Z A Bhutta

Summary

Affiliation: The Aga Khan University
Country: Pakistan

Publications

  1. doi request reprint Alma-Ata: Rebirth and Revision 6 Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 372:972-89. 2008
  2. doi request reprint Maternal micronutrient deficiencies in developing countries
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 371:186-7. 2008
  3. ncbi request reprint A comparative evaluation of multiple micronutrient and iron-folic acid supplementation during pregnancy in Pakistan: impact on pregnancy outcomes
    Zulfiqar A Bhutta
    The Aga Khan University, Karachi, Pakistan
    Food Nutr Bull 30:S496-505. 2009
  4. doi request reprint Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 375:2032-44. 2010
  5. ncbi request reprint Reducing maternal, newborn, and infant mortality globally: an integrated action agenda
    Zulfiqar A Bhutta
    International Pediatric Association, Geneva, Switzerland
    Int J Gynaecol Obstet 119:S13-7. 2012
  6. pmc Health equity: evidence synthesis and knowledge translation methods
    Vivian A Welch
    Institute of Population Health, University of Ottawa, 1 Stewart Street, Ottawa, ON K1N6N5, Canada
    Syst Rev 2:43. 2013
  7. pmc Household food access and child malnutrition: results from the eight-country MAL-ED study
    Stephanie Psaki
    Fogarty International Center, National Institutes of Health, Bethesda, USA
    Popul Health Metr 10:24. 2012
  8. doi request reprint Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 382:452-77. 2013
  9. pmc Improved accessibility of emergency obstetrics and newborn care (EmONC) services for maternal and newborn health: a community based project
    Ali Turab
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 13:136. 2013
  10. doi request reprint Reproductive, maternal, newborn, and child health in Pakistan: challenges and opportunities
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:2207-18. 2013

Detail Information

Publications99

  1. doi request reprint Alma-Ata: Rebirth and Revision 6 Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 372:972-89. 2008
    ..Strengthening MNCH at the primary health-care level should be a priority for countries to reach their Millennium Development Goal targets for reducing maternal and child mortality...
  2. doi request reprint Maternal micronutrient deficiencies in developing countries
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 371:186-7. 2008
  3. ncbi request reprint A comparative evaluation of multiple micronutrient and iron-folic acid supplementation during pregnancy in Pakistan: impact on pregnancy outcomes
    Zulfiqar A Bhutta
    The Aga Khan University, Karachi, Pakistan
    Food Nutr Bull 30:S496-505. 2009
    ..Intervention strategies largely consist of administration of iron-folic acid supplements during pregnancy...
  4. doi request reprint Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 375:2032-44. 2010
    ..However, much more can and should be done to address maternal and newborn health and improve coverage of interventions related to family planning, care around childbirth, and case management of childhood illnesses...
  5. ncbi request reprint Reducing maternal, newborn, and infant mortality globally: an integrated action agenda
    Zulfiqar A Bhutta
    International Pediatric Association, Geneva, Switzerland
    Int J Gynaecol Obstet 119:S13-7. 2012
    ..What is needed is the political will and partnerships to implement evidence-based interventions at scale...
  6. pmc Health equity: evidence synthesis and knowledge translation methods
    Vivian A Welch
    Institute of Population Health, University of Ottawa, 1 Stewart Street, Ottawa, ON K1N6N5, Canada
    Syst Rev 2:43. 2013
    ..Although systematic reviews are recognized as an important source for evidence-informed policy, they have been criticized for failing to assess effects on health equity...
  7. pmc Household food access and child malnutrition: results from the eight-country MAL-ED study
    Stephanie Psaki
    Fogarty International Center, National Institutes of Health, Bethesda, USA
    Popul Health Metr 10:24. 2012
    ..We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites...
  8. doi request reprint Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 382:452-77. 2013
    ....
  9. pmc Improved accessibility of emergency obstetrics and newborn care (EmONC) services for maternal and newborn health: a community based project
    Ali Turab
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 13:136. 2013
    ..Maternal and neonatal mortality remain to be unacceptably high in Pakistan especially in rural areas where more than half of births occur...
