Griffith D Parks

Summary

Publications

  1. pmc Paramyxovirus activation and inhibition of innate immune responses
    Griffith D Parks
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27157 1064, USA Electronic address
    J Mol Biol 425:4872-92. 2013
  2. ncbi request reprint Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors
    Patrick J Dillon
    Department of Microbiology and Immunology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1064, USA
    J Gen Virol 87:3643-8. 2006
  3. pmc Virus growth and antibody responses following respiratory tract infection of ferrets and mice with WT and P/V mutants of the paramyxovirus Simian Virus 5
    Gerald A Capraro
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Virology 376:416-28. 2008
  4. pmc A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 80:3416-27. 2006
  5. pmc Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge
    Kimberly M Clark
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 419:97-106. 2011
  6. pmc Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Room 5108, Gray Building, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 79:3339-49. 2005
  7. pmc Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:10975-85. 2008
  8. ncbi request reprint Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5
    Sharmila Pejawar-Gaddy
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Viral Immunol 20:76-87. 2007
  9. pmc A hyperfusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon
    Maria D Gainey
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:9369-80. 2008
  10. ncbi request reprint Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Immunol 231:14-9. 2004

Collaborators

  • Subhashini Arimilli
  • Tridib Ganguly
  • Hector C Aguilar
  • Douglas S Lyles
  • Benhur Lee
  • John B Johnson
  • Mary J Manuse
  • Patrick J Dillon
  • Martha A Alexander-Miller
  • Caitlin M Briggs
  • Elizabeth K Wansley
  • Maria D Gainey
  • Peter M Gray
  • Virginia A Young
  • Anne E Mayer
  • Kimberly M Clark
  • Gerald A Capraro
  • Nancy D Kock
  • Sharmila Pejawar-Gaddy
  • Sharmila S Pejawar
  • Michael A Keller
  • Anthony P Schmitt
  • Sean D Reid
  • Robert C Holder
  • Steven B Mizel
  • Ken Grant
  • Negin Gitiban-Vaghefi
  • Scott D Cramer
  • Ellen M Palmer
  • James Tam
  • Jason M Grayson

