Epigenetics mediate environment : gene effects on occupational sensitizationKarin A Pacheco
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver and Department of Environmental and Occupational Health, Colorado School of Public Health, Aurora, Colorado, USA
Curr Opin Allergy Clin Immunol 12:111-8. 2012
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Gene-environment interactions influence airways function in laboratory animal workersKarin A Pacheco
Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:232-40. 2010
..Functional variants of CD14 negatively affect lung function in farm workers and children exposed to animal allergens and endotoxin...
Characterization of endotoxin and mouse allergen exposures in mouse facilities and research laboratoriesKarin A Pacheco
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Ann Occup Hyg 50:563-72. 2006
..Endotoxin and mouse allergen are derived from the same animal source, but have different physicochemical attributes. It is not known if airborne exposures to these agents are correlated in the laboratory animal workplace...
Airborne endotoxin predicts symptoms in non-mouse-sensitized technicians and research scientists exposed to laboratory miceKarin A Pacheco
Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Crit Care Med 167:983-90. 2003
..8, p = 0.003). We conclude that airborne endotoxin is associated with respiratory symptoms to mice in non-mouse-sensitized scientists and technicians...
Work-related asthma: a case-based approach to managementKarin A Pacheco
Department of Medicine, National Jewish Health, Colorado School of Public Health, University of Colorado, CO, USA
Immunol Allergy Clin North Am 31:729-46, vi. 2011
..This article discusses the approaches that may be taken for patients with different forms of work-related asthma...
New insights into laboratory animal exposures and allergic responsesKarin A Pacheco
Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Curr Opin Allergy Clin Immunol 7:156-61. 2007
..To update the epidemiology of laboratory animal allergy, identify new exposures in the laboratory animal workplace, discuss complexities in the exposure-response relationship, and review the immunology of symptomatic and allergic responses...