Giuseppe Orlando

Summary

Publications

  1. ncbi request reprint Abdominal organ bioengineering: current status and future perspectives
    A Peloso
    Wake Forest School of Medicine Winston Salem, NC, USA
    Minerva Chir 70:43-55. 2015
  2. doi request reprint One-shot versus multidose perioperative antibiotic prophylaxis after kidney transplantation: a randomized, controlled clinical trial
    Giuseppe Orlando
    Wake Forest School of Medicine, Winston Salem, NC Electronic address
    Surgery 157:104-10. 2015
  3. doi request reprint Organ bioengineering and regeneration as the new Holy Grail for organ transplantation
    Giuseppe Orlando
    Section of Transplantation, Department of General Surgery, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Ann Surg 258:221-32. 2013
  4. doi request reprint Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies
    Giuseppe Orlando
    Department of General Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC, USA
    Biomaterials 34:5915-25. 2013
  5. doi request reprint Cell and organ bioengineering technology as applied to gastrointestinal diseases
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Gut 62:774-86. 2013
  6. doi request reprint Regeneration and bioengineering of the gastrointestinal tract: current status and future perspectives
    Giuseppe Orlando
    Department of General Surgery, Section of Transplantation, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Dig Liver Dis 44:714-20. 2012
  7. doi request reprint Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann Surg 256:363-70. 2012
  8. pmc Regenerative medicine as applied to general surgery
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA
    Ann Surg 255:867-80. 2012
  9. doi request reprint Immunosuppression-free transplantation reconsidered from a regenerative medicine perspective
    Giuseppe Orlando
    Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Expert Rev Clin Immunol 8:179-87. 2012
  10. pmc Liver bioengineering: current status and future perspectives
    Christopher Booth
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA
    World J Gastroenterol 18:6926-34. 2012

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Abdominal organ bioengineering: current status and future perspectives
    A Peloso
    Wake Forest School of Medicine Winston Salem, NC, USA
    Minerva Chir 70:43-55. 2015
    ..In this review, we describe these methods as well as contemporary successes for various organ systems. ..
  2. doi request reprint One-shot versus multidose perioperative antibiotic prophylaxis after kidney transplantation: a randomized, controlled clinical trial
    Giuseppe Orlando
    Wake Forest School of Medicine, Winston Salem, NC Electronic address
    Surgery 157:104-10. 2015
    ....
  3. doi request reprint Organ bioengineering and regeneration as the new Holy Grail for organ transplantation
    Giuseppe Orlando
    Section of Transplantation, Department of General Surgery, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Ann Surg 258:221-32. 2013
    ....
  4. doi request reprint Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies
    Giuseppe Orlando
    Department of General Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC, USA
    Biomaterials 34:5915-25. 2013
    ..Collectively, these results indicate that discarded human kidneys are a suitable source of renal scaffolds and their use for tissue engineering applications may be more clinically applicable than kidneys derived from animals...
  5. doi request reprint Cell and organ bioengineering technology as applied to gastrointestinal diseases
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Gut 62:774-86. 2013
    ..However, a myriad of technical hurdles must be overcome before transplantable, engineered organs become a reality...
  6. doi request reprint Regeneration and bioengineering of the gastrointestinal tract: current status and future perspectives
    Giuseppe Orlando
    Department of General Surgery, Section of Transplantation, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Dig Liver Dis 44:714-20. 2012
    ....
  7. doi request reprint Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Ann Surg 256:363-70. 2012
    ..Tissue engineering holds the potential to address this issue through the implementation of decellularization-recellularization technology...
  8. pmc Regenerative medicine as applied to general surgery
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA
    Ann Surg 255:867-80. 2012
    ....
  9. doi request reprint Immunosuppression-free transplantation reconsidered from a regenerative medicine perspective
    Giuseppe Orlando
    Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Expert Rev Clin Immunol 8:179-87. 2012
    ..Despite the several hurdles that must be overcome, regenerative medicine technologies offer alternative strategies aimed at establishing immediate, stable and durable IFS in solid organ graft recipients...
  10. pmc Liver bioengineering: current status and future perspectives
    Christopher Booth
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA
    World J Gastroenterol 18:6926-34. 2012
    ..As well, it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix, and how this latter supports and drives cell fate...
