Gopi Krishna Panicker

Summary

Publications

  1. doi request reprint Drug-induced QT prolongation when QT interval is measured in each of the 12 ECG leads in men and women in a thorough QT study
    Gopi Krishna Panicker
    Quintiles Cardiac Safety Services, Mumbai, India Electronic address
    J Electrocardiol 47:155-7. 2014
  2. doi request reprint Early repolarization and short QT interval in healthy subjects
    Gopi Krishna Panicker
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    Heart Rhythm 9:1265-71. 2012
  3. doi request reprint Z-score for benchmarking reader competence in a central ECG laboratory
    Gopi Krishna Panicker
    Quintiles ECG Services, Mumbai, India
    Ann Noninvasive Electrocardiol 14:19-25. 2009
  4. doi request reprint Intra- and interreader variability in QT interval measurement by tangent and threshold methods in a central electrocardiogram laboratory
    Gopi Krishna Panicker
    Research Section, Quintiles ECG Services, Mumbai, India
    J Electrocardiol 42:348-52. 2009
  5. pmc Choice of an alternative lead for QT interval measurement in serial ECGs when Lead II is not suitable for analysis
    Vaibhav Salvi
    Quintiles Cardiac Safety Services, Mumbai, India
    Indian Heart J 64:535-40. 2012
  6. doi request reprint Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers
    Vaibhav Salvi
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 44:96-104. 2011
  7. doi request reprint Semiautomated QT interval measurement in electrocardiograms from a thorough QT study: comparison of the grouped and ungrouped superimposed median beat methods
    Pooja Hingorani
    Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 45:225-30. 2012
  8. doi request reprint Limb lead interchange in thorough QT/QTc studies
    Vaibhav Salvi
    Quintiles Cardiac Safety Services, 502 A, Leela Business Park, M V Road, Andheri East, Mumbai 400 059, India
    J Clin Pharmacol 51:1468-73. 2011
  9. doi request reprint Reader variability in QT measurement due to measurement error and variability in leads selection: A simulation study comparing 2-way vs. 3-way interaction ANOVA model
    Mili Natekar
    Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 47:140-3. 2014
  10. doi request reprint Comparison of Two Methods of Estimating Reader Variability in QT Interval Measurements in Thorough QT/QTc Studies
    Vaibhav Salvi
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    Ann Noninvasive Electrocardiol 19:182-9. 2014

Collaborators

  • Vaibhav Salvi
  • Pooja Hingorani
  • Yash Lokhandwala
  • Mili Natekar
  • Mandar Shah
  • Vaibhav Kerkar
  • Dilip R Karnad
  • Arumugam Ramasamy
  • Snehal Kothari
  • Hein J J Wellens

