T H Jafar

Summary

Affiliation: The Aga Khan University
Country: Pakistan

Publications

  1. ncbi request reprint The growing burden of chronic kidney disease in Pakistan
    Tazeen H Jafar
    Section of Nephrology, Aga Khan University, Karachi, Pakistan
    N Engl J Med 354:995-7. 2006
  2. ncbi request reprint Hypertension and kidney disease in Asia
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    Curr Opin Nephrol Hypertens 15:291-5. 2006
  3. pmc High normal levels of albuminuria and risk of hypertension in Indo-Asian population
    Saleem Jessani
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Nephrol Dial Transplant 27:iii58-64. 2012
  4. pmc High prevalence of lack of knowledge of symptoms of acute myocardial infarction in Pakistan and its contribution to delayed presentation to the hospital
    Muhammad S Khan
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 7:284. 2007
  5. pmc Self-rated health in Pakistan: results of a national health survey
    Khabir Ahmad
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 5:51. 2005
  6. pmc Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, Pakistan
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    BMC Infect Dis 6:101. 2006
  7. pmc Knowledge of modifiable risk factors of heart disease among patients with acute myocardial infarction in Karachi, Pakistan: a cross sectional study
    Muhammad S Khan
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Cardiovasc Disord 6:18. 2006
  8. pmc Rise in childhood obesity with persistently high rates of undernutrition among urban school-aged Indo-Asian children
    T H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences and Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan
    Arch Dis Child 93:373-8. 2008
  9. ncbi request reprint Proteinuria in South Asian children: prevalence and determinants
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    Pediatr Nephrol 20:1458-65. 2005
  10. ncbi request reprint Heart disease epidemic in Pakistan: women and men at equal risk
    Tazeen H Jafar
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Am Heart J 150:221-6. 2005

