A H Gilani

Summary

Affiliation: The Aga Khan University
Country: Pakistan

Publications

  1. ncbi request reprint Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Life Sci 75:2377-89. 2004
  2. ncbi request reprint Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade
    Anwar Ul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 20:1080-4. 2006
  3. ncbi request reprint Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Basic Clin Pharmacol Toxicol 99:365-73. 2006
  4. doi request reprint Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
    Qaiser Jabeen
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:123-30. 2009
  5. ncbi request reprint Studies on antihypertensive and antispasmodic activities of Andropogon muricatus Retz
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Can J Physiol Pharmacol 85:911-7. 2007
  6. pmc Over prescription of antibiotics for adult pharyngitis is prevalent in developing countries but can be reduced using McIsaac modification of Centor scores: a cross-sectional study
    Amber Hanif Palla
    Department of Pharmacology, University of Karachi, Karachi, Pakistan
    BMC Pulm Med 12:70. 2012
  7. pmc Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents
    Naveed Muhammad
    Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan
    BMC Complement Altern Med 13:70. 2013
  8. pmc Evaluation of gut modulatory and bronchodilator activities of Amaranthus spinosus Linn
    Mueen Ahmad Chaudhary
    Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
    BMC Complement Altern Med 12:166. 2012
  9. doi request reprint Species differences in the antidiarrheal and antispasmodic activities of Lepidium sativum and insight into underlying mechanisms
    Anwarul Hassan Gilani
    Natural Product Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 27:1086-94. 2013
  10. pmc Fiber-free white flour with fructose offers a better model of metabolic syndrome
    Faridah Amin
    Natural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Lipids Health Dis 12:44. 2013

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Life Sci 75:2377-89. 2004
    ....
  2. ncbi request reprint Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade
    Anwar Ul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 20:1080-4. 2006
    ....
  3. ncbi request reprint Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Basic Clin Pharmacol Toxicol 99:365-73. 2006
    ..So Rooibos tea possesses a combination of dominant K(ATP) channel activation and weak Ca(++) antagonist mechanisms and hence justifies its use in hyperactive gastrointestinal disorders...
  4. doi request reprint Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
    Qaiser Jabeen
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:123-30. 2009
    ..Coriander (Coriandrum sativum) is traditionally used for various gastrointestinal and cardiovascular disorders and this study was designed to rationalize its use in dyspepsia, abdominal colic, diarrhea, hypertension and as diuretic...
  5. ncbi request reprint Studies on antihypertensive and antispasmodic activities of Andropogon muricatus Retz
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Can J Physiol Pharmacol 85:911-7. 2007
    ..This study shows potential with respect to its medicinal use in cardiovascular and gut disorders...
  6. pmc Over prescription of antibiotics for adult pharyngitis is prevalent in developing countries but can be reduced using McIsaac modification of Centor scores: a cross-sectional study
    Amber Hanif Palla
    Department of Pharmacology, University of Karachi, Karachi, Pakistan
    BMC Pulm Med 12:70. 2012
    ..Finally, we wanted to see the usefulness of modified McIsaac scores in predicting positive cultures...
  7. pmc Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents
    Naveed Muhammad
    Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan
    BMC Complement Altern Med 13:70. 2013
    ..The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation...
  8. pmc Evaluation of gut modulatory and bronchodilator activities of Amaranthus spinosus Linn
    Mueen Ahmad Chaudhary
    Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
    BMC Complement Altern Med 12:166. 2012
    ..The aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses...
  9. doi request reprint Species differences in the antidiarrheal and antispasmodic activities of Lepidium sativum and insight into underlying mechanisms
    Anwarul Hassan Gilani
    Natural Product Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 27:1086-94. 2013
    ..Rat tissues showed the highest potency. Based on the results, we recommend using multiple species to know the real pharmacological profile of medicinal products...
