Effects of obesity and sex on antimicrobial pharmacokinetics and acute kidney injury: validation of a preclinical modelManjunath P Pai
Albany College of Pharmacy and Health Sciences, Albany, New York, USA
Antimicrob Agents Chemother 57:716-22. 2013
..This preclinical model has the potential to aid with dose extrapolation for body size and improve assessment of the toxicology potential of antimicrobials in development...
Drug dosing based on weight and body surface area: mathematical assumptions and limitations in obese adultsManjunath P Pai
Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York 12186, USA
Pharmacotherapy 32:856-68. 2012
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- Clinical pharmacokinetics of oral controlled-release 5-fluorocytosine
Manjunath P Pai
Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, O Brien 204, Albany, NY 12208, USA
Antimicrob Agents Chemother 54:1237-41. 2010
..The gastric absorption profile of 5FC-CR was well predicted by in vitro dissolution. Future exploration of a gastroretentive 5FC-CR formulation could overcome the marked lack of bioequivalence observed in the present study...
- Estimating the glomerular filtration rate in obese adult patients for drug dosing
Manjunath P Pai
Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, NY 12208, USA
Adv Chronic Kidney Dis 17:e53-62. 2010
..The role of the alternate body size descriptor, lean body weight to estimate CLcr in obese patients is reviewed...
- Steady-state plasma pharmacokinetics of oral voriconazole in obese adults
Manjunath P Pai
Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, O Brien 204, Albany, NY 12208, USA
Antimicrob Agents Chemother 55:2601-5. 2011
..96) was identified between C(min) values and AUC(0-τ) values. Adjustment of voriconazole doses in individuals with class II obesity or greater does not appear to be necessary on the basis of body weight...
- Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients
Manjunath P Pai
Albany College of Pharmacy, 106 New Scotland Ave, O Brien Room 204, Albany, NY 12208, USA
Antimicrob Agents Chemother 55:4006-11. 2011
..45 liter/kg. Aminoglycoside dosing can be simplified across all weight strata with the use of lean body weight. The CKD-EPI equation best predicts aminoglycoside clearance...
- Oseltamivir and oseltamivir carboxylate pharmacokinetics in obese adults: dose modification for weight is not necessary
Manjunath P Pai
Albany College of Pharmacy and Health Sciences, Albany, New York 12208, USA
Antimicrob Agents Chemother 55:5640-5. 2011
..Since the systemic exposure of oseltamivir carboxylate is not reduced in class III obese adults with standard doses, a dose increment of oseltamivir is likely to be unnecessary...
- Refining vancomycin protein binding estimates: identification of clinical factors that influence protein binding
Jill M Butterfield
Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, NY 12208, USA
Antimicrob Agents Chemother 55:4277-82. 2011
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