Systematic review of clinical research on biomarkers for pediatric traumatic brain injuryLinda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL 32806, USA
J Neurotrauma 30:324-38. 2013
..Future studies of biomarkers for pediatric TBI will require rigorous and more uniform research methodology, common data elements, and consistent performance measures...
- Use of biomarkers for diagnosis and management of traumatic brain injury patients
Linda Papa
Director of Academic Clinical Research Orlando Regional Medical Center, Department of Emergency Medicine, 86 W Underwood S 200, Orlando, FL 32806, USA 1 407 237 6329 1 407 649 3083
Expert Opin Med Diagn 2:937-45. 2008
..Continuing studies by the authors' group are now being conducted to elucidate more fully the relationships between new biomarkers and severity of injury and clinical outcomes in all severities of TBI patients...
- Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention
Linda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
Ann Emerg Med 59:471-83. 2012
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- Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention
Linda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida 32806, USA
J Trauma Acute Care Surg 72:1335-44. 2012
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- Performance of the Canadian CT Head Rule and the New Orleans Criteria for predicting any traumatic intracranial injury on computed tomography in a United States Level I trauma center
Linda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
Acad Emerg Med 19:2-10. 2012
..Additionally, the performance of the CCHR was assessed in a larger cohort of those presenting with GCS of 13 to 15...
Assessing effectiveness of a mature trauma system: Association of trauma center presence with lower injury mortality rateLinda Papa
Department of Emergency Medicine, University of Florida, Gainesville, Florida 32608, USA
J Trauma 61:261-6; discussion 266-7. 2006
..To determine effectiveness of trauma center care in a mature trauma system by comparing motor vehicle crash (MVC) death rates in counties with a trauma center (TC) to those without a trauma center (NTC)...
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injuryLinda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
Crit Care Med 38:138-44. 2010
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- Does a waiting room video about what to expect during an emergency department visit improve patient satisfaction?
Linda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, University of Florida, Orlando, Florida 32806, USA
CJEM 10:347-54. 2008
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- Structure and function of emergency care research networks: strengths, weaknesses, and challenges
Linda Papa
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
Acad Emerg Med 16:995-1004. 2009
..By leveraging the strengths and addressing the weaknesses, strategies can be adopted to enhance the scientific value and productivity of these networks and give direction to future ECRNs...
- Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury
Stefania Mondello
Department of Anesthesiology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
Neurosurgery 70:666-75. 2012
..Brain damage markers released in cerebrospinal fluid (CSF) and blood may provide valuable information about diagnosis and outcome prediction after traumatic brain injury (TBI)...
- A systematic review and meta-analysis comparing outcome of severely injured patients treated in trauma centers following the establishment of trauma systems
Brian Celso
Department of Surgery, University of Florida, Jacksonville, Florida, USA
J Trauma 60:371-8; discussion 378. 2006
..We systematically reviewed the published literature to assess if outcome from severe traumatic injury is improved for patients following the establishment of a trauma system...
- Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study
Stefania Mondello
Department of Anesthesiology, University of Florida, 1600 S, W, Archer Road, Gainesville, FL 32610 0254, USA
Crit Care 15:R156. 2011
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- αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients
Stefania Mondello
Department of Clinical Programs and Center of Innovative Research, University of Florida, Gainesville, Florida, USA
J Neurotrauma 27:1203-13. 2010
..The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment...
- Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury
Jose A Pineda
Center for Traumatic Brain Injury Studies, E F and W L McKnight Brain Institute of the University of Florida, Gainesville, Florida, USA
J Neurotrauma 24:354-66. 2007
..Our data further suggests that both necrotic/oncotic and apoptotic cell death mechanisms are activated in humans following severe TBI, but with a different time course after injury...
- Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury
Stephen B Lewis
Department of Neurological Surgery, University of Florida, Gainesville 32610, USA
J Neurosurg 107:792-6. 2007
..In addition, all spectrin breakdown products (SBDPs) can provide information on the proteolytic mechanisms of injury...
