Daniel Paris

Summary

Publications

  1. ncbi request reprint Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 366:80-5. 2004
  2. doi request reprint Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease
    Ghania Ait-Ghezala
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 44:283-7. 2008
  3. ncbi request reprint Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res 999:53-61. 2004
  4. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
  5. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
  6. doi request reprint Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010
  7. doi request reprint Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide
    Nikunj S Patel
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Amyloid 15:5-19. 2008
  8. ncbi request reprint Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 514:1-15. 2005
  9. ncbi request reprint Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice
    Amita Quadros
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 353:66-8. 2003
  10. ncbi request reprint Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurol Res 25:642-51. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 366:80-5. 2004
    ..In addition, Tg APPsw mice show a reduction in vascular density in the cortex and hippocampus compared to control littermates. Altogether, our data suggest that the over expression of APPsw in the vasculature may oppose angiogenesis...
  2. doi request reprint Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease
    Ghania Ait-Ghezala
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 44:283-7. 2008
    ..Thus, we present preliminary evidence for potential usefulness for combination of plasma sCD40, sCD40L along with Abeta(1-40) and APOE epsilon4 in improving the clinical diagnosis of AD...
  3. ncbi request reprint Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res 999:53-61. 2004
    ..All together, these data suggest that nilvadipine might be useful for the treatment of oligemia associated with AD...
  4. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
    ....
  5. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
    ..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo...
  6. doi request reprint Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010
    ..Altogether, our data suggest that Abeta acts as an antagonist of VEGFR-2 and provide a mechanism explaining the anti-angiogenic activity of Abeta peptides...
  7. doi request reprint Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide
    Nikunj S Patel
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Amyloid 15:5-19. 2008
    ..Using normal and mutated peptide fragments, we show that the sequence VHHQKLVFF is sufficient to exhibit potent anti-angiogenic effects. This small peptide may therefore have clinical relevance as an anti-angiogenic agent...
  8. ncbi request reprint Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 514:1-15. 2005
    ..Altogether these data suggest that the gamma and beta-secretases play an essential role during angiogenesis and that inhibitors of the beta and gamma-secretases may constitute new classes of anti-angiogenic and anti-tumoral compounds...
  9. ncbi request reprint Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice
    Amita Quadros
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 353:66-8. 2003
    ..In conclusion, our data suggest that either activity or expression of Cox-2 is increased in TgAPPsw mice brains as a function of age, contributing to an increased production of pro-inflammatory eicosanoids and TNFalpha...
  10. ncbi request reprint Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurol Res 25:642-51. 2003
    ..Altogether, our data suggest a link between inflammation and the compromised cerebral hemodynamics in AD...
  11. doi request reprint Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Eur J Pharmacol 698:145-53. 2013
    ..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...
  12. ncbi request reprint Serum beta-amyloid correlates with neuropsychological impairment
    Cheryl A Luis
    Roskamp Institute, Sarasota, FL, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:203-18. 2009
    ....
  13. ncbi request reprint Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease
    Ghania Ait-Ghezala
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 140:73-85. 2005
    ..Taken together, our data also suggest that CD40 ligation in human microglia specifically perturbs many genes associated with APP processing...
  14. ncbi request reprint CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway
    Ghania Ait-Ghezala
    The Roskamp Institute, Sarasota, FL 34243, USA
    Eur J Neurosci 25:1685-95. 2007
    ..Taken together, our results further suggest that CD40L stimulation may be a key component in AD pathology and that elements of the NF-kappaB pathway may be suitable targets for therapeutic approaches against AD...
  15. doi request reprint The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production
    Claude Henry Volmar
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 42:336-44. 2008
    ..GM-CSF signaling may be a suitable therapeutic target against Abeta production in AD...
  16. doi request reprint Anatabine lowers Alzheimer's Aβ production in vitro and in vivo
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 670:384-91. 2011
    ..Altogether our data suggest that anatabine may represent an interesting compound for regulating brain Aβ accumulation...
  17. pmc Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:432-7. 2009
    ..In this subcohort of individuals at risk for AD, the association of Abeta with vascular risk factors and medications to treat these conditions did not interfere with Abeta's predictive value for MCI/AD...
  18. pmc Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, USA
    J Neurosci 30:11251-8. 2010
    ....
