Hai Feng Pan

Summary

Publications

  1. doi request reprint Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Rheumatol Int 33:2337-42. 2013
  2. doi request reprint Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mol Biol Rep 40:391-9. 2013
  3. pmc Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China
    Song Yao
    Anhui Provincial TB Research Institute, Hefei, China
    BMC Health Serv Res 11:341. 2011
  4. doi request reprint High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    Mol Biol Rep 37:1191-5. 2010
  5. doi request reprint Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis
    Man Man Lu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mod Rheumatol 23:686-93. 2013
  6. doi request reprint Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population
    Gui Mei Chen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Mutagenesis 28:351-5. 2013
  7. doi request reprint Association study of IFIH1 rs1990760 polymorphism with systemic lupus erythematosus in a Chinese population
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 36:444-8. 2013
  8. doi request reprint Association of RIP2 gene polymorphisms and systemic lupus erythematosus in a Chinese population
    Jing Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People s Republic of China
    Mutagenesis 27:319-22. 2012
  9. doi request reprint Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population
    Gui Mei Chen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, People s Republic of China
    Inflamm Res 62:791-5. 2013
  10. doi request reprint Genetic interaction between genes involved in NF-κB signaling pathway in systemic lupus erythematosus
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Mol Immunol 56:643-8. 2013

Collaborators

Detail Information

Publications90

  1. doi request reprint Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Rheumatol Int 33:2337-42. 2013
    ..030) in SLE patients. In summary, decreased serum level of IL-21 and its association with anemia indicate a possible role of IL-21 in human SLE. However, further studies are needed to confirm this preliminary results...
  2. doi request reprint Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mol Biol Rep 40:391-9. 2013
    ..In conclusion, SLE patients and normal controls showed different expression of a few genes in Th17 pathway, indicating that the pathway may be involved in the pathogenesis of SLE...
  3. pmc Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in mountainous areas in China
    Song Yao
    Anhui Provincial TB Research Institute, Hefei, China
    BMC Health Serv Res 11:341. 2011
    ..We carried out an investigation in five provinces in China to assess treatment adherence and identify factors associated with insufficient treatment adherence in tuberculosis (TB) patients in mountainous, rural areas of China...
  4. doi request reprint High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    Mol Biol Rep 37:1191-5. 2010
    ..In this review, we will briefly discuss the biological features of HMGB1 and summarize recent advances on the role of HMGB1 in the pathogenesis and treatment of SLE...
  5. doi request reprint Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis
    Man Man Lu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mod Rheumatol 23:686-93. 2013
    ....
  6. doi request reprint Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population
    Gui Mei Chen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Mutagenesis 28:351-5. 2013
    ..009, OR = 0.708, 95% CI: 0.546-0.918) with SLE. The findings suggest that the P2X7R gene might contribute to SLE susceptibility in the Chinese population...
  7. doi request reprint Association study of IFIH1 rs1990760 polymorphism with systemic lupus erythematosus in a Chinese population
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 36:444-8. 2013
    ..In conclusion, our study represents the first report demonstrating an association of the IFIH1 rs1990760 polymorphism with SLE susceptibility in a Chinese population...
  8. doi request reprint Association of RIP2 gene polymorphisms and systemic lupus erythematosus in a Chinese population
    Jing Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People s Republic of China
    Mutagenesis 27:319-22. 2012
    ..37, 95% CI 1.11-1.70; OR = 0.60, 95% CI 0.45-0.79). Our findings suggest that the RIP2 gene polymorphisms may be associated with susceptibility to SLE in the Chinese population...
  9. doi request reprint Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population
    Gui Mei Chen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, People s Republic of China
    Inflamm Res 62:791-5. 2013
    ..The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population...
  10. doi request reprint Genetic interaction between genes involved in NF-κB signaling pathway in systemic lupus erythematosus
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Mol Immunol 56:643-8. 2013
    ..03). Our results provide evidence for gene-gene interactions, which further support the important role of NF-κB signaling pathway in the genetic basis of SLE and the notion of genetic interactions accounting for missing heritability...
