Maria V Papadopoulou

Summary

Publications

  1. Papadopoulou M, Trunz B, Bloomer W, McKenzie C, Wilkinson S, Prasittichai C, et al. Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. J Med Chem. 2011;54:8214-23 pubmed publisher
    ..b. brucei trypomastigotes with elevated TbNTR levels were hypersensitive to tested compounds. Therefore, a novel class of affordable 3-nitro-1,2,4-triazole-based compounds with antitrypanosomal activity has been identified. ..
  2. Papadopoulou M, Bloomer W, Rosenzweig H, Kaiser M, Chatelain E, Ioset J. Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents. Bioorg Med Chem. 2013;21:6600-7 pubmed publisher
    ..cruzi amastigotes) from 117 to 1725 and 12 of 13 compounds were up to 39-fold more potent than the reference compound benznidazole. Detailed SARs are discussed. ..

Detail Information

Publications2

  1. Papadopoulou M, Trunz B, Bloomer W, McKenzie C, Wilkinson S, Prasittichai C, et al. Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. J Med Chem. 2011;54:8214-23 pubmed publisher
    ..b. brucei trypomastigotes with elevated TbNTR levels were hypersensitive to tested compounds. Therefore, a novel class of affordable 3-nitro-1,2,4-triazole-based compounds with antitrypanosomal activity has been identified. ..
  2. Papadopoulou M, Bloomer W, Rosenzweig H, Kaiser M, Chatelain E, Ioset J. Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents. Bioorg Med Chem. 2013;21:6600-7 pubmed publisher
    ..cruzi amastigotes) from 117 to 1725 and 12 of 13 compounds were up to 39-fold more potent than the reference compound benznidazole. Detailed SARs are discussed. ..