  10. pmc Fiber-free white flour with fructose offers a better model of metabolic syndrome
    Faridah Amin
    Natural Products Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Lipids Health Dis 12:44. 2013
    ..Developing an appropriate animal model for MS to achieve various therapeutic targets remains a challenge and this study aims to develop a rat model which closely depicts MS in humans...
  11. pmc Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    BMC Complement Altern Med 10:2. 2010
    ..The objective of this study was to explore the possible mode(s) of action for its antispasmodic, vasodilator and cardio-suppressant effects to rationalize its medicinal use in gut and cardiovascular disorders...
  12. pmc Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora
    - Najeeb-ur-Rehman
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    BMC Complement Altern Med 12:16. 2012
    ..This study was designed to provide pharmacological basis for the medicinal use of Fumaria parviflora in gut motility disorders...
  13. pmc Studies on the antihypertensive and antidyslipidemic activities of Viola odorata leaves extract
    Hasan S Siddiqi
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Lipids Health Dis 11:6. 2012
    ..This study was undertaken to provide pharmacological basis for the medicinal use of Viola odorata Linn. in hypertension and dyslipidemia using the in vivo and in vitro assays...
  14. pmc Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts
    Saf Ur Rehman Mandukhail
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Lipids Health Dis 9:88. 2010
    ..The objective of present study was to provide the pharmacological basis for the medicinal use of Morinda citrifolia Linn in dyslipidemia using the aqueous-ethanolic extracts of its fruits (Mc.Cr.F), leaves (Mc.Cr.L) and roots (Mc.Cr.R)...
  15. ncbi request reprint Antispasmodic and bronchodilator activities of St John's wort are putatively mediated through dual inhibition of calcium influx and phosphodiesterase
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Fundam Clin Pharmacol 19:695-705. 2005
    ..Furthermore, the presence of Ca2+ antagonist and PDE inhibitory-like constituents might also be contributing to some extent in the well established use of plant in depression...
  16. ncbi request reprint Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 21:541-4. 2007
    ..The presence of spasmolytic constituents of CCB-type more evident in the spontaneous contracting gut preparation may explain its use in spasms...
  17. ncbi request reprint Moringa oleifera: a food plant with multiple medicinal uses
    Farooq Anwar
    Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
    Phytother Res 21:17-25. 2007
    ..This review focuses on the detailed phytochemical composition, medicinal uses, along with pharmacological properties of different parts of this multipurpose tree...
  18. ncbi request reprint Blood pressure lowering effect of olive is mediated through calcium channel blockade
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Int J Food Sci Nutr 56:613-20. 2005
    ..Cr produced a dose-dependent rightward shift of the Ca2+ dose-response curves, similar to verapamil. These results suggest that the blood pressure lowering effect of olive is mediated through CCB, justifying its use in hypertension...
  19. ncbi request reprint Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 114:393-9. 2007
    ..In this study, we investigated the crude extract of Borago officinalis leaves (Bo.Cr) for its antispasmodic, bronchodilator, vasodilator and cardio-depressant activities to rationalize some of the traditional uses...
  20. ncbi request reprint Gut modulatory, blood pressure lowering, diuretic and sedative activities of cardamom
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan
    J Ethnopharmacol 115:463-72. 2008
    ..Cardamom (Elettaria cardamomum) is traditionally used in various gastrointestinal, cardiovascular and neuronal disorders...
  21. doi request reprint Gastrointestinal, selective airways and urinary bladder relaxant effects of Hyoscyamus niger are mediated through dual blockade of muscarinic receptors and Ca2+ channels
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Fundam Clin Pharmacol 22:87-99. 2008
    ..Cr occur at much lower concentrations in the trachea and bladder. This study offers explanations for the medicinal use of H. niger in treating gastrointestinal and respiratory disorders and bladder hyperactivity...
  22. doi request reprint Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia bellerica fruit
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 116:528-38. 2008
    ..The present investigation was carried out to provide the pharmacological basis for the medicinal use of Terminalia bellerica in hyperactive gastrointestinal and respiratory disorders...