  10. doi request reprint Reproductive, maternal, newborn, and child health in Pakistan: challenges and opportunities
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:2207-18. 2013
    ....
  11. doi request reprint Meeting the challenges of micronutrient malnutrition in the developing world
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Br Med Bull 106:7-17. 2013
    ..Major risk factors for undernutrition such as suboptimal breastfeeding and micronutrient deficiencies (vitamin A and zinc) are responsible for more than one-third of all under five child deaths and 11% of the global total disease burden...
  12. doi request reprint Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan
    Cochrane Database Syst Rev 3:CD006896. 2013
    ..to a decrease in serum folate concentration, resulting in a decrease in erythrocyte folate concentration, a rise in homocysteine concentration, and megaloblastic changes in the bone marrow and other tissues with rapidly dividing cells..
  13. doi request reprint Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost?
    Zulfiqar A Bhutta
    Division of Woman and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:1417-29. 2013
    ..Furthermore, several of these interventions could reduce morbidity and overall burden of disease, with possible benefits for developmental outcomes...
  14. doi request reprint Global nutrition epidemiology and trends
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Ann Nutr Metab 61:19-27. 2012
    ..This suggests that interventions requiring strong health systems or behavior change appear to be stalled and need to be re-examined to find more effective ways of delivery...
  15. pmc Solar water disinfection in household settings: hype or hope?
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    PLoS Med 6:e1000127. 2009
  16. doi request reprint Is it time to replace iron folate supplements in pregnancy with multiple micronutrients?
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 26:27-35. 2012
    ....
  17. pmc Effect of screening and management of diabetes during pregnancy on stillbirths
    Madiha Syed
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    BMC Public Health 11:S2. 2011
    ..We reviewed the potential impact of early detection and control of diabetes mellitus during pregnancy on stillbirths for possible inclusion in the Lives Saved Tool (LiST)...
  18. pmc Effect of breastfeeding promotion interventions on breastfeeding rates, with special focus on developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S24. 2011
    ..There is much interest in the effectiveness of breastfeeding promotion interventions on breastfeeding rates in early infancy...
  19. pmc Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths
    Mehnaz Jabeen
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S6. 2011
    ..We sought to review the effect of aspirin, calcium supplementation, antihypertensive agents and magnesium sulphate on risk stillbirths...
  20. pmc Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S18. 2011
    ..The purpose of this review was to evaluate preventive effect of calcium supplementation during pregnancy on gestational hypertensive disorders and related maternal and neonatal mortality in developing countries...
  21. pmc Elective induction for pregnancies at or beyond 41 weeks of gestation and its impact on stillbirths: a systematic review with meta-analysis
    Arwa Abbas Hussain
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    BMC Public Health 11:S5. 2011
    ..The purpose of this review was to study the possible impact of induction of labour (IOL) for post-term pregnancies compared to expectant management on stillbirths...
  22. pmc Impact of vitamin A supplementation on infant and childhood mortality
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S20. 2011
    ..The purpose of this paper was to get a point estimate of efficacy of vitamin A supplementation in reducing cause specific mortality by using Child Health Epidemiology Reference Group (CHERG) guidelines...
  23. pmc Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes
    Batool Azra Haider
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S19. 2011
    ....
  24. pmc Effect of balanced protein energy supplementation during pregnancy on birth outcomes
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S17. 2011
    ..This paper is a part of a series of reviews undertaken for getting estimates of effectiveness of an intervention for input to Lives Saved Tool (LiST) model...
  25. pmc Impact of maternal education about complementary feeding and provision of complementary foods on child growth in developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S25. 2011
    ..Recommendations have been made for input to the Lives Saved Tool (LiST) model by following standardized guidelines developed by Child Health Epidemiology Reference Group (CHERG)...
  26. pmc Screening and triage of intrauterine growth restriction (IUGR) in general population and high risk pregnancies: a systematic review with a focus on reduction of IUGR related stillbirths
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S1. 2011
    ..We have also reviewed effect of maternal body mass index (BMI) screening, symphysial-fundal height measurement and targeted ultrasound in detection and triage of IUGR in the community...
