Timothy F Osborne

Summary

Publications

  1. pmc Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR
    Hansook Kim Chong
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    BMC Genomics 13:51. 2012
  2. pmc Sterols for Oxygen: The Metabolic Burden of Microbial SREBP
    Timothy F Osborne
    Metabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mol Cell 44:172-4. 2011
  3. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, School of Biological Sciences, Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
    J Biol Chem 283:15089-96. 2008
  4. pmc Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
    Mary K Bennett
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 283:15628-37. 2008
  5. pmc Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
    Hansook Kim Chong
    Department of Molecular Biology and Biochemistry, Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA
    Nucleic Acids Res 38:6007-17. 2010
  6. ncbi request reprint A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor
    Karen E Matsukuma
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
    J Biol Chem 282:20164-71. 2007
  7. ncbi request reprint Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake
    Shrimati Datta
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
    J Biol Chem 281:807-12. 2006
  8. pmc Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
    Cell Metab 13:367-75. 2011
  9. ncbi request reprint Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
    Karen E Matsukuma
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    J Lipid Res 47:2754-61. 2006
  10. pmc Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13765-9. 2009

Collaborators

  • Xiaohui Xie
  • Li Wang
  • Bing Zhu
  • Michelina Plateroti
  • David D Moore
  • Vickie J Lamorte
  • Yanqiao Zhang
  • Peter J Espenshade
  • Young Kyo Seo
  • Dong Ju Shin
  • Seung Soon Im
  • Tae Il Jeon
  • Hansook Kim Chong
  • Shrimati Datta
  • Mary K Bennett
  • Karen E Matsukuma
  • Jacob Biesinger
  • Julia I Toth
  • Leyla Yousef
  • Stephen G Young
  • Aniello M Infante
  • Aikaterini Zoumi
  • Chengkang Zhang
  • Gregorio Gil
  • Janet Z Liu
  • Christoph Blaschitz
  • Robert A Edwards
  • Manuela Raffatellu
  • Peter A Edwards
  • Linda E Hammond
  • Loren G Fong
  • Cherryl Nugas-Selby
  • Jarrod L Larson
  • Jiansheng Huang
  • Jacques Samarut
  • Cristen J Wu
  • Lih Huei L Liaw
  • Gopi Manthripragada
  • Jyoti N Athanikar
  • Leonard P Freedman
  • Jose A Campos

