Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXRHansook Kim Chong
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
BMC Genomics 13:51. 2012
....
- Sterols for Oxygen: The Metabolic Burden of Microbial SREBP
Timothy F Osborne
Metabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
Mol Cell 44:172-4. 2011
..2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-binding activity and the degradation of the hypoxia regulated transcription factor, Sre1p...
- Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner
Dong Ju Shin
Department of Molecular Biology and Biochemistry, School of Biological Sciences, Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
J Biol Chem 283:15089-96. 2008
....
- Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
Mary K Bennett
Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
J Biol Chem 283:15628-37. 2008
..This underscores the mechanistic flexibility that has evolved at the individual gene/promoter level to maintain metabolic homeostasis in response to shifting nutritional states and environmental fluctuations...
- Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
Hansook Kim Chong
Department of Molecular Biology and Biochemistry, Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA
Nucleic Acids Res 38:6007-17. 2010
..Other broad gene clusters related to metabolism, transport, signaling and glycolysis were also significantly enriched. Thus, FXR may have a much wider role in cellular metabolism than previously appreciated...
A key role for orphan nuclear receptor liver receptor homologue-1 in activation of fatty acid synthase promoter by liver X receptorKaren E Matsukuma
Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, CA 92697 3900, USA
J Biol Chem 282:20164-71. 2007
..Taken together, these findings identify the first direct lipogenic gene target of LRH-1/SHP repression and provide a mechanistic explanation for bile acid repression of FAS and lipogenesis recently reported by others...
- Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake
Shrimati Datta
Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697 3900, USA
J Biol Chem 281:807-12. 2006
....
- Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
Young Kyo Seo
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
Cell Metab 13:367-75. 2011
..Thus, the lipid droplet could be viewed as a third source of cellular cholesterol, which along with sterol synthesis and uptake, is also regulated by SREBP-2...
- Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
Karen E Matsukuma
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
J Lipid Res 47:2754-61. 2006
..These findings provide the first evidence for direct regulation of lipogenesis by bile acids and also provide a mechanistic rationale for previously unexplained observations regarding bile acid control of FAS expression...
- Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif
Young Kyo Seo
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 106:13765-9. 2009
..SREBP-1 bound not only to many well-characterized SREBP-1 target genes but to several other previously unknown targets in lipid and carbohydrate metabolism as well as many putative target genes in other diverse biological pathways...
- Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer
Aikaterini Zoumi
University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Rd, East Irvine, CA 92612, USA
Mol Cell Biol 25:2946-56. 2005
..These findings provide new insight into the overall process of transcriptional activation mediated by the SREBP family...
- Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
Young Kyo Seo
Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697 3900, USA
Exp Cell Res 315:3133-9. 2009
....
- Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
Seung Soon Im
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
Mol Cell Biol 29:4864-72. 2009
..Our chromatin immunoprecipitation results support this hypothesis...
- A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein 1a (SREBP-1a)
Chengkang Zhang
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Biochem J 386:161-8. 2005
....
- PGC-1alpha activates CYP7A1 and bile acid biosynthesis
Dong Ju Shin
Department of Molecular Biology and Biochemistry, University of California, Irvine California 92697 3900, USA
J Biol Chem 278:50047-52. 2003
..Our studies provide further evidence of the fundamental role played by PGC-1alpha in oxidative metabolism and define PGC-1alpha as a link between diabetes and bile acid metabolism...
- Selective coactivator interactions in gene activation by SREBP-1a and -1c
Julia I Toth
Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92612 3900, USA
Mol Cell Biol 24:8288-300. 2004
..Finally, we demonstrate the recruitment of mediator to an SREBP-responsive promoter in a sterol-dependent manner...
- Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene
Dong Ju Shin
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
Nucleic Acids Res 34:3853-61. 2006
..These two independent TR-binding sites are closely spaced and both are required for full induction of the CYP7A1 promoter by thyroid hormone, although the DR-0 site was more crucial...
- Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers
Shrimati Datta
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
J Biol Chem 280:3338-45. 2005
....
- FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
Dong Ju Shin
Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
J Biol Chem 284:11110-20. 2009
....
- Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
Seung Soon Im
Metabolic Signaling and Disease Program, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
Cell Metab 13:540-9. 2011
....
- Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo
Mary K Bennett
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA
J Biol Chem 279:37360-7. 2004
..Taken together, our data support a model suggesting that chromatin modification is required during the initial stage of specific site recognition by SREBPs in native chromatin in vivo...
- Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK
Tae Il Jeon
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Biochem J 438:33-7. 2011
..We also show that PTC increases the efflux activity of ABCB1, suggesting that T2R signalling limits the absorption of bitter tasting/toxic substances through modulation of gut efflux membrane transporters...
- SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
Tae Il Jeon
Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
J Clin Invest 118:3693-700. 2008
....
- Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
Timothy F Osborne
Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA
Genes Dev 23:2578-91. 2009
..This review integrates classic features of the SREBP pathway with newer information regarding the regulation and sensing mechanisms that serve to assimilate different cellular physiologic processes for optimal function and growth...
- Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2)
Dong Ju Shin
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
J Biol Chem 278:34114-8. 2003
..Additionally, these results indicate that mutations or drugs that lower nuclear SREBP-2 would cause hypercholesterolemia...
- Liver x receptors in atherosclerosis and inflammation
Seung Soon Im
Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Lake Nona, Orlando, FL, USA
Circ Res 108:996-1001. 2011
..The antiinflammatory actions of LXR may be a direct response to the proinflammatory actions recently proposed for cholesterol on inflammasome activity in the vessel wall...