  11. pmc Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People s Republic of China
    PLoS ONE 7:e51090. 2012
    ..Our study identified novel gene-gene/gene-sex interactions in lupus. Furthermore, these findings highlight sex, interferon pathway, and Th17/B cells as important contributors to the pathogenesis of SLE...
  12. doi request reprint Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis
    Bin Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, PR China
    Gene 519:209-16. 2013
    ..To confirm these findings, more case-control studies with subtle study design based on adequately sized populations are required...
  13. doi request reprint Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis
    Yu Zhai
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032 Anhui, People s Republic of China
    Mol Biol Rep 39:8987-94. 2012
    ..283) and 1.133 (1.030-1.246), respectively. In conclusion, this meta-analysis demonstrates that the polymorphisms rs10489629 and rs7517847 of the IL-23R gene may be considered as risk factors for developing RA in European population...
  14. doi request reprint The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus
    Jing Tian
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, PR China
    Mol Med Rep 6:105-10. 2012
    ..043-2.656). In a subgroup analysis by clinical manifestation of lupus nephritis, no significant differences were found. These findings indicate that the TLR7 gene rs1634323 polymorphism may contribute to SLE susceptibility in females...
  15. doi request reprint Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population
    Wen Xian Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Mutagenesis 26:507-11. 2011
    ....
  16. doi request reprint Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Immunogenetics 64:935-8. 2012
    ..Further case-control studies based on larger sample sizes in diverse ethnic populations are required to clarify the role of AFF1 rs340630 in SLE...
  17. doi request reprint Study on clinical features and complications with systemic lupus erythematosus (SLE) activity in Chinese Han population
    Lian Hong Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Clin Rheumatol 28:1301-7. 2009
    ....
  18. pmc Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet's disease: an updated meta-analysis
    Min Zhang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, Anhui, PR China
    Mol Vis 19:1913-24. 2013
    ..The aim of this meta-analysis was to assess the association between TNF gene polymorphisms and BD...
  19. doi request reprint A single nucleotide polymorphism of IL-21 gene is associated with systemic lupus erythematosus in a Chinese population
    Lei Ding
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Inflammation 35:1781-5. 2012
    ..However, further studies are needed to determine the functional consequences of this polymorphism with SLE susceptibility...
  20. doi request reprint Increased serum interleukin 17 in patients with systemic lupus erythematosus
    Xue Fei Zhao
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    Mol Biol Rep 37:81-5. 2010
    ..However, no associations of serum IL-17 level with disease manifestations were found. Therefore, further studies are required to confirm this preliminary data...
  21. doi request reprint A meta-analysis of the association between cytokine gene polymorphisms and systemic sclerosis
    Wen jia Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mod Rheumatol 22:695-703. 2012
    ..74, 95% CI 0.66-0.83; T vs. G: OR 0.72, 95% CI 0.66-0.79), but there were no other statistically significant associations with other gene polymorphisms. Our study suggested that SSc is associated with STAT gene rs7574865 polymorphism...
  22. doi request reprint Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis
    Ke Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Gene 517:46-54. 2013
    ..41, P<0.001). Taken together, our study demonstrates that the TRAF1/C5 polymorphism (rs10818488) may confer susceptibility to RA in North Africa population, and in European population, it might be a contributory factor towards SLE...
  23. doi request reprint Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients
    Wei Zi Qin
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People s Republic of China
    Clin Exp Med 11:245-50. 2011
    ..01). In conclusion, increased frequencies of IL-22-positive CD4+ T cells in patients with SLE and positive correlation with SLEDAI score and lupus nephritis suggest that this cytokine may be implicated in the pathogenesis of the disease...
  24. doi request reprint IL-23: a promising therapeutic target for systemic lupus erythematosus
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China
    Arch Med Res 41:221-5. 2010
    ..In this opinion article, we will discuss the biological features of IL-23 and summarize recent advances on the role of IL-23 in the pathogenesis and treatment of SLE...
