Leif Ostergaard

Summary

Publications

  1. pmc The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage
    Leif Østergaard
    1 Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark 2 Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark
    J Cereb Blood Flow Metab 33:1825-37. 2013
  2. pmc The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism
    Sune N Jespersen
    Center of Functionally Integrative Neuroscience and MINDLab, NeuroCampus Aarhus, Aarhus University, Aarhus C, Denmark
    J Cereb Blood Flow Metab 32:264-77. 2012
  3. ncbi request reprint The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease
    Leif Ostergaard
    Department of Neuroradiology, Aarhus University Hospital, Building 10G, Nørrebrogade 44, 8000, Aarhus C, Denmark
    Basic Res Cardiol 109:409. 2014
  4. pmc The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model
    Leif Østergaard
    Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark
    J Cereb Blood Flow Metab 33:635-48. 2013
  5. doi request reprint The capillary dysfunction hypothesis of Alzheimer's disease
    Leif Østergaard
    Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark
    Neurobiol Aging 34:1018-31. 2013
  6. doi request reprint Predicting tissue outcome in stroke: new approaches
    Leif Ostergaard
    Center of Functionally Integrative Neuroscience, Department of Neuroradiology, University of Aarhus, Aarhus University Hospital, Aarhus, Denmark
    Curr Opin Neurol 22:54-9. 2009
  7. doi request reprint The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis
    Leif Ostergaard
    Authors Affiliations Center of Functionally Integrative Neuroscience and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus Denmark Department of Neuroradiology, and Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Cancer Res 73:5618-24. 2013
  8. doi request reprint Tapping polyrhythms in music activates language areas
    Peter Vuust
    Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark Royal Academy of Music, Aarhus, Denmark
    Neurosci Lett 494:211-6. 2011
  9. ncbi request reprint Microstructural changes in ischemic cortical gray matter predicted by a model of diffusion-weighted MRI
    Peter Vestergaard-Poulsen
    Center of Functionally Integrative Neuroscience Department of Neuroradiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
    J Magn Reson Imaging 26:529-40. 2007
  10. doi request reprint Carbogen inhalation increases oxygen transport to hypoperfused brain tissue in patients with occlusive carotid artery disease: increased oxygen transport to hypoperfused brain
    Mahmoud Ashkanian
    Center of Functionally Integrative Neuroscience CFIN, Aarhus University Hospital, Norrebrogade 44, Bygn 30, 8000 Aarhus C, Denmark
    Brain Res 1304:90-5. 2009

