Trends in the development of new antidepressants. Is there a light at the end of the tunnel?Pal Pacher
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic Studies, Rockville, MD 20852, USA
Curr Med Chem 11:925-43. 2004
..The goal of this review is to give a brief overview of the major advances from monoamine-based treatment strategies, and particularly focus on the new emerging approaches in the treatment of depression...
- A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging
Pal Pacher
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park Bldg Rm 445, 12420 Parklawn Drive, MSC 8115, Bethesda, MD 20892 8115, USA
J Pharmacol Exp Ther 311:485-91. 2004
..Thus, pharmacological inhibition of PARP may represent a novel approach to improve cardiac and vascular dysfunction associated with aging...
- Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy
Partha Mukhopadhyay
Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, National Institutes of Health NIAAA, Bethesda, Maryland 20892, USA
Nat Protoc 2:2295-301. 2007
..This method combined with fluorescent microscopy may be very useful to reveal important spatial-temporal changes in mitochondrial superoxide production and execution of programmed cell death in virtually any cell type...
- Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice
Norio Horiguchi
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 51:1724-34. 2010
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- Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies
Pal Pacher
Laboratory of Physiologic Studies, National Institutes of Health, NIAAA, Bethesda, MD 20892 9413, USA
Curr Med Chem 12:267-75. 2005
....
[Cardiovascular effects of selective serotonin reuptake inhibitor antidepressants]Pal Pacher
Semmelweis Egyetem, Általános Orvostudományi Kar, Farmakológiai és Farmakoterápiás Intézet, Budapest
Orv Hetil 145:425-31. 2004
..Taking all these into consideration, in depressed patients having also cardiac or liver disorders, these antidepressants should be also more rigorously applied...
- Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?
Pal Pacher
National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Laboratory Physiologic Studies, Bethesda, MD 20892 8115, USA
Curr Pharm Des 10:2463-75. 2004
..The primary goal of this review is to shed light on the recently observed clinically important cardiovascular effects of new antidepressants and antipsychotics and discuss the mechanism beyond this phenomenon...
- Nitrosative stress and pharmacological modulation of heart failure
Pal Pacher
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2S24, Bethesda, MD 20892 9413, USA
Trends Pharmacol Sci 26:302-10. 2005
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- CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model
Partha Mukhopadhyay
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 160:657-68. 2010
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- CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
Partha Mukhopadhyay
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, NIH NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Cardiovasc Res 85:773-84. 2010
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- Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
Partha Mukhopadhyay
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 296:H1466-83. 2009
..Thus, peroxynitrite is a major trigger of DOX-induced cell death both in vivo and in vivo, and the modulation of the pathways leading to its generation or its effective neutralization can be of significant therapeutic benefit...
- CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
Mohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H2210-8. 2007
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- Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 48:457-67. 2010
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- Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
Mohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
J Leukoc Biol 82:1382-9. 2007
..These findings suggest that selective CB(2) receptor agonists may represent a novel, protective strategy against I/R injury by attenuating oxidative stress, inflammatory response, and apoptosis...
- Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
Sandor Batkai
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health NIAAA, 5625 Fishers Ln, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H909-18. 2007
..These findings suggest that pharmacological inhibition of FAAH may represent a novel protective strategy against chronic inflammation, oxidative/nitrative stress, and apoptosis associated with cardiovascular aging and atherosclerosis...
- Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy
Mohanraj Rajesh
Laboratory of Physiological Studies, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Diabetes 61:716-27. 2012
..Conversely, CB(1) receptor inhibition may be beneficial in the treatment of diabetic cardiovascular complications...
- Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors
Sandor Batkai
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
Br J Pharmacol 165:2450-61. 2012
..Here, we assessed effects of Δ(8) -THCV and its metabolite 11-OH-Δ(8) -THCV on CB(2) receptors and against hepatic I/R injury...
- Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 50:179-95. 2011
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- Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells
Mohanraj Rajesh
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 160:688-700. 2010
....
- A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury
Bėla Horváth
Laboratory of Physiologic Studies Liver Disease, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
Br J Pharmacol 165:2462-78. 2012
..Cannabinoid CB(2) receptor activation has been reported to attenuate myocardial, cerebral and hepatic ischaemia-reperfusion (I/R) injury...
- Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors
Sandor Batkai
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
Am J Physiol Heart Circ Physiol 287:H595-600. 2004
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- Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 50:1368-81. 2011
..Thus, CBD may represent a novel, protective strategy against I/R injury by attenuating key inflammatory pathways and oxidative/nitrative tissue injury, independent of classical CB1/2 receptors...
- Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
Andrew M Miller
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Alcohol Clin Exp Res 34:719-25. 2010
..We have previously shown that IL-6 also activates STAT3 in sinusoidal endothelial cells (SECs). Thus, the purpose of this study was to investigate whether STAT3 in endothelial cells also plays a protective role in alcoholic liver injury...
- Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity
Partha Mukhopadhyay
Laboratory of Physiological Studies, NIH NIAAA, Bethesda, Maryland 20892, USA
J Am Coll Cardiol 50:528-36. 2007
..We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity...
- Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats
Sandor Batkai
Section on Neuroendocrinology, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, MSC 9413, Rm 2N17, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H1689-95. 2007
....
- Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy
Mohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, Bethesda, MD 20852, USA
J Cell Mol Med 13:2330-41. 2009
....
- Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase
Pal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiological Studies, 5625 Fishers Lane MSC 9413, Rm 2S24, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 289:H533-41. 2005
....
- β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner
Bėla Horváth
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 52:1325-33. 2012
..Given the excellent safety profile of BCP in humans it has tremendous therapeutic potential in a multitude of diseases associated with inflammation and oxidative stress...
- Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 52:497-506. 2012
..Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity...
- Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury
Sandor Batkai
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
FASEB J 21:1788-800. 2007
..We also demonstrate that CB2-/- mice have a normal hemodynamic profile...
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
Mohanraj Rajesh
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9413, USA
J Am Coll Cardiol 56:2115-25. 2010
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- Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations
Pal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 9413, USA
Hypertension 52:601-7. 2008
- Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure
Pal Pacher
National Institutes of Health, NAAA, Bethesda, MD 20892 9413, USA
Int J Mol Med 17:369-75. 2006
..The current data strengthen the view that PARP inhibition may represent an effective approach for the experimental therapy of various forms of acute and chronic heart failure...
- Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure
Pal Pacher
National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
Am J Physiol Heart Circ Physiol 287:H2132-7. 2004
..P-V analysis is a sensitive method to determine cardiac function in rats...
- The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications
Bėla Horváth
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Pathol 180:432-42. 2012
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- Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
Douglas Osei-Hyiaman
National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 115:1298-305. 2005
..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation...
- Endocannabinoids and cardiac contractile function: pathophysiological implications
Sandor Batkai
Phenotyping Core, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Pharmacol Res 60:99-106. 2009
..In this review we will discuss recent advances in understanding the role of CB1 receptors and endocannabinoids in the regulation of cardiac function in cirrhotic cardiomyopathy and in doxorubicin-induced heart failure...
- Simple quantitative detection of mitochondrial superoxide production in live cells
Partha Mukhopadhyay
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, Bethesda, MD 20892 9413, USA
Biochem Biophys Res Commun 358:203-8. 2007
..This method can also be adapted for immune cell studies with mixed population of T or B cells or their subsets to analyze mitochondrial superoxide levels using multiple labeled surface markers in individual populations...
- Blood pressure regulation by endocannabinoids and their receptors
Pal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
Neuropharmacology 48:1130-8. 2005
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- Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases
Pal Pacher
Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, Maryland 20892 9413, USA
Am J Physiol Gastrointest Liver Physiol 294:G850-4. 2008
..which play pivotal role in the early development and progression of inflammatory and other liver diseases...
- Cirrhotic cardiomyopathy: an endocannabinoid connection?
Pal Pacher
LPS, NIAAA, NIH, Bethesda, MD 20892 9413, USA
Br J Pharmacol 146:313-4. 2005
- Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 53:1123-38. 2012
..Mitochondrially generated oxidants play a central role in triggering the deleterious cascade of events associated with hepatic I/R, which may be targeted by novel antioxidants for therapeutic advantage...
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
Mohanraj Rajesh
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Physiol Heart Circ Physiol 293:H610-9. 2007
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- Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation
Mohanraj Rajesh
Laboratory of Physiological Studies, NIAAA, National Institutes of Health, Section on Oxidative Stress and Tissue Injury, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Biochem Biophys Res Commun 377:1248-52. 2008
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- Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes
Rachel Yue Gao
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Mol Med Rep 4:151-5. 2011
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- Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion
Kwan Hoon Moon
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 2092 9410, USA
Gastroenterology 135:1344-57. 2008
..We also studied the effects of a superoxide dismutase mimetic/peroxynitrite scavenger metalloporphyrin (MnTMPyP) on oxidatively modified proteins and their functions...
- Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury
Partha Mukhopadhyay
Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 51:1774-88. 2011
..g., triple-negative breast cancer)...
- The emerging role of the endocannabinoid system in cardiovascular disease
Pal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Semin Immunopathol 31:63-77. 2009
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- Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
Norio Horiguchi
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
Gastroenterology 134:1148-58. 2008
..Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure...
- The endocannabinoid system as an emerging target of pharmacotherapy
Pal Pacher
Laboratory of Physiological Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S 24, Bethesda, MD 20892 9413, USA
Pharmacol Rev 58:389-462. 2006
..Here, we provide a comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy...
- Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes
Pal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiologic Studies, 5625 Fishers Lane MSC 9413, Bethesda, Maryland 20852, USA
Curr Opin Pharmacol 6:136-41. 2006
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- MicroRNA signatures of resveratrol in the ischemic heart
Partha Mukhopadhyay
Laboratory of Physiologic Studies, NIAAA, National Institute of Health, Bethesda, Maryland, USA
Ann N Y Acad Sci 1215:109-16. 2011
..For example, a unique miRNA footprint is present in the heart treated with resveratrol. Targets of those miRNAs have potential implications for physiological and pathophysiological processes in health and disease...
- Restoration of altered microRNA expression in the ischemic heart with resveratrol
Partha Mukhopadhyay
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, Maryland, United States of America
PLoS ONE 5:e15705. 2010
..MicroRNAs are known regulators for genes involved in resveratrol-mediated cardiac remodeling and the regulatory pathway involving microRNA has not been studied so far...
- Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
Sandor Batkai
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
Circulation 110:1996-2002. 2004
..Endocannabinoids are novel lipid mediators with hypotensive and cardiodepressor activity. Here, we examined the possible role of the endocannabinergic system in cardiovascular regulation in hypertension...
- Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors
Pal Pacher
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health, NIAAA, Bethesda MD 20892 9413, USA
Cardiovasc Drug Rev 25:235-60. 2007
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- The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels
Grzegorz Godlewski
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
J Pharmacol Exp Ther 328:351-61. 2009
..3) Direct BK(Ca) channel activation probably contributes to the endothelium-independent component of ARA-S-induced mesenteric vasorelaxation. 4) O-1918 is a BK(Ca) channel inhibitor...
- Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol
Pal Pacher
Laboratory of Physiological Studies, National Institute on Alcohol Aabuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane MSC 9413, Room 2N 17, Bethesda, Maryland 20892 9413, USA
Pharmacol Rev 58:87-114. 2006
..Here we present a critical overview of the effects of XO inhibitors in various pathophysiological conditions and also review the various emerging therapeutic strategies offered by this approach...
- Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy
Carlos Enrique Guerrero-Beltrán
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
J Nutr Biochem 23:494-500. 2012
..SFN is able to prevent the CIS-induced renal injury by modulating these pathways, providing a novel approach for preventing this devastating complication of chemotherapy...
- Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme
Pal Pacher
National Institutes of Health, NIAAA, Laboratory of Physiologic Studies, Bethesda, MD 20892, USA
Antioxid Redox Signal 7:1568-80. 2005
..This review focuses on the role of PARP in diabetic complications and the unique therapeutic potential of PARP inhibition in the prevention or reversal of diabetic complications...
- Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease
Pal Pacher
Section on Oxidative Stress and Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, MD 20892 9413, USA
Am J Pathol 173:2-13. 2008
....
- Nitric oxide and peroxynitrite in health and disease
Pal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Physiol Rev 87:315-424. 2007
..Hence, novel pharmacological strategies aimed at removing peroxynitrite might represent powerful therapeutic tools in the future. Evidence supporting these novel roles of NO and peroxynitrite is presented in detail in this review...
- Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats
Pal Pacher
Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, National Institutes of Health NIAAA, 5625 Fishers Lane, MSC 9413, Bethesda, Maryland 20892 9413, USA
Nat Protoc 3:1422-34. 2008
..The completion of the protocol takes 1-4 h (depending on the experimental design/end points)...
Circulating anandamide and blood pressure in patients with obstructive sleep apneaStefan Engeli
aInstitute of Clinical Pharmacology, Hannover Medical School, Hannover bDepartment of Medicine, University of Leipzig, Leipzig cClinic for Endocrinology, Diabetes and Nutrition, Experimental and Clinical Research Center, Charite University Medicine, Berlin dInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany eLaboratory of Physiologic Studies, NIAAA, Bethesda, Maryland, USA
J Hypertens 30:2345-51. 2012
..Therefore, we hypothesized that increased blood pressure in patients with obstructive sleep apnea is associated with increased circulating endocannabinoid concentrations...
- Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP Inhibition or gene deficiency counteracts intraepi
Pal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health/NIAAA, 5625 Fishers Lane, Room 2-N17, MSC 9413, Bethesda, MD 20892-9413, USA
Free Radic Biol Med 44:969-71. 2008
- Targeting cannabinoid receptor CB(2) in cardiovascular disorders: promises and controversies
Sabine Steffens
Division of Cardiology, Department of Internal Medicine, University Hospital, Foundation for Medical Researches, Geneva, Switzerland
Br J Pharmacol 167:313-23. 2012
..their interplay and intracellular signalling mechanisms identified, as well as on experimental and clinical studies...
- Interplay of cannabinoid 2 (CB(2)) receptors with nitric oxide synthases, oxidative and nitrative stress, and cell death during remote neurodegeneration
Pal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
J Mol Med (Berl) 90:347-51. 2012
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- Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice
Pal Pacher
Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
J Physiol 558:647-57. 2004
..The role of TRPV(1) receptors is limited to the transient activation of the Bezold-Jarisch reflex by very high initial plasma concentrations of anandamide...