Detail Information

Publications15

  1. doi request reprint Drug-induced QT prolongation when QT interval is measured in each of the 12 ECG leads in men and women in a thorough QT study
    Gopi Krishna Panicker
    Quintiles Cardiac Safety Services, Mumbai, India Electronic address
    J Electrocardiol 47:155-7. 2014
    ..The 90% lower CI exceeded 5ms in these leads in women despite wide 90% CIs because of greater mean ΔΔQTcF. Leads III, aVL and V1 should be avoided when measuring QT interval in thorough QT studies. ..
  2. doi request reprint Early repolarization and short QT interval in healthy subjects
    Gopi Krishna Panicker
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    Heart Rhythm 9:1265-71. 2012
    ..These patients with ER have shorter QT intervals. Morphological variants of the ER pattern also have been associated with idiopathic VF, but their prevalence in healthy subjects is unclear...
  3. doi request reprint Z-score for benchmarking reader competence in a central ECG laboratory
    Gopi Krishna Panicker
    Quintiles ECG Services, Mumbai, India
    Ann Noninvasive Electrocardiol 14:19-25. 2009
    ..ECGs from thorough QT studies must be read in a central laboratory by trained experts. Standards of expertise are not presently defined. We, therefore, studied the use of Z-scores to define reader competence...
  4. doi request reprint Intra- and interreader variability in QT interval measurement by tangent and threshold methods in a central electrocardiogram laboratory
    Gopi Krishna Panicker
    Research Section, Quintiles ECG Services, Mumbai, India
    J Electrocardiol 42:348-52. 2009
    ..The QT interval can be measured by tangent (QT(Tan)) and threshold (QT(Thr)) methods; the better method is the one with lower reader variability...
  5. pmc Choice of an alternative lead for QT interval measurement in serial ECGs when Lead II is not suitable for analysis
    Vaibhav Salvi
    Quintiles Cardiac Safety Services, Mumbai, India
    Indian Heart J 64:535-40. 2012
    ..Conventionally, QT interval is measured in lead II. There are no data to select an alternative lead for QT measurement when it cannot be measured in Lead II for any reason...
  6. doi request reprint Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers
    Vaibhav Salvi
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 44:96-104. 2011
    ..We studied moxifloxacin-induced QT prolongation and proportion of categorical QTc outliers when 5 methods of QT measurement were used to analyze electrocardiograms (ECGs) from a thorough QT study...
  7. doi request reprint Semiautomated QT interval measurement in electrocardiograms from a thorough QT study: comparison of the grouped and ungrouped superimposed median beat methods
    Pooja Hingorani
    Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 45:225-30. 2012
    ....
  8. doi request reprint Limb lead interchange in thorough QT/QTc studies
    Vaibhav Salvi
    Quintiles Cardiac Safety Services, 502 A, Leela Business Park, M V Road, Andheri East, Mumbai 400 059, India
    J Clin Pharmacol 51:1468-73. 2011
    ..If correctly identified, QT measurement could be performed in a precordial lead. If undiagnosed, incorrect QT interval measurements and morphological diagnosis may confound results...
  9. doi request reprint Reader variability in QT measurement due to measurement error and variability in leads selection: A simulation study comparing 2-way vs. 3-way interaction ANOVA model
    Mili Natekar
    Quintiles Cardiac Safety Services, Mumbai, India
    J Electrocardiol 47:140-3. 2014
    ..The two-way model provides identical estimates when both reads are in same leads, but higher, more realistically estimates when measurements are made in different leads. ..
  10. doi request reprint Comparison of Two Methods of Estimating Reader Variability in QT Interval Measurements in Thorough QT/QTc Studies
    Vaibhav Salvi
    Research Section, Quintiles Cardiac Safety Services, Mumbai, India
    Ann Noninvasive Electrocardiol 19:182-9. 2014
    ..Two methods of estimating reader variability (RV) in QT measurements between 12 readers were compared...
  11. pmc Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development
    Vaibhav Salvi
    Quintiles ECG Services, Andheri East, Mumbai, India
    Br J Pharmacol 159:34-48. 2010
    ..Thus, paradoxically, the effectiveness of the E14 guidance itself has made prospective validation of new biomarkers difficult...
  12. doi request reprint Differences between QT and RR intervals in digital and digitized paper electrocardiograms: contribution of the printer, scanner, and digitization process
    Pooja Hingorani
    Research Section, Quintiles ECG Services, Mumbai, India
    J Electrocardiol 41:370-5. 2008
    ..These ECGs may differ from the original ECG because of variability introduced by the printer, scanner, or digitization software...
  13. ncbi request reprint Cardiovascular risk of oral antidiabetic drugs: current evidence and regulatory requirements for new drugs
    Gopi Krishna Panicker
    Quintiles Cardiac Safety Services, Mumbai, India
    J Assoc Physicians India 60:56-61. 2012
    ..We review here published data on cardiac safety of currently available oral antidiabetic drugs...
  14. ncbi request reprint Tilting at windmills
    Yash Lokhandwala
    Arrhythmia Associates, Mumbai, India
    J Assoc Physicians India 58:636-7. 2010
    ..At electrophysiology study, an easily inducible, self-terminated AV nodal re-entrant tachycardia was induced. At 1 year follow-up after radiofrequency ablation, he is asymptomatic...
  15. doi request reprint Left bundle-branch block with right axis deviation--a unique aberrancy during supraventricular tachycardia
    Yash Lokhandwala
    Arrhythmia Associates, Mumbai, India
    J Electrocardiol 42:674-6. 2009
    ..We present the case of a 34-year-old man showing atrioventricular nodal reentrant tachycardia with left bundle-branch block/right axis deviation as an exception to this rule...