Acute heart failure in patients with diabetes mellitus: clinical characteristics and predictors of in-hospital mortalityJohn T Parissis
Heart Failure Clinic and Secondary Cardiology Department, Attikon University Hospital, Athens, Greece
Int J Cardiol 157:108-13. 2012
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Clinical characteristics and predictors of in-hospital mortality in acute heart failure with preserved left ventricular ejection fractionJohn T Parissis
Heart Failure Clinic and Secondary Cardiology Department, Attikon University Hospital, Athens, Greece
Am J Cardiol 107:79-84. 2011
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Classical inotropes and new cardiac enhancersJohn T Parissis
Heart Failure Unit, Attikon University Hospital, Athens, Greece
Heart Fail Rev 12:149-56. 2007
..More data are needed regarding patient selection and the optimum regimen and dosing of levosimendan before this treatment modality become the first line therapy of acutely decompensated chronic heart failure patients...
Effects of levosimendan on right ventricular function in patients with advanced heart failureJohn T Parissis
Second Cardiology Department, Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Am J Cardiol 98:1489-92. 2006
..05). In conclusion, levosimendan could offer further therapeutic advantages in patients with advanced heart failure by improving systolic and diastolic RV function...
Effects of serial levosimendan infusions on left ventricular performance and plasma biomarkers of myocardial injury and neurohormonal and immune activation in patients with advanced heart failureJ T Parissis
Second Department of Cardiology and Heart Failure Clinic, Attikon University Hospital, Athens, Greece
Heart 92:1768-72. 2006
..The role, however, of repeated levosimendan infusions in the management of these patients has not yet been properly assessed...
Depression in coronary artery disease: novel pathophysiologic mechanisms and therapeutic implicationsJohn T Parissis
Second Department of Cardiology, Attikon University Hospital, Aftokratoros Irakliou 17, 15122 Maroussi, Athens, Greece
Int J Cardiol 116:153-60. 2007
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Levosimendan for the treatment of acute heart failure syndromesJohn T Parissis
Second Cardiology Department, Heart Failure Clinic, Attikon Univesity Hospital, Athens, Greece
Expert Opin Pharmacother 6:2741-51. 2005
..The most common adverse effects of levosimendan treatment are hypotension and headache. Overall, levosimendan represents an effective and safe option for the treatment of decompensated heart failure patients...
Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failureJohn T Parissis
Second Department of Cardiology and Heart Failure Clinic, Attikon University Hospital, Athens, Greece
Am J Cardiol 96:423-6. 2005
..Thus, levosimendan seems to be effective in improving left ventricular diastolic function and reducing neurohormonal activation in patients with severe heart failure...
Depression in chronic heart failure: novel pathophysiological mechanisms and therapeutic approachesJohn T Parissis
Attikon University Hospital Heart Failure Clinic, Aftocratoros Irakliou 17, 15122, Maroussi, Athens, Greece
Expert Opin Investig Drugs 14:567-77. 2005
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Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failureJohn T Parissis
Second Department of Cardiology, Attikon University Hospital, Rimini 1, 12461 Chaidari, Athens, Greece
Atherosclerosis 197:278-82. 2008
..We sought to investigate whether the calcium sensitizer levosimendan affects beneficially endothelial function and attenuates the deleterious effects of soluble adhesion molecules in patients with advanced CHF...
Sertraline for the treatment of depression in coronary artery disease and heart failureJohn Parissis
University of Athens, 17 Aftokratoros, Irakliou St 15122 Maroussi, Athens, Greece
Expert Opin Pharmacother 8:1529-37. 2007
..Intervention with sertraline has the potential to provide depressed patients with cardiac disease relief from their depressive symptoms, improvement in quality of life and a potential benefit in their cardiovascular risk profile...
Clinical and prognostic implications of self-rating depression scales and plasma B-type natriuretic peptide in hospitalised patients with chronic heart failureJ T Parissis
Heart Failure Clinic, Second Department of Cardiology, Attikon University Hospital, Athens, Greece
Heart 94:585-9. 2008
..Purpose: This study evaluated the clinical and prognostic value of depression scales (Beck Depression Inventory (BDI), Zung Self-rating Depression Scale (Zung SDS)) along with plasma B-type natriuretic peptide (BNP) in CHF...
Clinical and prognostic value of Duke's Activity Status Index along with plasma B-type natriuretic peptide levels in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathyJohn T Parissis
Heart Failure Clinic and Second Department of Cardiology, Attikon University Hospital, Athens, Greece
Am J Cardiol 103:73-5. 2009
..0001). In conclusion, functional status assessment by the DASI bears prognostic value, and its combination with plasma BNP may provide quite specific risk stratification in patients with chronic HF...
Levosimendan: from basic science to clinical practiceJohn T Parissis
Heart Failure Clinic and Second Cardiology Department, Attikon University Hospital, Maroussi, Athens, Greece
Heart Fail Rev 14:265-75. 2009
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Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failureJohn T Parissis
Heart Failure Clinic, Second Department of Cardiology, Attikon University Hospital, Navarinou 13, Maroussi, 15122 Athens, Greece
Eur J Heart Fail 11:163-9. 2009
..We investigated the correlation between health status and inflammation burden as well as its long-term prognostic value in CHF outpatients...
Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up studyJohn T Parissis
Second Department of Cardiology, Heart Failure Clinic, Attikon University Hospital, 15122 Maroussi, Athens, Greece
Eur J Heart Fail 11:967-72. 2009
..To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms...
Inotropes in cardiac patients: update 2011John T Parissis
Heart Failure Unit, Attikon University Hospital, Athens, Greece
Curr Opin Crit Care 16:432-41. 2010
..This review summarizes all the current knowledge about the use of conventional and new inotropic agents in various clinical entities of critically ill patients...
Acute pulmonary oedema: clinical characteristics, prognostic factors, and in-hospital managementJohn T Parissis
Heart Failure Clinic and Second Cardiology Department, Attikon University Hospital, University of Athens, Athens, Greece
Eur J Heart Fail 12:1193-202. 2010
..This subanalysis examines the clinical profile, prognostic factors, and management of APE patients (n = 1820, 36.7%) included in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF)...
Anti-cytokine therapies in chronic heart failure: is this concept still alive?John T Parissis
Second Department of Cardiology, Attikon University Hospital, Athens, Greece
Hellenic J Cardiol 46:101-7. 2005
Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathyJohn T Parissis
Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Centre Athens, Greece
Eur J Cardiovasc Prev Rehabil 12:164-8. 2005
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Novel biologic mechanisms of levosimendan and its effect on the failing heartJohn T Parissis
University of Athens and Attikon General Hospital, Heart Failure Clinic and Second Cardiology Department, Navarinou 13, 15122 Maroussi, Athens, Greece
Expert Opin Investig Drugs 17:1143-50. 2008
..Levosimendan, the most well-studied calcium sensitizer in the real clinical practice, produces greater hemodynamic and symptomatic improvement in patients with acute heart failure than traditional inotropes...
Plasma profiles of circulating granulocyte-macrophage colony-stimulating factor and soluble cellular adhesion molecules in acute myocardial infarction. Contribution to post-infarction left ventricular dysfunctionJohn T Parissis
First Department of Cardiology, Amalia Fleming Hospital, Athens Greece
Eur Cytokine Netw 15:139-44. 2004
..These monocyte-related inflammatory mediators may actively contribute to the pathophysiology of the disease and post-infarction cardiac dysfunction...
Elevated plasma amylase levels in advanced chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy: correlation with circulating interleukin-6 activityJohn T Parissis
First Department of Cardiology, Amalia Fleming Hospital, Athens, Greece
J Interferon Cytokine Res 23:329-33. 2003
..However, the lack of association between plasma IL-6 and amylase levels in mild heart failure patients indicates an independent correlation of each variable with the functional status of the disease...
Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depressionJohn T Parissis
Heart Failure Clinic, Amalia Fleming Hospital, Athens, Greece
Am J Cardiol 94:1326-8. 2004
..A disregulated cytokine network and activated apoptosis signaling molecules may be actively implicated in the pathophysiology of chronic emotional distress and depressive symptoms in patients with heart failure...