  23. doi request reprint Ethnopharmacological studies on antispasmodic and antiplatelet activities of Ficus carica
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 119:1-5. 2008
    ..The ripe dried fruit of Ficus carica Linn. (Moraceae) commonly known as "Fig" has medicinal value in traditional system of medicine for its use in gastrointestinal and inflammatory disorders...
  24. doi request reprint Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L
    Anwar H Gilani
    Drug Discovery and Natural Products Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 121:405-11. 2009
    ..The study was aimed to investigate the chemical composition and pharmacological basis for traditional use of essential oil of Nepeta cataria L. (Limiaceae) (Nc.Oil) in gastrointestinal and respiratory disorders...
  25. doi request reprint Presence of blood-pressure lowering and spasmolytic constituents in Buddleja crispa
    Anwarul H Gilani
    Drug Discovery and Natural Products Research Unit, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 23:492-7. 2009
    ..Among the pure compounds, Bdl-H3 is likely to be the active compound involved in the spasmolytic and possibly BP lowering effect of the parent crude extract...
  26. doi request reprint Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Pharm Biol 48:1240-6. 2010
    ..Holarrhena antidysenterica Wall. (Apocynaceae) is widely used in traditional medical system for treatment of constipation, colic, and diarrhea...
  27. ncbi request reprint Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 102:289-94. 2005
    ....
  28. ncbi request reprint Trends in ethnopharmocology
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 100:43-49. 2005
    ..While the ethnopharmacologists have a greater role to play in the rationalization of combination of activities, the phytochemist's role will slightly shift towards standardization of botanicals...
  29. pmc Antiurolithic activity of Origanum vulgare is mediated through multiple pathways
    Aslam Khan
    Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
    BMC Complement Altern Med 11:96. 2011
    ..Origanum vulgare Linn has traditionally been used in the treatment of urolithiasis. Therefore, we investigated the crude extract of Origanum vulgare for possible antiurolithic effect, to rationalize its medicinal use...
  30. ncbi request reprint Pharmacological basis for the use of peach leaves in constipation
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, 74800, Karachi, Pakistan
    J Ethnopharmacol 73:87-93. 2000
    ..Furthermore, the laxative effect of the plant reported in the traditional system of medicine may be partially due to the cholinergic action, which was dominant over the spasmolytic component...
  31. ncbi request reprint The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 14:436-42. 2000
    ..It is suggested that some of the traditional uses of this plant may be explained on the basis of these activities...
  32. ncbi request reprint Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, 74800, Karachi, Pakistan
    J Ethnopharmacol 71:161-7. 2000
    ..Its calcium channel blocking property may be mechanistically related to these activities. Its usefulness in folk medicine appears thus to be based on a sound mechanistic background...
  33. ncbi request reprint Studies on antihypertensive and antispasmodic activities of methanol extract of Acacia nilotica pods
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi 47800, Pakistan
    Phytother Res 13:665-9. 1999
    ....
  34. ncbi request reprint Pharmacological basis for the gut stimulatory activity of Raphanus sativus leaves
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 95:169-72. 2004
    ..The study shows the presence of a histaminergic component(s) along with a weak spasmolytic factor thus providing sound mechanistic basis for the traditional use of the plant in constipation...
  35. ncbi request reprint Pharmacological basis for the use of Fumaria indica in constipation and diarrhea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 96:585-9. 2005
    ..These data indicate that the presence of cholinergic and CCB constituents in Fi.Cr may explain the respective traditional use of Fumaria indica in constipation and diarrhoea...
  36. ncbi request reprint Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 100:347-52. 2005
    ..These results indicate that the antispasmodic and hypotensive effects of Valeriana wallichii are mediated possibly through K(ATP) channel activation, which justify its use in gastrointestinal and cardiovascular disorders...
