N-terminally fusion of Her2/neu to HSP70 decreases efficiency of Her2/neu DNA vaccineNafiseh Pakravan
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Ale Ahmad Avenue, P O Box 14115 331, Tehran, Iran
Cell Stress Chaperones 15:631-8. 2010
..Surprisingly, fusion of HSP70 to N-terminal of rat Her2/neu led to tumor progression. Our result proposes that fusion direction of biologic adjuvant is an important consideration when Her2/neu is used...
GP96 C-terminal improves Her2/neu DNA vaccineNafiseh Pakravan
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
J Gene Med 12:345-53. 2010
..On the basis of previous studies, we expected the C-terminal of GP96 to act as a package and as a suitable substitute for both cytokine and co-stimulatory genes...
Co-administration of GP96 and Her2/neu DNA vaccine in a Her2 breast cancer modelNafiseh Pakravan
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Ale Ahmad Avenue, P O Box 14115 331, Tehran, Iran
Cell Stress Chaperones 15:977-84. 2010
..Nevertheless, the graph of tumor size demonstrated a bi-phasic pattern in which partial control of tumor progression initially occurred, but finally its effectiveness was inversely affected by tumor size...
The effect of shark liver oil on the tumor infiltrating lymphocytes and cytokine pattern in miceMonire Hajimoradi
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
J Ethnopharmacol 126:565-70. 2009
..Shark Liver Oil (SLO) is a traditional medicine that has been widely used in Scandinavian folk to augment the immune response in some immune-related diseases, especially as an anti-cancer agent...
Adjuvant activity of GP96 C-terminal domain towards Her2/neu DNA vaccine is fusion direction-dependentNafiseh Pakravan
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Ale Ahmad Avenue, P O Box 14115 331, Tehran, Iran
Cell Stress Chaperones 16:41-8. 2011
..It suggests that adjuvant activity of gp96 C-terminal domain towards Her2/neu is fusion direction-dependent...
Comparison of intramuscular and footpad subcutaneous immunization with DNA vaccine encoding HSV-gD2 in miceMohammad Jazayeri
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, P O Box 14110 111, Tehran, Iran
Comp Immunol Microbiol Infect Dis 32:453-61. 2009
..Although DNA vaccine containing HSV-gD2 is effective in both intramuscular and footpad injection routes, the latter could induce significantly higher cellular responses against HSV-2...