Mikhail V Ovanesov

Summary

Publications

  1. doi request reprint Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution
    Mikhail V Ovanesov
    National Research Center for Hematology, Moscow, Russia
    Blood Coagul Fibrinolysis 19:743-55. 2008
  2. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
  3. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
  4. ncbi request reprint Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
  5. ncbi request reprint Effect of factor VIII on tissue factor-initiated spatial clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, Russian Academy of Medical Sciences, Moscow, Russia
    Thromb Haemost 89:235-42. 2003
  6. pmc Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively
    Mikhail A Panteleev
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biophys J 90:1489-500. 2006
  7. pmc Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation
    Mikhail A Panteleev
    Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
    Biophys J 98:1751-61. 2010
  8. pmc Activation of microglia by borna disease virus infection: in vitro study
    Mikhail V Ovanesov
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 121, Baltimore, MD 21287, USA
    J Virol 80:12141-8. 2006
  9. ncbi request reprint Hemophilia A and B are associated with abnormal spatial dynamics of clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biochim Biophys Acta 1572:45-57. 2002
  10. ncbi request reprint PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation
    Mikhail V Pletnikov
    Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosci Res 58:234-44. 2007

Detail Information

Publications10

  1. doi request reprint Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution
    Mikhail V Ovanesov
    National Research Center for Hematology, Moscow, Russia
    Blood Coagul Fibrinolysis 19:743-55. 2008
    ..Therefore, rate and extent of platelet-derived microparticles generation might be important with regard to rVIIa treatment safety...
  2. pmc Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:50. 2008
    ..The data are consistent with the hypothesis that microglia activation in the absence of neuronal damage may represent initial steps in the gradual neurodegeneration observed in brains of neonatally BDV-infected rats...
  3. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
    ..The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss...
  4. ncbi request reprint Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum
    Mikhail V Ovanesov
    Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neurovirol 13:185-94. 2007
    ..The present data are the first in vivo evidence that GLU excitotoxicity might contribute to BDV-associated neuronal injury in the striatum...
  5. ncbi request reprint Effect of factor VIII on tissue factor-initiated spatial clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, Russian Academy of Medical Sciences, Moscow, Russia
    Thromb Haemost 89:235-42. 2003
    ..05 U/ml fVIII restored the normal clot growth rate (44.9 +/- 2.5 microm/min) at high but not at low fibroblast density. Our results indicate that the functioning of the intrinsic tenase complex is critical for normal spatial clot growth...
  6. pmc Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively
    Mikhail A Panteleev
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biophys J 90:1489-500. 2006
    ..2 mm. These results identify roles of specific coagulation pathways at different stages of spatial clot formation (initiation, elongation, and termination) and provide a possible basis for their therapeutic targeting...
  7. pmc Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation
    Mikhail A Panteleev
    Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia
    Biophys J 98:1751-61. 2010
    ..We speculate that this pathway serves to lessen possibility of fibrin clot disruption by flow and subsequent thromboembolism...
  8. pmc Activation of microglia by borna disease virus infection: in vitro study
    Mikhail V Ovanesov
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 121, Baltimore, MD 21287, USA
    J Virol 80:12141-8. 2006
    ..Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia...
  9. ncbi request reprint Hemophilia A and B are associated with abnormal spatial dynamics of clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biochim Biophys Acta 1572:45-57. 2002
    ..The rate of clot growth in hemophilic plasma is significantly lower than normal and declines quickly. The resulting clots are thin, which may account for the bleeding disorder...
  10. ncbi request reprint PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation
    Mikhail V Pletnikov
    Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosci Res 58:234-44. 2007
    ..Thus, inducible expression of DISC1 in PC12 cell clones is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses...