Automated analysis of fluorescence lifetime imaging microscopy (FLIM) data based on the Laguerre deconvolution methodParitosh Pande
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77943, USA
IEEE Trans Biomed Eng 58:172-81. 2011
..This method will thus facilitate applications of FLIM requiring automatic estimation of the spatial distribution of fluorescence lifetimes, such as in in vivo tissue FLIM imaging...
Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopyJesung Park
Department of Biomedical Engineering, Texas A and M University, 5045 emerging Technology Building, College Station, TX 77843, United States
Atherosclerosis 220:394-401. 2012
..To investigate the potential of endogenous multispectral fluorescence lifetime imaging microscopy (FLIM) for biochemical characterization of human coronary atherosclerotic plaques...
- High-speed multispectral fluorescence lifetime imaging implementation for in vivo applications
Sebina Shrestha
Department of Biomedical Engineering, Texas A and M University, 337 Zachary Building, College Station, Texas 77843, USA
Opt Lett 35:2558-60. 2010
..We present a cost-effective scanning multispectral FLIM implementation capable of achieving pixel rates on the order of tens of kilohertz, which will facilitate the evaluation of FLIM for in vivo applications...
- Biochemical imaging of human atherosclerotic plaques with fluorescence lifetime angioscopy
Patrick Thomas
Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
Photochem Photobiol 86:727-31. 2010
..This study demonstrates the potential of FLIM angioscopy for biochemical imaging of human coronary atherosclerotic plaques...
- In vivo simultaneous morphological and biochemical optical imaging of oral epithelial cancer
Javier A Jo
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77840, USA
IEEE Trans Biomed Eng 57:2596-9. 2010
..While both sets of biomarkers can differentiate normal and cancerous tissue, we believe their combination will enable the discrimination of benign lesions possessing some of the indicated biomarkers, e.g., scarring or inflammation...
- Application of non-negative matrix factorization to multispectral FLIM data analysis
Paritosh Pande
Department of Biomedical Engineering, 5018 Emerging Technology Building, Texas A and M University, College Station, Texas 77843, USA
Biomed Opt Express 3:2244-62. 2012
..The NMF features were also compared against the standard intensity and lifetime features, in terms of their ability to discriminate between different types of atherosclerotic plaques...
- Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer
Sebina Shrestha
Department of Biomedical Engineering at Texas A and M University, College Station, TX, USA
Conf Proc IEEE Eng Med Biol Soc 2010:1970-3. 2010
..Here we report early favorable results from an animal study designed to measure the capacity of this approach for early diagnosis of oral cancer...
- Fully automated deconvolution method for on-line analysis of time-resolved fluorescence spectroscopy data based on an iterative Laguerre expansion technique
Aditi S Dabir
Texas A and M University, Department of Biomedical Engineering, College Station, Texas 77843, USA
J Biomed Opt 14:024030. 2009
..The proposed automated Laguerre deconvolution method will facilitate online applications of TRFS, such as real-time clinical tissue diagnosis...