Detail Information

Publications44

  1. ncbi request reprint The growing burden of chronic kidney disease in Pakistan
    Tazeen H Jafar
    Section of Nephrology, Aga Khan University, Karachi, Pakistan
    N Engl J Med 354:995-7. 2006
  2. ncbi request reprint Hypertension and kidney disease in Asia
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    Curr Opin Nephrol Hypertens 15:291-5. 2006
    ..The purpose of the review was to examine recent evidence about the burden and factors associated with hypertension and chronic kidney disease (CKD) in Asian countries...
  3. pmc High normal levels of albuminuria and risk of hypertension in Indo-Asian population
    Saleem Jessani
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Nephrol Dial Transplant 27:iii58-64. 2012
    ..The objective of this study was to examine the relationship of normal to high normal levels of UACR and incident hypertension...
  4. pmc High prevalence of lack of knowledge of symptoms of acute myocardial infarction in Pakistan and its contribution to delayed presentation to the hospital
    Muhammad S Khan
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 7:284. 2007
    ..We conducted an observational study to determine the delay in presentation to hospital, and its associates among patients experiencing first Acute Myocardial Infarction (AMI) in Karachi, Pakistan...
  5. pmc Self-rated health in Pakistan: results of a national health survey
    Khabir Ahmad
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 5:51. 2005
    ..We determined the prevalence of and risk factors for poor/fair SRH among individuals aged > or =15 years in Pakistan (n = 9442)...
  6. pmc Hepatitis B and C: prevalence and risk factors associated with seropositivity among children in Karachi, Pakistan
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    BMC Infect Dis 6:101. 2006
    ..This cross-sectional study estimated the prevalence and identified risk factors associated with Hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV) sero-positivity among children 1 to 15 years of age...
  7. pmc Knowledge of modifiable risk factors of heart disease among patients with acute myocardial infarction in Karachi, Pakistan: a cross sectional study
    Muhammad S Khan
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Cardiovasc Disord 6:18. 2006
    ....
  8. pmc Rise in childhood obesity with persistently high rates of undernutrition among urban school-aged Indo-Asian children
    T H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences and Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan
    Arch Dis Child 93:373-8. 2008
    ..Evidence for the transition in nutrition in Indo-Asian developing countries is lacking. We conducted these analyses to determine the trends in nutritional status of school-aged children in urban Pakistan...
  9. ncbi request reprint Proteinuria in South Asian children: prevalence and determinants
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    Pediatr Nephrol 20:1458-65. 2005
    ..Further studies are needed to determine factors in early life that may differentially predispose certain ethnic groups to proteinuria...
  10. ncbi request reprint Heart disease epidemic in Pakistan: women and men at equal risk
    Tazeen H Jafar
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Am Heart J 150:221-6. 2005
    ..We conducted this study to determine the prevalence of coronary artery disease (CAD) and its risk factors in Karachi, Pakistan...
  11. ncbi request reprint Blood pressure, diabetes, and increased dietary salt associated with stroke--results from a community-based study in Pakistan
    T H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    J Hum Hypertens 20:83-5. 2006
  12. ncbi request reprint The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease
    Tazeen H Jafar
    Division of Nephrology, New England Medical Center, Boston, Massachusetts, USA
    Kidney Int 67:265-71. 2005
    ..We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease progression in patients with PKD...
  13. ncbi request reprint Women in Pakistan have a greater burden of clinical cardiovascular risk factors than men
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Int J Cardiol 106:348-54. 2006
    ..We analyzed the National Health Survey of Pakistan (NHSP) (1990-1994) data to study the same in the population of Pakistan...
  14. pmc Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
    T H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences and Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan
    Heart 94:408-13. 2008
    ..The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men. Trial registration number: NCT00327574...
  15. doi request reprint Community-based interventions to promote blood pressure control in a developing country: a cluster randomized trial
    Tazeen H Jafar
    Aga Khan University, Karachi, Pakistan
    Ann Intern Med 151:593-601. 2009
    ..Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries...
  16. ncbi request reprint Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Clinical Epidemiology Unit, The Aga Khan University, P O Box 3500, Stadium Road, Karachi Sind 74800, Pakistan
    J Am Soc Nephrol 16:1413-9. 2005
    ..Inclusion of terms for ethnic and racial groups other than white and black might improve the performance of GFR estimating equations...
  17. pmc Cost-effectiveness of community-based strategies for blood pressure control in a low-income developing country: findings from a cluster-randomized, factorial-controlled trial
    Tazeen H Jafar
    Departments of Medicine and Community Health Sciences, Aga Khan University, Stadium Rd, Karachi, Pakistan
    Circulation 124:1615-25. 2011
    ..The comparator was no intervention (or usual care). The reduction in BP was most pronounced in the combined group. The present study examined the cost-effectiveness of these strategies...
  18. doi request reprint Level and determinants of kidney function in a South Asian population in Pakistan
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Am J Kidney Dis 58:764-72. 2011
    ..However, measured GFR in a general adult population of South Asian origin has not been studied...
  19. pmc Community based lifestyle intervention for blood pressure reduction in children and young adults in developing country: cluster randomised controlled trial
    Tazeen H Jafar
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    BMJ 340:c2641. 2010
    ..To assess the effectiveness of a community based lifestyle intervention on blood pressure in children and young adults in a developing country setting...
  20. ncbi request reprint Use of albumin creatinine ratio and urine albumin concentration as a screening test for albuminuria in an Indo-Asian population
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, The Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Nephrol Dial Transplant 22:2194-200. 2007
    ..We compared the use of spot urine albumin concentration and urine albumin to creatinine excretion ratio for detection of albuminuria in this population...
  21. ncbi request reprint Ethnic differences and determinants of proteinuria among South Asian subgroups in Pakistan
    Tazeen H Jafar
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Kidney Int 64:1437-44. 2003
    ..Prevalence of proteinuria is high in South Asians. However, ethnic subgroup differences and determinants of proteinuria within the South Asian population have not been explored...
  22. ncbi request reprint The rate of progression of renal disease may not be slower in women compared with men: a patient-level meta-analysis
