Shahid Pervez

..This threat can only be averted by implementation of stringent anti-tobacco rules and health education; prohibition of smoking in educational institutions at all levels and a ban on the sale of cigarettes to minors...

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..It was concluded that aneuploid (near-diploid) peaks, if ever present in atypical hyperplasias, may indicate an aggressive disease/neoplastic transformation...

..Stage A and B patients responded well to antibiotic treatment (tetracycline) with regression of the lesions while for stage C patients standard CHOP chemotherapy was administered...

..It was concluded that the prevalence of gastric MALToma was very low in contrast to a high H. pylori gastritis in the Pakistani population...

..This study was conducted to compare the predictive value of two novel prognostic / proliferative markers i.e. S-phase fraction (SPF) and proliferating cell nuclear antigen (PCNA) in parallel with mitotic index...

..Later it was recognized that weak BCL2 expression is still compatible with the diagnosis of BL. To verify or otherwise this current view this study was undertaken...

..To study the prevalence and immunohistochemical profile of the subtypes of anaplastic large cell lymphomas (ALCLs) at a major referral center of Pakistan...

..In such a dilemma IHC especially for assessment of myoepithelial lining is very useful to differentiate DCIS comedo from invasive carcinoma with central necrosis...

..The present study was conducted with the objective of examining epidemiological characteristics of soft tissue sarcomas (STSs) in Karachi...

..To determine in a large series of surgical biopsies, the frequency of various histologic types of primary solid malignant neoplasms in males and females in different age groups...

..The objective of the study was to determine the trends of cancer cervix in Karachi South during an eight (1995-2002) year period...

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..Provide an overview of the demographics and pathology of breast cancer in the female population of Karachi South during a 3 year period, 1995-1997...

..In contrast to other world regions, cancer esophagus was equally common in males and females in Pakistan. The high risk in Quetta warrants investigation for risk factors and a targeted cancer control program...

..These measures will improve survival and also contribute to a better quality of life. Primary prevention remains the only strategy for absolute cancer control...

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..To determine the frequency of various histologic types of primary solid malignant neoplasms in males and females, in our practice, in a large series of surgical biopsies...

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..Cancer prostate (CaP) is a commonly diagnosed cancer in western men, but there is sparse information about the demographics of this malignancy in Pakistan. The study objective was to provide an overview of CaP in Karachi, Pakistan...

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..South Asia is an enigma for gastric cancer, a low risk region with a contradictory high prevalence for Helicobacter pylori...

..No association was established between EBV variants differentiated on the basis of sequence heterogeneity in Bam HI K, N, E and Z regions with the manifestation of different subsets of T-NHL...

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..Early detection and standardized treatment will reduce the associated morbidity and mortality...

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..To determine BRCA1 status in breast carcinoma patients of Pakistani origin...

..To determine in a large series of surgical biopsies the role and significance of immunohistochemistry in the adequate and accurate characterization of malignant tumors...

..8%) out of 9 cases. CONCLUSION: The prevalence of AILT in the Pakistani population is slightly lower compared to other studies and that EBV is an etiological agent in pathogenesis of this disease...

..If found useful, this antibody could help us in reaching a correct diagnosis in difficult cases and allow appropriate patient management...

..7 years and a disease-free survival of 2.2 years. CONCLUSION: In this study PCNA proved to be an independent prognostic indicator in predicting disease-free and overall survival in breast carcinoma patients...

..This increase most likely represents increased number of neurosurgical procedures being performed. A major problem that we face as histopathologists is absence of clinical history or radiological films in a large number of cases...

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..However, morphologically benign looking thymomas can behave aggressively. Hence, tumour stage, extent of resection and histology should be combined to predict the clinical behaviour of thymomas...

..To study the prevalence and characterization of primary non Hodgkin's lymphoma of bone in a major referral center of Pakistan...

..Significant links of HER2 amplification was seen with ER andPR negativity and higher tumor grade. In addition, non-significant correlations were noted with other variables like tumor type, size and lymph node status...

