N Orsolic

Summary

Publications

  1. ncbi request reprint Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
    Toxicon 41:861-70. 2003
  2. ncbi request reprint Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000, Zagreb, Croatia
    Eur J Nutr 53:1217-27. 2014
  3. ncbi request reprint Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia
    Tumour Biol 35:6445-54. 2014
  4. doi request reprint Inhibitory effect of a propolis on Di-n-Propyl Disulfide or n-Hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia Electronic address
    Fitoterapia 93:18-30. 2014
  5. doi request reprint Assessment of DNA damage and lipid peroxidation in diabetic mice: effects of propolis and epigallocatechin gallate (EGCG)
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia Electronic address
    Mutat Res 757:36-44. 2013
  6. pmc Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Zagreb HR 10000, Croatia
    BMC Complement Altern Med 12:117. 2012
  7. doi request reprint Bee venom in cancer therapy
    Nada Orsolic
    Department of Animal Physiology, University of Zagreb, Zagreb, Croatia
    Cancer Metastasis Rev 31:173-94. 2012
  8. doi request reprint DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000 Zagreb, Croatia
    Eur J Pharmacol 656:110-8. 2011
  9. ncbi request reprint Prevention of peritoneal carcinomatosis in mice by combining hyperthermal intraperitoneal chemotherapy with the water extract from Burr parsley (Caucalis platycarpos L.)
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Planta Med 76:773-9. 2010
  10. doi request reprint Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Zagreb, 10000, Croatia
    Med Oncol 27:1346-58. 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
    Toxicon 41:861-70. 2003
    ..Apoptosis, necrosis, and lysis of tumor cells are other possible mechanisms by which bee venom inhibits tumor growth...
  2. ncbi request reprint Role of flavonoids on oxidative stress and mineral contents in the retinoic acid-induced bone loss model of rat
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000, Zagreb, Croatia
    Eur J Nutr 53:1217-27. 2014
    ..We developed a retinoic acid-induced bone loss model of rats to assess whether flavonoids and alendronate as positive control have role against oxidative stress and mineral contents in osteoporosis in vivo...
  3. ncbi request reprint Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia
    Tumour Biol 35:6445-54. 2014
    ....
  4. doi request reprint Inhibitory effect of a propolis on Di-n-Propyl Disulfide or n-Hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia Electronic address
    Fitoterapia 93:18-30. 2014
    ..The aim of the present study was to assess the usefulness of thermography in psoriatic lesion regression after topical treatment with bee propolis, recognised as potent antioxidants and anti-inflammatory agents...
  5. doi request reprint Assessment of DNA damage and lipid peroxidation in diabetic mice: effects of propolis and epigallocatechin gallate (EGCG)
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia Electronic address
    Mutat Res 757:36-44. 2013
    ..The results suggest that dietary supplementation with WSDP or EGCG could potentially contribute to nutritional strategies for the prevention and treatment of diabetes mellitus. ..
  6. pmc Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Zagreb HR 10000, Croatia
    BMC Complement Altern Med 12:117. 2012
    ..In addition, we examined whether different extract of propolis could prevent diabetic nephropathy and liver toxicity by inhibiting lipid peroxidation in vivo...
  7. doi request reprint Bee venom in cancer therapy
    Nada Orsolic
    Department of Animal Physiology, University of Zagreb, Zagreb, Croatia
    Cancer Metastasis Rev 31:173-94. 2012
    ..The recent applications of melittin in various cancers and a molecular explanation for the antiproliferative properties of bee venom are discussed...
  8. doi request reprint DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000 Zagreb, Croatia
    Eur J Pharmacol 656:110-8. 2011
    ..Various co-operative and synergistic action mechanisms of the tested flavonoids may lead to the protection of the whole organism against diabetes...
  9. ncbi request reprint Prevention of peritoneal carcinomatosis in mice by combining hyperthermal intraperitoneal chemotherapy with the water extract from Burr parsley (Caucalis platycarpos L.)
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Planta Med 76:773-9. 2010
    ..The stimulative effect of CPL on immunomodulation may be a possible mechanism which protects mice from developing peritoneal carcinomatosis and reduces the side effects of chemotherapy, increasing the life span of mice...
  10. doi request reprint Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Zagreb, 10000, Croatia
    Med Oncol 27:1346-58. 2010
    ....
  11. ncbi request reprint Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000 Zagreb, Croatia
    J Ethnopharmacol 84:265-73. 2003
    ..Based on results we postulate that the antimetastatic activity of propolis includes a pronounced immunomodulatory activity mainly toward augmentation of nonspecific antitumor resistance in mice via macrophage activation...
  12. ncbi request reprint Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Biol Pharm Bull 30:946-51. 2007
    ..Treatment with test components after lethal irradiation was ineffective. These results suggest that propolis and its polyphenolic compounds given to mice before irradiation protect mice from the lethal effects of whole-body irradiation...