Detail Information

Publications33

  1. pmc Paramyxovirus activation and inhibition of innate immune responses
    Griffith D Parks
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27157 1064, USA Electronic address
    J Mol Biol 425:4872-92. 2013
    ..We discuss the importance of innate responses in DC following paramyxovirus infection and their consequences for the ability to mount and maintain antiviral T cells. ..
  2. ncbi request reprint Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors
    Patrick J Dillon
    Department of Microbiology and Immunology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1064, USA
    J Gen Virol 87:3643-8. 2006
    ....
  3. pmc Virus growth and antibody responses following respiratory tract infection of ferrets and mice with WT and P/V mutants of the paramyxovirus Simian Virus 5
    Gerald A Capraro
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Virology 376:416-28. 2008
    ..We present a model for the effect of P/V gene substitutions on SV5 growth and immune responses in vivo...
  4. pmc A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 80:3416-27. 2006
    ....
  5. pmc Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge
    Kimberly M Clark
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 419:97-106. 2011
    ....
  6. pmc Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Room 5108, Gray Building, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Virol 79:3339-49. 2005
    ..These studies add to the growing evidence for immune dysregulation following viral infection of the respiratory tract...
  7. pmc Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:10975-85. 2008
    ....
  8. ncbi request reprint Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5
    Sharmila Pejawar-Gaddy
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Viral Immunol 20:76-87. 2007
    ..These findings provide evidence that different professional antigen-presenting cells can detect and respond to virus via distinct mechanisms...
  9. pmc A hyperfusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon
    Maria D Gainey
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:9369-80. 2008
    ..The potential advantages of SV5-based oncolytic vectors are discussed...
  10. ncbi request reprint Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cell Immunol 231:14-9. 2004
    ..Our results are the first demonstration of the control of avidity during the antiviral response through an engineered change to a viral antigen. The implications of our findings for vaccine development are discussed...
  11. pmc Role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing
    Mary J Manuse
    Department of Microbiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 83:9057-67. 2009
    ..Control of genomic promoter activity may be particularly important for viruses such as SV5, that express a V protein targeting mda-5 but do not encode antagonists such as the paramyxovirus C proteins, that specifically target RIG-I...
  12. pmc Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    J Virol 86:9929-40. 2012
    ..They also define pathways of virus complement-mediated neutralization and suggest the design of more effective viral vectors...
  13. pmc Activation of human macrophages by bacterial components relieves the restriction on replication of an interferon-inducing parainfluenza virus 5 (PIV5) P/V mutant
    Caitlin M Briggs
    Department of Microbiology and Immunology, Wake Forest University, School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, United States
    Microbes Infect 13:359-68. 2011
    ..We discuss these results in terms of the implications for mixed bacteria-virus infections and for the use of live RNA virus vectors that have been engineered to be attenuated for IFN sensitivity...
  14. pmc Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules
    Sharmila S Pejawar
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Virol 79:7544-57. 2005
    ..Further, they suggest that the amount of virus encountered and/or the permissivity of a dendritic cell to infection can alter the resulting maturation phenotype and functional capacity of the infected dendritic cell...
  15. ncbi request reprint Apoptosis induction and interferon signaling but not IFN-beta promoter induction by an SV5 P/V mutant are rescued by coinfection with wild-type SV5
    Elizabeth K Wansley
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 316:41-54. 2003
    ..A model is proposed for activation of host responses to infection with the rSV5-P/V-CPI- mutant and the steps that are blocked by rSV5-WT...
  16. ncbi request reprint Variants of the paramyxovirus Simian virus 5 with accelerated or delayed viral gene expression activate proinflammatory cytokine synthesis
    Virginia A Young
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    Virology 350:90-102. 2006
    ..Our data indicate a role for both the P/V and the M gene products as determinants of RANTES induction in response to SV5 infection...
  17. pmc Interactions of human complement with virus particles containing the Nipah virus glycoproteins
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 85:5940-8. 2011
    ....
  18. ncbi request reprint Growth sensitivity of a recombinant simian virus 5 P/V mutant to type I interferon differs between tumor cell lines and normal primary cells
    Elizabeth K Wansley
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Virology 335:131-44. 2005
    ..The implications of these results for the use of recombinant paramyxoviruses as vectors are discussed...
  19. pmc The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1064, USA
    J Virol 83:7602-11. 2009
    ..Our results support a model in which the rubulaviruses SV5 and MuV incorporate cell surface complement inhibitors into progeny virions as a mechanism to limit complement-mediated neutralization...
  20. pmc Role for the phosphoprotein P subunit of the paramyxovirus polymerase in limiting induction of host cell antiviral responses
    Patrick J Dillon
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 81:11116-27. 2007
    ..A model is presented for the mechanism by which both the P subunit of the viral polymerase and the V accessory protein contribute to the ability of a paramyxovirus to limit activation of antiviral responses...
  21. pmc Paramyxovirus-induced shutoff of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation
    Maria D Gainey
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    J Virol 82:828-39. 2008
    ....
  22. pmc TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5
    Mary J Manuse
    Department of Microbiology and Immunology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 397:231-41. 2010
    ..Implications for crosstalk between different innate immunity pathways in mounting antiviral responses to paramyxoviruses are discussed...
  23. pmc Replication-independent activation of human plasmacytoid dendritic cells by the paramyxovirus SV5 Requires TLR7 and autophagy pathways
    Mary J Manuse
    Department of Microbiology and Immunology, School of Medicine, Wake Forest University, Winston Salem, NC 27157 1064, USA
    Virology 405:383-9. 2010
    ..These results have implications for control of SV5 infections in vivo and for development of SV5 as a vaccine vector...
  24. pmc Point mutations in the paramyxovirus F protein that enhance fusion activity shift the mechanism of complement-mediated virus neutralization
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    J Virol 87:9250-9. 2013
    ..We present general models for the relationship between enhanced fusion activity in the paramyxovirus F protein and increased susceptibility to antibody-mediated neutralization. ..
  25. pmc TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways
    Subhashini Arimilli
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1064, USA
    Virology 365:144-56. 2007
    ....
  26. pmc Mumps virus inhibits migration of primary human macrophages toward a chemokine gradient through a TNF-alpha dependent mechanism
    Caitlin M Briggs
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 433:245-52. 2012
    ..MuV infection enhanced secretion of TNF-α, but not macrophage inhibitory factor (MIF). Antibody inhibition and add-back experiments demonstrated that TNF-α was both necessary and sufficient for MuV-mediate chemotaxis inhibition...
  27. ncbi request reprint Positive- and negative-acting signals combine to determine differential RNA replication from the paramyxovirus simian virus 5 genomic and antigenomic promoters
    Michael A Keller
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1064, USA
    Virology 306:347-58. 2003
    ..Possible functions for the SV5 promoter elements in determining RNA replication levels are proposed...
  28. ncbi request reprint High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract
    Peter M Gray
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 170:174-81. 2003
    ..However, as the response progresses, low avidity cells are activated/expanded to a greater extent compared with high avidity cells...
  29. ncbi request reprint The neutralizing capacity of antibodies elicited by parainfluenza virus infection of African Green Monkeys is dependent on complement
    Anne E Mayer
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC 27101, USA
    Virology 460:23-33. 2014
    ..These results highlight the importance of complement in the initial antibody response to parainfluenza viruses, with implications for understanding infant immune responses and design of vaccine strategies for these pediatric pathogens. ..
  30. pmc The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing
    Tridib Ganguly
    Department of Microbiology and Immunology, Medical Center Blvd, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    Cell Microbiol 16:1105-18. 2014
    ..pertussis colonization of the respiratory tract. These findings also make Bps a potential target for the prevention and therapy of whooping cough. ..
  31. pmc Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus
    John B Johnson
    Department of Microbiology and Immunology, Wake Forest University, School of Medicine, Winston Salem, NC 27157 1064, USA
    Virology 376:112-23. 2008
    ..The implications of our work for development of paramyxovirus vectors and vaccines are discussed...
  32. pmc Simian virus 5 is a poor inducer of chemokine secretion from human lung epithelial cells: identification of viral mutants that activate interleukin-8 secretion by distinct mechanisms
    Virginia A Young
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1064, USA
    J Virol 77:7124-30. 2003
    ..The isolation of two recombinant SV5 mutants that are defective in preventing chemokine induction will allow an identification of mechanisms utilized by WT SV5 to avoid activation of host cell innate immune responses to infection...
  33. pmc Naturally occurring substitutions in the P/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha/beta interferon synthesis and cell death
    Elizabeth K Wansley
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1064, USA
    J Virol 76:10109-21. 2002
    ..Our results confirm a role for the SV5 V protein in blocking IFN signaling but also suggest new roles for the P/V gene products in controlling viral gene expression, the induction of IFN-alpha/beta synthesis, and virus-induced apoptosis...