  11. doi request reprint Regeneration and bioengineering of transplantable abdominal organs: current status and future challenges
    Christina L Ross
    Wake Forest University School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA
    Expert Opin Biol Ther 13:103-13. 2013
    ..The present manuscript illustrates the state-of-the-art regenerative medicine (RM) investigations aiming to manufacturing abdominal organs for transplant purposes...
  12. pmc Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering
    Sayed Hadi Mirmalek-Sani
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 27157, USA
    Biomaterials 34:5488-95. 2013
    ....
  13. doi request reprint Considerations on the development of a model of kidney bioengineering and regeneration in rats
    Andrea Peloso
    Wake Forest School of Medicine, Winston Salem, NC, USA
    Expert Rev Med Devices 10:597-601. 2013
    ..In this invited commentary, we will address the most critical topics of organ regeneration starting from the above-mentioned experience with the kidney but eventually embracing the whole field of complex modular organs bioengineering. ..
  14. doi request reprint Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes
    Giuseppe Orlando
    Wake Forest School of Medicine, Winston Salem, NC
    Diabetes 63:1433-44. 2014
    ..Collaborative efforts across these subfields of regenerative medicine seek to ultimately produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes. ..
  15. pmc Immunoisolation: where regenerative medicine meets solid organ transplantation
    Rajesh Pareta
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Expert Rev Clin Immunol 8:685-92. 2012
    ..Significant progress achieved in experimental models is leading EPI and IC to clinical translation...
  16. doi request reprint Pancreas transplantation in C-Peptide positive patients: does "type" of diabetes really matter?
    Robert J Stratta
    Department of General Surgery Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Am Coll Surg 220:716-27. 2015
    ..In the past, type 2 (C-peptide positive) diabetes mellitus (DM) was a contraindication for simultaneous pancreas-kidney transplantation (SPKT)...
  17. doi request reprint Influence of recipient age on deceased donor kidney transplant outcomes in the expanded criteria donor era
    Yousef Al-Shraideh
    Department of General Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA
    Clin Transplant 28:1372-82. 2014
    ..We performed a retrospective single-center review of 884 deceased donor (DD) kidney transplants (KTs) in patients (pts) aged ≥40 yr...
  18. ncbi request reprint Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles
    Brian P Sanders
    From the Wake Forest University School of Medicine, Winston Salem, NC, USA
    Exp Clin Transplant 12:371-3. 2014
    ..Available data seem to support the hypothesis that osteogenic precursor cells, inducing factors, and a suitable environment are key for osseous metaplasia. ..
  19. doi request reprint Renal bioengineering with scaffolds generated from human kidneys
    Ravi Katari
    Wake Forest School of Medicine, Winston Salem, N C, USA
    Nephron Exp Nephrol 126:119. 2014
    ..The recellularization of extracellular matrix (ECM) scaffolds has the potential to meet the uniquely ambitious engineering challenges posed by complex solid organs such as the kidney...
  20. doi request reprint Evolving experience using kidneys from deceased donors with terminal acute kidney injury
    Alan C Farney
    Department of General Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Am Coll Surg 216:645-55; discussion 655-6. 2013
    ..Kidney transplantation from deceased donors with terminal acute kidney injury (AKI) is not widely accepted...
  21. doi request reprint Prospect for kidney bioengineering: shortcomings of the status quo
    Andrea Peloso
    Wake Forest School of Medicine, Winston Salem, NC, USA
    Expert Opin Biol Ther 15:547-58. 2015
    ..Regenerative medicine approaches are promising tools aiming to improve this condition...
  22. doi request reprint Depleting antibody induction in simultaneous pancreas-kidney transplantation: a prospective single-center comparison of alemtuzumab versus rabbit anti-thymocyte globulin
    Robert J Stratta
    Wake Forest School of Medicine, Department of General Surgery, Medical Center Blvd, Winston Salem, NC 27157, USA 1 336 716 0548 1 336 713 5055
    Expert Opin Biol Ther 14:1723-30. 2014
    ..The study purpose was to analyze midterm outcomes in a prospective trial of alemtuzumab (Alem) versus rabbit anti-thymocyte globulin (rATG) induction in simultaneous pancreas-kidney transplantation (SPKT)...
