad cross-protective immunity against multiple subtypes of influenza virus...
- Carbon nanotubes: on the road to deliver
Alberto Bianco
UPR 9021, CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
Curr Drug Deliv 2:253-9. 2005
..This opens new therapeutic and preventive opportunities to combat diseases. The scope of this review is to summarize our recent work in this rapidly growing field...
- Antigens onto bare skin: a 'painless' paradigm shift in vaccine delivery
Charalambos D Partidos
UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084, Strasbourg, France
Expert Opin Biol Ther 3:895-902. 2003
..However, despite these successes, there are several challenges ahead to be addressed before vaccines administered with a patch will be available over the counter...
- Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques
Katherine M Mladinich
Microbiology Doctoral Training Program, University of Wisconsin Madison, 1326 Microbial Sciences, 1550 Linden Drive, Madison, WI 53706, USA
Immunogenetics 64:111-21. 2012
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- Delivering vaccines into the skin without needles and syringes
Charalambos D Partidos
UPR 9021, CNRS, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg, France
Expert Rev Vaccines 2:753-61. 2003
..This article reviews current attempts to administer vaccines into the skin and discusses some of the scientific issues related to the emerging delivery technologies...
- Applying peptide antigens onto bare skin: induction of humoral and cellular immune responses and potential for vaccination
Charalambos D Partidos
UPR 9021, Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 rue Rene Descartes, F 67084, Strasbourg, France
J Control Release 85:27-34. 2002
..Therefore, they could be the most suitable candidate immunogens for skin immunisation. This review describes our recent observations on the immunogenicity of synthetic peptides applied onto bare skin in relation to vaccination...