  27. pmc Effect of routine iron supplementation with or without folic acid on anemia during pregnancy
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S21. 2011
    ..This article aims to address the impact of iron with and without folate supplementation on maternal anemia and provides outcome specific quality according to the Child Health Epidemiology Reference Group (CHERG) guidelines...
  28. pmc Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool
    Aamer Imdad
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S22. 2011
    ..We have updated and evaluated the available evidence according to Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria and tried to explain the difference in results of the previous reviews...
  29. pmc Effect of case management on neonatal mortality due to sepsis and pneumonia
    Anita K M Zaidi
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S13. 2011
    ..We have estimated the effect of providing oral, or injectable antibiotics at home or in first-level facilities, and of in-patient hospital care on neonatal mortality from pneumonia and sepsis for use in the Lives Saved Tool (LiST)...
  30. pmc Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S23. 2011
    ....
  31. pmc The effect of providing skilled birth attendance and emergency obstetric care in preventing stillbirths
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S7. 2011
    ..This review discusses the impact of skilled birth attendance (SBA) and the provision of Emergency Obstetric Care (EOC) on stillbirths and perinatal mortality...
  32. pmc The effect of folic acid, protein energy and multiple micronutrient supplements in pregnancy on stillbirths
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S4. 2011
    ..This paper is a part of a series to estimate the effect of interventions on stillbirths for input to Live Saved Tool (LiST) model...
  33. pmc Neonatal resuscitation and immediate newborn assessment and stimulation for the prevention of neonatal deaths: a systematic review, meta-analysis and Delphi estimation of mortality effect
    Anne C C Lee
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:S12. 2011
    ..03 million from complications of prematurity. No systematic assessment of mortality reduction from tactile stimulation or resuscitation has been published...
  34. pmc Effectiveness of interventions to screen and manage infections during pregnancy on reducing stillbirths: a review
    Sidra Ishaque
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S3. 2011
    ..This review presents the impact of interventions targeting various important infections during pregnancy on stillbirth or perinatal mortality...
  35. pmc Reducing stillbirths: behavioural and nutritional interventions before and during pregnancy
    Mohammad Yawar Yakoob
    Division of Maternal and Child Health, The Aga Khan University, Karachi 74800, Pakistan
    BMC Pregnancy Childbirth 9:S3. 2009
    ..Interventions to reduce these risks could reduce the resulting burden of stillbirths, but the evidence for the impact of such interventions has not yet been comprehensively evaluated...
  36. pmc Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions
    Fernando C Barros
    Post Graduate Course in Health and Behaviour, Universidade Catolica de Pelotas, Brazil
    BMC Pregnancy Childbirth 10:S3. 2010
    ..Survival of preterm newborns may also be improved with interventions given during these times or soon after birth. This comprehensive review assesses existing interventions for low- and middle-income countries (LMICs)...
  37. pmc Reducing stillbirths: interventions during labour
    Gary L Darmstadt
    Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Pregnancy Childbirth 9:S6. 2009
    ..The evidence for impact of intrapartum interventions on stillbirth and perinatal mortality outcomes has not yet been systematically examined...
  38. pmc Reducing stillbirths: screening and monitoring during pregnancy and labour
    Rachel A Haws
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    BMC Pregnancy Childbirth 9:S5. 2009
    ..2 million estimated annual stillbirths, as well as minimise maternal and neonatal morbidity and mortality...
  39. pmc 3.2 million stillbirths: epidemiology and overview of the evidence review
    Joy E Lawn
    Saving Newborn Lives Save the Children US, Cape Town, South Africa
    BMC Pregnancy Childbirth 9:S2. 2009
    ..This first paper in the series outlines issues in stillbirth data availability and quality, the global epidemiology of stillbirths, and describes the methodology and framework used for the review of interventions and strategies...
  40. pmc Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy
    Esme V Menezes
    Division of Maternal and Child Health, The Aga Khan University, Karachi 74800, Pakistan
    BMC Pregnancy Childbirth 9:S4. 2009
    ..Poorly recognised, untreated or inadequately treated maternal infections such as syphilis and malaria, and maternal conditions including hypertensive disorders, are known risk factors for stillbirth...