  23. pmc Long-term function of islets encapsulated in a redesigned alginate microcapsule construct in omentum pouches of immune-competent diabetic rats
    Rajesh Pareta
    From the Wake Forest Institute for Regenerative Medicine, Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences, and Department of Surgery, Wake Forest School of Medicine, Winston Salem, NC and Department of Biomedical Engineering, Illinois Institute of Technology, Chicago and Research Service, Hines Veterans Administration Hospital, Hines, IL
    Pancreas 43:605-13. 2014
    ..Our study aim was to determine encapsulated islet graft viability in an omentum pouch and the effect of fibroblast growth factor 1 (FGF-1) released from our redesigned alginate microcapsules on the function of the graft...
  24. doi request reprint Pancreas transplantation with portal venous drainage with an emphasis on technical aspects
    Jeffrey Rogers
    Section of Transplantation, Department of General Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Clin Transplant 28:16-26. 2014
    ..The purpose of this study is to review the existing literature on portal-enteric pancreas transplantation with an emphasis on surgical aspects and technical modifications/nuances that have been introduced with time and experience. ..
  25. doi request reprint Whole organ decellularization - a tool for bioscaffold fabrication and organ bioengineering
    Pedro M Baptista
    Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6526-9. 2009
    ..These bioscaffolds can further provide a tool to study cells in their natural three-dimensional environment, which is superior for drug discovery platform compared with cells cultured in two-dimensional petri dishes...
  26. doi request reprint Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels
    Luke R Burnett
    KeraNetics LLC, Winston Salem, NC, USA
    Biomaterials 34:2632-40. 2013
    ..These characteristics allow for a system that can be formulated into several varieties of cell-instructive biomaterials with potential uses in tissue engineering, regenerative medicine, drug and cell delivery, and trauma...
  27. ncbi request reprint Regenerative medicine and organ transplantation: past, present, and future
    Giuseppe Orlando
    1 Wake Forest Institute for Regenerative Medicine, Winston Salem, NC 2 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK 3 Department of General Surgery, Wake Forest University School of Medicine, Winston Salem, NC 4 Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC
    Transplantation 91:1310-7. 2011
    ..Ex vivo organ engineering may benefit from complementary investigations in the fields of developmental biology and stem cells and transplantation before its full potential can be realized...
  28. doi request reprint Simultaneous transplantation of the living donor kidney and deceased donor pancreas and other transplant options for diabetic and uremic patients
    Alan C Farney
    Department of General Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Curr Opin Organ Transplant 20:103-7. 2015
    ....
  29. doi request reprint Immunosuppression for pancreas transplantation with an emphasis on antibody induction strategies: review and perspective
    Robert J Stratta
    Department of General Surgery, Section of Transplantation, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC27157, USA
    Expert Rev Clin Immunol 10:117-32. 2014
    ..However, the development of non-nephrotoxic, nondiabetogenic, and nongastrointestinal toxic regimens is highly desirable to improve quality of life in all solid organ transplant recipients. ..
  30. doi request reprint Novel keratin (KeraStat™) and polyurethane (Nanosan(R)-Sorb) biomaterials are hemostatic in a porcine lethal extremity hemorrhage model
    Luke R Burnett
    1KeraNetics LLC, Winston Salem, NC, USA
    J Biomater Appl 28:869-79. 2014
    ..The Nanosan also swelled considerably and created pressure within the wound site even after direct pressure was removed. ..
  31. doi request reprint Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study
    Jan P Lerut
    Starzl Unit of Abdominal Transplantation Department of Pathology Department Immunology, and Department of Experimental Surgery, University Hospitals Saint Luc, Université catholique Louvain UCL, Brussels, Belgium Department of Liver Transplantation, University of Sao Paulo USP, Sao Paulo, Brazil Department of Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston Salem, NC Hepatobiliary Unit, Imbanaco Medical center, Cali, Colombia
    Ann Surg 260:886-91; discussion 891-2. 2014
    ..To investigate the safety of minimal immunosuppression (IS) in liver transplantation (LT)...
  32. doi request reprint Pancreas transplantation for type 2 diabetes mellitus
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina 27106, USA
    Curr Opin Organ Transplant 16:110-5. 2011
    ..This review will provide evidence that selected patients with type 2 diabetes mellitus (T2DM) may benefit from vascularized pancreas transplantation (PTX)...
  33. doi request reprint The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: the updated follow up at 78 months
    Giuseppe Orlando
    Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA
    Transpl Immunol 20:43-7. 2008
    ..We report the update of the Tor Vergata immunosuppression (IS) weaning protocol in stable hepatitis C virus (HCV) liver transplant (LT) recipients...