Plasma profiles of peripheral monocyte-related inflammatory markers in patients with arterial hypertension. Correlations with plasma endothelin-1John T Parissis
Department of Cardiology, Athens Euroclinic, Greece
Int J Cardiol 83:13-21. 2002
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Serum profiles of C-C chemokines in acute myocardial infarction: possible implication in postinfarction left ventricular remodelingJohn T Parissis
First Department of Cardiology, Amalia Fleming Hospital, Athens, Greece
J Interferon Cytokine Res 22:223-9. 2002
..The elevation of these chemotactic inflammatory factors may actively contribute to the pathophysiology of the disease and the subsequent left ventricular remodeling...
Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failureStamatis Adamopoulos
Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
Am J Cardiol 98:102-6. 2006
..05). In conclusion, the superiority of levosimendan over dobutamine in improving central hemodynamics and left ventricular performance in decompensated HF seems to be related to its anti-inflammatory and antiapoptotic effects...
Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failureKallirrhoe Kourea
Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Atherosclerosis 199:215-21. 2008
..044). In conclusion, darbepoetin-alpha reduces circulating pro-inflammatory cytokine IL-6 and apoptotic mediator soluble Fas ligand in CHF patients with anemia, with a parallel improvement of cardiac performance and exercise capacity...
A glossary of circulating cytokines in chronic heart failureS Adamopoulos
Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Zinonos 9, Halandri, 15234, Athens, Greece
Eur J Heart Fail 3:517-26. 2001
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Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathyStamatis Adamopoulos
Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
Am Heart J 144:359-64. 2002
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Carvedilol improves left atrial and left ventricular function and reserve in dilated cardiomyopathy after 1 year of treatmentIoannis Paraskevaidis
Second Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
J Card Fail 13:108-13. 2007
..The aim of this study was to evaluate the effects of carvedilol therapy on left atrial (LA) function in patients with heart failure from nonischemic dilated cardiomyopathy...
Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failureIoannis A Paraskevaidis
Heart Failure Unit and Second Cardiology Department, Attikon University Hospital, Athens, Greece
Am J Cardiol 102:1225-9. 2008
..In conclusion, dobutamine-induced changes in longitudinal systolic strain rate are associated with clinical and neurohumoral improvement after levosimendan treatment in patients with ADCHF...
Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failureIgnatios Ikonomidis
Second Cardiology Department and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Eur J Heart Fail 9:1172-7. 2007
..Levosimendan has inotropic and vasodilatory effects. We investigated the effects of levosimendan on coronary flow and associated changes in neurohormonal activation and cardiac performance in patients with advanced heart failure...
Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathyVasiliki Bistola
Second Department of Cardiology and Heart Failure Unit, Attikon University Hospital, Athens, Greece
Am J Cardiol 105:249-54. 2010
..01) and increased BNP (p <0.05) predicted the combined end point. In conclusion, RV TDI indexes combined with increased plasma BNP additively predict adverse cardiac outcomes in advanced CHF...
Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patientsStamos Kyrzopoulos
Second Department of Cardiovascular Medicine and Laboratory of Molecular Immunology and Histocompatibility, Onassis Cardiac Surgery Center, Maroussi, Athens 15122, Greece
Int J Cardiol 99:409-13. 2005
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Functional electrical stimulation is more effective in severe symptomatic heart failure patients and improves their adherence to rehabilitation programsApostolos Karavidas
Cardiology Department, General Hospital G Genimmatas, Athens, Greece
J Card Fail 16:244-9. 2010
..This study compares the effectiveness of FES on exercise capacity, endothelial function, neurohormonal status, and emotional stress in New York Heart Association (NYHA) III-IV versus NYHA II patients...
Effects of growth hormone on circulating cytokine network, and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathyStamatis Adamopoulos
Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece
Eur Heart J 24:2186-96. 2003
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Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathyJohn T Parissis
Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Am Heart J 155:751.e1-7. 2008
..We sought to investigate the effects of recombinant human erythropoietin analogue darbepoetin alpha on left (LV) and right ventricular (RV) function and neurohormonal activation in patients with CHF and anemia...
Prolonged activation of tumor necrosis factor (TNF)-alpha and its soluble receptors in chronic heart failure patients both in the compensated and decompensated state. Interplay between their levels and metalloproteinase-3Dimitrios Tziakas
Department of Cardiology, Democritus University of Thrace, Alexandroupolis, Greece
Eur Cytokine Netw 15:231-9. 2004
..The second goal of this study was to determine if a relationship exists between serum MMPs profiles (MMP-1, MMP-2, MMP-3) and circulating TNF-alpha or its soluble receptors...
Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failureKallirrhoe Kourea
Second Department of Cardiology and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Eur J Cardiovasc Prev Rehabil 15:365-9. 2008
..This study investigates the effects of recombinant human erythropoietin analog darbepoetin-alpha on quality of life and emotional stress, evaluated by relevant questionnaires in patients with CHF and anemia...
The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillationDionyssios I Leftheriotis
ATTIKON University Hospital of Athens, Department of Cardiology, Athens, Greece
Int J Cardiol 135:361-9. 2009
..The aim of this study is to evaluate these markers as predictors of sinus rhythm (SR) maintenance, in patients with persistent lone AF...
Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failureDimitrios Farmakis
Second Department of Cardiology and Heart Failure Unit, Attiko University Hospital, Athens, Greece
Int J Cardiol 139:75-9. 2010
..We sought to identify predictors of long-term response to levosimendan therapy among patients' baseline features and treatment-induced changes in acutely decompensated chronic heart failure (ADHF)...
Current drugs and medical treatment algorithms in the management of acute decompensated heart failureFilippos Triposkiadis
Department of Cardiology, University of Thessaly Medical School, Larissa University Hospital, Larissa, Greece
Expert Opin Investig Drugs 18:695-707. 2009
..New agents and strategies are under investigation in order to effectively reduce the mortality and morbidity in these patients...
Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failureJohn T Parissis
Second Department of Cardiology, Amalia Fleming Hospital, Athens, Greece
Am J Cardiol 93:1309-12. 2004
..These immunomodulatory effects may lead to improvement of symptoms and echocardiographic markers of cardiac contractile performance in these patients...
Effect of levosimendan on ventricular arrhythmias and prognostic autonomic indexes in patients with decompensated advanced heart failure secondary to ischemic or dilated cardiomyopathyPanayota Flevari
Second Department of Cardiology, Attikon University Hospital, Athens, Greece
Am J Cardiol 98:1641-5. 2006
..At the same time, it is associated with improvements in cardiac function and neurohormonal response. These findings may have important clinical and prognostic implications...
Effects of levosimendan on quality of life and emotional stress in advanced heart failure patientsJohn T Parissis
Second Cardiology Department and Heart Failure Unit, University of Athens Medical School, Attikon University Hospital, Athens, Greece
Cardiovasc Drugs Ther 21:263-8. 2007
..However, its effects on quality of life, emotional stress and functional capacity of patients with advanced CHF have not been properly investigated...
Functional electrical stimulation improves endothelial function and reduces peripheral immune responses in patients with chronic heart failureApostolos I Karavidas
Department of Cardiology, General National Hospital, Athens, Greece
Eur J Cardiovasc Prev Rehabil 13:592-7. 2006
..This study evaluates the impact of FES on endothelial function and peripheral markers of immune activation in patients with moderate to severe heart failure...
Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failureJohn T Parissis
Heart Failure Unit, Attikon University Hospital, Athens, Greece
Atherosclerosis 195:e210-5. 2007
..We sought to investigate if the calcium sensitizer levosimendan beneficially modulates circulating markers of oxidative and nitrosative stress thus lessening their deleterious effects in patients with advanced CHF...
Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokinesDimitrios N Tziakas
Department of Cardiology, University of Thrace, Leoforos Dimokratias 116, Alexandroupolis 68100, Greece
Int J Cardiol 92:169-75. 2003
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Effects of Darbepoetin Alfa on plasma mediators of oxidative and nitrosative stress in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathyJohn T Parissis
Heart Failure Clinic, Attikon University Hospital, University of Athens, Greece
Am J Cardiol 103:1134-8. 2009
..63, p <0.05). In conclusion, darbepoetin alfa attenuated deleterious effects of oxidative and nitrosative stress into the cardiovascular system of anemic patients with CHF, improving also cardiac function and exercise capacity...