  41. pmc Evaluation of health workforce competence in maternal and neonatal issues in public health sector of Pakistan: an Assessment of their training needs
    Shabina Ariff
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Health Serv Res 10:319. 2010
    ..The high mortality rates are partially attributable to scarcity of trained skilled birth attendants and paucity of resources. Empowerment of health care providers with adequate knowledge and skills can serve as instrument of change...
  42. pmc Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    BMC Genomics 10:36. 2009
    ..The accumulation of pseudogenes is a key feature of these and other host-adapted pathogens, and overlapping pseudogene complements are evident in Paratyphi A and Typhi...
  43. pmc Delivering interventions to reduce the global burden of stillbirths: improving service supply and community demand
    Zulfiqar A Bhutta
    Division of Maternal and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 9:S7. 2009
    ....
  44. pmc Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan
    Sajid Bashir Soofi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Res Notes 5:6. 2012
    ..abstract:..
  45. pmc Beyond Bellagio: addressing the challenge of sustainable child health in developing countries
    Z A Bhutta
    The Husein Lalji Dewraj of Paediatrics and Child Health, The Aga Khan University, Karachi 74800, Pakistan
    Arch Dis Child 89:483-7. 2004
    ....
  46. pmc Current concepts in the diagnosis and treatment of typhoid fever
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMJ 333:78-82. 2006
  47. ncbi request reprint Persistent and chronic diarrhea and malabsorption: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Zulfiqar A Bhutta
    J Pediatr Gastroenterol Nutr 39:S711-6. 2004
  48. pmc The Million Death Study in India: cam it help in monitoring the millennium development goals?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    PLoS Med 3:e103. 2006
  49. pmc Reducing length of stay in hospital for very low birthweight infants by involving mothers in a stepdown unit: an experience from Karachi (Pakistan)
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    BMJ 329:1151-5. 2004
    ..The Aga Khan University Medical Center in Karachi, Pakistan, established a neonatal intensive care unit in 1987. By 1993-4, very low birthweight infants remained in hospital for 18-21 days...
  50. doi request reprint Linkages among reproductive health, maternal health, and perinatal outcomes
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Semin Perinatol 34:434-45. 2010
    ..This would also allow for greater efficiency in training, monitoring, and supervision of health care workers and would also help families and communities to access and use services easily...
  51. pmc Beyond informed consent
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    Bull World Health Organ 82:771-7. 2004
    ..Further research is needed to examine the validity and user friendliness of innovations in information sharing procedures for obtaining consent in different cultural settings...
  52. doi request reprint Stillbirths: what difference can we make and at what cost?
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 377:1523-38. 2011
    ..The overall costs for these interventions are within the general estimates of cost-effective interventions for maternal care, especially in view of the effects on outcomes across maternal, fetal, and neonatal health...
  53. ncbi request reprint Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence
    Zulfiqar A Bhutta
    Department of Pediatrics and Child Health, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Pediatrics 115:519-617. 2005
    ..A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developing-country communities has not been reported...
  54. ncbi request reprint What does absorption capacity not measure?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 368:428-30. 2006
  55. pmc Maternal and child health: is South Asia ready for change?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    BMJ 328:816-9. 2004
  56. pmc Implementing community-based perinatal care: results from a pilot study in rural Pakistan
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 86:452-9. 2008
    ..This pilot study investigated the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan...
  57. ncbi request reprint Is management of neonatal respiratory distress syndrome feasible in developing countries? Experience from Karachi (Pakistan)
    Z A Bhutta
    Department of Paediatrics, Aga Khan University Hospital, Karachi, Pakistan
    Pediatr Pulmonol 27:305-11. 1999
    ....
  58. pmc Insulin-like growth factor I response during nutritional rehabilitation of persistent diarrhoea
    Z A Bhutta
    Department of Paediatrics, The Aga Khan University Medical Center, PO Box 3500, Stadium Road, Karachi 74800, Pakistan
    Arch Dis Child 80:438-42. 1999
    ..Evaluation of nutritional recovery, intestinal permeability, and insulin-like growth factor I (IGF-I) response in malnourished children with persistent diarrhoea and their relation to concomitant systemic infection(s)...