..This mutation can be added to the pool of known BRCA1 mutations in Pakistani population, which will help in developing a local screening panel of BRCA1 mutations...

..Further studies based on epidemiologic and etiological factors are required to look into this marked difference of occurrence of these indolent lymphomas...

..In conclusion, we document an astonishingly high number of DLBCL amounting to an emerging epidemic in Pakistan, with a consideration of probable etiopathogenetic factors...

..BCL2 gene was further investigated for potential alterations at the DNA level and correlated with OS...

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..Occurrence of this tumor in a young female as seen in our case warrants inclusion of PEComa in the diferential diagnosis of all epithelioid and clear cell neoplasms of uterus irrespective of age...

..No genetic study for LMS has been published in Pakistan; these studies are recommended to determine the biological pattern of LMS in our population...

..Thus, the early detection and resection (while the disease is still in an early stage) are essential in our population using better surgical techniques, for proper staging of these tumors...

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..They lack deep dermal involvement. Hyperkeratosis and acanthosis were also seen in most of the cases. No clinical data was available to assess systemic disease. A higher incidence of of AC in tongue is seen in our study...

..The tumor cells were found to be positive for CD21 which is a specific marker for follicular dendritic cells...

..To determine the role of glutathione monoester on reducing the development of plaque formation in an animal model...

..Ascites has rarely been reported as a presenting feature of angiosarcoma in literature. Both patients died. To date, surgery, chemotherapy, and radiotherapy have not improved the outcome of malignant vascular tumors of liver...

..All six cases were negative for HTLV-1 (tax region) by PCR. It was concluded that the prevalence of MF in Pakistani population is comparable to the Western data, and that EBV association to MF cases was higher than in Western studies...

..We believe that large geographic variation and lifestyle environmental factors associated with the development of gallbladder metaplasia and cancer mortality are concealed in our study that needs to be further explored...

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..Endometrial pathology is dependent on duration of exposure to Tamoxifen, therefore, close follow up of such patients is recommended...

..e. ER/PR, EGFR, PCNA and metastatic potential, there was no significant difference in the OS of PAC vs. control group if compared stage for stage...

..It may be very difficult to differentiate between primary and secondary cases in intestine and especially when the tumour exhibits epithelioid morphology...

..In conclusion, our study group does exhibit characteristics which are suggestive of a distinct breast cancer phenotype (ERalpha-PR+) with a different etiology and prognosis...

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..However a targeted cancer and tobacco control program does not presently exist in Pakistan...

..To determine the frequency of membranous glomerulonephritis(MGN) in the renal biopsy specimens. To observe the presenting features and the demographics to determine association, if any, between MGN and hepatitis B in these patients...

..Pediatricians and family physicians should also be aware of the possibility of this disease entity occurring at an earlier age so as to decrease delay in diagnosis and initiation of treatment...

..We conclude that 'Leucocyte Cell Antigen' (LCA) is the only marker that was consistently positive in PMLBL and negative in cHL. Other IHC markers, though still helpful, may be expressed in either entity...

..All patients died within a week of diagnosis...

..In Pakistan, screening for HPV in female patients is not commonly practiced, and as a consequence, the degree of HPV prevalence and its correlation with cervical cancer is unknown...

..Lymphoplasmacytic infiltrate was seen along with lymphoid follicles, dystrophic and ossifying calcification. Tumor cells were focally positive for alpha smooth muscle actin and negative for anaplastic lymphoma kinase protein...

..A good quality, large-scale pathology data with demographic details of the patient recorded can also be extended to give coverage to the population...

..A series of cases of Hodgkin's lymphoma is reported in which the biopsy specimens from different parts of the body portrayed caseating granulomatous lesions...

..Cytogenetic studies are advised for a better understanding of biologic differences in RMS cases in this population...

..The present study was conducted with the objective of examining descriptive epidemiological and pathological characteristics of cancer cervix in Karachi South, an all urban district population of Karachi, Pakistan...