Xiaohu Ouyang

Summary

Publications

  1. ncbi request reprint Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors
    Xiaohu Ouyang
    Department of Chemistry, ImClone Systems, 710 Parkside Avenue, Suite 2, Brooklyn, NY 11226, USA
    Bioorg Med Chem Lett 15:5154-9. 2005
  2. ncbi request reprint Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines
    Xiaohu Ouyang
    Department of Chemistry, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA
    Bioorg Med Chem Lett 16:1191-6. 2006
  3. ncbi request reprint Tricyclic azepine derivatives: pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors
    Leon Smith
    Department of Chemistry, ImClone Systems, 180 Varick Street, New York, NY 10014, USA
    Bioorg Med Chem Lett 16:1643-6. 2006
  4. doi request reprint Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors
    Eugene L Piatnitski Chekler
    Department of Chemistry, ImClone Systems Incorporated, New York, NY 10014, USA
    Bioorg Med Chem Lett 18:4344-7. 2008
  5. ncbi request reprint Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding
    Premilla N Arasasingham
    Department of Small Molecule Drug Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 46:9-11. 2003
  6. ncbi request reprint Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates
    Alexander S Kiselyov
    Small Molecule Drug Discovery, Chemical Diversity, Inc, 11558 Sorrento Valley Road, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:3550-7. 2007
  7. ncbi request reprint 1H-1,2,4-triazol-3-yl-anilines: novel potent inhibitors of vascular endothelial growth factor receptors 1 and 2
    Alexander S Kiselyov
    ChemDiv Inc, 6605 Nancy Ridge Drive, San Diego, CA 92121, USA
    Chem Biol Drug Des 69:331-7. 2007
  8. ncbi request reprint Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr
    Celia Dominguez
    Chemistry Research and Discovery, One Amgen Center Drive Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6003-8. 2007

Collaborators

  • Ying Wang
  • Leon Smith
  • Eugene L Piatnitski Chekler
  • Xin Chen
  • Alex S Kiselyov
  • Christopher Fotsch
  • Celia Dominguez
  • Premilla N Arasasingham
  • Danlin Chen
  • Richard Kendall
  • Gondi Kumar
  • Angela Coxon
  • Sesha Neervannan
  • Tae Seong Kim
  • James Bready
  • Timothy Harvey
  • Joseph Kim
  • Qi Huang
  • Ling Wang
  • Michael Zhang
  • Anthony Polverino
  • Paul Chen
  • Charles Starnes
  • Chester Yuan
  • Andrew Tasker
  • Lynn Cai
  • Yongmei Gan
  • Rashid Syed
  • Nuria A Tamayo
  • Martha Zambrano
  • Bill Karbon
  • Clarence Hale
  • Janet Cheetham
  • Mark H Norman
  • James W Baumgartner
  • Kevin L Stark
  • Michael G Kelly

Detail Information

Publications8

  1. ncbi request reprint Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors
    Xiaohu Ouyang
    Department of Chemistry, ImClone Systems, 710 Parkside Avenue, Suite 2, Brooklyn, NY 11226, USA
    Bioorg Med Chem Lett 15:5154-9. 2005
    ..The syntheses and structure-activity relationship studies for the triazole derivatives are described herein...
  2. ncbi request reprint Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines
    Xiaohu Ouyang
    Department of Chemistry, ImClone Systems Incorporated, 180 Varick Street, New York, NY 10014, USA
    Bioorg Med Chem Lett 16:1191-6. 2006
    ....
  3. ncbi request reprint Tricyclic azepine derivatives: pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors
    Leon Smith
    Department of Chemistry, ImClone Systems, 180 Varick Street, New York, NY 10014, USA
    Bioorg Med Chem Lett 16:1643-6. 2006
    ..Such compounds demonstrate anti-EGFR activity within a class that is different from any known EGFR inhibitor scaffolds. They also provide a basis for the design of kinase inhibitors with the desired selectivity profile...
  4. doi request reprint Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors
    Eugene L Piatnitski Chekler
    Department of Chemistry, ImClone Systems Incorporated, New York, NY 10014, USA
    Bioorg Med Chem Lett 18:4344-7. 2008
    ..In addition, the lead candidate 8 displayed acceptable exposure levels when administered orally to mice...
  5. ncbi request reprint Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding
    Premilla N Arasasingham
    Department of Small Molecule Drug Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 46:9-11. 2003
    ..Novel inhibitors of the AGRP/MC4 binding based on (piperazinylethyl)piperazines were prepared, and their structure-activity relationship was established...
  6. ncbi request reprint Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates
    Alexander S Kiselyov
    Small Molecule Drug Discovery, Chemical Diversity, Inc, 11558 Sorrento Valley Road, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:3550-7. 2007
    ..High permeability of active compounds across the Caco-2 cell monolayer (>40 x 10(-5)cm/min) is indicative of their potential for intestinal absorption upon oral administration...
  7. ncbi request reprint 1H-1,2,4-triazol-3-yl-anilines: novel potent inhibitors of vascular endothelial growth factor receptors 1 and 2
    Alexander S Kiselyov
    ChemDiv Inc, 6605 Nancy Ridge Drive, San Diego, CA 92121, USA
    Chem Biol Drug Des 69:331-7. 2007
    ..Several active molecules feature high intrinsic permeability (>30 x 10(-5) cm/min) across Caco-2 cell monolayer...
  8. ncbi request reprint Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr
    Celia Dominguez
    Chemistry Research and Discovery, One Amgen Center Drive Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6003-8. 2007
    ..The clinical utility of inhibitors of this receptor tyrosine kinase is currently under intense investigation. Herein we report our efforts in this arena...