Lars Ostergaard

Summary

Publications

  1. pmc Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA
    Randi K Berg
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 7:e29291. 2012
  2. ncbi request reprint HIV-infected individuals with high coping self-efficacy are less likely to report depressive symptoms: a cross-sectional study from Denmark
    L Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark Electronic address
    Int J Infect Dis 22:67-72. 2014
  3. ncbi request reprint Disclosure decisions: HIV-positive persons coping with disease-related stressors
    Lotte Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Qual Health Res 21:1249-59. 2011
  4. ncbi request reprint Depression in patients with HIV is under-diagnosed: a cross-sectional study in Denmark
    L Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    HIV Med 11:46-53. 2010
  5. doi request reprint Changes in depression in a cohort of Danish HIV-positive individuals: time for routine screening
    Lotte Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Sex Health 8:214-21. 2011
  6. pmc Anti-inflammatory effect of a retrovirus-derived immunosuppressive peptide in mouse models
    Martin Tolstrup
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark
    BMC Immunol 14:51. 2013
  7. doi request reprint Central nervous system infections among individuals with and without end-stage renal disease
    Jesper D Gunst
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark
    J Infect 67:19-26. 2013
  8. doi request reprint Risk and prognosis of hospitalization for pneumonia among individuals with and without functioning renal transplants in Denmark: a population-based study
    Lise H Nielsen
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardvej 100, Aarhus 8200, Denmark
    Clin Infect Dis 55:679-86. 2012
  9. pmc Morbidity and risk of subsequent diagnosis of HIV: a population based case control study identifying indicator diseases for HIV infection
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    PLoS ONE 7:e32538. 2012
  10. ncbi request reprint Pneumococcal conjugate vaccination in persons with HIV: the effect of highly active antiretroviral therapy
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    AIDS 24:1315-22. 2010