  37. ncbi request reprint Hypotensive action of coumarin glycosides from Daucus carota
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan
    Phytomedicine 7:423-6. 2000
    ..These results indicate that DC-2 and DC-3 may be acting through blockade of calcium channels and this effect may be responsible for the blood pressure lowering effect of the compounds observed in the in vivo studies...
  38. ncbi request reprint Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract
    A H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi 74800, Pakistan
    J Ethnopharmacol 98:127-35. 2005
    ..These results indicate the presence of calcium antagonist(s) in Carum copticum seeds and thus provides sound mechanistic basis for some of their folkloric uses...
  39. ncbi request reprint Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna
    Anwar ul Hassan Giliani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Planta Med 71:120-5. 2005
    ..Furthermore, these characteristic compounds with dual activity may be good candidates for further studies on their usefulness in Alzheimer's disease...
  40. ncbi request reprint Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Sindh, Pakistan
    Life Sci 76:3089-105. 2005
    ..Furthermore, curcumin, the main active principle, does not share all effects of turmeric...
  41. ncbi request reprint Hepatoprotective activity of aqueous-methanol extract of Artemisia vulgaris
    Anwarul Hassan Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 19:170-2. 2005
    ..These findings scientifically validated the traditional use of Artemisia vulgaris for various liver disorders...
  42. ncbi request reprint Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses
    A H Gilani
    Department of Physiology and Pharmacology, Aga Khan University Medical College, Karachi
    J Pak Med Assoc 51:115-20. 2001
    ..Its usefulness for diarrhoea and asthma in traditional medicine, appears thus to be based on a sound mechanistic background...
  43. ncbi request reprint Wortmannin inhibits platelet aggregation produced by interaction of gamma-aminobutyric acid and the calcium tonophore, A23187
    S A Saeed
    Department of Physiology and Pharmacology, The Aga Khan University, Karachi, Pakistan
    Res Commun Mol Pathol Pharmacol 109:87-93. 2001
    ..These results suggest that the GABA effect is not mediated by traditional neuronal GABA receptors. We propose that wortmannin inhibits aggregation at a nexus downstream from membrane mechanisms triggered by the GABA-A23187 interaction...
  44. doi request reprint Cardiovascular inhibitory effects of Hyoscyamus niger
    A U Khan
    Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
    Methods Find Exp Clin Pharmacol 30:295-300. 2008
    ..These data indicate that Hyoscyamus niger lowers BP through a Ca(++)-antagonist mechanism...
  45. ncbi request reprint Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling
    B H Shah
    Department of Physiology and Pharmacology, The Aga Khan University, Karachi, Pakistan
    Biochem Pharmacol 58:1167-72. 1999
    ..These results suggest that the curcumin-mediated preferential inhibition of PAF- and AA-induced platelet aggregation involves inhibitory effects on TXA2 synthesis and Ca2+ signaling, but without the involvement of PKC...
  46. ncbi request reprint The antiplatelet aggregatory activity of Acacia nilotica is due to blockade of calcium influx through membrane calcium channels
    B H Shah
    Department of Physiology and Pharmacology, Aga Khan University, Karachi, Pakistan
    Gen Pharmacol 29:251-5. 1997
    ..4. These results indicate that the antiplatelet aggregatory activity of the extract of A. nilotica is mainly due to blockade of Ca2+ channels, although evidence also suggests the involvement of protein kinase C...
  47. ncbi request reprint Cardio-selective inhibitory effect of the betel nut extract: possible explanation
    M N Ghayur
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Pharmazie 62:67-71. 2007
    ..Cr in the gut though the preferential binding of the constituents of betel nut extract at muscarinic receptor subtypes in heart cannot be ignored...
  48. ncbi request reprint The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx
    B H Shah
    Department of Physiology and Pharmacology, The Aga Khan University, Karachi, Pakistan
    Biochem Pharmacol 56:955-60. 1998
    ..These results suggest that antiplatelet effects of cinchonine are mediated mainly through inhibition of Ca2+-influx and protein kinase C pathways in platelets...
