Hilmi Ozcelik

Summary

Publications

  1. pmc Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2
    Eric Tram
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    PLoS ONE 8:e62468. 2013
  2. pmc Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia
    Zeynep Sena Ağım
    Neurodegeneration Research Laboratory, Molecular Biology and Genetics Department, Bogazici University, Istanbul, Turkey
    PLoS ONE 8:e53042. 2013
  3. pmc Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis
    Noel Pabalan
    School of Natural Sciences, Saint Louis University, Baguio City, Philippines
    PLoS ONE 7:e32389. 2012
  4. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
  5. doi request reprint Long-range PCR and next-generation sequencing of BRCA1 and BRCA2 in breast cancer
    Hilmi Ozcelik
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    J Mol Diagn 14:467-75. 2012
  6. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  7. doi request reprint Family-based association study of IGF1 microsatellites and height, weight, and body mass index
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    J Hum Genet 55:255-8. 2010
  8. ncbi request reprint Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 118:415-24. 2009
  9. doi request reprint Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression
    Liyang Liu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Int J Cancer 129:2454-62. 2011
  10. pmc Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:99. 2007

Collaborators

Detail Information

Publications48

  1. pmc Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2
    Eric Tram
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    PLoS ONE 8:e62468. 2013
    ..We propose that rare VUS affecting phosphorylation may be a novel and important mechanism for which BRCA1 and BRCA2 functions are disrupted in breast cancer...
  2. pmc Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia
    Zeynep Sena Ağım
    Neurodegeneration Research Laboratory, Molecular Biology and Genetics Department, Bogazici University, Istanbul, Turkey
    PLoS ONE 8:e53042. 2013
    ..These findings suggest that these haplotypes play an important role in the development of schizophrenia by affecting transcription factor binding affinity...
  3. pmc Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis
    Noel Pabalan
    School of Natural Sciences, Saint Louis University, Baguio City, Philippines
    PLoS ONE 7:e32389. 2012
    ....
  4. pmc Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
    Antonis C Antoniou
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge CB1 8RN, UK
    Breast Cancer Res 14:R33. 2012
    ..2)...
  5. doi request reprint Long-range PCR and next-generation sequencing of BRCA1 and BRCA2 in breast cancer
    Hilmi Ozcelik
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    J Mol Diagn 14:467-75. 2012
    ..Advances in NGS will play an important role in enabling molecular diagnostics and personalized treatment of breast and ovarian cancers...
  6. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  7. doi request reprint Family-based association study of IGF1 microsatellites and height, weight, and body mass index
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    J Hum Genet 55:255-8. 2010
    ..This study does not support an association between IGF1 and these anthropometric measures. Study limitations, including sample size and capturing genetic variation at IGF1 with these markers, could mean associations were missed...
  8. ncbi request reprint Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 118:415-24. 2009
    ..14; 5'CA 18-20, P = 0.25; 5'CA >20, P = 0.20). The associations we found could be due to chance as many comparisons were made. Our results do not strongly support an association between these IGF1 variants and breast cancer risk...
  9. doi request reprint Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression
    Liyang Liu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Int J Cancer 129:2454-62. 2011
    ..017). Our study demonstrated that quantitative increase in promoter methylation levels of APC, HOXD3 and TGFβ2 are associated with PCa progression...
  10. pmc Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
    Jane C Figueiredo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 7:99. 2007
    ..In this study, we focus on a rare non-synonymous polymorphism in cMyc (N11S) and a common polymorphism in p27 (V109G) and determine their role in risk and prognosis using data collected from the Ontario Breast Cancer Family Registry...
  11. ncbi request reprint Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Proteins 58:697-705. 2005
    ..Our study strongly suggests the presence of naturally occurring genetic variations in the cell cycle proteins that may affect their interactions and functions with possible roles in complex human diseases, such as cancer...
  12. ncbi request reprint Are CYP17 genotypes a biomarker for ovarian cancer in patients with cancer history in their family?
    Hulya Yazici
    Department of Basic Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey
    Oncol Res 16:43-7. 2006
    ..Our data indicate that the CYP17 A2 allele polymorphism may confer an increased risk and can provide a biomarker for ovarian cancer patients in whom no mutations in the BRCA genes are observed...
  13. pmc Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk
    Ummiye V Onay
    Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 8:6. 2008
    ..Several studies have also shown the relationship between estrogen and cell cycle progression through activation of CCND1 transcription...
  14. doi request reprint Meta-analysis of two ERCC2 (XPD) polymorphisms, Asp312Asn and Lys751Gln, in breast cancer
    Noel Pabalan
    College of Natural Sciences, Saint Louis University, Baguio City, 2600, Philippines
    Breast Cancer Res Treat 124:531-41. 2010
    ..Increased risk effect was more visible when the adduct studies are considered, suggesting the role of these polymorphisms in the presence of exposure to DNA damaging agents...
  15. pmc SNP-SNP interactions in breast cancer susceptibility
    Venüs Ummiye Onay
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    BMC Cancer 6:114. 2006