  13. ncbi request reprint Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells
    Nada Orsolic
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Sci 97:952-60. 2006
    ..In conclusion, adaphostin showed significant and selective activity against CML and AML cells and its development for clinical testing is warranted...
  14. ncbi request reprint Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10 000 Zagreb, Croatia
    J Ethnopharmacol 102:37-45. 2005
    ..It is likely that part of the antitumor efficacy of the assayed components against EAT cells was the results of increased macrophage activity...
  15. ncbi request reprint Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Planta Med 72:20-7. 2006
    ....
  16. ncbi request reprint Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb 10000 Zagreb, Rooseveltov trg 6, Croatia
    Biol Pharm Bull 28:1928-33. 2005
    ..Based on these results, we postulate that the antitumor activity of polyphenolic compounds includes direct cytotoxic effects on tumor cells...
  17. ncbi request reprint Inhibitory effect of water-soluble derivative of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: a possible mode of antitumor action
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Nutr Cancer 47:156-63. 2003
    ....
  18. ncbi request reprint Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP)
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, Croatia
    Biomed Pharmacother 59:561-70. 2005
    ....
  19. ncbi request reprint Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity
    N Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
    Vet Res Commun 29:575-93. 2005
    ....
  20. ncbi request reprint Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds
    Nada Orsolic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000, Croatia
    J Ethnopharmacol 94:307-15. 2004
    ..The experimental data support that WSDP, CA, CAPE and QU could be potentially useful in the control of tumor growth in experimental models...
  21. doi request reprint DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test
    G Brozovic
    Department of Anaesthesiology and ICU, University Hospital for Tumours, HR 10 000 Zagreb, Ilica 197, Croatia
    J Appl Genet 51:79-86. 2010
    ..Number of micronuclei in reticulocytes showed a statistically significant increase, as compared with the control group at all observed times after the treatment...
  22. ncbi request reprint Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice
    V Benkovic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
    Biomed Pharmacother 61:292-7. 2007
    ..These results suggest that clinical trials using a propolis preparation EEP combined with irinotecan may be beneficial in maximizing antitumor activity and minimizing post-chemotherapeutic reactions to the cytostatic drug...
  23. doi request reprint Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay
    V Benkovic
    Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR 10000 Zagreb, Rooseveltov trg 6, Croatia
    Phytomedicine 15:851-8. 2008
    ..The exact mechanisms of radioprotection by these compounds and their effects on DNA repair processes are still to be elucidated...
  24. doi request reprint Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane
    G Brozovic
    University Hospital for Tumours, Department of Anaesthesiology and ICU, Zagreb, Croatia
    Eur J Anaesthesiol 25:642-7. 2008
    ..The influence of the combined application of cisplatin and sevoflurane on a variety of cell types of healthy mice or mice bearing Ehrlich ascites tumour has been investigated in an in vivo study...
  25. ncbi request reprint Quercetin vs chrysin: effect on liver histopathology in diabetic mice
    D Sirovina
    1Division of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
    Hum Exp Toxicol 32:1058-66. 2013
    ..The protective role of flavonoids against the reactive oxygen species-induced damages in diabetic mice gives a hope that they may exert similar protective action in humans. ..
  26. doi request reprint Carbendazim combined with imazalil or cypermethrin potentiate DNA damage in hepatocytes of mice
    D Ðikić
    Department of Animal Physiology, University of Zagreb, Zagreb, Croatia
    Hum Exp Toxicol 31:492-505. 2012
    ....
  27. ncbi request reprint Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukaemia: preclinical evaluation
    Nada Orsolic
    Department of Leukemia, M D Anderson Cancer Center, The University of Texas, Houston 77030 4009, USA
    Br J Haematol 124:727-38. 2004
    ..These data indicate that the combination of troxacitabine and IM has significant preclinical activity in advanced CML and that clinical evaluation of this combination is warranted...
  28. ncbi request reprint Proportions and phenotypic expression of peripheral blood leucocytes in pigs vaccinated with an attenuated C strain and a subunit E2 vaccine against classical swine fever
    S Terzic
    Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia
    J Vet Med B Infect Dis Vet Public Health 50:166-71. 2003
    ..Thus, both vaccines were able to influence the porcine immune system, by activating different subsets of the immune effector/accessory cells...
  29. ncbi request reprint MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells
    Mirna Golemovic
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Invest New Drugs 28:402-12. 2010
    ..This agent, therefore, combines low in vivo toxicity with formidable in vitro pro-apoptotic ROS-mediated activity, and may represent a novel OAD suitable for clinical development against a variety of hematological malignancies...