Collaborators

Detail Information

Publications29

  1. pmc Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA
    Randi K Berg
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 7:e29291. 2012
    ..However, knowledge on specific HIV PAMPs and cellular PRRs responsible for inducing innate immune responses remains sparse...
  2. ncbi request reprint HIV-infected individuals with high coping self-efficacy are less likely to report depressive symptoms: a cross-sectional study from Denmark
    L Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark Electronic address
    Int J Infect Dis 22:67-72. 2014
    ..This study investigated the relationship between coping self-efficacy levels, as determined by the Coping Self-Efficacy Scale (CSE), HIV status disclosure, and depression in a Danish cohort...
  3. ncbi request reprint Disclosure decisions: HIV-positive persons coping with disease-related stressors
    Lotte Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Qual Health Res 21:1249-59. 2011
    ....
  4. ncbi request reprint Depression in patients with HIV is under-diagnosed: a cross-sectional study in Denmark
    L Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    HIV Med 11:46-53. 2010
    ..The aim of this study was to investigate the prevalence of depression among HIV-positive patients in an out-patient clinic in Denmark and to detect factors of importance for the development of depression...
  5. doi request reprint Changes in depression in a cohort of Danish HIV-positive individuals: time for routine screening
    Lotte Rodkjaer
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Sex Health 8:214-21. 2011
    ..The aim of this study was to follow a cohort of HIV-positive individuals for 3 years in order to assess changes in depression, adherence, unsafe sex and emotional strains from living with HIV...
  6. pmc Anti-inflammatory effect of a retrovirus-derived immunosuppressive peptide in mouse models
    Martin Tolstrup
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200 Aarhus, Denmark
    BMC Immunol 14:51. 2013
    ..Here we test the hypothesis that such immunosuppressive peptides may serve as immunomodulatory reagents for treatment of inflammatory disorders...
  7. doi request reprint Central nervous system infections among individuals with and without end-stage renal disease
    Jesper D Gunst
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark
    J Infect 67:19-26. 2013
    ..Individuals with immunodeficiencies are at increased risk of central nervous system (CNS) infections. Data are limited on the risk of CNS infections in patients with end-stage renal disease (ESRD)...
  8. doi request reprint Risk and prognosis of hospitalization for pneumonia among individuals with and without functioning renal transplants in Denmark: a population-based study
    Lise H Nielsen
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardvej 100, Aarhus 8200, Denmark
    Clin Infect Dis 55:679-86. 2012
    ..Pneumonia is commonly diagnosed in immunosuppressed individuals. The risk and attributable morbidity of first hospitalization for pneumonia among renal transplant candidates and recipients were compared to those of population controls...
  9. pmc Morbidity and risk of subsequent diagnosis of HIV: a population based case control study identifying indicator diseases for HIV infection
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    PLoS ONE 7:e32538. 2012
    ..Early identification of persons with undiagnosed HIV infection is an important health care issue. We examined associations between diseases diagnosed in hospitals and risk of subsequent HIV diagnosis...
  10. ncbi request reprint Pneumococcal conjugate vaccination in persons with HIV: the effect of highly active antiretroviral therapy
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    AIDS 24:1315-22. 2010
    ..We aimed to determine HAART's impact on seven-valent pneumococcal conjugate (7vPnC) vaccine immunization with or without a Toll-like receptor 9 (TLR9) agonist adjuvant...
  11. pmc T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication
    Randi K Berg
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 9:e84513. 2014
    ..This phenomenon could contribute to the high permissiveness of CD4+ T cells for HIV-1. ..
  12. pmc Use of population based background rates of disease to assess vaccine safety in childhood and mass immunisation in Denmark: nationwide population based cohort study
    Thomas A Rasmussen
    Department of Infectious Diseases, Aarhus University Hospital, DK 8200 Aarhus N, Denmark
    BMJ 345:e5823. 2012
    ..To predict the number of selected outcomes temporally associated but not caused by vaccination, to aid causality assessment of adverse events arising after mass immunisation in a paediatric population...
  13. ncbi request reprint HIV late presenters in Denmark: need for increased diagnostic awareness among general practitioners
    Peter Derek Christian Leutscher
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Dan Med Bull 58:A4253. 2011
    ..The study objective was to describe demographic and clinical characteristics among HIV late presenters in a Danish university hospital...
  14. pmc Clinical features and predictors of mortality in admitted patients with community- and hospital-acquired legionellosis: a Danish historical cohort study
    Sanne Jespersen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark
    BMC Infect Dis 10:124. 2010
    ..Community-acquired [CAL] and hospital-acquired legionellosis [HAL] may have different presentations and outcome. We aimed to compare clinical characteristics and examine predictors of mortality for CAL and HAL...
  15. ncbi request reprint Comparison of the immunogenicity and reactogenicity of Cervarix and Gardasil human papillomavirus vaccines in HIV-infected adults: a randomized, double-blind clinical trial
    Lars Toft
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    J Infect Dis 209:1165-73. 2014