Selective serotonin re-uptake inhibitors for the treatment of depression in coronary artery disease and chronic heart failure: evidence for pleiotropic effectsIoannis Paraskevaidis
Second Department of Cardiology and Heart Failure Clinic, University of Athens, Greece
Cardiovasc Hematol Agents Med Chem 4:361-7. 2006
..These bio-modulatory properties of SSRIs may be translated into improvement of patient clinical outcomes beyond their anti-depressant action...
Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: a novel mechanism of drug-induced improvement in contractile performance of the failing heartIoannis A Paraskevaidis
2nd Department of Cardiology, Attikon University Hospital, Athens, Greece
Curr Med Chem Cardiovasc Hematol Agents 3:243-7. 2005
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New aspects for the role of physical training in the management of patients with chronic heart failureStamatis Adamopoulos
Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Athens, Greece
Int J Cardiol 90:1-14. 2003
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New insight into "heart-hand" syndromes: a newly discovered chromosomal abnormality in a family with "heart-hand" syndromeStamatis Adamopoulos
Second Department of Cardiovascular Medicine, Onassis Cardiac Surgery Center, Riga Ferreou Str. 18-20, Maroussi 15122, Athens, Greece
Int J Cardiol 97:129-32. 2004
..This newly discovered chromosomal abnormality confirms once more the genetic heterogeneity of the syndrome...
Anticoagulants, antiplatelets, and statins in heart failureDimitrios Farmakis
University of Athens Medical School, Attikon University Hospital, Athens, Greece
Cardiol Clin 26:49-58, vi. 2008
..This article outlines the current knowledge regarding the use of antiplatelet and anticoagulant agents and statins in patients who have heart failure...
Severe anaemia and subcapital femur fracture in a patient with Left Ventricular Assist Device Heart Mate II: the cardiologist's management of this rare patientBill D Gogas
Second Department of Cardiology, Heart Failure Unit, Attikon University Hospital, 1 Rimini Street, Athens, Greece
Eur J Heart Fail 11:806-8. 2009
..The patient was managed successfully by a team approach, which included a cardiologist, anaesthesiologist, orthopaedic surgeon, and LVAD technician...
Levosimendan therapy in decompensated chronic heart failure: favourable haemodynamic and neurohormonal effects but for how long?John T Parissis
Eur J Heart Fail 8:215; author reply 218. 2006
Levosimendan for the treatment of acute heart failure syndromes: time to identify subpopulations of responding patientsJohn T Parissis
Am J Cardiol 99:146-7. 2007
Overview of emerging pharmacologic agents for acute heart failure syndromesLeonardo De Luca
Department of Cardiovascular Sciences, European Hospital, Rome, Italy
Eur J Heart Fail 10:201-13. 2008
..There is, therefore, an unmet need for new pharmacologic agents for the early management of AHFS that may improve both short- and long-term outcomes...
Anti-inflammatory effects of levosimendan in decompensated heart failure: impact on weight loss and anemiaJohn T Parissis
Am J Cardiol 95:923-4. 2005
Serum profiles of matrix metalloproteinases and their tissue inhibitor in patients with acute coronary syndromes. The effects of short-term atorvastatin administrationDimitrios N Tziakas
Cardiology Department, University of Thrace, Leoforos Dimokratias 116, GR 68100 Alexandroupolis, Greece
Int J Cardiol 94:269-77. 2004
..The reduction of these factors by short-term atorvastatin administration may provide a new insight into the pleiotropic effects of statins on unstable coronary artery disease...
Giant unruptured aneurysm of right valsalva sinus detected by magnetic resonance imagingJohn T Parissis
Int J Cardiol 96:299-301. 2004
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An atypical left atrial myxoma causing intracavitary pressure gradient and typical diastolic transmitral flow of severe mitral stenosisJohn T Parissis
Int J Cardiol 102:165-7. 2005
A rare case of large mediastinal germ cell tumor detected by echocardiographySpilios M Karas
Int J Cardiol 101:159-61. 2005
..CT scanning and histological findings after tumor resection confirmed diagnosis. This case demonstrates the clinical importance of echocardiography in diagnosis of extra-cardiac masses...
Estrogen administration in patients with chronic heart failure: not ready for prime timeGerasimos Filippatos
Eur J Heart Fail 5:113-6. 2003