Collaborators

Detail Information

Publications22

  1. pmc The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage
    Leif Østergaard
    1 Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark 2 Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark
    J Cereb Blood Flow Metab 33:1825-37. 2013
    ..Irreversible changes in capillary morphology and function are predicted to contribute to long-term relative tissue hypoxia, inflammation, and neurodegeneration. We discuss diagnostic and therapeutic implications of these predictions. ..
  2. pmc The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism
    Sune N Jespersen
    Center of Functionally Integrative Neuroscience and MINDLab, NeuroCampus Aarhus, Aarhus University, Aarhus C, Denmark
    J Cereb Blood Flow Metab 32:264-77. 2012
    ..We propose that conditions with altered capillary morphology, such as amyloid, diabetic or hypertensive microangiopathy, and ischemia-reperfusion, may disturb CTTH and thereby flow-metabolism coupling and cerebral oxygen metabolism...
  3. ncbi request reprint The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease
    Leif Ostergaard
    Department of Neuroradiology, Aarhus University Hospital, Building 10G, Nørrebrogade 44, 8000, Aarhus C, Denmark
    Basic Res Cardiol 109:409. 2014
    ..We discuss these predictions in the context of MVD, myocardial infarction, and reperfusion injury. ..
  4. pmc The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model
    Leif Østergaard
    Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark
    J Cereb Blood Flow Metab 33:635-48. 2013
    ..In this review, we discuss the possible implications of these findings for the prevention, diagnosis, and treatment of acute stroke...
  5. doi request reprint The capillary dysfunction hypothesis of Alzheimer's disease
    Leif Østergaard
    Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark
    Neurobiol Aging 34:1018-31. 2013
    ..Salient features of the model are discussed in the context of AD pathology along with potential sources of increased capillary flow heterogeneity...
  6. doi request reprint Predicting tissue outcome in stroke: new approaches
    Leif Ostergaard
    Center of Functionally Integrative Neuroscience, Department of Neuroradiology, University of Aarhus, Aarhus University Hospital, Aarhus, Denmark
    Curr Opin Neurol 22:54-9. 2009
    ..The review describes techniques to more accurately image and model penumbral infarct risk...
  7. doi request reprint The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis
    Leif Ostergaard
    Authors Affiliations Center of Functionally Integrative Neuroscience and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus Denmark Department of Neuroradiology, and Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Cancer Res 73:5618-24. 2013
    ....
  8. doi request reprint Tapping polyrhythms in music activates language areas
    Peter Vuust
    Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark Royal Academy of Music, Aarhus, Denmark
    Neurosci Lett 494:211-6. 2011
    ..This data indicates that the activation is linked to polyrhythmic tension, regardless of whether it arises from the stimulus or the task...
  9. ncbi request reprint Microstructural changes in ischemic cortical gray matter predicted by a model of diffusion-weighted MRI
    Peter Vestergaard-Poulsen
    Center of Functionally Integrative Neuroscience Department of Neuroradiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
    J Magn Reson Imaging 26:529-40. 2007
    ....
  10. doi request reprint Carbogen inhalation increases oxygen transport to hypoperfused brain tissue in patients with occlusive carotid artery disease: increased oxygen transport to hypoperfused brain
    Mahmoud Ashkanian
    Center of Functionally Integrative Neuroscience CFIN, Aarhus University Hospital, Norrebrogade 44, Bygn 30, 8000 Aarhus C, Denmark
    Brain Res 1304:90-5. 2009
    ..Further studies with more subjects are, however, needed to investigate the applicability of carbogen for long-term inhalation and to assess its therapeutic benefits in acute stroke patients...
  11. doi request reprint Interrater agreement for final infarct MRI lesion delineation
    Anders B Neumann
    Center of Functionally Integrative Neuroscience, Aarhus University Hospitals, Aarhus, Denmark
    Stroke 40:3768-71. 2009
    ..The objective of this study was to quantify the geometric interrater agreement for lesion delineation of chronic infarcts on T2-weighted and fluid-attenuated inverse recovery (FLAIR) MRI...
  12. doi request reprint Distinct neural responses to chord violations: a multiple source analysis study
    Eduardo A Garza Villarreal
    Center of Functionally Integrative Neuroscience, University of Aarhus, Danish Neuroscience Center, Aarhus University Hospital, Nørrebrogade 44 Building 10G 5, 8000 Aarhus, Denmark
    Brain Res 1389:103-14. 2011
    ..These findings suggest a predominant role of the auditory cortices in detecting sequential scale regularities and the posterior prefrontal cortex in parsing hierarchical regularities in music...
  13. doi request reprint The effect of impermeable boundaries of arbitrary geometry on the apparent diffusion coefficient
    Astrid F Frøhlich
    Department of Neuroradiology, Center of Functionally Integrative Neuroscience CFIN, University Hospital of Aarhus, Nørrebrogade 44, Building 30, 8000 Aarhus C, Denmark
    J Magn Reson 194:128-35. 2008
    ..The application of the results are discussed in relation to determination of the microscopic structure of brain white matter...
  14. ncbi request reprint Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition
    Albert Gjedde
    Pathophysiology and Experimental Tomography Center, Aarhus University Hospital in Aarhus, Aarhus, Denmark
    J Cereb Blood Flow Metab 25:1183-96. 2005
    ..The adjustment of cytochrome c oxidase affinity to the declining oxygen delivery could be ascribed to a hypothetical factor with several properties in common with nitric oxide...
  15. ncbi request reprint Automatic selection of arterial input function using cluster analysis
    Kim Mouridsen
    Centre for Functionally Integrative Neuroscience CFIN, Department of Neuroradiology, Arhus University Hospital, Denmark
    Magn Reson Med 55:524-31. 2006
    ....
  16. pmc Superior analgesic effect of an active distraction versus pleasant unfamiliar sounds and music: the influence of emotion and cognitive style
    Eduardo A Garza Villarreal
    Center of Functionally Integrative Neuroscience, University of Aarhus, Aarhus, Denmark
    PLoS ONE 7:e29397. 2012
    ..These findings suggest that familiarity may be key in the influence of the cognitive and emotional mechanisms of music-induced analgesia, and that cognitive styles may influence pain perception...
  17. pmc Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI
    Line Lunau
    Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark
    BMJ Open 2:e000368. 2012
    ..To assess functional changes measured by cerebral blood flow (CBF) in the presymptomatic stage of frontotemporal dementia linked to chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B...
  18. doi request reprint Predictive coding of music--brain responses to rhythmic incongruity
    Peter Vuust
    Centre of Functionally Integrative Neuroscience, University of Aarhus, and PET Center, Aarhus University Hospital, Aarhus, Denmark
    Cortex 45:80-92. 2009
    ..We propose that these differences trace a functional adaptation and/or a genetic pre-disposition in experts which allows for a more precise rhythmic prediction...
  19. doi request reprint Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression
    Rikke Beese Dalby
    Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Risskov, Denmark
    Psychiatry Res 184:38-48. 2010
    ..In conclusion, depression severity correlates with the tract-specific localization of WMLs. WMLs have a pronounced effect on white matter integrity in the pathways they intersect...
  20. pmc Visualization of altered neurovascular coupling in chronic stroke patients using multimodal functional MRI
    Jakob U Blicher
    Research Unit, Hammel Neurocentre, Aarhus University Hospital, Hammel, Denmark
    J Cereb Blood Flow Metab 32:2044-54. 2012
    ..A table is provided outlining distinct vascular and metabolic uncoupling possibilities that elicit different BOLD responses, and the strengths and limitations of the multimodal protocol are summarized...
  21. doi request reprint Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial
    Kristina Dupont Hougaard
    From the Department of Neurology K D H, N H, P v W M, C Z S, D D, H G, K S, P V R, G A, Department of Neuroradiology L S, A N, L Ø, Department of Cardiology H E B, and Mobil Emergency Care Unit Aarhus T M H, Aarhus University Hospital, Aarhus, Denmark Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark K D H, N H, D Z, L R R, I K M, K N, L Ø, K M Stroke Department, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, University of Lyon, Lyon, France T H C and Division of Cardiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Milano
    Stroke 45:159-67. 2014
    ..Remote ischemic preconditioning is neuroprotective in models of acute cerebral ischemia. We tested the effect of prehospital rPerC as an adjunct to treatment with intravenous alteplase in patients with acute ischemic stroke...
  22. ncbi request reprint Bayesian regularization of diffusion tensor images
    Jesper Frandsen
    Department of Neuroradiology, Centre for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark
    Biostatistics 8:784-99. 2007
    ..In this paper, we develop a Bayesian procedure for regularizing the diffusion tensor field, fully utilizing the available 3D information of fiber orientation. The use of the procedure is exemplified on synthetic and in vivo data...