  25. doi request reprint Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus
    Hui Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Clin Rheumatol 32:1255-66. 2013
    ..A better understanding of the regulation of IL-10 and its receptors (IL-10R) can likely provide more valuable clues to the pathogenic mechanisms underlying specific forms of SLE, so as to pave the way toward more effective therapeutics. ..
  26. doi request reprint Prevalence of systemic lupus erythematosus and risk factors in rural areas of Anhui Province
    Yan Feng Zou
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Rheumatol Int 34:347-56. 2014
    ..05). Our large population-based epidemiological survey estimated the prevalence of SLE at 37.56 per 100,000 persons. Multiple environmental factors were associated with the development of SLE...
  27. doi request reprint Meta-analysis of association between cytokine gene polymorphisms and Behcet's disease risk
    Yan Liang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
    Int J Rheum Dis 16:616-24. 2013
    ..The present study might suggest that TNF-α -308A/G, IL-10 -1082G/A, -819C/T, -592C/A polymorphisms are associated with BD susceptibility...
  28. doi request reprint The association of IL1α and IL1β polymorphisms with susceptibility to systemic lupus erythematosus: a meta-analysis
    Bin Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, PR China
    Gene 527:95-101. 2013
    ..We could not draw a definite conclusion between IL1β-511C/T polymorphism and risk of SLE owing to the limited data. Further large sample-sized studies should be required. ..
  29. doi request reprint Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People s Republic of China
    Mol Biol Rep 40:941-8. 2013
    ..In summary, the present study suggests that the RANTES-28, -403 polymorphisms do not associate with SLE, but the MBL2 A/O polymorphism might associate with SLE...
  30. doi request reprint D18S880 microsatellite polymorphism of carnosinase gene and diabetic nephropathy: a meta-analysis
    Ji min Zhu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Genet Test Mol Biomarkers 17:289-94. 2013
    ..The aim of this study was to determine whether the CNDP1 (carnosinase gene) D18S880 microsatellite polymorphism confers susceptibility to diabetic nephropathy (DN)...
  31. doi request reprint Prevalence and correlates of suicidal ideation in SLE inpatients: Chinese experience
    Lun Fang Xie
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui People s Republic of China
    Rheumatol Int 32:2707-14. 2012
    ..Although the association of suicidal ideation to religions and medical factors is still to be investigated, these findings may give some references to suicide prevention efforts for SLE patients in China...
  32. doi request reprint Association of TNF-α promoter-308 A/G polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People s Republic of China
    Rheumatol Int 32:2083-92. 2012
    ..856-1.702, P = 0.283) and African population (A versus G: OR = 1.225, 95% CI = 0.597-2.516, P = 0.580). In summary, this meta-analysis indicated that TNF-α promoter-308-A/G polymorphism is associated with susceptibility to SLE...
  33. pmc Association of c-Jun gene polymorphism with susceptibility to systemic lupus erythematosus in a Chinese population
    Yan Ma
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR China
    DNA Cell Biol 31:1274-8. 2012
    ..Our findings suggest that the c-Jun polymorphism (rs3748814) may be significantly associated with the susceptibility to SLE in a Chinese population...
  34. doi request reprint A meta-analysis of the association of STAT4 polymorphism with systemic lupus erythematosus
    Hui Yuan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People s Republic of China
    Mod Rheumatol 20:257-62. 2010
    ..Our results also suggest that STAT4 rs7601754 polymorphism might be associated with SLE risk...
  35. doi request reprint IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population
    Hui Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 36:1218-24. 2013
    ..Our observations indicate that IL-10RB rs2834167 (A/G) polymorphism may be a potential biomarker for susceptibility to SLE...
  36. doi request reprint Impact of environmental factors on efficacy of glucocorticoids in Chinese population with systemic lupus erythematosus
    Yan Feng Zou
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
    Inflammation 36:1424-30. 2013
    ..These results indicate that environmental factors, including salt intake, personality, experience with negative life events, and history of allergy, may play an important role in the efficacy of GCs in the Chinese population with SLE...