    ..However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination...
  16. pmc Genome-wide copy number variation in sporadic amyotrophic lateral sclerosis in the Turkish population: deletion of EPHA3 is a possible protective factor
    Ozgün Uyan
    Suna and İnan Kıraç Foundation Neurodegeneration Research Laboratory, Molecular Biology and Genetics Department, Bogazici University, Istanbul, Turkey
    PLoS ONE 8:e72381. 2013
    ..0065024). Based on the knowledge that EPHA4 has been previously shown to rescue SOD1 transgenic mice from ALS phenotype and prolongs survival, EPHA3 may be a promising candidate for therepuetic interventions. ..
  17. pmc Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines
    Lawson Eng
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada
    BMC Med Genomics 4:18. 2011
    ..Ingenuity Pathway Analysis software helped us understand how our identified genes may alter the cellular response to paclitaxel...
  18. pmc Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs
    Sevtap Savas
    Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5, ON, Canada
    BMC Cancer 5:107. 2005
    ..Non-synonymous single nucleotide polymorphisms (nsSNPs) result in the substitution of the encoded amino acids and thus are likely to alter the phosphorylation motifs in the proteins...
  19. doi request reprint Association between IGF1 CA microsatellites and mammographic density, anthropometric measures, and circulating IGF-I levels in premenopausal Caucasian women
    Gordon Fehringer
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Breast Cancer Res Treat 116:413-23. 2009
    ..Therefore, we examined the association of IGF1 polymorphisms with circulating IGF-I levels and mammographic density...
  20. doi request reprint Cyclin D1 Pro241Pro (CCND1-G870A) polymorphism is associated with increased cancer risk in human populations: a meta-analysis
    Noel Pabalan
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 60 Murray Street, Room L6 304, Box 29, Toronto, Ontario, Canada M5T 3L9
    Cancer Epidemiol Biomarkers Prev 17:2773-81. 2008
    ..6-7.1). In conclusion, our study strongly supports the increased cancer risk associated with CCND1-A870G polymorphism in the human population...
  21. ncbi request reprint Polymorphisms XRCC1-R399Q and XRCC3-T241M and the risk of breast cancer at the Ontario site of the Breast Cancer Family Registry
    Jane C Figueiredo
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Cancer Epidemiol Biomarkers Prev 13:583-91. 2004
    ..Our results suggest that these polymorphisms may influence breast cancer risk by modifying the effect of risk factors such as FH. There is a need for further study into the role of these polymorphisms as effect modifiers...
  22. pmc Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)
    Eric Tram
    Fred A, Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, 60 Murray St, Toronto, ON M5T 3L9, Canada
    Breast Cancer Res 13:R77. 2011
    ..Thus, it is currently unknown whether germline SMAD3 and SMAD4 mutations are involved in breast cancer predisposition...
  23. pmc Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario
    Laurent Briollais
    Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, M5T 3L9, Canada
    BMC Med 5:22. 2007
    ....
  24. doi request reprint Passive cigarette smoke exposure during various periods of life, genetic variants, and breast cancer risk among never smokers
    Laura N Anderson
    Department of Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada
    Am J Epidemiol 175:289-301. 2012
    ..Although the results of this study were largely null, it is possible that premenopausal women exposed to passive smoke or carrying certain genetic variants may be at higher risk of breast cancer...
  25. doi request reprint Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine
    Hamdi Jarjanazi
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Hum Mutat 29:461-7. 2008
    ..The results obtained using this novel methodology can be used to better design the clinical trials for effective study of the chemotherapeutic agents and thus provide a basis for individualized chemotherapy...
  26. doi request reprint Association between BRIP1 (BACH1) polymorphisms and breast cancer risk: a meta-analysis
    Noel Pabalan
    School of Natural Sciences, Saint Louis University, 2600, Baguio, Philippines
    Breast Cancer Res Treat 137:553-8. 2013
    ..The premenopausal findings and variable outcomes in postmenopausal women require more studies for confirmation...
  27. pmc Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer
    Ekaterina Olkhov-Mitsel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Epigenetics 7:1037-45. 2012
    ..A similar trend for KLK6 DNA methylation was observed. The results suggest that KLK6 and KLK10 DNA methylation distinguishes organ confined from locally invasive PCa and may have prognostic value...
  28. pmc A whole-genome SNP association study of NCI60 cell line panel indicates a role of Ca2+ signaling in selenium resistance
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 5:e12601. 2010
    ....
  29. doi request reprint DNA methylation of HOXD3 as a marker of prostate cancer progression
    Ken J Kron
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Lab Invest 90:1060-7. 2010
    ..028). The results indicate that HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones and may also have prognostic value when considered together with pathological stage...
  30. ncbi request reprint Human non-synonymous single nucleotide polymorphisms can influence ubiquitin-mediated protein degradation
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    OMICS 11:200-8. 2007
    ..Although experimental analyses are required to confirm these results, they suggest that nsSNPs can induce changes in ubiquitin-mediated protein degradation...
  31. pmc Genome wide screening of CAG trinucleotide repeat lengths in breast cancer
    Hamdi Jarjanazi
    F Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont, Canada
    Dis Markers 22:343-9. 2006
    ..These repeats may potentially affect the function of cancer predisposition genes, with a similar mechanism as in neurodegenerative and neuromuscular disorders...
  32. ncbi request reprint Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry
    Julia A Knight
    Division of Epidemiology and Biostatistics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 13:146-9. 2004
    ..30 for carriers versus noncarriers). There is a significant trend of increasing risk with increasing number of alleles with four GCG repeats (P = 0.03). This variant has not previously been reported to be associated with breast cancer...
  33. pmc Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Hum Genomics 2:287-96. 2006
    ....
  34. pmc Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays
    Ken Kron
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 4:e4830. 2009
    ..Such occurrences often lead to the silencing of these key genes and thus they may contribute to the development of cancer, including prostate cancer...
  35. ncbi request reprint Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Physiol Genomics 29:109-17. 2007
    ..The nsSNPs reported in here can be characterized by experimental approaches to elucidate their exact biological roles and whether they are related to human disease...
  36. ncbi request reprint Identifying functional genetic variants in DNA repair pathway using protein conservation analysis
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Avenue Room 992A, Toronto, ON M5G 1X5, Canada
    Cancer Epidemiol Biomarkers Prev 13:801-7. 2004
    ..The strategy developed and applied in this study has the potential to identify functional protein variants of DNA repair pathway that may be associated with cancer predisposition...
  37. ncbi request reprint Biological implications of SNPs in signal peptide domains of human proteins
    Hamdi Jarjanazi
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Proteins 70:394-403. 2008
    ..Functional evaluation of candidates identified herein may reveal effects on major cellular processes including immune cell function, cell recognition and adhesion, and signal transduction...
  38. ncbi request reprint Type of TP53 mutation and ERBB2 amplification affects survival in node-negative breast cancer
    Hilmi Ozcelik
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray St, Room 6 303 O, Toronto, ON, Canada, M5T 3L9
    Breast Cancer Res Treat 105:255-65. 2007
    ..Our study suggests that the type of TP53 mutation, especially missense mutation, is a strong prognostic indicator for DFS and DSS in node-negative breast cancer, particularly in combination with ERBB2 amplification...
  39. pmc Human SNPs resulting in premature stop codons and protein truncation
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Hum Genomics 2:274-86. 2006
    ..We believe that the SNPs reported here are likely to affect gene/protein function, although their biological and evolutionary roles need to be further investigated...
  40. pmc ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population
    Suna Lahut
    Bogazici University, Molecular Biology and Genetics Department, Neurodegeneration Research Laboratory, Istanbul, Turkey
    PLoS ONE 7:e42956. 2012
    ..Our novel observations suggest that genotyping of SNPs at this locus may be useful for the study of ALS risk in a high percentage of individuals and that ATXN2 and SH2B3 variants may interact in modulating the disease pathway...
  41. pmc NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells
    Sevtap Savas
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    PLoS ONE 6:e18306. 2011
    ..Our results indicated genes involved in the cellular response to these statins and siRNA studies confirmed the role of the EAF2 in response to these drugs in HCT-116 colon cancer cells...
  42. ncbi request reprint The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer
    Shelley B Bull
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 22:86-96. 2004
    ..On the basis of evidence that p53 mutation is involved in the development of human neoplasia, we examined the prognostic value of p53 alterations in combination with neu/erbB-2 amplification...
  43. ncbi request reprint Genetic variation and the mitogen-activated protein kinase (MAPK) signaling pathway
    Stewart Cho
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    OMICS 10:66-81. 2006
    ..This strategy can effectively determine which nsSNPs potentially alter protein function, and can be utilized to study the genetic architecture and disease association of other biological protein complexes and networks...
  44. ncbi request reprint Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations
    Irene L Andrulis
    Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Mutat 20:65-73. 2002
    ..It will continue to be important to use complementary methods for mutational analysis...
  45. ncbi request reprint BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer patients: a high incidence of mutations in non-familial cases
    Hulya Yazici
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Hum Mutat 20:28-34. 2002
    ....
  46. ncbi request reprint HER-2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry
    Louise A Quenneville
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 95:2068-75. 2002
    ..The Ontario Familial Breast Cancer Registry collects clinical and family history data in familial breast carcinoma cases, and unselected Ashkenazi breast carcinomas, and acts as a tumor tissue repository...
  47. doi request reprint Secretome proteins as candidate biomarkers for aggressive thyroid carcinomas
    Seham Chaker
    Alex and Simona Shnaider Laboratory in Molecular Oncology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Proteomics 13:771-87. 2013
    ..995, p < 0.001). In conclusion, some of these proteins show potential for future development as serum and/or tissue-based biomarkers for TC and warrant further investigation in a large cohort of patients...
  48. ncbi request reprint Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies
    Robert G Bristow
    Department of Medical Biophysics, University of Toronto and Princess Margaret Hospital University Health Network, Toronto, Canada
    Radiother Oncol 83:220-30. 2007
    ..This review highlights DNA-dsb in prostate cancer research in terms of novel molecular inhibitors, the role of the microenvironment in DNA-dsb repair and potential DNA-dsb biomarkers for clinical trials...