Early repolarization and short QT interval in healthy subjectsGopi Krishna Panicker
Research Section, Quintiles Cardiac Safety Services, Mumbai, India
Heart Rhythm 9:1265-71. 2012
..These patients with ER have shorter QT intervals. Morphological variants of the ER pattern also have been associated with idiopathic VF, but their prevalence in healthy subjects is unclear...
- Z-score for benchmarking reader competence in a central ECG laboratory
Gopi Krishna Panicker
Quintiles ECG Services, Mumbai, India
Ann Noninvasive Electrocardiol 14:19-25. 2009
..ECGs from thorough QT studies must be read in a central laboratory by trained experts. Standards of expertise are not presently defined. We, therefore, studied the use of Z-scores to define reader competence...
- Intra- and interreader variability in QT interval measurement by tangent and threshold methods in a central electrocardiogram laboratory
Gopi Krishna Panicker
Research Section, Quintiles ECG Services, Mumbai, India
J Electrocardiol 42:348-52. 2009
..The QT interval can be measured by tangent (QT(Tan)) and threshold (QT(Thr)) methods; the better method is the one with lower reader variability...
- Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers
Vaibhav Salvi
Research Section, Quintiles Cardiac Safety Services, Mumbai, India
J Electrocardiol 44:96-104. 2011
..We studied moxifloxacin-induced QT prolongation and proportion of categorical QTc outliers when 5 methods of QT measurement were used to analyze electrocardiograms (ECGs) from a thorough QT study...
- Semiautomated QT interval measurement in electrocardiograms from a thorough QT study: comparison of the grouped and ungrouped superimposed median beat methods
Pooja Hingorani
Quintiles Cardiac Safety Services, Mumbai, India
J Electrocardiol 45:225-30. 2012
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- Choice of an alternative lead for QT interval measurement in serial ECGs when Lead II is not suitable for analysis
Vaibhav Salvi
Research Section, Quintiles Cardiac Safety Services, 502 A, Leela Business Park, M V Road, Andheri East, Mumbai 400 059, India Electronic address
Indian Heart J 64:535-40. 2012
..Conventionally, QT interval is measured in lead II. There are no data to select an alternative lead for QT measurement when it cannot be measured in Lead II for any reason...
- Limb lead interchange in thorough QT/QTc studies
Vaibhav Salvi
Quintiles Cardiac Safety Services, 502 A, Leela Business Park, M V Road, Andheri East, Mumbai 400 059, India
J Clin Pharmacol 51:1468-73. 2011
..If correctly identified, QT measurement could be performed in a precordial lead. If undiagnosed, incorrect QT interval measurements and morphological diagnosis may confound results...
Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug developmentVaibhav Salvi
Quintiles ECG Services, Andheri East, Mumbai, India
Br J Pharmacol 159:34-48. 2010
..Thus, paradoxically, the effectiveness of the E14 guidance itself has made prospective validation of new biomarkers difficult...
- Differences between QT and RR intervals in digital and digitized paper electrocardiograms: contribution of the printer, scanner, and digitization process
Pooja Hingorani
Research Section, Quintiles ECG Services, Mumbai, India
J Electrocardiol 41:370-5. 2008
..These ECGs may differ from the original ECG because of variability introduced by the printer, scanner, or digitization software...
Cardiovascular risk of oral antidiabetic drugs: current evidence and regulatory requirements for new drugsGopi Krishna Panicker
Quintiles Cardiac Safety Services, Mumbai, India
J Assoc Physicians India 60:56-61. 2012
..We review here published data on cardiac safety of currently available oral antidiabetic drugs...
- Tilting at windmills
Yash Lokhandwala
Arrhythmia Associates, Mumbai, India
J Assoc Physicians India 58:636-7. 2010
..At electrophysiology study, an easily inducible, self-terminated AV nodal re-entrant tachycardia was induced. At 1 year follow-up after radiofrequency ablation, he is asymptomatic...
- Left bundle-branch block with right axis deviation--a unique aberrancy during supraventricular tachycardia
Yash Lokhandwala
Arrhythmia Associates, Mumbai, India
J Electrocardiol 42:674-6. 2009
..We present the case of a 34-year-old man showing atrioventricular nodal reentrant tachycardia with left bundle-branch block/right axis deviation as an exception to this rule...