    ..We compared the immunogenicity and reactogenicity of Cervarix or Gardasil human papillomavirus (HPV) vaccines in adults infected with the human immunodeficiency virus (HIV)...
  16. doi request reprint Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection
    Line Vibholm
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    AIDS Res Hum Retroviruses 28:1404-11. 2012
    ..Therefore, this model would be suitable for evaluating present and future microbicide candidates. Furthermore, the present study warrants further investigation of TDF in microbicides...
  17. pmc Induction of humoral and cellular immune responses against the HIV-1 envelope protein using γ-retroviral virus-like particles
    Tea Kirkegaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Virol J 8:381. 2011
    ..Lastly, we identified stronger IgG2a class switching in the two particle-delivered antigen vaccinations modalities compared to recombinant gp160...
  18. ncbi request reprint Transmission of HIV-1 drug-resistant variants: prevalence and effect on treatment outcome
    Martin R Jakobsen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Clin Infect Dis 50:566-73. 2010
    ....
  19. pmc HSV-1-induced chemokine expression via IFI16-dependent and IFI16-independent pathways in human monocyte-derived macrophages
    Stine Søby
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej 100, Aarhus N, DK 8200, Denmark
    Herpesviridae 3:6. 2012
    ..abstract:..
  20. pmc Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals
    Anne Roslev Bukh
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 6:e21275. 2011
    ..Microbial translocation may contribute to the immunopathogenesis in HIV infection. We investigated if microbial translocation and inflammation were associated with innate and adaptive immune responses in adults with HIV...
  21. ncbi request reprint Use of InfCare HIV to identify and characterize suboptimally treated HIV patients at a Danish HIV clinic: a cross-sectional cohort study
    Lars Skov Dalgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Scand J Infect Dis 44:108-14. 2012
    ..This study investigated the usefulness of InfCare HIV for identifying and characterizing suboptimally treated HIV-infected patients at a Danish HIV clinic...
  22. pmc Hepatitis B and Delta virus are prevalent but often subclinical co-infections among HIV infected patients in Guinea-Bissau, West Africa: a cross-sectional study
    Bo Langhoff Hønge
    Bandim Health Project, INDEPTH Network, Bissau, Guinea Bissau Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 9:e99971. 2014
    ..Co or super-infection with hepatitis Delta virus (HDV) may worsen the liver disease and complicate treatment possibilities...
  23. ncbi request reprint Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa
    Bo Langhoff Hønge
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark Bandim Health Project, INDEPTH Network, Bissau, Guinea Bissau National HIV Programme, Ministry of Health, Bissau, Guinea Bissau National Public Health Laboratory, Bissau, Guinea Bissau GloHAU, Center for Global Health, School of Public Health, Aarhus University, Aarhus, Denmark and Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark
    J Acquir Immune Defic Syndr 65:87-90. 2014
    ..8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation...
  24. doi request reprint Reproductive patterns and fertility wishes among HIV-infected patients: survey from six outpatient clinics in Denmark
    Tinne Laursen
    Department of Infectious Diseases, Aarhus University Hospital, Brendstrupgaardsvej, Skejby, 8200 Aarhus N, Denmark
    Int J Infect Dis 17:e851-6. 2013
    ..Reproductive patterns among HIV patients in Denmark have not previously been described. We aimed to uncover the fertility wishes among Danish HIV-infected persons...
  25. doi request reprint Hospitalization for pneumonia among individuals with and without HIV infection, 1995-2007: a Danish population-based, nationwide cohort study
    Ole S Sogaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Clin Infect Dis 47:1345-53. 2008
    ..We compared incidence rates of pneumonia among individuals with and without HIV infection and explored risk factors for pneumonia in the HIV-infected population...
  26. ncbi request reprint Mitochondrial DNA levels in fat and blood cells from patients with lipodystrophy or peripheral neuropathy and the effect of 90 days of high-dose coenzyme Q treatment: a randomized, double-blind, placebo-controlled pilot study
    Eva Rabing Christensen
    Research Unit Q, Department of Infectious Diseases, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Clin Infect Dis 39:1371-9. 2004
    ..Studies aimed at increasing the oxidative capacity in HIV-infected patients have been sparse...
  27. ncbi request reprint Pre-screening HIV-1 reverse transcriptase resistance mutations in subtype B patients using a novel multiplex primer extension assay
    Martin Roelsgaard Jakobsen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Brendstrupgaardvej 100, DK 8200 Aarhus N, Denmark
    Curr HIV Res 7:398-409. 2009
    ..Thus, the HIV-SNaPshot is a method capable to support standard genotyping for the determination of minority HIV-1 resistance mutations, with equivalent and perhaps greater sensitivity than Viroseq...
  28. doi request reprint Immunogenicity, reactogenicity and persistence of meningococcal A, C, W-135 and Y-tetanus toxoid candidate conjugate (MenACWY-TT) vaccine formulations in adolescents aged 15-25 years
    Lars Ostergaard
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    Vaccine 27:161-8. 2009
    ..Our results present five investigational MenACWY-TT conjugate vaccine formulations which are well tolerated and highly immunogenic in adolescents...
  29. ncbi request reprint Full fusion competence rescue of the enfuvirtide resistant HIV-1 gp41 genotype (43D) by a prevalent polymorphism (137K)
    Martin Tolstrup
    Department of Infectious Diseases, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark
    AIDS 21:519-21. 2007