Seithikurippu R Pandi-Perumal

Summary

Publications

  1. ncbi request reprint Melatonin: Nature's most versatile biological signal?
    S R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS J 273:2813-38. 2006
  2. ncbi request reprint Sleep disorders, sleepiness and traffic safety: a public health menace
    S R Pandi-Perumal
    Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Braz J Med Biol Res 39:863-71. 2006
  3. ncbi request reprint Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1-11. 2007
  4. ncbi request reprint Could agomelatine be the ideal antidepressant?
    S R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, 1176 5 Avenue, 6 Floor, Box 1232, New York, NY 10029, USA
    Expert Rev Neurother 6:1595-608. 2006
  5. ncbi request reprint Drug Insight: the use of melatonergic agonists for the treatment of insomnia-focus on ramelteon
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Neurol 3:221-8. 2007
  6. doi request reprint The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    World J Biol Psychiatry 10:342-54. 2009
  7. doi request reprint Ramelteon: a review of its therapeutic potential in sleep disorders
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, 8790 112th Street, Richmond Hill, New York, NY 11418 2317, USA
    Adv Ther 26:613-26. 2009
  8. ncbi request reprint Role of the melatonin system in the control of sleep: therapeutic implications
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mt Sinai School of Medicine, New York, New York 10029, USA
    CNS Drugs 21:995-1018. 2007
  9. doi request reprint Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, Richmond Hill, New York, NY 11418 2317, USA
    Prog Neurobiol 88:264-71. 2009
  10. doi request reprint The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, 8790 112t Street, New York, NY 11418 2317, USA
    Nat Clin Pract Neurol 4:436-47. 2008

Detail Information

Publications19

  1. ncbi request reprint Melatonin: Nature's most versatile biological signal?
    S R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS J 273:2813-38. 2006
    ..Taken together, this evidence implicates melatonin in a broad range of effects with a significant regulatory influence over many of the body's physiological functions...
  2. ncbi request reprint Sleep disorders, sleepiness and traffic safety: a public health menace
    S R Pandi-Perumal
    Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Braz J Med Biol Res 39:863-71. 2006
    ....
  3. ncbi request reprint Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1-11. 2007
    ..DLMO marker is also useful for identifying optimal application times for therapies such as bright light or exogenous melatonin treatment...
  4. ncbi request reprint Could agomelatine be the ideal antidepressant?
    S R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, 1176 5 Avenue, 6 Floor, Box 1232, New York, NY 10029, USA
    Expert Rev Neurother 6:1595-608. 2006
    ..In summary, the clinical advantage of agomelatine is attributed to its novel mechanism of action, which helps not only to exert antidepressant action, but also to regulate the sleep-wake rhythm...
  5. ncbi request reprint Drug Insight: the use of melatonergic agonists for the treatment of insomnia-focus on ramelteon
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Neurol 3:221-8. 2007
    ..Although ramelteon's metabolism and pharmacokinetics differ from those of melatonin, its safety seems to be sufficient for short-term application. Its long-term effects remain to be determined...
  6. doi request reprint The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    World J Biol Psychiatry 10:342-54. 2009
    ..These properties underline the use of melatonin analogues as a promising alternative for the treatment of depression...
  7. doi request reprint Ramelteon: a review of its therapeutic potential in sleep disorders
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, 8790 112th Street, Richmond Hill, New York, NY 11418 2317, USA
    Adv Ther 26:613-26. 2009
    ..The adverse symptoms reported with ramelteon are mild. All long-term investigations that have been carried out support the conclusion that ramelteon is a well tolerated and effective drug for the treatment of insomnia...
  8. ncbi request reprint Role of the melatonin system in the control of sleep: therapeutic implications
    Seithikurippu R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mt Sinai School of Medicine, New York, New York 10029, USA
    CNS Drugs 21:995-1018. 2007
    ....
  9. doi request reprint Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, Richmond Hill, New York, NY 11418 2317, USA
    Prog Neurobiol 88:264-71. 2009
    ..Disruptions in melatonin secretion or availability may be the common factor, which underlies depressive disorder and its prominent signs and symptoms such as sleep and circadian rhythm abnormalities...
  10. doi request reprint The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders
    Seithikurippu R Pandi-Perumal
    Somnogen Inc, 8790 112t Street, New York, NY 11418 2317, USA
    Nat Clin Pract Neurol 4:436-47. 2008
    ..In this Review, we focus on the use of exogenous melatonin and light therapy to treat the disturbed sleep-wake rhythms seen in CRSDs...
  11. ncbi request reprint Melatonin in mood disorders
    Venkataramanujan Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan
    World J Biol Psychiatry 7:138-51. 2006
    ..Bright light treatment, that suppresses melatonin production, is effective in treating bipolar affective disorder and SAD, winter type. This review discusses the role of melatonin in the pathophysiology of bipolar disorder and SAD...
  12. doi request reprint Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, Room BB813, NY 10032, USA
    Prog Neurobiol 85:335-53. 2008
    ..It further considers their relevance to circadian physiology and pathogenesis of certain human diseases, with a focus on the brain, the cardiovascular and immune systems, and cancer...
  13. doi request reprint Melatonergic drugs in clinical practice
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Universityof Göttingen, Gottingen, Germany
    Arzneimittelforschung 58:1-10. 2008
    ..g., on reproductive functions. According to current data, both compounds seem to be safe during short-term treatment..
  14. doi request reprint Jet lag: therapeutic use of melatonin and possible application of melatonin analogs
    Venkataramanujan Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan Malaysia
    Travel Med Infect Dis 6:17-28. 2008
    ....
  15. doi request reprint 24-hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or alpha-ketoglutarate
    Perumal Subramanian
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
    Redox Rep 13:78-86. 2008
    ..The results indicate that melatonin and alpha-KG are effective in protecting from NDEA-induced perturbation of 24-h rhythms in oxidative stress. Melatonin augmented antioxidant defense in rats...
  16. ncbi request reprint Role of melatonin in the eye and ocular dysfunctions
    Per O Lundmark
    Department of Optometry and Vision Sciences, Buskerud University College, Kongsberg, Norway
    Vis Neurosci 23:853-62. 2006
    ..Melatonin cytoprotective properties may have practical implications in the treatment of ocular diseases, like glaucoma and age-related macular degeneration...
  17. doi request reprint Immunomodulation by melatonin: its significance for seasonally occurring diseases
    Venkataramanujam Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Malaysia
    Neuroimmunomodulation 15:93-101. 2008
    ..The clinical significance of the seasonally changing immunomodulatory role of melatonin is discussed in this review...
  18. ncbi request reprint Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine
    Perumal Subramanian
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
    J Pineal Res 43:305-12. 2007
    ..Melatonin administration significantly curtailed tumor development and counteracted all the biochemical effects...
  19. ncbi request reprint Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats
    Perumal Subramanian
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Eur J Pharmacol 571:116-9. 2007
    ..These results offer a support to the hypothesis that melatonin in pharmacological amounts effectively reduces oxidative stress and acts as an antihyperlipidemic agent...