  59. pmc Dealing with childhood pneumonia in developing countries: how can we make a difference?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Arch Dis Child 92:286-8. 2007
  60. ncbi request reprint Tracking inequity: assessments of poverty-related outcomes
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 369:804-6. 2007
  61. pmc Failure of short-course ceftriaxone chemotherapy for multidrug-resistant typhoid fever in children: a randomized controlled trial in Pakistan
    Z A Bhutta
    Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
    Antimicrob Agents Chemother 44:450-2. 2000
    ..In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy...
  62. doi request reprint Management of newborn infections in primary care settings: a review of the evidence and implications for policy?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 28:S22-30. 2009
    ..There is an urgent need to define the role of community-based management for neonates with serious bacterial infections--both at home and at first-level facilities...
  63. pmc Children of war: the real casualties of the Afghan conflict
    Zulfiqar Ahmed Bhutta
    Aga Khan University, Karachi, Pakistan
    BMJ 324:349-52. 2002
  64. pmc Ethics in international health research: a perspective from the developing world
    Zulfiqar Ahmed Bhutta
    Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 80:114-20. 2002
    ..Only through such proactive measures can we address the emerging ethical dilemmas and challenges that globalization and the genomics revolution will bring in their wake...
  65. pmc Child health and survival in the Eastern Mediterranean region
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMJ 333:839-42. 2006
  66. doi request reprint Micronutrient needs of malnourished children
    Zulfiqar A Bhutta
    The Aga Khan University, Karachi, Pakistan
    Curr Opin Clin Nutr Metab Care 11:309-14. 2008
    ..This review focuses on recent advances in our understanding of undernutrition and micronutrient deficiencies during childhood from a review of the literature over the last 18 months (August 2006-January 2008)...
  67. doi request reprint Recent advances and evidence gaps in persistent diarrhea
    Z A Bhutta
    Department of Pediatrics and Child Health, The Aga Khan University and Hospital, Karachi, Pakistan
    J Pediatr Gastroenterol Nutr 47:260-5. 2008
  68. pmc Rise in childhood obesity with persistently high rates of undernutrition among urban school-aged Indo-Asian children
    T H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences and Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan
    Arch Dis Child 93:373-8. 2008
    ..Evidence for the transition in nutrition in Indo-Asian developing countries is lacking. We conducted these analyses to determine the trends in nutritional status of school-aged children in urban Pakistan...
  69. ncbi request reprint Frequency of isolation of shigella serogroups/serotypes and their antimicrobial susceptibility pattern in children from slum areas in Karachi
    Afia Zafar
    Department of Pathology Microbiology, The Aga Khan University, Karachi
    J Pak Med Assoc 55:184-8. 2005
    ..To assess the frequency of serogroups and serotypes, as well as the antimicrobial susceptibility pattern of Shigella species isolated from known cases of diarrhoea and dysentery from Karachi, Pakistan...
  70. doi request reprint What works? Interventions for maternal and child undernutrition and survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 371:417-40. 2008
    ..To eliminate stunting in the longer term, these interventions should be supplemented by improvements in the underlying determinants of undernutrition, such as poverty, poor education, disease burden, and lack of women's empowerment...
  71. ncbi request reprint Health care utilization for diarrhea and fever in 4 urban slums in Karachi
    S Shujaat H Zaidi
    Department of Paediatrics, The Aga Khan University, Karachi, Pakistan
    J Coll Physicians Surg Pak 16:245-8. 2006
    ..To estimate the fraction of fever and diarrhea patients making use of private practitioners, self-treatment, hospital care, drug vendors, community health centers and traditional healers...
  72. ncbi request reprint Hospital-acquired neonatal infections in developing countries
    Anita K M Zaidi
    Department of Paediatrics and Child Health, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Lancet 365:1175-88. 2005
    ..Low-cost, "bundled" interventions using systems quality improvement approaches for improved infection control are possible, but should be supported by evidence in developing country settings...
  73. doi request reprint Incidence and pattern of unintentional injuries and resulting disability among children under 5 years of age: results of the National Health Survey of Pakistan
    Zafar Fatmi
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 23:229-38. 2009
    ..These results are useful for planning further research and for prioritising prevention programmes nationally and in other developing countries with similar situation...