  49. ncbi request reprint Presence of calcium antagonist activity explains the use of Syzygium samarangense in diarrhoea
    M N Ghayur
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 20:49-52. 2006
    ..These results indicate that the presence of compounds with spasmolytic and calcium antagonist activity may be responsible for the medicinal use of the plant in diarrhoea...
  50. doi request reprint In vivo anthelmintic activity of Azadirachta indica A. Juss seeds against gastrointestinal nematodes of sheep
    Z Iqbal
    Department of Parasitology, University of Agriculture, Faisalabad, Pakistan
    Vet Parasitol 168:342-5. 2010
    ..001). Though of low efficacy compared with levamisole, the use of A. indica seeds against gastrointestinal nematodes may be justified in some situations, depending on the nature and intensity of the helminth infections...
  51. ncbi request reprint Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore
    J D Connor
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
    Life Sci 69:2759-64. 2001
    ..We conclude that the synergistic interaction between 5-HT and ionophore may be mediated by activation of PLC/Ca2+ and PI 3-kinase signalling pathways, but definitive proof will require other enzyme inhibitors with greater specificity...
  52. ncbi request reprint Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 20:906-10. 2006
    ....
  53. ncbi request reprint The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds
    M A U Khan
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 17:183-6. 2003
    ..These results indicate that the aqueous extract of Nigella sativa seeds exhibits inhibitory effect against candidiasis and this study validates the traditional use of the plant in fungal infections...
  54. ncbi request reprint Preliminary screening of Trachyspermum ammi (L.) seed for anthelmintic activity in sheep
    M Lateef
    Chemotherapy Laboratory, Department of Veterinary Parasitology, University of Agriculture, Faisalabad 38040, Pakistan
    Trop Anim Health Prod 38:491-6. 2006
  55. ncbi request reprint The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production
    M Saeed Mahmood
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 17:921-4. 2003
    ..In view of the fact that nitric oxide is a pro-inflammatory mediator, this study validates the traditional use of the Nigella sativa seeds for the treatment of rheumatism...
  56. ncbi request reprint Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 19:679-83. 2005
    ..These results indicate that Carthamus oxycantha contains a combination of spasmogenic (cholinergic) and spasmolytic (calcium antagonist) constituents...
  57. ncbi request reprint Plasma from rheumatoid patients taking low dose methotrexate enhances platelet aggregation
    S A Saeed
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
    Res Commun Mol Pathol Pharmacol 111:69-76. 2002
    ..However, a serum factor may be produced by MTX that modulates the activity of cyclooxygenase, thereby influencing aggregation...
  58. ncbi request reprint Kushta(s): unique herbo-mineral preparations used in South Asian traditional medicine
    N Aziz
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    Med Hypotheses 59:468-72. 2002
    ..Some recommendations have also been given to provide the path to initiate research in this area of potential therapeutic value and public concern...
  59. doi request reprint Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease
    T Ahmed
    Natural Products Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Neuroscience 169:1296-306. 2010
    ....
  60. doi request reprint Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats
    Samra Bashir
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 24:1250-5. 2010
    ..These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis...
  61. doi request reprint Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:106-16. 2009
    ..Bergenia ligulata is widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis...
  62. ncbi request reprint Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    Zhong Xi Yi Jie He Xue Bao 9:619-25. 2011
    ..To investigate the possible mechanism and the compound(s) responsible for the antiplatelet and acetylcholinesterase (AChE) inhibitory effects of Areca catechu crude extract (Ac.Cr)...
  63. doi request reprint Studies on the antioxidant and analgesic activities of Aztec marigold (Tagetes erecta) flowers
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 22:1692-4. 2008
    ..The antioxidant and analgesic activities obtained seem to be in good accordance with the medicinal uses of Aztec marigold as an anti-inflammatory and analgesic...