Detail Information

Publications26

  1. pmc Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR
    Hansook Kim Chong
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    BMC Genomics 13:51. 2012
    ....
  2. pmc Sterols for Oxygen: The Metabolic Burden of Microbial SREBP
    Timothy F Osborne
    Metabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Mol Cell 44:172-4. 2011
    ..2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-binding activity and the degradation of the hypoxia regulated transcription factor, Sre1p...
  3. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, School of Biological Sciences, Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
    J Biol Chem 283:15089-96. 2008
    ....
  4. pmc Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
    Mary K Bennett
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 283:15628-37. 2008
    ..This underscores the mechanistic flexibility that has evolved at the individual gene/promoter level to maintain metabolic homeostasis in response to shifting nutritional states and environmental fluctuations...
  5. pmc Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
    Hansook Kim Chong
    Department of Molecular Biology and Biochemistry, Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA
    Nucleic Acids Res 38:6007-17. 2010
    ..Other broad gene clusters related to metabolism, transport, signaling and glycolysis were also significantly enriched. Thus, FXR may have a much wider role in cellular metabolism than previously appreciated...
  6. ncbi request reprint A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptor
    Karen E Matsukuma
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
    J Biol Chem 282:20164-71. 2007
    ..Taken together, these findings identify the first direct lipogenic gene target of LRH-1/SHP repression and provide a mechanistic explanation for bile acid repression of FAS and lipogenesis recently reported by others...
  7. ncbi request reprint Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake
    Shrimati Datta
    Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
    J Biol Chem 281:807-12. 2006
    ....
  8. pmc Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
    Cell Metab 13:367-75. 2011
    ..Thus, the lipid droplet could be viewed as a third source of cellular cholesterol, which along with sterol synthesis and uptake, is also regulated by SREBP-2...
  9. ncbi request reprint Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
    Karen E Matsukuma
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    J Lipid Res 47:2754-61. 2006
    ..These findings provide the first evidence for direct regulation of lipogenesis by bile acids and also provide a mechanistic rationale for previously unexplained observations regarding bile acid control of FAS expression...
  10. pmc Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13765-9. 2009
    ..SREBP-1 bound not only to many well-characterized SREBP-1 target genes but to several other previously unknown targets in lipid and carbohydrate metabolism as well as many putative target genes in other diverse biological pathways...
  11. pmc Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer
    Aikaterini Zoumi
    University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Rd, East Irvine, CA 92612, USA
    Mol Cell Biol 25:2946-56. 2005
    ..These findings provide new insight into the overall process of transcriptional activation mediated by the SREBP family...
  12. pmc Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697 3900, USA
    Exp Cell Res 315:3133-9. 2009
    ....
  13. pmc Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
    Seung Soon Im
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Mol Cell Biol 29:4864-72. 2009
    ..Our chromatin immunoprecipitation results support this hypothesis...
  14. pmc A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein 1a (SREBP-1a)
    Chengkang Zhang
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Biochem J 386:161-8. 2005
    ....
  15. ncbi request reprint PGC-1alpha activates CYP7A1 and bile acid biosynthesis
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine California 92697 3900, USA
    J Biol Chem 278:50047-52. 2003
    ..Our studies provide further evidence of the fundamental role played by PGC-1alpha in oxidative metabolism and define PGC-1alpha as a link between diabetes and bile acid metabolism...
  16. pmc Selective coactivator interactions in gene activation by SREBP-1a and -1c
    Julia I Toth
    Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92612 3900, USA
    Mol Cell Biol 24:8288-300. 2004
    ..Finally, we demonstrate the recruitment of mediator to an SREBP-responsive promoter in a sterol-dependent manner...
  17. pmc Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    Nucleic Acids Res 34:3853-61. 2006
    ..These two independent TR-binding sites are closely spaced and both are required for full induction of the CYP7A1 promoter by thyroid hormone, although the DR-0 site was more crucial...
  18. ncbi request reprint Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers
    Shrimati Datta
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 280:3338-45. 2005
    ....
  19. pmc FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 284:11110-20. 2009
    ....
  20. pmc Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
    Seung Soon Im
    Metabolic Signaling and Disease Program, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Cell Metab 13:540-9. 2011
    ....
  21. ncbi request reprint Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo
    Mary K Bennett
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 279:37360-7. 2004
    ..Taken together, our data support a model suggesting that chromatin modification is required during the initial stage of specific site recognition by SREBPs in native chromatin in vivo...
  22. pmc Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK
    Tae Il Jeon
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Biochem J 438:33-7. 2011
    ..We also show that PTC increases the efflux activity of ABCB1, suggesting that T2R signalling limits the absorption of bitter tasting/toxic substances through modulation of gut efflux membrane transporters...
  23. pmc SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    Tae Il Jeon
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    J Clin Invest 118:3693-700. 2008
    ....
  24. pmc Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
    Timothy F Osborne
    Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA
    Genes Dev 23:2578-91. 2009
    ..This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth...
  25. ncbi request reprint Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2)
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 278:34114-8. 2003
    ..Additionally, these results indicate that mutations or drugs that lower nuclear SREBP-2 would cause hypercholesterolemia...
  26. pmc Liver x receptors in atherosclerosis and inflammation
    Seung Soon Im
    Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Lake Nona, Orlando, FL, USA
    Circ Res 108:996-1001. 2011
    ..The antiinflammatory actions of LXR may be a direct response to the proinflammatory actions recently proposed for cholesterol on inflammasome activity in the vessel wall...