Nathan Pankratz

Summary

Publications

  1. pmc Genetics of Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 525, USA
    NeuroRx 1:235-42. 2004
  2. ncbi request reprint Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease
    Nathan Pankratz
    Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:2257-60. 2006
  3. pmc Alpha-synuclein and familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Mov Disord 24:1125-31. 2009
  4. pmc Significant linkage of Parkinson disease to chromosome 2q36-37
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Am J Hum Genet 72:1053-7. 2003
  5. pmc Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    Nathan Pankratz
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Hum Genet 124:593-605. 2009
  6. ncbi request reprint Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families
    Nathan Pankratz
    Indiana University School of Medicine, Department of Medical and Molecular Genetics IB 130, 975 West Walnut Street, Indianapolis, IN 46202 5251, USA
    Hum Mol Genet 12:2599-608. 2003
  7. pmc Clinical correlates of depressive symptoms in familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    Mov Disord 23:2216-23. 2008
  8. ncbi request reprint Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:45-9. 2006
  9. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
  10. pmc Copy number variation in familial Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e20988. 2011

Detail Information

Publications21

  1. pmc Genetics of Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 525, USA
    NeuroRx 1:235-42. 2004
    ..Important lessons can be learned from the implementation of counseling protocols for other neurodegenerative disorders, such as Huntington disease and Alzheimer disease...
  2. ncbi request reprint Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease
    Nathan Pankratz
    Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:2257-60. 2006
    ..These results indicate that, although the G2019S mutation remains the most common mutation identified in familial PD patients, other mutations in LRRK2 are infrequent...
  3. pmc Alpha-synuclein and familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Mov Disord 24:1125-31. 2009
    ..29; empirical P-value = 0.01), but not age of onset (P = 0.40). These data suggest that dosage and sequence changes are a rare cause of PD, but variation in the promoter and 3' region of SNCA convey an increased risk for PD...
  4. pmc Significant linkage of Parkinson disease to chromosome 2q36-37
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Am J Hum Genet 72:1053-7. 2003
    ..1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility...
  5. pmc Genomewide association study for susceptibility genes contributing to familial Parkinson disease
    Nathan Pankratz
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Hum Genet 124:593-605. 2009
    ..8 x 10(-6); additive model: p = 4.8 x 10(-5)). These data suggest the identification of new susceptibility alleles for PD in the GAK/DGKQ region, and also provide further support for the role of SNCA and MAPT in PD susceptibility...
  6. ncbi request reprint Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families
    Nathan Pankratz
    Indiana University School of Medicine, Department of Medical and Molecular Genetics IB 130, 975 West Walnut Street, Indianapolis, IN 46202 5251, USA
    Hum Mol Genet 12:2599-608. 2003
    ..4) and X (LOD=3.2). These findings demonstrate consistent evidence of linkage to chromosomes 2 and X and also support the hypothesis that gene-by-gene interactions are important in PD susceptibility...
  7. pmc Clinical correlates of depressive symptoms in familial Parkinson's disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    Mov Disord 23:2216-23. 2008
    ..33; P = 4 x 10(-48)). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms...
  8. ncbi request reprint Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana, USA
    Mov Disord 21:45-9. 2006
    ..It appears the similarities between PD and AD may be due to an overlap in the diseases' genetic etiology...
  9. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  10. pmc Copy number variation in familial Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e20988. 2011
    ..Thus, only the CNVs within the PARK2 locus could be molecularly validated and associated with PD susceptibility...
  11. pmc Standard linkage and association methods identify the mechanism of four susceptibility genes for a simulated complex disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, IN, USA
    BMC Genet 6:S142. 2005
    ..This highlights the need in real life situations for careful examination of the phenotypic data prior to genetic analysis...
  12. pmc Mutations in DJ-1 are rare in familial Parkinson disease
    Nathan Pankratz
    Indiana University Medical Center, Indianapolis, IN, USA
    Neurosci Lett 408:209-13. 2006
    ..No additional missense mutations and no exon deletions or duplications were detected. Our results, in combination with those of previous studies, suggest that alterations in DJ-1 are not a common cause of familial PD...
  13. pmc Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2
    Nathan Pankratz
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann Neurol 71:370-84. 2012
    ..Genome-wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes associated with PD susceptibility...
  14. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011
    ..Replication in larger samples is important, after which regions detected here may be promising targets for resequencing...
  15. ncbi request reprint Genetics of Parkinson disease
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Genet Med 9:801-11. 2007
    ..Furthermore, because treatment is unaltered by the presence or absence of mutations in these genes, restraint is recommended when considering the value of screening for mutations in a clinical setting...
  16. ncbi request reprint Chromosome 5 and Parkinson disease
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Eur J Hum Genet 14:1106-10. 2006
    ..Evidence for a locus contributing to the age of onset of PD is modest at best (empirical P-value=0.07)...
  17. pmc Identification of genes for complex disease using longitudinal phenotypes
    Nathan Pankratz
    Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    BMC Genet 4:S58. 2003
    ..Power to detect linkage can be improved by identifying the most heritable phenotype, ensuring normality of the trait distribution and maximizing the information utilized through novel longitudinal designs for genetic analysis...
  18. pmc Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations
    Nathan Pankratz
    Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis 46202 5251, USA
    Am J Hum Genet 71:124-35. 2002
    ..7) and to chromosome 2 (LOD score 2.5). Evidence of linkage was also found to chromosomes 4, 5, and 13 (LOD scores >1.5). Our findings are consistent with those of other linkage studies that have reported linkage to chromosomes 5 and X...
  19. ncbi request reprint R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation
    William C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Mov Disord 22:254-7. 2007
    ..We believe it is imperative that the causative nature of any newly identified genetic variant be determined before it is included in any panel for diagnostic testing...
  20. ncbi request reprint Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
    William C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Lancet 365:410-2. 2005
    ..Thus, our results suggest that a single LRRK2 mutation causes Parkinson's disease in 5% of individuals with familial disease. Screening for this mutation should be a component of genetic testing for Parkinson's disease...
  21. ncbi request reprint Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease
    William C Nichols
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Mov Disord 19:649-55. 2004
    ..Taken together, these data suggest that genetic alteration at the Nurr1 locus is not a significant risk factor for the development of Parkinson's disease in our large sample of familial PD patients...