  37. doi request reprint Anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythematosus and lupus nephritis
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Inflammation 31:260-5. 2008
    ..Taken together, ANCA might be used as a potential complementary parameter to differentiate LN from SLE without nephritis. In addition, ANCA may serve as a useful marker of the disease activity of SLE...
  38. doi request reprint The dual nature of Ets-1: focus to the pathogenesis of systemic lupus erythematosus
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Autoimmun Rev 10:439-43. 2011
    ..Hopefully the information obtained will lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for SLE...
  39. doi request reprint CTLA-4 -1722T/C polymorphism and systemic lupus erythematosus susceptibility: a meta-analysis involving ten separate studies
    Ji min Zhu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, PR China
    Immunol Invest 42:91-105. 2013
    ..09, 95% CI = 1.13-3.85, P = 0.018; T/C VS C/C: OR = 1.53, 95% CI = 0.87-2.69, P = 0.141; T/T VS T/C: OR = 1.42, 95% CI = 0.97-2.09, P = 0.070). In summary, the CTLA-4 -1722T/C polymorphism confers to SLE risk, especially in Asians...
  40. ncbi request reprint Association between the FAS/FASL polymorphisms and gastric cancer risk: a meta-analysis
    Jing Tian
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
    Asian Pac J Cancer Prev 13:945-51. 2012
    ..FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed...
  41. doi request reprint Increased serum RANTES in patients with systemic lupus erythematosus
    Man Man Lu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People s Republic of China
    Rheumatol Int 32:1231-3. 2012
    ..Nevertheless, no association of serum RANTES level with SLEDAI was found. Taken together, serum RANTES level was significantly higher in SLE patients, suggesting that RANTES might be involved in the pathogenesis of SLE...
  42. doi request reprint Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese
    Chang Juan Xu
    Department of Epidemiology, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People s Republic of China
    Mol Biol Rep 36:2245-8. 2009
    ..004, P = 0.045067). Our study suggests that a single nucleotide polymorphism (rs352140) in the exon 2 region of TLR9 gene may be a susceptibility factor for SLE in Chinese population...
  43. doi request reprint Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus: relation to the organ damage and lymphocytes apoptosis
    Lian Hong Li
    Department of Epidemiology, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, China
    Mol Biol Rep 36:2047-52. 2009
    ..Taken together, our study showed that Fas-expressing PBLs were increased in SLE patients, especially in patients with higher SDI score, and the expression levels of mFas were correlated to the organ damage and lymphocytes apoptosis...
  44. doi request reprint Gender and age influence on clinical and laboratory features in Chinese patients with systemic lupus erythematosus: 1,790 cases
    Jin Bao Feng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Anhui, Hefei, People s Republic of China
    Rheumatol Int 30:1017-23. 2010
    ..We conclude that women of childbearing age possess a distinct clinical and laboratory profile. In addition, differences in disease manifestations seem to be correlated with female sex hormones rather than age...
  45. doi request reprint Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus
    Wen Xian Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Clin Rheumatol 29:315-23. 2010
    ....
  46. doi request reprint Association of CTLA-4 variants with susceptibility to inflammatory bowel disease: a meta-analysis
    Min Zhang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Hum Immunol 75:227-33. 2014
    ..The aim of this study was to determine whether CTLA-4 gene variants were associated with susceptibility to inflammatory bowel disease (IBD)...
  47. doi request reprint Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis
    Hui Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Immunol Invest 41:484-96. 2012
    ..This meta-analysis suggests a possible association between the PTPN22 C1858T polymorphism and T1D, especially in European and American populations...
  48. doi request reprint IL-33: a potential therapeutic target in autoimmune diseases
    Song Wang
    Medical Administration Department, the Second Hospital of Anhui Medical University, Anhui, PR China
    J Investig Med 60:1151-6. 2012
    ..Hence, in this review, we discuss the biological features of IL-33 and summarize recent advances on the role of IL-33 in the pathogenesis and treatment of autoimmune diseases...