  19. ncbi request reprint Inhibition of angiogenesis by Abeta peptides
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Angiogenesis 7:75-85. 2004
    ..Similarly to the intra-tumoral injection regimen, Abeta delivered intraperitoneally also suppressed the growth of human lung adenocarcinoma tumor xenografts. Altogether our data show that Abeta is an angiogenesis inhibitor...
  20. ncbi request reprint Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 136:212-30. 2005
    ..Altogether, these data provide new molecular clues regarding the pathological activity of Dutch A(beta) peptide in the cerebrovasculature...
  21. ncbi request reprint Inhibition of Abeta production by NF-kappaB inhibitors
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 415:11-6. 2007
    ..Altogether our data suggest that NF-kappaB inhibitors may be of therapeutic importance for the treatment of AD pathology not only by blocking inflammatory processes but also by directly inhibiting the production of Abeta peptides...
  22. ncbi request reprint A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, Sarasota, FL 34243, USA
    Neurodegener Dis 11:13-21. 2013
    ..While apolipoprotein E4 (apoE4) is highly correlated with the development of Alzheimer's disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) removal from the brain, is not clearly defined...
  23. pmc High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:95-100. 2009
    ..Longitudinal evaluation of blood Abeta in this cohort will provide a better understanding of the significance of this association in AD etiology...
  24. ncbi request reprint The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, United States
    Neurosci Lett 428:53-8. 2007
    ....
  25. ncbi request reprint Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brain
    Daniel Paris
    The Roskamp Institute, University of South Florida, Tampa 33613, USA
    Prostaglandins Other Lipid Mediat 70:1-12. 2002
    ..Our data provide evidence that fsAbeta triggers a pro-inflammatory reaction in rat brain, and suggest that the cerebrovasculature may constitute an important source of pro-inflammatory eicosanoids...
  26. doi request reprint Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 659:124-9. 2011
    ..This dual mechanism of action may be particularly effective in attenuating Aβ brain burden in Alzheimer's disease and could open the door to a new class of therapies for the treatment of this disease...
  27. doi request reprint Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier
    Corbin Bachmeier
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    J Mol Neurosci 49:270-6. 2013
    ..Thus, RXR activation could mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of AD...
  28. ncbi request reprint Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding protein
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Biochem Biophys Res Commun 332:585-92. 2005
    ..We hypothesize that in a similar fashion to AF-Sm1, RNA interacts with Abeta in the beta-hairpin (beta-turn-beta) structure and prevents fibril formation...
  29. pmc Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Bioinformation 6:229-36. 2011
    ..Altogether, our data suggest that flavonoids inhibit Aβ and sAPPβ production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity...
  30. ncbi request reprint Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA Electronic address
    Mol Cell Neurosci 56:255-62. 2013
    ..These findings provide insight into the mechanism by which cannabinoid treatment reduces Aβ burden in the AD brain and offer additional evidence on the utility of this pathway as a treatment for AD. ..
  31. doi request reprint Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier
    Corbin J Bachmeier
    The Roskamp Institute, Sarasota, Florida, USA
    Microcirculation 18:373-9. 2011
    ..To investigate the role of RAGE in the epitope-dependent effects of Aβ antibodies used as a peripheral sink therapy in AD...
  32. pmc A 3D-QSAR model based screen for dihydropyridine-like compound library to identify inhibitors of amyloid beta (Aβ) production
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Bioinformation 5:122-7. 2010
    ..We describe here our in silico model building strategy, model selection parameters and the chemical features that are useful for successful screening of DHP and DHP-like chemical libraries for Aβ inhibitors...
  33. ncbi request reprint A novel physico-chemical property based model for studying the effects of mutation on the aggregation of peptides
    Venkatarajan S Mathura
    Roskamp Institute, 2040, Whitfield Avenue, Sarasota, FL 34243, USA
    Protein Pept Lett 16:991-8. 2009
    ..We also show that sequences containing beta-sheet classes of Structural Classification of Proteins (SCOP) have a higher propensity for aggregation...
  34. pmc Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Cytotechnology 62:519-29. 2010
    ..These studies establish the HBMEC as a representative in vitro model of the BBB and offer a rapid fluorometric method of assessing Aβ exchange between the periphery and the brain...
  35. ncbi request reprint Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae
    Daniel Paris
    Department of Psychiatry, The Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Atherosclerosis 161:293-9. 2002
    ..Taken together these data show that statins can antagonize the effect of A beta in different assays and provide new clues to understand the prophylactic action of the statins against Alzheimer's disease...
  36. ncbi request reprint Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor
    Jiazhi Sun
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 64:3586-92. 2004
    ..Taken together, these results demonstrate that a synthetic molecule capable of disrupting the binding of VEGF to its receptor selectively inhibits VEGF-dependent signaling and suppresses angiogenesis and tumorigenesis...