- End-tidal carbon dioxide is associated with mortality and lactate in patients with suspected sepsis
Christopher L Hunter
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL 32806, USA
Am J Emerg Med 31:64-71. 2013
..Exhaled end-tidal carbon dioxide (ETCO(2)) concentration is associated with lactate levels in febrile patients. We assessed the association of ETCO(2) with mortality and lactate levels in patients with suspected sepsis...
- Protein C as an early biomarker to distinguish pneumonia from sepsis
Scott Gutovitz
Department of Emergency Medicine, University of Kansas Hospital, Kansas City, KS 66160, USA
J Crit Care 26:330.e9-12. 2011
..Patients with pneumonia often are unrecognized as also having sepsis. We evaluated protein C, as a potential biomarker, to differentiate between patients with pneumonia and sepsis...
- Systematic review of definitions for drowning incidents
Linda Papa
Department of Emergency Medicine, University of Florida, 1329 SW 16th Street Suite 2204, Gainesville, FL 32608, USA
Resuscitation 65:255-64. 2005
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- Shoulder MRI accuracy in the community setting
Carlton G Houtz
Orlando Health, Orlando, FL, USA
J Shoulder Elbow Surg 20:537-42. 2011
..Evaluate the accuracy for shoulder magnetic resonance imaging (MRI) interpretations of typical community radiologists and compare this to selected fellowship trained musculoskeletal radiologists...
- Do United States Medical Licensing Examination (USMLE) scores predict in-training test performance for emergency medicine residents?
Josef G Thundiyil
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida 32806, USA
J Emerg Med 38:65-9. 2010
..Residency selection committees commonly utilize USMLE scores as criteria to screen residency applicants...
- Middle ear pressure and symptoms after skydiving
Scott Gutovitz
Department of Emergency Medicine Orlando Regional Healthcare, Orlando, FL 32806, USA
Aviat Space Environ Med 79:533-6. 2008
..those who did not, and pressures in those who attempted equalization vs. not...
- A comparison of tele-education versus conventional lectures in wound care knowledge and skill acquisition
Marisa Haney
Department of Emergency Medicine, Orlando Regional Medical Center, 86 W Underwood Street, Suite 200, Orlando, FL 32806, USA
J Telemed Telecare 18:79-81. 2012
..0 (IQR 5.5-6.0) in the live lecture group and 4.0 (IQR 3.0-5.0) in the video group (P < 0.001). Videoconferencing was at least as effective as live didactic presentation...
- Botfly myiasis: a case report
Ken G Ofordeme
Department of Emergency Medicine, Emergency Medicine Residency Program, University of Florida Shands Jacksonville, Jacksonville, Florida, USA
CJEM 9:380-2. 2007
..We present and discuss the case of a 50-year-old man with furuncular myiasis acquired in Belize. Parasitic infestation should be included in the differential diagnosis of a new skin lesion in patients who have travelled to endemic areas...
- Progression of emergency medicine resident productivity
Daniel F Brennan
Department of Emergency Medicine, Emergency Medicine Residency Program, Orlando Regional Medical Center, Orlando, FL, USA
Acad Emerg Med 14:790-4. 2007
..To evaluate the progression in productivity of emergency medicine (EM) residents by postgraduate year, as measured by hourly work in relative value units (RVUs)...
- Risk factors for complications of drug-induced seizures
Josef G Thundiyil
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando Health, Orlando, FL 32806, USA
J Med Toxicol 7:16-23. 2011
..0 [95% CI 1.4-11.3]). Significant clinical factors associated with complications of drug-related seizures include stimulant exposure, suicide attempt, initial hypotension, and admission acidosis or hyperglycemia...
- Ultrasound can accurately guide gastrostomy tube replacement and confirm proper tube placement at the bedside
Teresa S Wu
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida 32806, USA
J Emerg Med 36:280-4. 2009
..Although a few reports have described the use of ultrasound guidance during the initial percutaneous insertion, no data are available concerning its role during subsequent G-tube replacements...