  49. doi request reprint Expression of human tumor necrosis factor-like weak inducer of apoptosis in patients with systemic lupus erythematosus
    Chao Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China
    Clin Rheumatol 31:335-9. 2012
    ..In this study, patients with SLE express low levels of TWEAK mRNA but high levels of sTWEAK. Additionally, sTWEAK level was associated with several clinical manifestations of SLE, indicating that TWEAK may play a complex role in SLE...
  50. doi request reprint The association between GSTM1 polymorphism and gastric cancer risk: a meta-analysis
    Yu Zhu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People s Republic of China
    Mol Biol Rep 39:685-91. 2012
    ..However, this meta-analysis did not provide an evidence of confirming association between GSTM1 polymorphism and gastric cancer in Caucasians...
  51. doi request reprint Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis
    Jing Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Dig Dis Sci 55:1818-23. 2010
    ..The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results...
  52. doi request reprint Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis
    Hui Yuan
    Department of Epidemiology and Biostatistics, Anhui Medical University, Anhui, People s Republic of China
    Rheumatol Int 31:1017-21. 2011
    ..Taken together, our results suggest that FcγRIIIb might not be a susceptibility gene for SLE and lupus nephritis...
  53. doi request reprint Role of microRNA-155 in autoimmunity
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Cytokine Growth Factor Rev 22:141-7. 2011
    ..Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity...
  54. doi request reprint Anti-alpha-actinin antibodies in relation to new-onset systemic lupus erythematosus and lupus nephritis
    Wen Hui Zhang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    Mol Biol Rep 37:1341-5. 2010
    ..352, P = 0.035). Anti-alpha-actinin Abs may be a useful marker of the disease activity of SLE; in addition, it may be used as a complementary parameter to differentiate LN from SLE without nephritis...
  55. doi request reprint Association of signaling transducers and activators of transcription 1 and systemic lupus erythematosus
    Yan Liang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, PR China
    Autoimmunity 47:141-5. 2014
    ..Hopefully, the information obtained will lead to a better understanding of the development and pathogenesis of systemic autoimmune diseases, as well as its clinical implications and therapeutic potential. ..
  56. doi request reprint Interleukin-7 Receptor Single Nucleotide Polymorphism rs6897932 (C/T) and the Susceptibility to Systemic Lupus Erythematosus
    Xiao Song Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 37:615-20. 2014
    ....
  57. doi request reprint MicroRNA-21 with therapeutic potential in autoimmune diseases
    Wang Dong Xu
    Anhui Medical University, School of Public Health, Department of Epidemiology and Biostatistics, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Expert Opin Ther Targets 17:659-65. 2013
    ..Functional analysis indicated that miR-21 played a crucial role in a plethora of biological functions and diseases including development, cancer and inflammation, especially correlated with the pathogenesis of autoimmune diseases...
  58. doi request reprint Associations of interleukin-4 receptor gene polymorphisms (Q551R, I50V) with rheumatoid arthritis: evidence from a meta-analysis
    Hui Peng
    1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People s Republic of China
    Genet Test Mol Biomarkers 17:768-74. 2013
    ..Published data on the associations between interleukin-4 receptor (IL-4R) gene polymorphisms (Q551R, I50V) and rheumatoid arthritis (RA) risk are controversial. To quantitatively evaluate the relationships, a meta-analysis was performed...
  59. doi request reprint Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis
    Han Cen
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China
    Autoimmunity 46:455-62. 2013
    ..Our result provides further evidence for the notion of common gene underlying multiple autoimmune diseases...
  60. pmc Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects
    Yan Feng Zou
    1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China
    Genet Test Mol Biomarkers 17:926-31. 2013
    ..The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis...
  61. doi request reprint Emerging role of interleukin-22 in autoimmune diseases
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
    Cytokine Growth Factor Rev 24:51-7. 2013
    ..In this review, we discuss the recent progression of the involvement of IL-22 in the development and pathogenesis of autoimmune diseases, as well as its clinical implications and therapeutic potential...
  62. doi request reprint Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: a meta-analysis
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, PR China
    Joint Bone Spine 79:566-9. 2012
    ..The aim of the study was to determine whether polymorphisms of toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and ankylosing spondylitis (AS)...