  74. ncbi request reprint Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Pakistan, 74800
    Cochrane Database Syst Rev 11:CD007754. 2010
    ....
  75. doi request reprint Improvement of perinatal and newborn care in rural Pakistan through community-based strategies: a cluster-randomised effectiveness trial
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan zulfi
    Lancet 377:403-12. 2011
    ....
  76. doi request reprint A comparison of disease caused by Shigella and Campylobacter species: 24 months community based surveillance in 4 slums of Karachi, Pakistan
    Sajid Bashir Soofi
    Department of Paediatrics and Child Health, Aga Khan University, Pakistan
    J Infect Public Health 4:12-21. 2011
    ..In the face of these facts it is empirically important to develop a low cost effective vaccine that can protect these populations for a longer duration...
  77. pmc Prenatal exposure to wood fuel smoke and low birth weight
    AMNA R SIDDIQUI
    Department of Public Health Sciences, University of California, Davis, California, USA
    Environ Health Perspect 116:543-9. 2008
    ..Maternal exposure to wood fuel smoke may lead to impaired fetal growth due to hypoxia and or oxidative stress from smoke constituents such as carbon monoxide and particulate matter...
  78. ncbi request reprint Community-based newborn care: are we there yet?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan zulfi
    Lancet 372:1124-6. 2008
  79. doi request reprint Frequency of isolation of various subtypes and antimicrobial resistance of Shigella from urban slums of Karachi, Pakistan
    Afia Zafar
    Department of Pathology and Microbiology, Aga Khan University Hospitals, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Int J Infect Dis 13:668-72. 2009
    ..Therefore we conducted a prospective study to determine the frequency of isolation of Shigella serotypes and antimicrobial resistance...
  80. ncbi request reprint Enhanced detection rate of typhoid fever in children in a periurban slum in Karachi, Pakistan using polymerase chain reaction technology
    S Q Nizami
    Department of Pediatrics, The Aga Khan University and Hospital, Karachi, Pakistan
    Scand J Clin Lab Invest 66:429-36. 2006
    ..Two periurban communities in Karachi were selected for an epidemiological study of typhoid fever. The aim of the study was to assess whether PCR increased the detection rate of typhoid fever in children in the community...
  81. ncbi request reprint Hepatic dysfunction in paediatric typhoidal salmonellosis
    Z A Bhutta
    Department of Paediatrics, Aga Khan University and Hospital, Karachi, Pakistan
    Ann Trop Paediatr 11:203-5. 1991
    ..001) at presentation and had higher mortality (p less than 0.002) than those with normal liver function. Two children presented with a picture of fulminant hepatic failure with fatal outcome...
  82. ncbi request reprint Quinolone-resistant Salmonella paratyphi B meningitis in a newborn: a case report
    Z A Bhutta
    Department of Paediatrics, The Aga Khan University Medical Center, Karachi, Pakistan
    J Infect 35:308-10. 1997
    ..We present a case report of a newborn with meningitis due to a quinolone-resistant strain of S. paratyphi B presenting to the Aga Khan University Hospital (AKUH)...
  83. ncbi request reprint Maternal health and survival in Pakistan: issues and options
    Yasir P Khan
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    J Obstet Gynaecol Can 31:920-9. 2009
    ..Notwithstanding these observations, there are evidence-based interventions available that, if implemented at scale, could make important contributions towards reducing the burden of maternal mortality in Pakistan...
  84. ncbi request reprint Consecutive outbreaks of Vibrio cholerae O139 and V. cholerae O1 cholera in a fishing village near Karachi, Pakistan
    Fahad J Siddiqui
    Department of Paediatrics, Aga Khan University, P O Box 3500, Stadium Road, Karachi 74800, Pakistan
    Trans R Soc Trop Med Hyg 100:476-82. 2006
    ..Geographically, cases were clustered during the first outbreak but not during the second. Person-to-person contact and water reservoirs appear to be the main transmission routes for cholera in this setting...