    Tazeen H Jafar
    New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 18:2047-53. 2003
    ..Therefore, we undertook this analysis to explore the independent association of renal disease progression with gender...
  23. doi request reprint Organ trafficking: global solutions for a global problem
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    Am J Kidney Dis 54:1145-57. 2009
    ..Ultimately, physicians and transplant surgeons have the responsibility to ensure to the best of their ability that the organs they transplant were obtained upholding the highest standards of ethics...
  24. ncbi request reprint Ethnic differences and determinants of diabetes and central obesity among South Asians of Pakistan
    T H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, The Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Diabet Med 21:716-23. 2004
    ..To study the within ethnic subgroup variations in diabetes and central obesity among South Asians...
  25. pmc Prevalence of microalbuminuria and associated electrocardiographic abnormalities in an Indo-Asian population
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    Nephrol Dial Transplant 24:2111-6. 2009
    ..Major electrocardiographic (ECG) changes are predictive of cardiovascular mortality. We determined the association of MA with major ECG changes in the general population of Pakistan...
  26. ncbi request reprint General practitioners' approach to hypertension in urban Pakistan: disturbing trends in practice
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, PO Box 3500, Stadium Road, Karachi, 74800, Pakistan
    Circulation 111:1278-83. 2005
    ..Control of blood pressure (BP) remains suboptimal worldwide. The objective of this study was to determine whether (primary) general practitioners' (GPs) approach to high BP is in accordance with international guidelines...
  27. ncbi request reprint Children in South Asia have higher body mass-adjusted blood pressure levels than white children in the United States: a comparative study
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Circulation 111:1291-7. 2005
    ....
  28. pmc Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian population
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    CMAJ 175:1071-7. 2006
    ....
  29. ncbi request reprint Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data
    T H Jafar
    Department of Medicine, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    Ann Intern Med 135:73-87. 2001
    ..Angiotensin-converting inhibitors are indicated for treatment of nondiabetic patients with chronic renal disease and proteinuria and, possibly, those without proteinuria...
  30. ncbi request reprint Prevalence and determinants of blood pressure screening in Pakistan
    Khabir Ahmad
    Clinical Epidemiology Unit, Department of Community Health, Aga Khan University, Karachi, Pakistan
    J Hypertens 23:1979-84. 2005
    ..We analysed data collected during a nationwide cross-sectional household survey to estimate the prevalence of, and to identify factors associated with, blood pressure screening in Pakistan...
  31. ncbi request reprint Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease
    T H Jafar
    Division of Nephrology, New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 60:1131-40. 2001
    ..The current level of urine protein excretion is a modifiable risk factor for the progression of non-diabetic renal disease. ACE inhibitors provide greater beneficial effect at all levels of current urine protein excretion...
  32. ncbi request reprint Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease...
  33. ncbi request reprint Ethnic subgroup differences in hypertension in Pakistan
    Tazeen H Jafar
    Department of Community Health Sciences, Tufts University Medical School, Boston, Massachusetts, USA
    J Hypertens 21:905-12. 2003
    ..We conducted this study to explore the variations in hypertension within ethnic subgroups among South Asians...
  34. pmc Risk factors for non-fatal myocardial infarction in young South Asian adults
    J Ismail
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Heart 90:259-63. 2004
    ..To determine the risk factors for premature myocardial infarction among young South Asians...
  35. ncbi request reprint Prevalence and predictors of smoking in Pakistan: results of the National Health Survey of Pakistan
    Khabir Ahmad
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Eur J Cardiovasc Prev Rehabil 12:203-8. 2005
    ..We analysed data collected during a nationwide cross-sectional household survey to estimate the prevalence of and identify factors associated with smoking in Pakistan...
  36. doi request reprint Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis
    M Islam
    Department of Community Health Sciences, Aga Khan University, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan
    Diabetologia 55:2193-204. 2012
    ..We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses...
  37. ncbi request reprint Systemic hypertension and nondiabetic chronic kidney disease: the best evidence-based therapeutic approach today
    T H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University Karachi Pakistan
    Eur Rev Med Pharmacol Sci 9:1-12. 2005
    ..Following these recommendations is likely to minimize the risk of development of kidney failure and cardiovascular disease...
  38. pmc Effect of general practitioner education on adherence to antihypertensive drugs: cluster randomised controlled trial
    Nudrat Noor Qureshi
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, P O Box 3500, Stadium Road, Karachi, 74800, Pakistan
    BMJ 335:1030. 2007
    ..To determine the impact of a simple educational package for general practitioners on adherence to antihypertensive drugs...
  39. ncbi request reprint Constructing a database of individual clinical trials for longitudinal analysis
    Christopher H Schmid
    Biostatistics Research Center, Division of Clinical Care Research, Department of Medicine, New England Medical Center Box 63, 750 Washington Street, Boston, MA 02111, USA
    Control Clin Trials 24:324-40. 2003
    ..Funding agencies must be encouraged to provide support to collaborative groups combining databases...
  40. doi request reprint Disproportionately high risk of left ventricular hypertrophy in Indo-Asian women: a call for more studies
    Fahim H Jafary
    Section of Cardiology, Department of Medicine, Aga Khan University, Karachi, Pakistan
    Echocardiography 25:812-9. 2008
    ..Estimates and determinants of left ventricular hypertrophy (LVH) in this population are not known. We sought to determine the prevalence of and risk factors for LVH in Karachi, Pakistan...
  41. doi request reprint Effect of low vs. high dietary sodium on blood pressure levels in a normotensive Indo-Asian population
    Saleem Jessani
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Am J Hypertens 21:1238-44. 2008
    ..We assessed the effect of a low vs. high-sodium diet on blood pressure in normotensive Indo-Asian adults...
  42. ncbi request reprint Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 63, Boston, MA 02111, USA
    J Am Soc Nephrol 18:1959-65. 2007
    ..Patients with proteinuria <500 mg/d do not seem to benefit, even when at relatively high risk for progression...
  43. ncbi request reprint Variations in levels of blood pressure: of prognostic value or not?
    Tazeen H Jafar
    Am J Kidney Dis 52:638-41. 2008
  44. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors on progression of nondiabetic renal disease
    Tazeen H Jafar
    Ann Intern Med 137:298-9. 2002