  63. doi request reprint IL-32 with potential insights into rheumatoid arthritis
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Clin Immunol 147:89-94. 2013
    ..Hopefully the information obtained will benefit for developing novel therapeutic strategies...
  64. doi request reprint Low level of serum interleukin 27 in patients with systemic lupus erythematosus
    Ting Ting Li
    Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, PR China
    J Investig Med 58:737-9. 2010
    ..05). In summary, a decrease in serum IL-27 level in patients with SLE suggested that this cytokine might be implicated in the pathomechanism of this disease...
  65. doi request reprint Role of CREM in systemic lupus erythematosus
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Cell Immunol 276:10-5. 2012
    ..Therefore, we will discuss the association of CREM and SLE based on current knowledge to unravel the mechanism of CREM performance...
  66. doi request reprint Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis
    Wen jia Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 39:6851-5. 2012
    ..Publication bias was absent in all analyses. However, larger scale primary studies are required to further evaluate the IL-10 polymorphism and SSc...
  67. doi request reprint Influence of social support on health-related quality of life in patients with systemic lupus erythematosus
    Yuan Zheng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Clin Rheumatol 28:265-9. 2009
    ..Taken together, this data suggested that patients with SLE have significant impairment of their HRQOL and less social support. HRQOL may be affected by social support, age, and SLEDAI...
  68. doi request reprint Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis
    Jing Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, People s Republic of China
    Clin Rheumatol 27:1557-63. 2008
    ..Taken together, our results show that moderate alcohol drinking might be protective for SLE...
  69. doi request reprint TIM-3 as a new therapeutic target in systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 37:395-8. 2010
    ..In this review, we will discuss the TIM-3 pathway and the therapeutic potential of modulating the pathway in SLE...
  70. doi request reprint Matrix metalloproteinases: a review of their structure and role in systemic sclerosis
    Wen jia Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    J Clin Immunol 32:1409-14. 2012
    ..This review describes the structure, function and regulation of MMPs and shortly summarizes current understanding on experimental findings, genetic associations of MMPs in SSc...
  71. doi request reprint Association of MicroRNA-146a with autoimmune diseases
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 35:1525-9. 2012
    ..In this review, emphasis will be laid on the recent progress in the functional roles of miR-146a in these autoimmune diseases...
  72. doi request reprint Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis
    Wen Xian Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People s Republic of China
    Rheumatol Int 32:2051-5. 2012
    ..01). Taken together, our results suggest that ICOS co-stimulatory pathway is important in the pathogenesis of LN; blockade of the pathway might represent a novel therapeutic strategy for the treatment of LN...
  73. doi request reprint Prognostic value of matrix metalloproteinase 9 expression in patients with non-small cell lung cancer
    Wen jia Peng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
    Clin Chim Acta 413:1121-6. 2012
    ..The role of matrix metalloproteinase 9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. We performed a systematic review of the literature with meta-analysis...
  74. doi request reprint BMI, disease activity, and health-related quality-of-life in systemic lupus erythematosus
    Li Wei Zhu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Clin Rheumatol 29:1413-7. 2010
    ..An increased BMI and SLEDAI are independently associated with quality-of-life in patients with SLE. Optimizing weight merits investigation to see if it can significantly improve the HRQoL of SLE patients...
  75. doi request reprint IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases
    Rui Xue Leng
    Anhui Medical University, School of Public Health, Department of Epidemiology and Biostatistics, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Expert Opin Ther Targets 15:119-26. 2011
    ..Hopefully the information obtained will lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for autoimmune diseases...
  76. doi request reprint Role and therapeutic potential of Glycodelin A in systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, Anhui Medical University, Anhui, People s Republic of China
    Rheumatol Int 31:563-5. 2011
    ..It is the intention of the article to provide insights that may assist in the development of GdA-based approaches for the treatment of SLE...
  77. doi request reprint Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention
    Ning Zhang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Mol Cell Biochem 353:41-6. 2011
    ..In summary, Th22 cell plays an important and complicated role in inflammatory and autoimmune disease...
