Darius A Paduch

Summary

Publications

  1. ncbi request reprint The laboratory diagnosis of testosterone deficiency
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY Electronic address
    Urology 83:980-8. 2014
  2. ncbi request reprint Reproduction in men with Klinefelter syndrome: the past, the present, and the future
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA
    Semin Reprod Med 27:137-48. 2009
  3. doi request reprint Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, New York, New York Electronic address
    Fertil Steril 100:970-4. 2013
  4. doi request reprint A novel sorting technology allows for highly efficient selection of sperm without chromatin damage
    Michael G Funaro
    Department of Urology, Weill Cornell Medical College, New York, New York 10065, USA
    Syst Biol Reprod Med 59:172-7. 2013
  5. ncbi request reprint Methylation-specific PCR allows for fast diagnosis of X chromosome disomy and reveals skewed inactivation of the X chromosome in men with Klinefelter syndrome
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, 525 E 68th St, Box 580, New York, NY 10021, USA
    J Androl 33:955-62. 2012
  6. pmc Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis
    Laurent Vaucher
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, New York, United States of America Population Council, Center for Biomedical Research, New York, New York, United States of America Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 9:e92425. 2014
  7. pmc Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital Cornell, New York, NY 10065, USA
    Asian J Androl 14:676-82. 2012
  8. ncbi request reprint Bulbocavernosus muscle area measurement: a novel method to assess androgenic activity
    Ali A Dabaja
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, USA
    Asian J Androl 16:618-22. 2014
  9. doi request reprint Endocrinological issues and hormonal manipulation in children and men with Klinefelter syndrome
    Matthew S Wosnitzer
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Am J Med Genet C Semin Med Genet 163:16-26. 2013
  10. doi request reprint Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    BJU Int 111:334-43. 2013