  85. pmc Drug Resistant Infections in Poor Countries: A major burden on children
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    BMJ 336:948-9. 2008
  86. ncbi request reprint The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence
    Batool A Haider
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Food Nutr Bull 30:S41-59. 2009
    ..Zinc deficiency is now widely recognized as a leading risk factor for morbidity and mortality and is estimated to be responsible for approximately 800,000 excess deaths annually among children under 5 years of age...
  87. ncbi request reprint Profile and factors determining outcome in a cohort of cystic fibrosis patients seen at the Aga Khan University Hospital, Karachi, Pakistan
    Uzma Shah
    Pediatric Gastroenterology, Hepatology and Nutrition, The Aga Khan University Hospital, Karachi, Pakistan
    J Trop Pediatr 52:132-5. 2006
    ..The clinical parameters studied suggest a severe form of CF in Pakistani patients and provides a foundation for future studies to define genotype/phenotype correlations of the specific mutations involved in Pakistani CF patients...
  88. ncbi request reprint A review of rotavirus diarrhea in Pakistan: how much do we know?
    Nadia Kabiruddin Ali
    Department of Paediatrics, The Aga Khan University Hospital, Karachi
    J Coll Physicians Surg Pak 13:297-301. 2003
    ..Rotavirus diarrhea has a worldwide distribution, infecting almost all children by the age of 3-5 years...
  89. ncbi request reprint Birth asphyxia in developing countries: current status and public health implications
    Batool Azra Haider
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Curr Probl Pediatr Adolesc Health Care 36:178-88. 2006
  90. pmc A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis
    Durrane Thaver
    Department of Paediatrics and Child Health, The Aga Khan University, PO Box 3500, Karachi 74800, Pakistan
    BMJ 338:b1865. 2009
    ..To review evidence supporting use of fluoroquinolones as first line agents over other antibiotics for treating typhoid and paratyphoid fever (enteric fever)...
  91. pmc Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial
    Mohammad Imran Khan
    Department of Paediatrics, Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 84:72-7. 2006
    ..This, however, poses enormous challenges in practice. The process and outcome of recruiting private practice clinics for surveillance in a vaccine trial are described...
  92. ncbi request reprint Typhoid fever in children: some epidemiological considerations from Karachi, Pakistan
    Fahad Javaid Siddiqui
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Int J Infect Dis 10:215-22. 2006
    ..Pakistan falls into this region. There is also a considerable seasonal variation of typhoid fever, carrying significant public health importance. Children are worst affected. Population-based data from Pakistan are scarce...
  93. ncbi request reprint Helicobacter pylori colonization in infants in a peri-urban community in Karachi, Pakistan
    Shaikh Qamaruddin Nizami
    Department of Pediatrics, The Aga Khan University, Karachi, Pakistan
    J Pediatr Gastroenterol Nutr 41:191-4. 2005
    ..The prevalence and incidence of Helicobacter pylori in children in Pakistan is not known...
  94. ncbi request reprint Incidence of acute respiratory infections in children 2 months to 5 years of age in periurban communities in Karachi, Pakistan
    Shaikh Qamaruddin Nizami
    Department of Pediatrics, The Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:163-7. 2006
    ..To measure the incidence of acute respiratory infections and burden of respiratory pathogens in children aged two months to five years...
  95. ncbi request reprint Effect of infections and environmental factors on growth and nutritional status in developing countries
    Zulfiqar Ahmed Bhutta
    J Pediatr Gastroenterol Nutr 43:S13-21. 2006
    ..The growing body of evidence on the key role of zinc supplementation in accelerating recovery from diarrheal illnesses in developing countries supports its use in public health strategies...
  96. pmc Thinking the unthinkable!
    Zulfiqar Ahmed Bhutta
    BMJ 324:1405-6. 2002
  97. ncbi request reprint Child's gender and household food insecurity are associated with stunting among young Pakistani children residing in urban squatter settlements
    Naila Baig-Ansari
    Program in International Nutrition, University of California, Davis, California 95616, USA
    Food Nutr Bull 27:114-27. 2006
    ....
  98. ncbi request reprint Evidence-based global health
    Pierre Buekens
    JAMA 291:2639-41. 2004
  99. ncbi request reprint Values and leadership. Global leadership is in disarray
    Zulfiqar Ahmed Bhutta
    BMJ 326:657. 2003