  78. doi request reprint Targeting IRF4 in autoimmune diseases
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Autoimmun Rev 11:918-24. 2012
    ..In this review, we summarize recent advances on the pathological roles of IRF4 in autoimmunity and discuss the therapeutic significance of these new findings...
  79. doi request reprint Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors
    Jie Yang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People s Republic of China
    Rheumatol Int 32:2393-9. 2012
    ..713, P < 0.01), and sunshine duration (r = 0.769, P < 0.01) and negative correlation with barometric pressure (r = -0.664, P < 0.05). The disease activity of patients with SLE is affected by seasons and climate factors...
  80. doi request reprint IRF7, a functional factor associates with systemic lupus erythematosus
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Cytokine 58:317-20. 2012
    ..Therefore, we will discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in...
  81. doi request reprint Tuberculosis in systemic lupus erythematosus in Chinese patients
    Jing Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China
    Trop Doct 39:165-7. 2009
    ..Our results show that SLE patients with TB (SLE-TB) might be a subgroup of patients with distinct clinical and laboratory features. Therefore, specific treatment should be given in order to provide a better outcome for SLE-TB patients...
  82. doi request reprint Therapeutic potential of IL-27 in systemic lupus erythematosus
    Hai Feng Pan
    Anhui Medical University, School of Public Health, Department of Epidemiology and Biostatistics, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Expert Opin Ther Targets 14:479-84. 2010
    ..Even though IL-27 has shown therapeutic potential in SLE, further research, particularly in humans, is needed in order to establish the precise role of IL-27 in SLE...
  83. doi request reprint Meta analysis on the association between FcgammaRIIa-R/H131 polymorphisms and systemic lupus erythematosus
    Hui Yuan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, Peoples Republic of China
    Mol Biol Rep 36:1053-8. 2009
    ..Taken together, our study suggests that the FcgammaRIIa-R/H131 polymorphism might contribute to the susceptibility to SLE and lupus nephritis...
  84. doi request reprint Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus
    Jing Li
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 38:4077-81. 2011
    ..All these findings suggest that IL-21 may have promise as a potential therapeutic target for SLE. In this review, we will discuss the biological features of IL-21, the IL-21 signaling and its potential role in SLE...
  85. doi request reprint Clinical and serological correlates of anti-Sm autoantibodies in Chinese patients with systemic lupus erythematosus: 1,584 cases
    Jin Dong Ni
    Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Medical College, Dongguan, China
    Rheumatol Int 29:1323-6. 2009
    ..In conclusion, Anti-Sm antibodies are associated with lupus related clinical and laboratory profiles and correlated significantly with disease activity...
  86. doi request reprint TWEAK as a target for therapy in systemic lupus erythematosus
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 38:587-92. 2011
    ..In this review, we will discuss the TWEAK-Fn14 pathway and the therapeutic potential of modulating this pathway in SLE...
  87. doi request reprint AIDS awareness and condom use among patients in a high-HIV-prevalence area in rural northern Anhui, China
    Nai Ling Mao
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    J Investig Med 58:801-3. 2010
    ..In conclusion, despite a high level of awareness of HIV/AIDS issues, self-perceived risk was low, condom use was infrequent, and especially men continued to have multiple sexual partners...
  88. doi request reprint Epidemiological investigation of scarlet fever in Hefei City, China, from 2004 to 2008
    Jing Wang
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China
    Trop Doct 40:225-6. 2010
    ..Knowledge of these factors could help clinicians to provide the appropriate interventions for scarlet fever...
  89. doi request reprint Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, Anhui Provincial Hospital, Hefei, Anhui, China
    Nat Clin Pract Rheumatol 4:352-3. 2008
  90. ncbi request reprint Clinical and laboratory profiles of systemic lupus erythematosus associated with Sjögren syndrome in China: a study of 542 patients
    Hai Feng Pan
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 69 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Clin Rheumatol 27:339-43. 2008
    ..To improve the treatment outcomes in SLE-SS patients, more specific treatment should be applied based on those factors...