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The laboratory diagnosis of testosterone deficiency
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY Electronic address
    Urology 83:980-8. 2014
    ..Rigid interpretation of T ranges should not dictate clinical decision making or define coverage of treatment by third party payers. ..
  2. ncbi request reprint Reproduction in men with Klinefelter syndrome: the past, the present, and the future
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA
    Semin Reprod Med 27:137-48. 2009
    ..This review provides the latest update in our understanding of the pathophysiology, natural history, and evolving paradigms of therapy in adolescents and men with KS...
  3. doi request reprint Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, New York, New York Electronic address
    Fertil Steril 100:970-4. 2013
    ..To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT)...
  4. doi request reprint A novel sorting technology allows for highly efficient selection of sperm without chromatin damage
    Michael G Funaro
    Department of Urology, Weill Cornell Medical College, New York, New York 10065, USA
    Syst Biol Reprod Med 59:172-7. 2013
    ..Further research is needed to determine if the reduction in TUNEL positive sperm using PF-1 will improve in vitro fertilization (IVF) outcomes...
  5. ncbi request reprint Methylation-specific PCR allows for fast diagnosis of X chromosome disomy and reveals skewed inactivation of the X chromosome in men with Klinefelter syndrome
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, 525 E 68th St, Box 580, New York, NY 10021, USA
    J Androl 33:955-62. 2012
    ..Men with KS can have incomplete inactivation of supernumerary X chromosomes. M-PCR is a sensitive, specific, fast, and relatively inexpensive test for the diagnosis of X chromosome disomy...
  6. pmc Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis
    Laurent Vaucher
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, New York, United States of America Population Council, Center for Biomedical Research, New York, New York, United States of America Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 9:e92425. 2014
    ..The aim of this study was to evaluate GPER-1 expression in the testis, and its role in estradiol dependent regulation of steroidogenesis in isolated rat Leydig cells and human testis...
  7. pmc Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital Cornell, New York, NY 10065, USA
    Asian J Androl 14:676-82. 2012
    ..These observations suggest that impairments in CDY2 or HSFY expression could be implicated in the pathogenesis of MA...
  8. ncbi request reprint Bulbocavernosus muscle area measurement: a novel method to assess androgenic activity
    Ali A Dabaja
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, USA
    Asian J Androl 16:618-22. 2014
    ..01). The number of CAGn in the AR correlates with the area of the BCM. Ultrasound assessment of the BCM is an effective surrogate to evaluate end-organ activity of androgens. The number of CAGn may increase with age. ..
  9. doi request reprint Endocrinological issues and hormonal manipulation in children and men with Klinefelter syndrome
    Matthew S Wosnitzer
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Am J Med Genet C Semin Med Genet 163:16-26. 2013
    ..The decision to institute hormonal therapy should be part of a multidisciplinary approach including physical, speech, behavioral, and occupational therapy. © 2013 Wiley Periodicals, Inc...
  10. doi request reprint Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    BJU Int 111:334-43. 2013
    ..To determine the effects of post-treatment ejaculatory dysfunction (EjD) and orgasmic dysfunction (OD) on measures of sexual satisfaction...
  11. doi request reprint New concepts in Klinefelter syndrome
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Curr Opin Urol 18:621-7. 2008
    ..This review is aimed to provide the practicing urologist with an important source of clinically relevant information about Klinefelter syndrome...
  12. pmc Ubiquitin Specific Protease 26 (USP26) Expression Analysis in Human Testicular and Extragonadal Tissues Indicates Diverse Action of USP26 in Cell Differentiation and Tumorigenesis
    Matthew S Wosnitzer
    Department of Urology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 9:e98638. 2014
    ..USP26/AR expression and interaction in spermatogenesis and androgen-dependent cancer warrants additional study and may prove useful in diagnosis and management of male infertility. ..
  13. doi request reprint Flow cytometric characterization of apoptosis and chromatin damage in spermatozoa
    Howard H Kim
    Departments of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Reprod Biomed Online 26:393-5. 2013
    ..These results strongly suggest that the drop in mitochondrial potential precedes changes in membrane phospholipids, and thus suggest apoptotic activation through mitochondrial pathway in human spermatozoa...
  14. doi request reprint Factors associated with ejaculatory and orgasmic dysfunction in men with erectile dysfunction: analysis of clinical trials involving the phosphodiesterase type 5 inhibitor tadalafil
    Darius A Paduch
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    BJU Int 109:1060-7. 2012
    ..To determine frequencies of, and risk factors for, ejaculatory dysfunction (EjD) and orgasmic dysfunction (OD) in men with different degrees of erectile dysfunction (ED)...
  15. ncbi request reprint Novel markers of male infertility
    Michael Funaro
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY, USA
    Methods Mol Biol 1154:233-50. 2014
    ..Next-generation genome sequencing and the discovery of small noncoding RNAs in sperm already are changing the field and permit further insight into the biology of male reproduction as well as offer new diagnostic tests. ..
  16. doi request reprint Klinefelter syndrome: an argument for early aggressive hormonal and fertility management
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 98:274-83. 2012
    ..To investigate the impact of early hormone replacement therapy (HT) on sperm retrieval rates in patients with Klinefelter syndrome (KS)...
  17. doi request reprint Prolactin in men's health and disease
    Alexander Bolyakov
    Department of Urology and Reproductive Medicine, Male Infertility Genetics Laboratory, Weill Cornell Medical College, New York, NY, USA
    Curr Opin Urol 21:527-34. 2011
    ..To review physiology of prolactin (PRL), cause and managment of hyperprolactinemia, and discuss evolving diverse roles of PRL in men's health...
  18. doi request reprint Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 96:303-8. 2011
    ..To evaluate heat shock factor Y chromosome (HSFY) mRNA as a biomarker for the presence of retrievable testicular sperm...
  19. doi request reprint Evolving techniques to evaluate ejaculatory function
    Laurent Vaucher
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Curr Opin Urol 19:606-14. 2009
    ..Recent findings in the physiology and neurobiology of ejaculation have expanded our understanding of male sexual function and have allowed the development of new instruments to investigate ejaculatory and orgasmic disorders...
  20. ncbi request reprint Testicular cancer and male infertility
    Darius A Paduch
    Department of Urology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Curr Opin Urol 16:419-27. 2006
    ..In this review, we provide current literature on links between infertility and testicular cancer, and new developments in the management of testicular cancer aimed at improving quality of life in men with testicular cancer...