PAX2 and PAX8 expression in primary and metastatic renal tumors: a comprehensive comparisonAyhan Ozcan
Department of Pathology, The Methodist Hospital, Houston, Texas, USA
Arch Pathol Lab Med 136:1541-51. 2012
..The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small-needle biopsies. PAX2 and PAX8 transcription factors are known to be expressed by several histologic types of renal neoplasms...
Nuclear morphometry in the differential diagnosis of eosinophilic renal epithelial tumorsAyhan Ozcan
Department of Pathology, Gulhane Military Medical Academy, Ankara, Turkey
Anal Quant Cytol Histol 34:145-8. 2012
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- PAX2 and PAX8 expression in primary and metastatic müllerian epithelial tumors: a comprehensive comparison
Ayhan Ozcan
Department of Pathology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
Am J Surg Pathol 35:1837-47. 2011
..In contrast, PAX2 expression is always less than PAX8, and exclusive staining for PAX2 is not seen. PAX8 supersedes PAX2 as probably the best epithelial marker hitherto for primary or metastatic müllerian epithelial tumors...
- PAX-2 expression in non-neoplastic, primary neoplastic, and metastatic neoplastic tissue: A comprehensive immunohistochemical study
Qihui Jim Zhai
Departments of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Appl Immunohistochem Mol Morphol 18:323-32. 2010
..PAX-2 is a sensitive and specific marker for tumors of renal or Müllerian origin in both primary and metastatic contexts...
- PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin
Ayhan Ozcan
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Arch Pathol Lab Med 134:1121-9. 2010
..The diagnosis of metastatic renal cell carcinoma (RCC) remains problematic...
- PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study
Ayhan Ozcan
Departments of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Mod Pathol 24:751-64. 2011
..This tissue/cell-specific expression is maintained during both neoplastic transformation and metastasis. PAX 8 is a sensitive and specific marker for tumors of renal, Müllerian, or thyroid origin in both primary and metastatic sites...
- Ozone therapy prevents renal inflammation and fibrosis in a rat model of acute pyelonephritis
Bahadir Caliskan
Department of Pediatric Surgery, Gulhane Military Medical Faculty, Etlik, Ankara, Turkey
Scand J Clin Lab Invest 71:473-80. 2011
..This study was conducted to evaluate the effect of ozone therapy (OT), as an immunomodulator and antioxidant, on the renal function, morphology and biochemical parameters of oxidative stress in an experimental model of APN in rats...
- PAX-2 in the diagnosis of primary renal tumors: immunohistochemical comparison with renal cell carcinoma marker antigen and kidney-specific cadherin
Ayhan Ozcan
Department of Pathology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey
Am J Clin Pathol 131:393-404. 2009
..PAX-2 seems to have a significant role in renal neogenesis and may represent a novel therapeutic target...
- The effects of medical ozone therapy on renal ischemia/reperfusion injury
Muzaffer Oztosun
Health Services Command, Turkish Armed Forces, Ankara, Turkey
Ren Fail 34:921-5. 2012
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- Fascin expression and its potential significance in gastrointestinal stromal tumors
Ayhan Ozcan
Gülhane Military Medical Academy Department of Pathology, Etlik, Ankara, Turkey
Turk J Gastroenterol 22:363-8. 2011
..However, there are only a few studies related to its expression in mesenchymal tumors. We investigated fascin expression in gastrointestinal stromal tumors...
- Fractal dimension of microvasculature in renal oncocytomas and chromophobe renal cell carcinomas
Yildirim Karslioglu
Department of Pathology, Gulhane Military Medical Academy and School of Medicine, Ankara, Turkey
Pathol Res Pract 205:677-81. 2009
..Similar studies investigating larger series are needed before a final conclusion can be made...
- Nuclear planimetry on the samples from cytologically overlapping proliferative breast lesions
Bulent Kurt
Gulhane Military Medical Academy and Medical School, Department of Pathology, General Tevfik Saglam Cad, 06018 Ankara, Turkey
Pathol Res Pract 205:325-9. 2009
..However, with a systematic and reproducible selection of the values with a proper "bias", morphometry may provide some discriminatory information in overlapping lesions...
- Lymphoid cell proliferation in renal transplants: biologic and diagnostic implications
Hulya Akgun
Department of Pathology, The Methodist Hospital, Houston, TX, USA
Clin Transplant 21:472-80. 2007
..Proliferation of IIC involves predominantly T lymphocytes. These observations provide support for the concept of in situ alloimmunization, and facilitate the diagnosis of ACR...
- Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats
Suzi Demirbag
Department of Pediatric Surgery, Gulhane Military Medical Academy, Etlik 06018, Ankara, Turkey
Ren Fail 32:493-7. 2010
..In conclusion, our study results are consistent with encouraging data for ozone therapy on APAP-induced nephrotoxicity in rats by improving antioxidant mechanism and oxidative stress...
- Alpha-fetoprotein producing tumor cells in children with Wilms' tumor
Vural Kesik
Department of Pediatric Oncology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey
Fetal Pediatr Pathol 29:127-32. 2010
..Herein, we report three patients with Wilms tumor whose serum AFP levels were elevated and who had diffuse WT-1 and focal AFP expression in all tumors, immunohistochemically...
- Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays
Emin Oztas
Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
Exp Mol Pathol 89:182-9. 2010
..These novel monoclonal antibodies may help elucidate the role of SIP1 in tumor development...
- CD138 expression in renal tumors and its usage in the differential diagnosis
Ayhan Ozcan
Department of Pathology, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey
Turk Patoloji Derg 27:110-5. 2011
..This study aims to investigate the possible contribution of CD138 expression in the differential diagnosis of kidney tumors with eosinophilic cytoplasm...
- Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity
Zeki Ilker Kunak
Department of CBRN Defense, Gulhane Military Medical Academy, Ankara, Turkey
J Surg Res 175:e17-23. 2012
..In this study, we aimed to investigate the protective effects of melatonin (MEL) and S-methylisothiourea (SMT) on mechlorethamine (MEC) induced nephrotoxicity...
- Quantitative evaluation of immunohistochemical staining in gastrointestinal stromal tumors
Ayhan Ozcan
Department of Pathology, School of Medicine, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey
Anal Quant Cytol Histol 29:159-65. 2007
..To evaluate the differences among pathologists' interpretations in gastrointestinal stromal tumors (GISTs) and to demonstrate the usefulness of quantitative pathology in the assessment of immunohistochemical staining...
- Expression of GLUT1 in primary renal tumors: morphologic and biologic implications
Ayhan Ozcan
Department of Pathology, Methodist Hospital, Houston, TX 77030, USA
Am J Clin Pathol 128:245-54. 2007
..GLUT1 may be a novel target for immunotherapy and a useful marker in the differential diagnosis and classification of renal tumors...
- Nutcracker syndrome in a child with familial Mediterranean fever (FMF) disease: renal ultrastructural features
Ayhan Ozcan
Department of Pathology, Gulhane Military Medical Academy, Etlik, Ankara, 06018, Turkey
Int Urol Nephrol 41:1047-53. 2009
..Radiolucent expansion of the lamina rara interna of the glomerular basement membrane in the presenting case would seem to support these data...
