I G Otterness

Summary

Publications

  1. ncbi Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 15:666-72. 2007
  2. ncbi Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 16:34-40. 2008
  3. ncbi Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing
    Ivan G Otterness
    School of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA
    Arthritis Rheum 56:3644-9. 2007
  4. ncbi Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation
    Christopher B Little
    Connective Tissue Biology Laboratory, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Matrix Biol 21:271-88. 2002
  5. ncbi Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis
    Marie-Pierre Hellio Le Graverand
    Faculty of Medicine, McCaig Center for Joint Injury and Arthritis Research, University of Calgary HSC, Alberta, Canada
    J Orthop Res 20:535-44. 2002
  6. ncbi Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids
    Clare L Curtis
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Arthritis Rheum 46:1544-53. 2002
  7. ncbi Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1
    Lawrence A Reiter
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 14:3389-95. 2004

Collaborators

  • F Eckstein
  • Kenneth D Brandt
  • S A Mazzuca
  • Eric Vignon
  • Christopher B Little
  • Lawrence A Reiter
  • Clare L Curtis
  • Marie-Pierre Hellio Le Graverand
  • Lisa M Tobiassen
  • Gary J Martinelli
  • Shunda M McGahee
  • Marcie L Vaughn-Bowser
  • James D Eskra
  • Santo R Cortina
  • Peter G Mitchell
  • Lori L Lopresti-Morrow
  • Marcia L Bliven
  • Jennifer Liras
  • Arturo Lopez-Anaya
  • Kathleen M Donahue
  • Sue A Yocum
  • Christopher S Jones
  • Richard J Griffiths
  • Kim F McClure
  • Mary E Lame
  • Matthew R Reese
  • Ralph P Robinson
  • Leona Barclay
  • David A Hart
  • Colin M Dent
  • Chris Wilson
  • Sarah G Rees
  • Clare E Hughes
  • John L Harwood
  • Carl R Flannery
  • Jonna Eggerer
  • Bruce Caterson

Detail Information

Publications7

  1. ncbi Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 15:666-72. 2007
    ..Here we examine the hypothesis that women have smaller joint surfaces than men, independent of weight and height, and thus encounter higher articular pressures that might contribute to the higher incidence of OA in the female knee...
  2. ncbi Allometric relationships between knee cartilage volume, thickness, surface area and body dimensions
    I G Otterness
    Division of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
    Osteoarthritis Cartilage 16:34-40. 2008
    ..To determine if anthropometric factors obtainable on routine examination can be used to estimate premorbid knee total subchondral bone area (tAB), cartilage surface area (AC), cartilage thickness (ThC), and cartilage volume (VC)...
  3. ncbi Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing
    Ivan G Otterness
    School of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA
    Arthritis Rheum 56:3644-9. 2007
    ....
  4. ncbi Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation
    Christopher B Little
    Connective Tissue Biology Laboratory, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK
    Matrix Biol 21:271-88. 2002
    ..Furthermore, analysis of aggrecan metabolites resulting from both C-terminal and IGD cleavage by MMPs may prove useful in monitoring different stages in the progression of cartilage degeneration...
  5. ncbi Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis
    Marie-Pierre Hellio Le Graverand
    Faculty of Medicine, McCaig Center for Joint Injury and Arthritis Research, University of Calgary HSC, Alberta, Canada
    J Orthop Res 20:535-44. 2002
    ..These results show that following ACL transection, complex molecular, as well as structural changes occur early in cartilage and that the observed changes are both region-specific and time-dependent...
  6. ncbi Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids
    Clare L Curtis
    Connective Tissue Biology Laboratories, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, Wales, UK
    Arthritis Rheum 46:1544-53. 2002
    ..CONCLUSION: These studies show that the pathologic indicators manifested in human OA cartilage can be significantly altered by exposure of the cartilage to n-3 PUFA, but not to other classes of fatty acids...
  7. ncbi Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1
    Lawrence A Reiter
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 14:3389-95. 2004
    ..Despite the sparing of MMP-1, pre-clinical and clinical studies revealed that fibrosis in rats and MSS in humans is still produced...